In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
In vitro Permeation of Nicotine and Tobacco Specific Nitrosamines from Smokeless Tobacco Product Extracts in a 3D Buccal Tissue Model
Toxicol Lett. 2023 Dec 22:S0378-4274(23)01120-7. doi: 10.1016/j.toxlet.2023.12.013. Online ahead of print.ABSTRACTTobacco product use is a risk factor in the development of oral cancer, although epidemiology studies show this risk is far less with smokeless tobacco product use than cigarette smoking. While smokeless tobacco contains harmful and potentially harmful constituents (HPHCs), the oral permeation of HPHCs in oral tobacco products is not completely understood. To improve the understanding, three different extract concentrations of the CORESTA reference products (CRP) for snus (CRP1.1) and moist snuff (CRP2.1) were ...
Source: Toxicology Letters - December 24, 2023 Category: Toxicology Authors: Brian M Keyser Hannah Flockton Randy A Weidman Rebecca Payne Jannell Rowe Kristen G Jordan Source Type: research
Acrolein suppresses anticancer drug-induced toxicity mediated by activating claudin-1 and Nrf2 axis in a spheroid model of human lung squamous cell carcinoma cells
In this study, we found that acrolein increases the mRNA and protein levels of CLDN1 in RERF-LC-AI cells derived from human lung squamous cell carcinoma (SCC). Acrolein increased the p-extracellular signal-regulated kinase (ERK) 1/2 levels without affecting the p-Akt level. The acrolein-induced elevation of CLDN1 expression was attenuated by U0126, a mitogen-activated protein kinase kinas (MEK) inhibitor. These results indicate that the activation of MEK/ERK pathway is involved in the acrolein-induced elevation of CLDN1 expression. In a spheroid model, acrolein suppressed the accumulation and toxicity of doxorubicin (DXR),...
Source: Toxicology Letters - December 23, 2023 Category: Toxicology Authors: Hiroaki Eguchi Yaqing Yu Toshiyuki Matsunaga Yuta Yoshino Akira Ikari Source Type: research
Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury
In conclusion, the metabolic activation of the furan ring of dictamnine resulted in the protein adduction by multiple hepatic aldehydes and the protein modification played a crucial role in dictamnine-induced liver injury.PMID:38128889 | DOI:10.1016/j.toxlet.2023.12.010 (Source: Toxicology Letters)
Source: Toxicology Letters - December 21, 2023 Category: Toxicology Authors: Qi Luo Yang Shen Guohong Zhai Lin Chen Furong Ou Luxi Yi Danli Yang Hong Pan Fuguo Shi Source Type: research
Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury
In conclusion, the metabolic activation of the furan ring of dictamnine resulted in the protein adduction by multiple hepatic aldehydes and the protein modification played a crucial role in dictamnine-induced liver injury.PMID:38128889 | DOI:10.1016/j.toxlet.2023.12.010 (Source: Toxicology Letters)
Source: Toxicology Letters - December 21, 2023 Category: Toxicology Authors: Qi Luo Yang Shen Guohong Zhai Lin Chen Furong Ou Luxi Yi Danli Yang Hong Pan Fuguo Shi Source Type: research
Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury
In conclusion, the metabolic activation of the furan ring of dictamnine resulted in the protein adduction by multiple hepatic aldehydes and the protein modification played a crucial role in dictamnine-induced liver injury.PMID:38128889 | DOI:10.1016/j.toxlet.2023.12.010 (Source: Toxicology Letters)
Source: Toxicology Letters - December 21, 2023 Category: Toxicology Authors: Qi Luo Yang Shen Guohong Zhai Lin Chen Furong Ou Luxi Yi Danli Yang Hong Pan Fuguo Shi Source Type: research
Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via downregulation of aquaporins
In conclusion, we demonstrate that PFOA exposure can damage the renal filtration barrier and reduce the expression level of AQPs in renal tissues, leading to renal filtration and reabsorption disorders.PMID:38123106 | DOI:10.1016/j.toxlet.2023.12.003 (Source: Toxicology Letters)
Source: Toxicology Letters - December 20, 2023 Category: Toxicology Authors: Li Wang Weiqiang Sun Xinzhuang Ma Nathan Griffin Hui Liu Source Type: research
Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via downregulation of aquaporins
In conclusion, we demonstrate that PFOA exposure can damage the renal filtration barrier and reduce the expression level of AQPs in renal tissues, leading to renal filtration and reabsorption disorders.PMID:38123106 | DOI:10.1016/j.toxlet.2023.12.003 (Source: Toxicology Letters)
Source: Toxicology Letters - December 20, 2023 Category: Toxicology Authors: Li Wang Weiqiang Sun Xinzhuang Ma Nathan Griffin Hui Liu Source Type: research
The Mechanism of Blood Coagulation Induced by Sodium Dehydroacetate via the Regulation of the mTOR/ERK Pathway in Rats
Toxicol Lett. 2023 Dec 14:S0378-4274(23)01117-7. doi: 10.1016/j.toxlet.2023.12.009. Online ahead of print.ABSTRACTDehydroacetic acid (DHA-S), a potent antifungal and antibacterial agent, is widely used in food, feed and cosmetics. However, recent studies have shown that DHA-S could pose a risk for human and animal health. We had previously reported that DHA-S could cause coagulation disorders in rats and chicken. In the present study, we further confirmed that DHA-S induced blood coagulation via VKORC1 and VKORC1L1 in rats, and elucidated the role played by mTOR/ERK signaling. The in vivo studies demonstrated that PT, APTT...
Source: Toxicology Letters - December 16, 2023 Category: Toxicology Authors: Meng Zhang Qingqi Zhang Weiya Zhao Xin Chen Yumei Zhang Source Type: research
The Mechanism of Blood Coagulation Induced by Sodium Dehydroacetate via the Regulation of the mTOR/ERK Pathway in Rats
Toxicol Lett. 2023 Dec 14:S0378-4274(23)01117-7. doi: 10.1016/j.toxlet.2023.12.009. Online ahead of print.ABSTRACTDehydroacetic acid (DHA-S), a potent antifungal and antibacterial agent, is widely used in food, feed and cosmetics. However, recent studies have shown that DHA-S could pose a risk for human and animal health. We had previously reported that DHA-S could cause coagulation disorders in rats and chicken. In the present study, we further confirmed that DHA-S induced blood coagulation via VKORC1 and VKORC1L1 in rats, and elucidated the role played by mTOR/ERK signaling. The in vivo studies demonstrated that PT, APTT...
Source: Toxicology Letters - December 16, 2023 Category: Toxicology Authors: Meng Zhang Qingqi Zhang Weiya Zhao Xin Chen Yumei Zhang Source Type: research
