Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Anorexia nervosa: diagnostic, therapeutic, and risk biomarkers in clinical practice
Trends Mol Med. 2024 Feb 8:S1471-4914(24)00002-9. doi: 10.1016/j.molmed.2024.01.002. Online ahead of print.ABSTRACTIn anorexia nervosa (AN), measurable biological parameters can inform the process of treating patients. Such biomarkers include established laboratory parameters as well as a range of potential future biomarkers, including genetic, metabolomic, microbiomic, endocrine, immunological, hematological, electrophysiological, and neuroimaging parameters. In this opinion article we discuss how these biomarkers can support diagnosic and therapeutic processes at specific steps during the AN treatment cycle, that is, the...
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Hubertus Himmerich Janet Treasure Source Type: research
Hyaluronan deposition during COVID-19 - helpful or harmful?
Trends Mol Med. 2024 Feb 7:S1471-4914(24)00003-0. doi: 10.1016/j.molmed.2024.01.003. Online ahead of print.ABSTRACTHyaluronan (HA), an extracellular matrix polysaccharide, is increased in the lungs during COVID-19 and correlates with severity. HA acts as an immune mediator that aids cell trafficking and intracellular signaling, but its role in COVID-19 is debated. Although HA is implicated in pulmonary viral disease pathogenesis, some studies suggest a potential protective function in COVID-19.PMID:38331701 | DOI:10.1016/j.molmed.2024.01.003 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 8, 2024 Category: Molecular Biology Authors: Duncan Hart William A Petri Source Type: research
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation
Trends Mol Med. 2024 Feb 5:S1471-4914(24)00001-7. doi: 10.1016/j.molmed.2024.01.001. Online ahead of print.ABSTRACTThe intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically target inflammatory mediators and have led to improvement of clinical outcomes; however, a significant proportion of patients exp...
Source: Trends in Molecular Medicine - February 6, 2024 Category: Molecular Biology Authors: Annika Hausmann Casper Steenholdt Ole H Nielsen Kim B Jensen Source Type: research
TIM-3 inhibitors: a promising strategy for tumor immunotherapy
Trends Mol Med. 2024 Jan 31:S1471-4914(24)00004-2. doi: 10.1016/j.molmed.2024.01.004. Online ahead of print.ABSTRACTMa et al. recently reported a systematic screening of small-molecule compounds targeting the FG-CC' cleft of T cell immunoglobulin and mucin-containing molecule 3 (TIM-3). They identified a functional Tim-3 inhibitor, ML-T7, that, as a single agent or in combination with anti-PD-1, demonstrated strong antitumor activity in preclinical mouse tumor models, supporting its potential for further clinical translation.PMID:38302316 | DOI:10.1016/j.molmed.2024.01.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - February 1, 2024 Category: Molecular Biology Authors: Lu Lu Liufu Deng Source Type: research
