Roles of Breast Cancer Resistance Protein and Organic Anion Transporting Polypeptide 2B1 in Gastrointestinal Toxicity Induced by SN-38 under Inflammatory Conditions
In this study, we investigated the roles of drug transporters involved in transport of SN-38, which is an active metabolite of irinotecan, in the intestine under inflammatory conditions in vitro and determined their functional consequences. The expression alterations of breast cancer resistance protein (BCRP) and organic anion transporting polypeptide (OATP) 2B1 were determined at the mRNA and protein levels, and the subsequent functional alterations were evaluated via an accumulation study with the representative transporter substrates [prazosin and dibromofluorescein (DBF)] and SN-38. We also determined the cytotoxicity ...
Source: Toxicology Letters - February 29, 2024 Category: Toxicology Authors: Aneela Gulnaz Kyeong-Ryoon Lee Min-Ji Kang Ji-Eun Chang Yoon-Jee Chae Source Type: research
A Chirality-Sensitive Approach to Predict Chemical Transfer Across the Human Placental Barrier
In conclusion, we demonstrate the need of a chirality-sensitive approach for modelling placental transfer of chemicals, and present two predictive QSPR models that may reliably be used for prediction of placental transfer.PMID:38423482 | DOI:10.1016/j.toxlet.2024.02.012 (Source: Toxicology Letters)
Source: Toxicology Letters - February 29, 2024 Category: Toxicology Authors: Anish Gomatam Evans Coutinho Source Type: research
hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways
Toxicol Lett. 2024 Feb 24:S0378-4274(24)00029-8. doi: 10.1016/j.toxlet.2024.02.003. Online ahead of print.ABSTRACTPolycyclic aromatic hydrocarbons (PAHs) are major organic pollutants attached to fine particulate matter in the atmosphere. They induce lung inflammation, asthma, and other lung diseases. Exploring the toxic mechanism of PAHs on lung epithelial cells may provide a theoretical basis for the prevention and treatment of respiratory diseases induced by PAHs. In our study, 16 human bronchial epithelial (16HBE) cells were exposed to different concentrations of gypsum dust, Benzo(a)pyrene (BaP), and BaP-loaded gypsum ...
Source: Toxicology Letters - February 26, 2024 Category: Toxicology Authors: Yujun Wang Juan Song Jiarui He Xu Zhang Zhenzhen Lv Faqin Dong Jianjun Deng Source Type: research
hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways
Toxicol Lett. 2024 Feb 24:S0378-4274(24)00029-8. doi: 10.1016/j.toxlet.2024.02.003. Online ahead of print.ABSTRACTPolycyclic aromatic hydrocarbons (PAHs) are major organic pollutants attached to fine particulate matter in the atmosphere. They induce lung inflammation, asthma, and other lung diseases. Exploring the toxic mechanism of PAHs on lung epithelial cells may provide a theoretical basis for the prevention and treatment of respiratory diseases induced by PAHs. In our study, 16 human bronchial epithelial (16HBE) cells were exposed to different concentrations of gypsum dust, Benzo(a)pyrene (BaP), and BaP-loaded gypsum ...
Source: Toxicology Letters - February 26, 2024 Category: Toxicology Authors: Yujun Wang Juan Song Jiarui He Xu Zhang Zhenzhen Lv Faqin Dong Jianjun Deng Source Type: research
hsa_circ_0008500 regulates Benzo(a)pyrene-loaded gypsum-induced inflammation and apoptosis in human bronchial epithelial cells via activation of Ahr/C-myc pathways
Toxicol Lett. 2024 Feb 24:S0378-4274(24)00029-8. doi: 10.1016/j.toxlet.2024.02.003. Online ahead of print.ABSTRACTPolycyclic aromatic hydrocarbons (PAHs) are major organic pollutants attached to fine particulate matter in the atmosphere. They induce lung inflammation, asthma, and other lung diseases. Exploring the toxic mechanism of PAHs on lung epithelial cells may provide a theoretical basis for the prevention and treatment of respiratory diseases induced by PAHs. In our study, 16 human bronchial epithelial (16HBE) cells were exposed to different concentrations of gypsum dust, Benzo(a)pyrene (BaP), and BaP-loaded gypsum ...
