Bavachin induces liver injury and cell apoptosis by targeting Wnt/ β-catenin/DRP1 signaling pathway mediated mitochondrial dysfunction
Toxicol Lett. 2023 Sep 23:S0378-4274(23)01043-3. doi: 10.1016/j.toxlet.2023.09.006. Online ahead of print.ABSTRACTPsraleae Fructus (PF) is a well-known traditional Chinese medicine in China. While numerous liver injury reports caused by PF limits its clinical application. Bavachin, a flavonoid compound isolated from the fruits of Psoralea corylifolia L., has been validated to induce direct apoptosis in hepatocytes and liver tissues in our previous studies. However, the subcellular mechanisms of bavachin induced liver injury is still elusive. Here, utilizing 6-week-old C57BL/6J mice and human embryonic hepatocytes (L02 cell...
Source: Toxicology Letters - September 25, 2023 Category: Toxicology Authors: Ying Yang Wei Zhou Yihao Wang Yunxuan Ge Zheng Fan Qingquan Liu Yue Gao Source Type: research
Course-, dose-, and stage-dependent toxic effects of prenatal acetaminophen exposure on fetal long bone development
In conclusion, PAcE caused development toxicity and multi-cellular function inhibition in fetal long bone, particularly in the high dose, multiple treatments and mid-pregnancy group, and the alteration of canonical Wnt signalling pathway may be its potential mechanism.PMID:37741353 | DOI:10.1016/j.toxlet.2023.09.007 (Source: Toxicology Letters)
Source: Toxicology Letters - September 23, 2023 Category: Toxicology Authors: Chi Ma Xufeng Li Hao Xiao Bin Li Hanwen Gu Yu Guo Hui Wang Yinxian Wen Liaobin Chen Source Type: research
Course-, dose-, and stage-dependent toxic effects of prenatal acetaminophen exposure on fetal long bone development
In conclusion, PAcE caused development toxicity and multi-cellular function inhibition in fetal long bone, particularly in the high dose, multiple treatments and mid-pregnancy group, and the alteration of canonical Wnt signalling pathway may be its potential mechanism.PMID:37741353 | DOI:10.1016/j.toxlet.2023.09.007 (Source: Toxicology Letters)
Source: Toxicology Letters - September 23, 2023 Category: Toxicology Authors: Chi Ma Xufeng Li Hao Xiao Bin Li Hanwen Gu Yu Guo Hui Wang Yinxian Wen Liaobin Chen Source Type: research
Blocked erythroid differentiation and delayed enucleation of erythroblasts may contribute to murine embryonic toxicity upon exposure to low dose of cadmium
In this study, we treated mice with a low dose of Cd before and after mating to minimize Cd-induced maternal anemia. Although most embryos developed normally, embryonic atrophy was still observed in a small percentage of embryos from Cd-exposed pregnant mice. Compared to the embryos from the control pregnant mice, a complete blockage of erythroid differentiation was observed in the atrophic embryos but no obvious alteration of erythroid differentiation in the non-atrophic embryos, respectively. Moreover, our results suggested delayed enucleation of erythroblasts in these non-atrophic embryos. Mechanically, the inhibited ir...
Source: Toxicology Letters - September 22, 2023 Category: Toxicology Authors: Quanshu Wang Jia Li Wanqi Ma Li Sun Bingke Zhang Yiming Zhao Shuping Zhang Source Type: research
Blocked erythroid differentiation and delayed enucleation of erythroblasts may contribute to murine embryonic toxicity upon exposure to low dose of cadmium
In this study, we treated mice with a low dose of Cd before and after mating to minimize Cd-induced maternal anemia. Although most embryos developed normally, embryonic atrophy was still observed in a small percentage of embryos from Cd-exposed pregnant mice. Compared to the embryos from the control pregnant mice, a complete blockage of erythroid differentiation was observed in the atrophic embryos but no obvious alteration of erythroid differentiation in the non-atrophic embryos, respectively. Moreover, our results suggested delayed enucleation of erythroblasts in these non-atrophic embryos. Mechanically, the inhibited ir...
