The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chengshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chenshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The metabolic activation of pentachlorophenol to chloranil as a potent inhibitor of human and rat placental 3 β-hydroxysteroid dehydrogenases
In conclusion, PCP is metabolically activated to chloranil as a potent inhibitor of human 3β-HSD1.PMID:38555059 | DOI:10.1016/j.toxlet.2024.03.007 (Source: Toxicology Letters)
Source: Toxicology Letters - March 30, 2024 Category: Toxicology Authors: Weibing Zhang Ming Su Hao Lin Chenshuang Pan Yunbing Tang Ren-Shan Ge Qianjin Fei Source Type: research
The disrupting effect of chlormequat chloride on growth hormone is associated with pregnancy
Toxicol Lett. 2024 Mar 27;395:17-25. doi: 10.1016/j.toxlet.2024.03.004. Online ahead of print.ABSTRACTSince chlormequat chloride is widely applied as a plant growth regulator in agriculture and horticulture, its exposure through food consumption is common. We demonstrated previously that chlormequat chloride exposure during pregnancy led to embryos with bigger sizes associated with higher levels of growth hormone (GH) on gestation day 11 (GD11). However, the dose-effect relationship of chlormequat chloride at a lower dose range was not established, and the underlying mechanisms of its promoting effects on embryonic growth ...
Source: Toxicology Letters - March 29, 2024 Category: Toxicology Authors: Zongzhen Wu Long Ma Deqi Su Bayindala Xiagedeer Source Type: research
Cyclosporine A-Induced Systemic Metabolic Perturbations in Rats: A Comprehensive Metabolome Analysis
Toxicol Lett. 2024 Mar 27:S0378-4274(24)00063-8. doi: 10.1016/j.toxlet.2024.03.009. Online ahead of print.ABSTRACTA better understanding of cyclosporine A (CsA)-induced nephro- and hepatotoxicity at the molecular level is necessary for safe and effective use. Utilizing a sophisticated study design, this study explored metabolic alterations after long-term CsA treatment in vivo. Rats were exposed to CsA with 4, 10, and 25mg/kg for 4 weeks and then sacrificed to obtain liver, kidney, urine, and serum for untargeted metabolomics analysis. Differential network analysis was conducted to explore the biological relevance of metab...
Source: Toxicology Letters - March 29, 2024 Category: Toxicology Authors: Nguyen Thi Hai Yen Nguyen Tran Nam Tien Nguyen Thi Van Anh Quoc-Viet Le Cho Eunsu Ho-Sook Kim Kyoung-Sik Moon Huy Truong Nguyen Dong Hyun Kim Nguyen Phuoc Long Source Type: research
Enhanced study design for acute inhalation studies with hydrophobic surface-treated particles to determine toxicological effects including suffocation
Toxicol Lett. 2024 Mar 20:S0378-4274(24)00054-7. doi: 10.1016/j.toxlet.2024.03.006. Online ahead of print.ABSTRACTHigh concentrations of low-density particles may cause effects in acute inhalation toxicity studies which can be easily underestimated or misinterpreted following strictly the OECD TG 436, i.e., limited parameters as mortality and gross lesions will be evaluated only. Seven particle types (synthetic amorphous silica (SAS) HMDZ-SAS, silica gel, pyrogenic SAS, and precipitated SAS, calcium carbonate, aluminum oxide pyrogenic alumina, organic red pigment) were chosen at the highest technically feasible concentrati...
Source: Toxicology Letters - March 22, 2024 Category: Toxicology Authors: Gustav Gerd Bruer Otto Creutzenberg Paula Janssen Nils Krueger J ürgen Nolde Mehmet Ramazanoglu Dirk Schaudien Tobias B Schuster Michael Stintz Nils Warfving Benno Wessely Klaus Weber Source Type: research
Enhanced study design for acute inhalation studies with hydrophobic surface-treated particles to determine toxicological effects including suffocation
Toxicol Lett. 2024 Mar 20:S0378-4274(24)00054-7. doi: 10.1016/j.toxlet.2024.03.006. Online ahead of print.ABSTRACTHigh concentrations of low-density particles may cause effects in acute inhalation toxicity studies which can be easily underestimated or misinterpreted following strictly the OECD TG 436, i.e., limited parameters as mortality and gross lesions will be evaluated only. Seven particle types (synthetic amorphous silica (SAS) HMDZ-SAS, silica gel, pyrogenic SAS, and precipitated SAS, calcium carbonate, aluminum oxide pyrogenic alumina, organic red pigment) were chosen at the highest technically feasible concentrati...
