Emerging roles of MRG15 in liver metabolic diseases
Trends Mol Med. 2024 Mar 22:S1471-4914(24)00057-1. doi: 10.1016/j.molmed.2024.03.002. Online ahead of print.ABSTRACTMORF4 (mortality factor on chromosome 4)-related gene 15 (MRG15) is a chromodomain protein that exists in various multiprotein complexes involved in transcription, DNA repair, and development. Here we summarize the recent advances involving MRG15 in modulating liver metabolism, both through its chromatin-binding capability and independently of it, highlighting MRG15 as a potential therapeutic target for liver metabolic diseases.PMID:38521716 | DOI:10.1016/j.molmed.2024.03.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 23, 2024 Category: Molecular Biology Authors: Cheng Tian Xiaosong Gu Chunping Jiang Qiurong Ding Source Type: research
Emerging roles of MRG15 in liver metabolic diseases
Trends Mol Med. 2024 Mar 22:S1471-4914(24)00057-1. doi: 10.1016/j.molmed.2024.03.002. Online ahead of print.ABSTRACTMORF4 (mortality factor on chromosome 4)-related gene 15 (MRG15) is a chromodomain protein that exists in various multiprotein complexes involved in transcription, DNA repair, and development. Here we summarize the recent advances involving MRG15 in modulating liver metabolism, both through its chromatin-binding capability and independently of it, highlighting MRG15 as a potential therapeutic target for liver metabolic diseases.PMID:38521716 | DOI:10.1016/j.molmed.2024.03.002 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 23, 2024 Category: Molecular Biology Authors: Cheng Tian Xiaosong Gu Chunping Jiang Qiurong Ding Source Type: research
Science around the world
Trends Mol Med. 2024 Mar 21:S1471-4914(24)00040-6. doi: 10.1016/j.molmed.2024.02.015. Online ahead of print.NO ABSTRACTPMID:38519348 | DOI:10.1016/j.molmed.2024.02.015 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Fernando Fernandez-Aranda Jue Chen Claire Foldi Hubertus Himmerich Janet Treasure Jiayi Xu Source Type: research
New media facilitate adolescents' body dissatisfaction and eating disorders in Mainland China
Trends Mol Med. 2024 Mar 22:S1471-4914(24)00036-4. doi: 10.1016/j.molmed.2024.02.011. Online ahead of print.ABSTRACTNew media play a significant role in adolescents' body dissatisfaction and eating disorders in Mainland China, through shaping social standards, peers, and family dynamics. How to mitigate their adverse effects on adolescents, reduce body dissatisfaction, and prevent eating disorders is a significant social issue that demands serious consideration.PMID:38519349 | DOI:10.1016/j.molmed.2024.02.011 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Jue Chen Sufang Peng Yaohui Wei Source Type: research
Amphiphysin-2 (BIN1) functions and defects in cardiac and skeletal muscle
Trends Mol Med. 2024 Mar 20:S1471-4914(24)00030-3. doi: 10.1016/j.molmed.2024.02.005. Online ahead of print.ABSTRACTAmphiphysin-2 is a ubiquitously expressed protein also known as bridging integrator 1 (BIN1), playing a critical role in membrane remodeling, trafficking, and cytoskeleton dynamics in a wide range of tissues. Mutations in the gene encoding BIN1 cause centronuclear myopathies (CNM), and recent evidence has implicated BIN1 in heart failure, underlining its crucial role in both skeletal and cardiac muscle. Furthermore, altered expression of BIN1 is linked to an increased risk of late-onset Alzheimer's disease an...
Source: Trends in Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Quentin Giraud Jocelyn Laporte Source Type: research
Amphiphysin-2 (BIN1) functions and defects in cardiac and skeletal muscle
Trends Mol Med. 2024 Mar 20:S1471-4914(24)00030-3. doi: 10.1016/j.molmed.2024.02.005. Online ahead of print.ABSTRACTAmphiphysin-2 is a ubiquitously expressed protein also known as bridging integrator 1 (BIN1), playing a critical role in membrane remodeling, trafficking, and cytoskeleton dynamics in a wide range of tissues. Mutations in the gene encoding BIN1 cause centronuclear myopathies (CNM), and recent evidence has implicated BIN1 in heart failure, underlining its crucial role in both skeletal and cardiac muscle. Furthermore, altered expression of BIN1 is linked to an increased risk of late-onset Alzheimer's disease an...
Source: Trends in Molecular Medicine - March 21, 2024 Category: Molecular Biology Authors: Quentin Giraud Jocelyn Laporte Source Type: research
The current sociocultural background of eating disorders
Trends Mol Med. 2024 Mar 18:S1471-4914(24)00035-2. doi: 10.1016/j.molmed.2024.02.010. Online ahead of print.ABSTRACTEating disorders (EDs) are complex phenomena that are partly influenced by sociocultural factors. The thin body ideal of Western civilization, disseminated by mass media and reinforced by the fashion industry, plays a significant role. In this cultural environment, the social perception of the human body has undergone a change.PMID:38503682 | DOI:10.1016/j.molmed.2024.02.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Nikolett Bog ár Bea P ászthy Ferenc T úry Source Type: research
Established and emerging treatments for eating disorders
Trends Mol Med. 2024 Mar 18:S1471-4914(24)00034-0. doi: 10.1016/j.molmed.2024.02.009. Online ahead of print.ABSTRACTEating disorders (EDs) are common mental health conditions that carry exceedingly high morbidity and mortality rates. Evidence-based treatment options include a range of psychotherapies and some, mainly adjunctive, pharmacological interventions. However, around 20-30% of people fail to respond to the best available treatments and develop a persistent treatment-refractory illness. Novel treatments for these disorders are emerging, but their efficacy and clinical relevance need further investigation. In this re...