Source: Toxicology Letters - September 22, 2023 Category: Toxicology Authors: Quanshu Wang Jia Li Wanqi Ma Li Sun Bingke Zhang Yiming Zhao Shuping Zhang Source Type: research
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
In conclusion, low-dose copper treatment altered critical proteins involved in mitochondrial, neurodevelopmental, and inflammatory responses and affected mitochondria's ROS and ATP production levels.PMID:37717680 | DOI:10.1016/j.toxlet.2023.09.004 (Source: Toxicology Letters)
Source: Toxicology Letters - September 17, 2023 Category: Toxicology Authors: Jie Chen Xufang Gao Chengyou Zheng Chen Zhang Peimao Li Kaiwu He Gongping Liu Xinfeng Huang Jianjun Liu Yongmei Xie Xifei Yang Source Type: research
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
In conclusion, low-dose copper treatment altered critical proteins involved in mitochondrial, neurodevelopmental, and inflammatory responses and affected mitochondria's ROS and ATP production levels.PMID:37717680 | DOI:10.1016/j.toxlet.2023.09.004 (Source: Toxicology Letters)
Source: Toxicology Letters - September 17, 2023 Category: Toxicology Authors: Jie Chen Xufang Gao Chengyou Zheng Chen Zhang Peimao Li Kaiwu He Gongping Liu Xinfeng Huang Jianjun Liu Yongmei Xie Xifei Yang Source Type: research
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
In conclusion, low-dose copper treatment altered critical proteins involved in mitochondrial, neurodevelopmental, and inflammatory responses and affected mitochondria's ROS and ATP production levels.PMID:37717680 | DOI:10.1016/j.toxlet.2023.09.004 (Source: Toxicology Letters)
Source: Toxicology Letters - September 17, 2023 Category: Toxicology Authors: Jie Chen Xufang Gao Chengyou Zheng Chen Zhang Peimao Li Kaiwu He Gongping Liu Xinfeng Huang Jianjun Liu Yongmei Xie Xifei Yang Source Type: research
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
In conclusion, low-dose copper treatment altered critical proteins involved in mitochondrial, neurodevelopmental, and inflammatory responses and affected mitochondria's ROS and ATP production levels.PMID:37717680 | DOI:10.1016/j.toxlet.2023.09.004 (Source: Toxicology Letters)
Source: Toxicology Letters - September 17, 2023 Category: Toxicology Authors: Jie Chen Xufang Gao Chengyou Zheng Chen Zhang Peimao Li Kaiwu He Gongping Liu Xinfeng Huang Jianjun Liu Yongmei Xie Xifei Yang Source Type: research
Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease
In conclusion, low-dose copper treatment altered critical proteins involved in mitochondrial, neurodevelopmental, and inflammatory responses and affected mitochondria's ROS and ATP production levels.PMID:37717680 | DOI:10.1016/j.toxlet.2023.09.004 (Source: Toxicology Letters)
Source: Toxicology Letters - September 17, 2023 Category: Toxicology Authors: Jie Chen Xufang Gao Chengyou Zheng Chen Zhang Peimao Li Kaiwu He Gongping Liu Xinfeng Huang Jianjun Liu Yongmei Xie Xifei Yang Source Type: research
Initial Evaluation of USP Apparatus 4 for Measuring Dissolution Profile of Man-Made Vitreous Fibers
We report the successful evaluation of a US Pharmacopeia Apparatus 4 (USP-4) system in measuring the dissolution profiles of man-made vitreous fibers (MMVF)i. Glass and stone wool fibers with different (high- and low-) solubility profiles were tested in closed-loop configuration using a sodium/potassium phosphate buffer solution or an acetate buffer, respectively. Results confirm a need to operate in diluted conditions to avoid silicon saturation in the simulant solution and suppression of fiber dissolution. A clear fiber-to-fiber differentiation with good cell-to-cell reproducibility was achieved. These findings support t...
Source: Toxicology Letters - September 16, 2023 Category: Toxicology Authors: J W Hoffman D V Okhrimenko E Chaudan Q Herault N Drnovsek E Pezennec A Aznar N Mascaraque S Haddouchi M Lecluse A A Badissi J de Cruz L Hi éronimus M Solvang Source Type: research
Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
Estrogen receptor α mediates alternariol-induced apoptosis and modulation of the invasiveness of ovarian cancer cells
In conclusion, we postulate that AOH might significantly affect the viability and invasiveness of ovarian cancer cells via modulation of ERα and therefore possibly act as an endocrine disruptive agent in ovarian cancer cells.PMID:37683805 | DOI:10.1016/j.toxlet.2023.09.001 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Marta Justyna Kozie ł Dominika Ewa Habrowska-G órczyńska Kinga Anna Urbanek Kamila Domi ńska Agnieszka Wanda Piastowska-Ciesielska Karolina Kowalska Source Type: research
An in silico insight on the mechanistic aspects of gelsenicine toxicity: A reverse screening study pointing to the possible involvement of acetylcholine binding receptor
Toxicol Lett. 2023 Sep 6;386:1-8. doi: 10.1016/j.toxlet.2023.09.003. Online ahead of print.ABSTRACTGelsedine-type alkaloids are highly toxic plant secondary metabolites produced by shrubs belonging to the Gelsemium genus. Gelsenicine is one of the most concerning gelsedine-type alkaloids with a lethal dose lower than 1 mg/Kg in mice. Several reported episodes of poisoning in livestock and fatality cases in humans due to the usage of Gelsemium plants extracts were reported. Also, gelsedine-type alkaloids were found in honey constituting a potential food safety issue. However, their toxicological understanding is scarce and ...
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Lorenzo Pedroni Jean Lou C M Dorne Chiara Dall'Asta Luca Dellafiora Source Type: research
Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
