TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP
In conclusion, TP presensitizes hepatocytes and enhances the sensitivity of hepatocytes to the Fas/FasL pathway by inhibiting the protein expression of XIAP, leading to hepatocyte apoptosis.PMID:37944651 | DOI:10.1016/j.toxlet.2023.11.001 (Source: Toxicology Letters)
Source: Toxicology Letters - November 9, 2023 Category: Toxicology Authors: Xue Fan Yangping Zhu Shuang Peng Yingying Miao Qian Lu Luyong Zhang Zhenzhou Jiang Qinwei Yu Source Type: research
Formaldehyde promotes tumor-associated macrophage polarizations and functions through induction of HIF-1 α-mediated glycolysis
Toxicol Lett. 2023 Nov 7:S0378-4274(23)01087-1. doi: 10.1016/j.toxlet.2023.11.002. Online ahead of print.ABSTRACTFormaldehyde (FA) exposure has been positively correlated with many diseases including various types of cancers. However, the mechanisms of FA-related carcinogenesis are still unclear. Tumor-associated macrophages (TAMs) are the most abundant immune cells in tumor microenvironment, which is a heterogeneous population consist of both pro-inflammatory (M1) and immunosuppressive (M2) cells. TAMs are deeply involved in tumor development and progression. Our previous studies demonstrated that FA enhanced M1 polarizat...
Source: Toxicology Letters - November 9, 2023 Category: Toxicology Authors: Qi Shu Huijuan Ma Tingqian Wang Peiyao Wang Huan Xu Source Type: research
TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP
In conclusion, TP presensitizes hepatocytes and enhances the sensitivity of hepatocytes to the Fas/FasL pathway by inhibiting the protein expression of XIAP, leading to hepatocyte apoptosis.PMID:37944651 | DOI:10.1016/j.toxlet.2023.11.001 (Source: Toxicology Letters)
Source: Toxicology Letters - November 9, 2023 Category: Toxicology Authors: Xue Fan Yangping Zhu Shuang Peng Yingying Miao Qian Lu Luyong Zhang Zhenzhou Jiang Qinwei Yu Source Type: research
Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats
Toxicol Lett. 2023 Nov 3:S0378-4274(23)01085-8. doi: 10.1016/j.toxlet.2023.10.016. Online ahead of print.ABSTRACTWe previously performed comprehensive analyses of genes hypermethylated promoter regions and downregulated transcripts in the hippocampal dentate gyrus (DG) of rats upon weaning at postnatal day (PND) 21 after developmental exposure to 6-propyl-2-thiouracil (PTU), valproic acid, and glycidol (GLY), all of which are known to show irreversible effects on hippocampal neurogenesis in adulthood on PND 77. Here, we selected neurotransmitter and neurogenesis-related genes for validation analysis of methylation and expr...
Source: Toxicology Letters - November 5, 2023 Category: Toxicology Authors: Yasunori Takahashi Ryota Ojiro Risako Yamashita Saori Shimizu Natsuno Maeda Xinyu Zou Qian Tang Shunsuke Ozawa Gye-Hyeong Woo Toshinori Yoshida Makoto Shibutani Source Type: research
Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats
Toxicol Lett. 2023 Nov 3:S0378-4274(23)01085-8. doi: 10.1016/j.toxlet.2023.10.016. Online ahead of print.ABSTRACTWe previously performed comprehensive analyses of genes hypermethylated promoter regions and downregulated transcripts in the hippocampal dentate gyrus (DG) of rats upon weaning at postnatal day (PND) 21 after developmental exposure to 6-propyl-2-thiouracil (PTU), valproic acid, and glycidol (GLY), all of which are known to show irreversible effects on hippocampal neurogenesis in adulthood on PND 77. Here, we selected neurotransmitter and neurogenesis-related genes for validation analysis of methylation and expr...
Source: Toxicology Letters - November 5, 2023 Category: Toxicology Authors: Yasunori Takahashi Ryota Ojiro Risako Yamashita Saori Shimizu Natsuno Maeda Xinyu Zou Qian Tang Shunsuke Ozawa Gye-Hyeong Woo Toshinori Yoshida Makoto Shibutani Source Type: research
Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats
Toxicol Lett. 2023 Nov 3:S0378-4274(23)01085-8. doi: 10.1016/j.toxlet.2023.10.016. Online ahead of print.ABSTRACTWe previously performed comprehensive analyses of genes hypermethylated promoter regions and downregulated transcripts in the hippocampal dentate gyrus (DG) of rats upon weaning at postnatal day (PND) 21 after developmental exposure to 6-propyl-2-thiouracil (PTU), valproic acid, and glycidol (GLY), all of which are known to show irreversible effects on hippocampal neurogenesis in adulthood on PND 77. Here, we selected neurotransmitter and neurogenesis-related genes for validation analysis of methylation and expr...
