Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms
Trends Mol Med. 2023 Nov 7:S1471-4914(23)00250-2. doi: 10.1016/j.molmed.2023.10.007. Online ahead of print.ABSTRACTAge-related loss of brain function has been seen as inevitable, yet recent work leveraging the systemic environment challenges this notion. Schroer et al. demonstrate that youth-associated platelet factor 4 (PF4) partially restores brain function in aged mice while reducing peripheral immune dysfunction, supporting periphery-based approaches to treat age-associated brain disorders.PMID:37945435 | DOI:10.1016/j.molmed.2023.10.007 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 9, 2023 Category: Molecular Biology Authors: Brittany M Hemmer Sarah M Philippi Joseph M Castellano Source Type: research
Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms
Trends Mol Med. 2023 Nov 7:S1471-4914(23)00250-2. doi: 10.1016/j.molmed.2023.10.007. Online ahead of print.ABSTRACTAge-related loss of brain function has been seen as inevitable, yet recent work leveraging the systemic environment challenges this notion. Schroer et al. demonstrate that youth-associated platelet factor 4 (PF4) partially restores brain function in aged mice while reducing peripheral immune dysfunction, supporting periphery-based approaches to treat age-associated brain disorders.PMID:37945435 | DOI:10.1016/j.molmed.2023.10.007 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 9, 2023 Category: Molecular Biology Authors: Brittany M Hemmer Sarah M Philippi Joseph M Castellano Source Type: research
Postdoctoral mentorship needs a reform
Trends Mol Med. 2023 Oct 31:S1471-4914(23)00237-X. doi: 10.1016/j.molmed.2023.10.002. Online ahead of print.ABSTRACTTo retain talented scientists in academia, there is a need for structural reform to postdoctoral researcher (postdoc) mentorship. These changes include mentorship training for postdocs and their mentors, formalizing postdoc mentorship networks and postdoc cohorts within a department, and incorporating mentorship development plans (MDPs) in funding decisions for principal investigators (PIs).PMID:37919226 | DOI:10.1016/j.molmed.2023.10.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 2, 2023 Category: Molecular Biology Authors: Navika Gangrade W Marcus Lambert Source Type: research
Postdoctoral mentorship needs a reform
Trends Mol Med. 2023 Oct 31:S1471-4914(23)00237-X. doi: 10.1016/j.molmed.2023.10.002. Online ahead of print.ABSTRACTTo retain talented scientists in academia, there is a need for structural reform to postdoctoral researcher (postdoc) mentorship. These changes include mentorship training for postdocs and their mentors, formalizing postdoc mentorship networks and postdoc cohorts within a department, and incorporating mentorship development plans (MDPs) in funding decisions for principal investigators (PIs).PMID:37919226 | DOI:10.1016/j.molmed.2023.10.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 2, 2023 Category: Molecular Biology Authors: Navika Gangrade W Marcus Lambert Source Type: research
Postdoctoral mentorship needs a reform
Trends Mol Med. 2023 Oct 31:S1471-4914(23)00237-X. doi: 10.1016/j.molmed.2023.10.002. Online ahead of print.ABSTRACTTo retain talented scientists in academia, there is a need for structural reform to postdoctoral researcher (postdoc) mentorship. These changes include mentorship training for postdocs and their mentors, formalizing postdoc mentorship networks and postdoc cohorts within a department, and incorporating mentorship development plans (MDPs) in funding decisions for principal investigators (PIs).PMID:37919226 | DOI:10.1016/j.molmed.2023.10.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 2, 2023 Category: Molecular Biology Authors: Navika Gangrade W Marcus Lambert Source Type: research
Postdoctoral mentorship needs a reform
Trends Mol Med. 2023 Oct 31:S1471-4914(23)00237-X. doi: 10.1016/j.molmed.2023.10.002. Online ahead of print.ABSTRACTTo retain talented scientists in academia, there is a need for structural reform to postdoctoral researcher (postdoc) mentorship. These changes include mentorship training for postdocs and their mentors, formalizing postdoc mentorship networks and postdoc cohorts within a department, and incorporating mentorship development plans (MDPs) in funding decisions for principal investigators (PIs).PMID:37919226 | DOI:10.1016/j.molmed.2023.10.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 2, 2023 Category: Molecular Biology Authors: Navika Gangrade W Marcus Lambert Source Type: research
Postdoctoral mentorship needs a reform
Trends Mol Med. 2023 Oct 31:S1471-4914(23)00237-X. doi: 10.1016/j.molmed.2023.10.002. Online ahead of print.ABSTRACTTo retain talented scientists in academia, there is a need for structural reform to postdoctoral researcher (postdoc) mentorship. These changes include mentorship training for postdocs and their mentors, formalizing postdoc mentorship networks and postdoc cohorts within a department, and incorporating mentorship development plans (MDPs) in funding decisions for principal investigators (PIs).PMID:37919226 | DOI:10.1016/j.molmed.2023.10.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 2, 2023 Category: Molecular Biology Authors: Navika Gangrade W Marcus Lambert Source Type: research
Postdoctoral mentorship needs a reform
Trends Mol Med. 2023 Oct 31:S1471-4914(23)00237-X. doi: 10.1016/j.molmed.2023.10.002. Online ahead of print.ABSTRACTTo retain talented scientists in academia, there is a need for structural reform to postdoctoral researcher (postdoc) mentorship. These changes include mentorship training for postdocs and their mentors, formalizing postdoc mentorship networks and postdoc cohorts within a department, and incorporating mentorship development plans (MDPs) in funding decisions for principal investigators (PIs).PMID:37919226 | DOI:10.1016/j.molmed.2023.10.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - November 2, 2023 Category: Molecular Biology Authors: Navika Gangrade W Marcus Lambert Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
CXCR2 chemokine receptor - a master regulator in cancer and physiology
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00218-6. doi: 10.1016/j.molmed.2023.09.003. Online ahead of print.ABSTRACTRecent findings have modified our understanding of the roles of chemokine receptor CXCR2 and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific knockout mice show that this receptor is involved in, among other things, cancer, central nervous system (CNS) function, metabolism, reproduction, COVID-19, and the response to circadian cycles. Moreover, CXCR2 involvement in neutrophil function has been revisited not only in physiology but also for its major contribution to cancers. T...
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Gwendal Lazennec Krishna Rajarathnam Ann Richmond Source Type: research
Time-restricted feeding and Alzheimer's disease: you are when you eat
Trends Mol Med. 2023 Oct 21:S1471-4914(23)00239-3. doi: 10.1016/j.molmed.2023.10.004. Online ahead of print.ABSTRACTTime-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.PMID:37872024 | DOI:10.1016/j.molmed.2023.10.004 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - October 23, 2023 Category: Molecular Biology Authors: Melvin W King Yining Chen Erik S Musiek Source Type: research