Source: Toxicology Letters - February 26, 2024 Category: Toxicology Authors: Yujun Wang Juan Song Jiarui He Xu Zhang Zhenzhen Lv Faqin Dong Jianjun Deng Source Type: research
Dimethylmonothioarsinic acid (DMMTA < sup > V < /sup > ) differentially modulates the expression of AHR-regulated cytochrome P450 1A enzymes in vivo and in vitro
Toxicol Lett. 2024 Feb 23:S0378-4274(24)00033-X. doi: 10.1016/j.toxlet.2024.02.007. Online ahead of print.ABSTRACTDimethylmonothioarsinic acid (DMMTAV), a pentavalent thio-arsenic derivative, has been found in bodily fluids and tissues including urine, liver, kidney homogenates, plasma, and red blood cells. Although DMMTAV is a minor metabolite in humans and animals, its substantial toxicity raises concerns about potential carcinogenic effects. This toxicity could be attributed to arsenicals' ability to regulate cytochrome P450 1A (CYP1A) enzymes, pivotal in procarcinogen activation or detoxification. The current study inv...
Source: Toxicology Letters - February 25, 2024 Category: Toxicology Authors: Sara R El-Mahrouk Mahmoud A El-Ghiaty Mohammed A Alqahtani Ayman O S El-Kadi Source Type: research
Combined in vitro and in silico mechanistic approach to explore the potential of Alternaria mycotoxins alternariol and altertoxin II to hamper γH2AX formation in DNA damage signaling pathways
This study combined in vitro/in silico approaches to elucidate the potential of AOH and ATXII to induce double-strand breaks (DSBs) in HepG2 cells. Furthermore, it examines the impact of co-exposure to AOH and the DSB-inducing drug doxorubicin (Doxo) on γH2AX expression. AOH slightly increased γH2AX expression, whereas ATXII did not elicit this response. Interestingly, AOH suppressed Doxo-induced γH2AX expression, despite evidence of increased DNA damage in the comet assay. Building on these observations, AOH was postulated to inhibit γH2AX-forming kinases. Along this line, in silico analysis supported AOH potential in...
Source: Toxicology Letters - February 25, 2024 Category: Toxicology Authors: Francesco Crudo Luca Dellafiora Chenyifan Hong Lena Burger Maximilian Jobst Giorgia Del Favero Doris Marko Source Type: research
Dimethylmonothioarsinic acid (DMMTA < sup > V < /sup > ) differentially modulates the expression of AHR-regulated cytochrome P450 1A enzymes in vivo and in vitro
Toxicol Lett. 2024 Feb 23:S0378-4274(24)00033-X. doi: 10.1016/j.toxlet.2024.02.007. Online ahead of print.ABSTRACTDimethylmonothioarsinic acid (DMMTAV), a pentavalent thio-arsenic derivative, has been found in bodily fluids and tissues including urine, liver, kidney homogenates, plasma, and red blood cells. Although DMMTAV is a minor metabolite in humans and animals, its substantial toxicity raises concerns about potential carcinogenic effects. This toxicity could be attributed to arsenicals' ability to regulate cytochrome P450 1A (CYP1A) enzymes, pivotal in procarcinogen activation or detoxification. The current study inv...
Source: Toxicology Letters - February 25, 2024 Category: Toxicology Authors: Sara R El-Mahrouk Mahmoud A El-Ghiaty Mohammed A Alqahtani Ayman O S El-Kadi Source Type: research
Combined in vitro and in silico mechanistic approach to explore the potential of Alternaria mycotoxins alternariol and altertoxin II to hamper γH2AX formation in DNA damage signaling pathways
This study combined in vitro/in silico approaches to elucidate the potential of AOH and ATXII to induce double-strand breaks (DSBs) in HepG2 cells. Furthermore, it examines the impact of co-exposure to AOH and the DSB-inducing drug doxorubicin (Doxo) on γH2AX expression. AOH slightly increased γH2AX expression, whereas ATXII did not elicit this response. Interestingly, AOH suppressed Doxo-induced γH2AX expression, despite evidence of increased DNA damage in the comet assay. Building on these observations, AOH was postulated to inhibit γH2AX-forming kinases. Along this line, in silico analysis supported AOH potential in...
Source: Toxicology Letters - February 25, 2024 Category: Toxicology Authors: Francesco Crudo Luca Dellafiora Chenyifan Hong Lena Burger Maximilian Jobst Giorgia Del Favero Doris Marko Source Type: research
Particle Aerosol Generation and potential Altering in Airflow used for Acute/Repeated Inhalation Toxicity Testing
This study describes the transport influence in the airflow on the change of powder aerosols and on their respirability. A simplified short tube set-up was developed for the aerosol transport pre-tests, which allows the determination of the optimal aerosol formation conditions for the inhalation tests. The particles were measured with low shear using laser diffraction measurement or optical particle counters. The calculation of the aerodynamic particle sizes prescribed in the guidelines requires knowledge of the effective particle density of the porous aerosol particles. A practicable method for determining these is presen...