Source: Toxicology Letters - November 5, 2023 Category: Toxicology Authors: Yasunori Takahashi Ryota Ojiro Risako Yamashita Saori Shimizu Natsuno Maeda Xinyu Zou Qian Tang Shunsuke Ozawa Gye-Hyeong Woo Toshinori Yoshida Makoto Shibutani Source Type: research
Suppression of neurogranin expression by disruption of epigenetic DNA methylation in hippocampal mature granule cells after developmental exposure to neurotoxicants in rats
Toxicol Lett. 2023 Nov 3:S0378-4274(23)01085-8. doi: 10.1016/j.toxlet.2023.10.016. Online ahead of print.ABSTRACTWe previously performed comprehensive analyses of genes hypermethylated promoter regions and downregulated transcripts in the hippocampal dentate gyrus (DG) of rats upon weaning at postnatal day (PND) 21 after developmental exposure to 6-propyl-2-thiouracil (PTU), valproic acid, and glycidol (GLY), all of which are known to show irreversible effects on hippocampal neurogenesis in adulthood on PND 77. Here, we selected neurotransmitter and neurogenesis-related genes for validation analysis of methylation and expr...
Source: Toxicology Letters - November 5, 2023 Category: Toxicology Authors: Yasunori Takahashi Ryota Ojiro Risako Yamashita Saori Shimizu Natsuno Maeda Xinyu Zou Qian Tang Shunsuke Ozawa Gye-Hyeong Woo Toshinori Yoshida Makoto Shibutani Source Type: research
Use of the TD50 99% CI for single dose rodent carcinogenicity studies
Toxicol Lett. 2023 Nov 1:S0378-4274(23)01084-6. doi: 10.1016/j.toxlet.2023.10.015. Online ahead of print.ABSTRACTThe Tumorigenic dose 50 (TD50) is a widely used measure of carcinogenic potency representing the dosage at which 50% of animals exposed to a compound will develop tumours. The popularity of the TD50 is in part due to the large amount of publicly available data. TD50s were calculated for a large number of compounds in the Carcinogenic Potency Database, which has since been extended in the freely available Lhasa Carcinogenicity database, containing TD50s from over 7,500 studies and 1,700 compounds. However, due to...
Source: Toxicology Letters - November 3, 2023 Category: Toxicology Authors: Robert Thomas Anax F Oliveira David J Ponting Andrew Thresher Source Type: research
Usage of model combination in computational toxicology
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01076-7. doi: 10.1016/j.toxlet.2023.10.013. Online ahead of print.ABSTRACTNew Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and methodological. The mechanistic complexity arises from interconnected biological processes within a network that are challenging to model in a single step. In the s...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Pablo Rodr íguez-Belenguer Eric March-Vila Manuel Pastor Victor Mangas-Sanjuan Emilio Soria-Olivas Source Type: research
Differentiated and non-differentiated HepaRG < sup > TM < /sup > cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01077-9. doi: 10.1016/j.toxlet.2023.10.014. Online ahead of print.ABSTRACTMany xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRGTM cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human hepatoma/hepatocarcinoma cell-lines to characterize the benign/malignant phenotype. Reaction of d-/nd-HepaRG t...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Michael Gutmann Emily Stimpfl Gregor Langmann Helga Koudelka Birgit Mir-Karner Bettina Grasl-Kraupp Source Type: research
Usage of model combination in computational toxicology
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01076-7. doi: 10.1016/j.toxlet.2023.10.013. Online ahead of print.ABSTRACTNew Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and methodological. The mechanistic complexity arises from interconnected biological processes within a network that are challenging to model in a single step. In the s...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Pablo Rodr íguez-Belenguer Eric March-Vila Manuel Pastor Victor Mangas-Sanjuan Emilio Soria-Olivas Source Type: research
Differentiated and non-differentiated HepaRG < sup > TM < /sup > cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01077-9. doi: 10.1016/j.toxlet.2023.10.014. Online ahead of print.ABSTRACTMany xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRGTM cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human hepatoma/hepatocarcinoma cell-lines to characterize the benign/malignant phenotype. Reaction of d-/nd-HepaRG t...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Michael Gutmann Emily Stimpfl Gregor Langmann Helga Koudelka Birgit Mir-Karner Bettina Grasl-Kraupp Source Type: research
Usage of model combination in computational toxicology
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01076-7. doi: 10.1016/j.toxlet.2023.10.013. Online ahead of print.ABSTRACTNew Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and methodological. The mechanistic complexity arises from interconnected biological processes within a network that are challenging to model in a single step. In the s...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Pablo Rodr íguez-Belenguer Eric March-Vila Manuel Pastor Victor Mangas-Sanjuan Emilio Soria-Olivas Source Type: research
Differentiated and non-differentiated HepaRG < sup > TM < /sup > cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01077-9. doi: 10.1016/j.toxlet.2023.10.014. Online ahead of print.ABSTRACTMany xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRGTM cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human hepatoma/hepatocarcinoma cell-lines to characterize the benign/malignant phenotype. Reaction of d-/nd-HepaRG t...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Michael Gutmann Emily Stimpfl Gregor Langmann Helga Koudelka Birgit Mir-Karner Bettina Grasl-Kraupp Source Type: research
Usage of model combination in computational toxicology
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01076-7. doi: 10.1016/j.toxlet.2023.10.013. Online ahead of print.ABSTRACTNew Approach Methodologies (NAMs) have ushered in a new era in the field of toxicology, aiming to replace animal testing. However, despite these advancements, they are not exempt from the inherent complexities associated with the study's endpoint. In this review, we have identified three major groups of complexities: mechanistic, chemical space, and methodological. The mechanistic complexity arises from interconnected biological processes within a network that are challenging to model in a single step. In the s...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Pablo Rodr íguez-Belenguer Eric March-Vila Manuel Pastor Victor Mangas-Sanjuan Emilio Soria-Olivas Source Type: research
