Efficacy of the oxime HI-6 dimethanesulphonate in the treatment of guinea-pigs exposed to the nerve agents GB and GD
Toxicol Lett. 2023 Dec 2:S0378-4274(23)01104-9. doi: 10.1016/j.toxlet.2023.11.007. Online ahead of print.ABSTRACTThe bispyridinium oxime HI-6 DMS is in development as an improved therapy for the treatment of patients exposed to organophosphorus nerve agents. The aim of the work described in this paper was to provide non-clinical data to support regulatory approval of HI-6 DMS, by demonstrating efficacy against an oxime-sensitive agent, GB and an oxime-resistant agent, GD. We investigated the dose-dependent protection afforded by therapy including atropine, avizafone and HI-6 DMS in guinea-pigs challenged with GB or GD. We ...
Source: Toxicology Letters - December 4, 2023 Category: Toxicology Authors: Helen Rice Sarah J Whitfield Sarah J Fairhall Iain R Scott Glyn B Steventon John Eh Tattersall Source Type: research
Phospholipid Chlorohydrins as Chlorine Exposure Biomarkers in a Large Animal Model
This study represents the first published dataset in BALF revealing chlorine biomarkers detected in a large animal. Furthermore, these biomarkers are distinct in that they originate from molecular chlorine rather than hypochlorous acid.PMID:38048885 | DOI:10.1016/j.toxlet.2023.11.008 (Source: Toxicology Letters)
Source: Toxicology Letters - December 4, 2023 Category: Toxicology Authors: Petrus Hemstr öm Bronwen Jugg Rachel Watkins Sofia Jonasson Linda Elfsmark Steve Rutter Crister Åstot Pernilla Lind én Source Type: research
Efficacy of the oxime HI-6 dimethanesulphonate in the treatment of guinea-pigs exposed to the nerve agents GB and GD
Toxicol Lett. 2023 Dec 2:S0378-4274(23)01104-9. doi: 10.1016/j.toxlet.2023.11.007. Online ahead of print.ABSTRACTThe bispyridinium oxime HI-6 DMS is in development as an improved therapy for the treatment of patients exposed to organophosphorus nerve agents. The aim of the work described in this paper was to provide non-clinical data to support regulatory approval of HI-6 DMS, by demonstrating efficacy against an oxime-sensitive agent, GB and an oxime-resistant agent, GD. We investigated the dose-dependent protection afforded by therapy including atropine, avizafone and HI-6 DMS in guinea-pigs challenged with GB or GD. We ...
Source: Toxicology Letters - December 4, 2023 Category: Toxicology Authors: Helen Rice Sarah J Whitfield Sarah J Fairhall Iain R Scott Glyn B Steventon John Eh Tattersall Source Type: research
BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPAR α-induced abnormal fatty acid oxidation in BALB/c mice
Toxicol Lett. 2023 Nov 29:S0378-4274(23)01097-4. doi: 10.1016/j.toxlet.2023.11.006. Online ahead of print.ABSTRACTThe widespread existence of 2,2',4,4'-tetra-bromodiphenyl ether (BDE-47) in the environment has aroused great concern. BDE-47 induces the occurrence of metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanism has not been fully elucidated. Here, we further investigate the underlying mechanism using BALB/c mice. After BDE-47 exposure, the livers of mice enlarged, the serum levels of ALT, ALP, TG and TC enhanced, and hepatic steatosis occurred. Transcriptome sequencing identifies 2250 d...
Source: Toxicology Letters - December 1, 2023 Category: Toxicology Authors: Beibei Xia Rongfei Yu Junxiong Liu Dongmeng Liu Shasha Li Liu Yang Nan Liu Bosen Liang Jiajing Zeng Jinhua Wei Guimiao Lin Source Type: research
BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPAR α-induced abnormal fatty acid oxidation in BALB/c mice
Toxicol Lett. 2023 Nov 29:S0378-4274(23)01097-4. doi: 10.1016/j.toxlet.2023.11.006. Online ahead of print.ABSTRACTThe widespread existence of 2,2',4,4'-tetra-bromodiphenyl ether (BDE-47) in the environment has aroused great concern. BDE-47 induces the occurrence of metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanism has not been fully elucidated. Here, we further investigate the underlying mechanism using BALB/c mice. After BDE-47 exposure, the livers of mice enlarged, the serum levels of ALT, ALP, TG and TC enhanced, and hepatic steatosis occurred. Transcriptome sequencing identifies 2250 d...