Source: Toxicology Letters - February 24, 2024 Category: Toxicology Authors: Franz Lohse Benno Wessely Michael Stintz Juergen Nolde Otto Creutzenberg Gustav Bruer Source Type: research
Association between brominated flame retardants and risk of endocrine-related cancer: A systematic review and meta-analysis
CONCLUSIONS: In conclusion, although this meta-analysis has several limitations, our results suggest that BFR exposure is a significant risk factor for breast cancer, and low-brominated BDE-28 exposure could significantly increase the risk of endocrine-related cancers. Further research is essential to clarify the potential causal relationships between BFRs and endocrine-related cancers, and their carcinogenic mechanisms.PMID:38387762 | DOI:10.1016/j.toxlet.2024.02.002 (Source: Toxicology Letters)
Source: Toxicology Letters - February 22, 2024 Category: Toxicology Authors: Chengchen Shen Kui Zhang Jingyi Shi Jingxuan Yang Yu Wang Zhuo Li Hao Dai Wenxing Yang Source Type: research
Can mothers consume caffeine? The issue of early life exposure and metabolic changes in offspring
Toxicol Lett. 2024 Feb 20:S0378-4274(24)00031-6. doi: 10.1016/j.toxlet.2024.02.005. Online ahead of print.ABSTRACTCaffeine is a substance with central and metabolic effects. Although it is recommended that its use be limited during pregnancy, many women continue to consume caffeine. Direct and indirect actions of caffeine in fetuses and newborns promote adaptive changes, according to the Developmental Origins of Health and Diseases (DOHaD) concept. In fact, epidemiological and experimental evidence reveals the impact of early caffeine exposure. Here, we reviewed these findings with an emphasis on experimental models with r...
Source: Toxicology Letters - February 22, 2024 Category: Toxicology Authors: Luana L Souza Egberto G Moura Patricia C Lisboa Source Type: research
Screening for New Ligands of the MB327-PAM-1 Binding Site of the Nicotinic Acetylcholine Receptor
Toxicol Lett. 2024 Feb 20:S0378-4274(24)00030-4. doi: 10.1016/j.toxlet.2024.02.004. Online ahead of print.ABSTRACTIntoxications with organophosphorus compounds (OPCs) effect a severe impairment of cholinergic neurotransmission that, as a result of overstimulation may lead to desensitization of nicotinic acetylcholine receptors (nAChRs) and finally to death due to respiratory paralysis. So far, therapeutics, that are capable to address and revert desensitized neuromuscular nAChRs into their resting, i.e. functional state are still missing. Still, among a class of compounds termed bispyridinium salts, which are characterized...
Source: Toxicology Letters - February 22, 2024 Category: Toxicology Authors: Sonja Sichler Georg H öfner Valentin Nitsche Karin V Niessen Thomas Seeger Franz Worek Franz F Paintner Klaus T Wanner Source Type: research
Association between brominated flame retardants and risk of endocrine-related cancer: A systematic review and meta-analysis
CONCLUSIONS: In conclusion, although this meta-analysis has several limitations, our results suggest that BFR exposure is a significant risk factor for breast cancer, and low-brominated BDE-28 exposure could significantly increase the risk of endocrine-related cancers. Further research is essential to clarify the potential causal relationships between BFRs and endocrine-related cancers, and their carcinogenic mechanisms.PMID:38387762 | DOI:10.1016/j.toxlet.2024.02.002 (Source: Toxicology Letters)
Source: Toxicology Letters - February 22, 2024 Category: Toxicology Authors: Chengchen Shen Kui Zhang Jingyi Shi Jingxuan Yang Yu Wang Zhuo Li Hao Dai Wenxing Yang Source Type: research
Can mothers consume caffeine? The issue of early life exposure and metabolic changes in offspring
Toxicol Lett. 2024 Feb 20:S0378-4274(24)00031-6. doi: 10.1016/j.toxlet.2024.02.005. Online ahead of print.ABSTRACTCaffeine is a substance with central and metabolic effects. Although it is recommended that its use be limited during pregnancy, many women continue to consume caffeine. Direct and indirect actions of caffeine in fetuses and newborns promote adaptive changes, according to the Developmental Origins of Health and Diseases (DOHaD) concept. In fact, epidemiological and experimental evidence reveals the impact of early caffeine exposure. Here, we reviewed these findings with an emphasis on experimental models with r...
Source: Toxicology Letters - February 22, 2024 Category: Toxicology Authors: Luana L Souza Egberto G Moura Patricia C Lisboa Source Type: research