Source: Trends in Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Callum Bryson Daire Douglas Ulrike Schmidt Source Type: research
The current sociocultural background of eating disorders
Trends Mol Med. 2024 Mar 18:S1471-4914(24)00035-2. doi: 10.1016/j.molmed.2024.02.010. Online ahead of print.ABSTRACTEating disorders (EDs) are complex phenomena that are partly influenced by sociocultural factors. The thin body ideal of Western civilization, disseminated by mass media and reinforced by the fashion industry, plays a significant role. In this cultural environment, the social perception of the human body has undergone a change.PMID:38503682 | DOI:10.1016/j.molmed.2024.02.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Nikolett Bog ár Bea P ászthy Ferenc T úry Source Type: research
Established and emerging treatments for eating disorders
Trends Mol Med. 2024 Mar 18:S1471-4914(24)00034-0. doi: 10.1016/j.molmed.2024.02.009. Online ahead of print.ABSTRACTEating disorders (EDs) are common mental health conditions that carry exceedingly high morbidity and mortality rates. Evidence-based treatment options include a range of psychotherapies and some, mainly adjunctive, pharmacological interventions. However, around 20-30% of people fail to respond to the best available treatments and develop a persistent treatment-refractory illness. Novel treatments for these disorders are emerging, but their efficacy and clinical relevance need further investigation. In this re...
Source: Trends in Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Callum Bryson Daire Douglas Ulrike Schmidt Source Type: research
The current sociocultural background of eating disorders
Trends Mol Med. 2024 Mar 18:S1471-4914(24)00035-2. doi: 10.1016/j.molmed.2024.02.010. Online ahead of print.ABSTRACTEating disorders (EDs) are complex phenomena that are partly influenced by sociocultural factors. The thin body ideal of Western civilization, disseminated by mass media and reinforced by the fashion industry, plays a significant role. In this cultural environment, the social perception of the human body has undergone a change.PMID:38503682 | DOI:10.1016/j.molmed.2024.02.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Nikolett Bog ár Bea P ászthy Ferenc T úry Source Type: research
Established and emerging treatments for eating disorders
Trends Mol Med. 2024 Mar 18:S1471-4914(24)00034-0. doi: 10.1016/j.molmed.2024.02.009. Online ahead of print.ABSTRACTEating disorders (EDs) are common mental health conditions that carry exceedingly high morbidity and mortality rates. Evidence-based treatment options include a range of psychotherapies and some, mainly adjunctive, pharmacological interventions. However, around 20-30% of people fail to respond to the best available treatments and develop a persistent treatment-refractory illness. Novel treatments for these disorders are emerging, but their efficacy and clinical relevance need further investigation. In this re...
Source: Trends in Molecular Medicine - March 19, 2024 Category: Molecular Biology Authors: Callum Bryson Daire Douglas Ulrike Schmidt Source Type: research
mRNA vaccine platforms to prevent bacterial infections
This article discusses recent advances and limitations of mRNA vaccines to prevent bacterial diseases and provides perspectives on future research directions.PMID:38485647 | DOI:10.1016/j.molmed.2024.02.013 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 14, 2024 Category: Molecular Biology Authors: Carson Bergstrom Nicholas O Fischer Jessica Z Kubicek-Sutherland Zachary R Stromberg Source Type: research
Eating disorders and obesity: bridging clinical, neurobiological, and therapeutic perspectives
Trends Mol Med. 2024 Mar 13:S1471-4914(24)00032-7. doi: 10.1016/j.molmed.2024.02.007. Online ahead of print.ABSTRACTEating disorders (EDs) and obesity are complex health conditions sharing various risk and maintenance factors, intensified in cases of comorbidity. This review explores the similarities and connections between these conditions, examining different facets from a multidisciplinary perspective, among them comorbidities, metabolic and psychological factors, neurobiological aspects, and management and therapy implications. We aim to investigate the common characteristics and complexities of weight and EDs and expl...
Source: Trends in Molecular Medicine - March 14, 2024 Category: Molecular Biology Authors: Lucia Camacho-Barcia Katrin Elisabeth Giel Susana Jim énez-Murcia Julio Álvarez Pitti Nadia Micali Ignacio Lucas Romina Miranda-Olivos Lucero Munguia Manuel Tena-Sempere Stephan Zipfel Fernando Fern ández-Aranda Source Type: research
mRNA vaccine platforms to prevent bacterial infections
This article discusses recent advances and limitations of mRNA vaccines to prevent bacterial diseases and provides perspectives on future research directions.PMID:38485647 | DOI:10.1016/j.molmed.2024.02.013 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - March 14, 2024 Category: Molecular Biology Authors: Carson Bergstrom Nicholas O Fischer Jessica Z Kubicek-Sutherland Zachary R Stromberg Source Type: research