Source: Toxicology Letters - March 22, 2024 Category: Toxicology Authors: Gustav Gerd Bruer Otto Creutzenberg Paula Janssen Nils Krueger J ürgen Nolde Mehmet Ramazanoglu Dirk Schaudien Tobias B Schuster Michael Stintz Nils Warfving Benno Wessely Klaus Weber Source Type: research
Enhanced study design for acute inhalation studies with hydrophobic surface-treated particles to determine toxicological effects including suffocation
Toxicol Lett. 2024 Mar 20:S0378-4274(24)00054-7. doi: 10.1016/j.toxlet.2024.03.006. Online ahead of print.ABSTRACTHigh concentrations of low-density particles may cause effects in acute inhalation toxicity studies which can be easily underestimated or misinterpreted following strictly the OECD TG 436, i.e., limited parameters as mortality and gross lesions will be evaluated only. Seven particle types (synthetic amorphous silica (SAS) HMDZ-SAS, silica gel, pyrogenic SAS, and precipitated SAS, calcium carbonate, aluminum oxide pyrogenic alumina, organic red pigment) were chosen at the highest technically feasible concentrati...
Source: Toxicology Letters - March 22, 2024 Category: Toxicology Authors: Gustav Gerd Bruer Otto Creutzenberg Paula Janssen Nils Krueger J ürgen Nolde Mehmet Ramazanoglu Dirk Schaudien Tobias B Schuster Michael Stintz Nils Warfving Benno Wessely Klaus Weber Source Type: research
Enhanced study design for acute inhalation studies with hydrophobic surface-treated particles to determine toxicological effects including suffocation
Toxicol Lett. 2024 Mar 20:S0378-4274(24)00054-7. doi: 10.1016/j.toxlet.2024.03.006. Online ahead of print.ABSTRACTHigh concentrations of low-density particles may cause effects in acute inhalation toxicity studies which can be easily underestimated or misinterpreted following strictly the OECD TG 436, i.e., limited parameters as mortality and gross lesions will be evaluated only. Seven particle types (synthetic amorphous silica (SAS) HMDZ-SAS, silica gel, pyrogenic SAS, and precipitated SAS, calcium carbonate, aluminum oxide pyrogenic alumina, organic red pigment) were chosen at the highest technically feasible concentrati...
Source: Toxicology Letters - March 22, 2024 Category: Toxicology Authors: Gustav Gerd Bruer Otto Creutzenberg Paula Janssen Nils Krueger J ürgen Nolde Mehmet Ramazanoglu Dirk Schaudien Tobias B Schuster Michael Stintz Nils Warfving Benno Wessely Klaus Weber Source Type: research
Enhanced study design for acute inhalation studies with hydrophobic surface-treated particles to determine toxicological effects including suffocation
Toxicol Lett. 2024 Mar 20:S0378-4274(24)00054-7. doi: 10.1016/j.toxlet.2024.03.006. Online ahead of print.ABSTRACTHigh concentrations of low-density particles may cause effects in acute inhalation toxicity studies which can be easily underestimated or misinterpreted following strictly the OECD TG 436, i.e., limited parameters as mortality and gross lesions will be evaluated only. Seven particle types (synthetic amorphous silica (SAS) HMDZ-SAS, silica gel, pyrogenic SAS, and precipitated SAS, calcium carbonate, aluminum oxide pyrogenic alumina, organic red pigment) were chosen at the highest technically feasible concentrati...
Source: Toxicology Letters - March 22, 2024 Category: Toxicology Authors: Gustav Gerd Bruer Otto Creutzenberg Paula Janssen Nils Krueger J ürgen Nolde Mehmet Ramazanoglu Dirk Schaudien Tobias B Schuster Michael Stintz Nils Warfving Benno Wessely Klaus Weber Source Type: research
Enhanced study design for acute inhalation studies with hydrophobic surface-treated particles to determine toxicological effects including suffocation
Toxicol Lett. 2024 Mar 20:S0378-4274(24)00054-7. doi: 10.1016/j.toxlet.2024.03.006. Online ahead of print.ABSTRACTHigh concentrations of low-density particles may cause effects in acute inhalation toxicity studies which can be easily underestimated or misinterpreted following strictly the OECD TG 436, i.e., limited parameters as mortality and gross lesions will be evaluated only. Seven particle types (synthetic amorphous silica (SAS) HMDZ-SAS, silica gel, pyrogenic SAS, and precipitated SAS, calcium carbonate, aluminum oxide pyrogenic alumina, organic red pigment) were chosen at the highest technically feasible concentrati...