Source: Toxicology Letters - December 1, 2023 Category: Toxicology Authors: Beibei Xia Rongfei Yu Junxiong Liu Dongmeng Liu Shasha Li Liu Yang Nan Liu Bosen Liang Jiajing Zeng Jinhua Wei Guimiao Lin Source Type: research
BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPAR α-induced abnormal fatty acid oxidation in BALB/c mice
Toxicol Lett. 2023 Nov 29:S0378-4274(23)01097-4. doi: 10.1016/j.toxlet.2023.11.006. Online ahead of print.ABSTRACTThe widespread existence of 2,2',4,4'-tetra-bromodiphenyl ether (BDE-47) in the environment has aroused great concern. BDE-47 induces the occurrence of metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanism has not been fully elucidated. Here, we further investigate the underlying mechanism using BALB/c mice. After BDE-47 exposure, the livers of mice enlarged, the serum levels of ALT, ALP, TG and TC enhanced, and hepatic steatosis occurred. Transcriptome sequencing identifies 2250 d...
Source: Toxicology Letters - December 1, 2023 Category: Toxicology Authors: Beibei Xia Rongfei Yu Junxiong Liu Dongmeng Liu Shasha Li Liu Yang Nan Liu Bosen Liang Jiajing Zeng Jinhua Wei Guimiao Lin Source Type: research
Regulation of Long Non-Coding RNA Expression by Aryl Hydrocarbon Receptor Activation
Toxicol Lett. 2023 Nov 28:S0378-4274(23)01095-0. doi: 10.1016/j.toxlet.2023.11.004. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AhR) is a cytosolic transcription factor that can be activated by endogenous or xenobiotic ligands. Upon activation, the AhR translocates to the nucleus, dimerizes with the AhR nuclear translator (ARNT), and binds to specific DNA sequences called xenobiotic response elements (XRE) to promote target gene transcription, including cytochrome P450 (e.g., CYP1A1) expression. In addition to mRNA, the AhR may also regulate long non-coding RNA (lncRNA) expression. lncRNA are transcripts m...
Source: Toxicology Letters - November 30, 2023 Category: Toxicology Authors: Aeshah Alluli Gregory Fonseca Jason Matthews David H Eidelman Carolyn J Baglole Source Type: research
Regulation of Long Non-Coding RNA Expression by Aryl Hydrocarbon Receptor Activation
Toxicol Lett. 2023 Nov 28:S0378-4274(23)01095-0. doi: 10.1016/j.toxlet.2023.11.004. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AhR) is a cytosolic transcription factor that can be activated by endogenous or xenobiotic ligands. Upon activation, the AhR translocates to the nucleus, dimerizes with the AhR nuclear translator (ARNT), and binds to specific DNA sequences called xenobiotic response elements (XRE) to promote target gene transcription, including cytochrome P450 (e.g., CYP1A1) expression. In addition to mRNA, the AhR may also regulate long non-coding RNA (lncRNA) expression. lncRNA are transcripts m...