Source: Toxicology Letters - March 22, 2024 Category: Toxicology Authors: Gustav Gerd Bruer Otto Creutzenberg Paula Janssen Nils Krueger J ürgen Nolde Mehmet Ramazanoglu Dirk Schaudien Tobias B Schuster Michael Stintz Nils Warfving Benno Wessely Klaus Weber Source Type: research
Systemic Inflammation Indices as Hematological Biomarkers of Inflammatory Response in Non-silicotic Workers Exposed to Respirable Silica Dust
Toxicol Lett. 2024 Mar 19:S0378-4274(24)00053-5. doi: 10.1016/j.toxlet.2024.03.005. Online ahead of print.ABSTRACTThis cross-sectional study was performed to assess whether systemic inflammatory indices, including systemic inflammation response index (SIRI), systemic immune‑inflammation index (SII), and aggregate index of systemic inflammation (AISI), can be considered as possible inflammatory markers in silica-exposed workers with no diagnosis of silicosis. We studied 371 non-silicotic workers exposed to respirable silica dust (RSD) and 1422 reference workers. The workers' exposure to RSD were assessed and the inflammat...
Source: Toxicology Letters - March 21, 2024 Category: Toxicology Authors: Amirmohammad Rezaei Mohammad Ebrahim Ghafari Younes Sohrabi Fereshteh Aliasghari Saeed Yousefinejad Esmaeel Soleimani Saeed Jafari Source Type: research
Systemic Inflammation Indices as Hematological Biomarkers of Inflammatory Response in Non-silicotic Workers Exposed to Respirable Silica Dust
Toxicol Lett. 2024 Mar 19:S0378-4274(24)00053-5. doi: 10.1016/j.toxlet.2024.03.005. Online ahead of print.ABSTRACTThis cross-sectional study was performed to assess whether systemic inflammatory indices, including systemic inflammation response index (SIRI), systemic immune‑inflammation index (SII), and aggregate index of systemic inflammation (AISI), can be considered as possible inflammatory markers in silica-exposed workers with no diagnosis of silicosis. We studied 371 non-silicotic workers exposed to respirable silica dust (RSD) and 1422 reference workers. The workers' exposure to RSD were assessed and the inflammat...
Source: Toxicology Letters - March 21, 2024 Category: Toxicology Authors: Amirmohammad Rezaei Mohammad Ebrahim Ghafari Younes Sohrabi Fereshteh Aliasghari Saeed Yousefinejad Esmaeel Soleimani Saeed Jafari Source Type: research
Reactive Skin Decontamination Lotion (RSDL) safety with clinical antiseptics and hemostatic agents
Toxicol Lett. 2024 Mar 12:S0378-4274(24)00039-0. doi: 10.1016/j.toxlet.2024.02.014. Online ahead of print.ABSTRACTReactive skin decontamination lotion (RSDL) is a Health Canada approved product used by the Canadian Armed Forces for removal and inactivation of toxic chemicals on skin. Although it is considered very safe when used as directed, questions have been raised regarding whether topical RSDL in the medical setting will react exothermically with antiseptic compounds on the casualty's epidermis that could result in thermal burns. Benchtop experiments were conducted to investigate reactivity of RSDL with various antise...
Source: Toxicology Letters - March 14, 2024 Category: Toxicology Authors: Jessica Franken John Mikler Source Type: research
Reactive Skin Decontamination Lotion (RSDL) safety with clinical antiseptics and hemostatic agents
Toxicol Lett. 2024 Mar 12:S0378-4274(24)00039-0. doi: 10.1016/j.toxlet.2024.02.014. Online ahead of print.ABSTRACTReactive skin decontamination lotion (RSDL) is a Health Canada approved product used by the Canadian Armed Forces for removal and inactivation of toxic chemicals on skin. Although it is considered very safe when used as directed, questions have been raised regarding whether topical RSDL in the medical setting will react exothermically with antiseptic compounds on the casualty's epidermis that could result in thermal burns. Benchtop experiments were conducted to investigate reactivity of RSDL with various antise...
Source: Toxicology Letters - March 14, 2024 Category: Toxicology Authors: Jessica Franken John Mikler Source Type: research