Source: Toxicology Letters - November 30, 2023 Category: Toxicology Authors: Aeshah Alluli Gregory Fonseca Jason Matthews David H Eidelman Carolyn J Baglole Source Type: research
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: insight on the molecular mechanisms in HepG2/THP-1 co-culture model
In conclusion; the study makes a significant contribution to strengthening the infrastructure we have on in vitro toxicity mechanism evaluations, which are the basis of preclinical toxicity studies.PMID:37992977 | DOI:10.1016/j.toxlet.2023.11.005 (Source: Toxicology Letters)
Source: Toxicology Letters - November 22, 2023 Category: Toxicology Authors: Tugce Boran Ozge Sultan Zengin Zehra Seker Aysenur Gunaydin Akyildiz Ezgi Oztas G ül Özhan Source Type: research
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: insight on the molecular mechanisms in HepG2/THP-1 co-culture model
In conclusion; the study makes a significant contribution to strengthening the infrastructure we have on in vitro toxicity mechanism evaluations, which are the basis of preclinical toxicity studies.PMID:37992977 | DOI:10.1016/j.toxlet.2023.11.005 (Source: Toxicology Letters)
Source: Toxicology Letters - November 22, 2023 Category: Toxicology Authors: Tugce Boran Ozge Sultan Zengin Zehra Seker Aysenur Gunaydin Akyildiz Ezgi Oztas G ül Özhan Source Type: research
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: insight on the molecular mechanisms in HepG2/THP-1 co-culture model
In conclusion; the study makes a significant contribution to strengthening the infrastructure we have on in vitro toxicity mechanism evaluations, which are the basis of preclinical toxicity studies.PMID:37992977 | DOI:10.1016/j.toxlet.2023.11.005 (Source: Toxicology Letters)
Source: Toxicology Letters - November 22, 2023 Category: Toxicology Authors: Tugce Boran Ozge Sultan Zengin Zehra Seker Aysenur Gunaydin Akyildiz Ezgi Oztas G ül Özhan Source Type: research
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: insight on the molecular mechanisms in HepG2/THP-1 co-culture model
In conclusion; the study makes a significant contribution to strengthening the infrastructure we have on in vitro toxicity mechanism evaluations, which are the basis of preclinical toxicity studies.PMID:37992977 | DOI:10.1016/j.toxlet.2023.11.005 (Source: Toxicology Letters)
Source: Toxicology Letters - November 22, 2023 Category: Toxicology Authors: Tugce Boran Ozge Sultan Zengin Zehra Seker Aysenur Gunaydin Akyildiz Ezgi Oztas G ül Özhan Source Type: research
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: insight on the molecular mechanisms in HepG2/THP-1 co-culture model
In conclusion; the study makes a significant contribution to strengthening the infrastructure we have on in vitro toxicity mechanism evaluations, which are the basis of preclinical toxicity studies.PMID:37992977 | DOI:10.1016/j.toxlet.2023.11.005 (Source: Toxicology Letters)
Source: Toxicology Letters - November 22, 2023 Category: Toxicology Authors: Tugce Boran Ozge Sultan Zengin Zehra Seker Aysenur Gunaydin Akyildiz Ezgi Oztas G ül Özhan Source Type: research
The cyclin-dependent kinase inhibitor abemaciclib-induced hepatotoxicity: insight on the molecular mechanisms in HepG2/THP-1 co-culture model
In conclusion; the study makes a significant contribution to strengthening the infrastructure we have on in vitro toxicity mechanism evaluations, which are the basis of preclinical toxicity studies.PMID:37992977 | DOI:10.1016/j.toxlet.2023.11.005 (Source: Toxicology Letters)
Source: Toxicology Letters - November 22, 2023 Category: Toxicology Authors: Tugce Boran Ozge Sultan Zengin Zehra Seker Aysenur Gunaydin Akyildiz Ezgi Oztas G ül Özhan Source Type: research
Corrigendum to "Cytoprotective effect of deferiprone against aluminum chloride-induced oxidative stress and apoptosis in lymphocytes" [Toxicol. Lett. 285 (2018) 132-138]
Toxicol Lett. 2023 Nov 10:S0378-4274(23)01088-3. doi: 10.1016/j.toxlet.2023.11.003. Online ahead of print.NO ABSTRACTPMID:37953205 | DOI:10.1016/j.toxlet.2023.11.003 (Source: Toxicology Letters)
Source: Toxicology Letters - November 12, 2023 Category: Toxicology Authors: Cuicui Zhuang Yue She Haiyang Zhang Miao Song Yanfei Han Yanfei Li Yanzhu Zhu Source Type: research
