Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
Estrogen receptor α mediates alternariol-induced apoptosis and modulation of the invasiveness of ovarian cancer cells
In conclusion, we postulate that AOH might significantly affect the viability and invasiveness of ovarian cancer cells via modulation of ERα and therefore possibly act as an endocrine disruptive agent in ovarian cancer cells.PMID:37683805 | DOI:10.1016/j.toxlet.2023.09.001 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Marta Justyna Kozie ł Dominika Ewa Habrowska-G órczyńska Kinga Anna Urbanek Kamila Domi ńska Agnieszka Wanda Piastowska-Ciesielska Karolina Kowalska Source Type: research
An in silico insight on the mechanistic aspects of gelsenicine toxicity: A reverse screening study pointing to the possible involvement of acetylcholine binding receptor
Toxicol Lett. 2023 Sep 6;386:1-8. doi: 10.1016/j.toxlet.2023.09.003. Online ahead of print.ABSTRACTGelsedine-type alkaloids are highly toxic plant secondary metabolites produced by shrubs belonging to the Gelsemium genus. Gelsenicine is one of the most concerning gelsedine-type alkaloids with a lethal dose lower than 1 mg/Kg in mice. Several reported episodes of poisoning in livestock and fatality cases in humans due to the usage of Gelsemium plants extracts were reported. Also, gelsedine-type alkaloids were found in honey constituting a potential food safety issue. However, their toxicological understanding is scarce and ...
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Lorenzo Pedroni Jean Lou C M Dorne Chiara Dall'Asta Luca Dellafiora Source Type: research
Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
Estrogen receptor α mediates alternariol-induced apoptosis and modulation of the invasiveness of ovarian cancer cells
In conclusion, we postulate that AOH might significantly affect the viability and invasiveness of ovarian cancer cells via modulation of ERα and therefore possibly act as an endocrine disruptive agent in ovarian cancer cells.PMID:37683805 | DOI:10.1016/j.toxlet.2023.09.001 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Marta Justyna Kozie ł Dominika Ewa Habrowska-G órczyńska Kinga Anna Urbanek Kamila Domi ńska Agnieszka Wanda Piastowska-Ciesielska Karolina Kowalska Source Type: research
An in silico insight on the mechanistic aspects of gelsenicine toxicity: A reverse screening study pointing to the possible involvement of acetylcholine binding receptor
Toxicol Lett. 2023 Sep 6;386:1-8. doi: 10.1016/j.toxlet.2023.09.003. Online ahead of print.ABSTRACTGelsedine-type alkaloids are highly toxic plant secondary metabolites produced by shrubs belonging to the Gelsemium genus. Gelsenicine is one of the most concerning gelsedine-type alkaloids with a lethal dose lower than 1 mg/Kg in mice. Several reported episodes of poisoning in livestock and fatality cases in humans due to the usage of Gelsemium plants extracts were reported. Also, gelsedine-type alkaloids were found in honey constituting a potential food safety issue. However, their toxicological understanding is scarce and ...
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Lorenzo Pedroni Jean Lou C M Dorne Chiara Dall'Asta Luca Dellafiora Source Type: research
Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
Estrogen receptor α mediates alternariol-induced apoptosis and modulation of the invasiveness of ovarian cancer cells
In conclusion, we postulate that AOH might significantly affect the viability and invasiveness of ovarian cancer cells via modulation of ERα and therefore possibly act as an endocrine disruptive agent in ovarian cancer cells.PMID:37683805 | DOI:10.1016/j.toxlet.2023.09.001 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Marta Justyna Kozie ł Dominika Ewa Habrowska-G órczyńska Kinga Anna Urbanek Kamila Domi ńska Agnieszka Wanda Piastowska-Ciesielska Karolina Kowalska Source Type: research
An in silico insight on the mechanistic aspects of gelsenicine toxicity: a reverse screening study pointing to the possible involvement of acetylcholine binding receptor
Toxicol Lett. 2023 Sep 6:S0378-4274(23)01034-2. doi: 10.1016/j.toxlet.2023.09.003. Online ahead of print.ABSTRACTGelsedine-type alkaloids are highly toxic plant secondary metabolites produced by shrubs belonging to the Gelsemium genus. Gelsenicine is one of the most concerning gelsedine-type alkaloids with a lethal dose lower than 1mg/Kg in mice. Several reported episodes of poisoning in livestock and fatality cases in humans due to the usage of Gelsemium plants extracts were reported. Also, gelsedine-type alkaloids were found in honey constituting a potential food safety issue. However, their toxicological understanding i...
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Lorenzo Pedroni Jean Lou C M Dorne Chiara Dall'Asta Luca Dellafiora Source Type: research
Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
Estrogen receptor α mediates alternariol-induced apoptosis and modulation of the invasiveness of ovarian cancer cells
In conclusion, we postulate that AOH might significantly affect the viability and invasiveness of ovarian cancer cells via modulation of ERα and therefore possibly act as an endocrine disruptive agent in ovarian cancer cells.PMID:37683805 | DOI:10.1016/j.toxlet.2023.09.001 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Marta Justyna Kozie ł Dominika Ewa Habrowska-G órczyńska Kinga Anna Urbanek Kamila Domi ńska Agnieszka Wanda Piastowska-Ciesielska Karolina Kowalska Source Type: research
An in silico insight on the mechanistic aspects of gelsenicine toxicity: a reverse screening study pointing to the possible involvement of acetylcholine binding receptor
Toxicol Lett. 2023 Sep 6:S0378-4274(23)01034-2. doi: 10.1016/j.toxlet.2023.09.003. Online ahead of print.ABSTRACTGelsedine-type alkaloids are highly toxic plant secondary metabolites produced by shrubs belonging to the Gelsemium genus. Gelsenicine is one of the most concerning gelsedine-type alkaloids with a lethal dose lower than 1mg/Kg in mice. Several reported episodes of poisoning in livestock and fatality cases in humans due to the usage of Gelsemium plants extracts were reported. Also, gelsedine-type alkaloids were found in honey constituting a potential food safety issue. However, their toxicological understanding i...
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Lorenzo Pedroni Jean Lou C M Dorne Chiara Dall'Asta Luca Dellafiora Source Type: research
Halogenated bisphenol A derivatives potently inhibit human, rat, and mouse gonadal 3 β-hydroxysteroid dehydrogenases: structure-activity relationship and in silico molecular docking analysis
In conclusion, halogenated BPA derivatives are more potent inhibitors of three 3β-HSDs than BPA and there is structure-dependent inhibition. SYNOPSIS: Chlorinated bisphenol derivatives after water chlorination process and other halogenated bisphenols effectively inhibit human and rat 3β-HSD activity, thereby leading to steroid hormone deficiency.PMID:37683804 | DOI:10.1016/j.toxlet.2023.09.002 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Yang Yu Mengyun Wang Ya Chen Chengshuang Pan Qianjin Fei Yang Zhu Huitao Li Ren-Shan Ge Source Type: research
Estrogen receptor α mediates alternariol-induced apoptosis and modulation of the invasiveness of ovarian cancer cells
In conclusion, we postulate that AOH might significantly affect the viability and invasiveness of ovarian cancer cells via modulation of ERα and therefore possibly act as an endocrine disruptive agent in ovarian cancer cells.PMID:37683805 | DOI:10.1016/j.toxlet.2023.09.001 (Source: Toxicology Letters)
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Marta Justyna Kozie ł Dominika Ewa Habrowska-G órczyńska Kinga Anna Urbanek Kamila Domi ńska Agnieszka Wanda Piastowska-Ciesielska Karolina Kowalska Source Type: research
An in silico insight on the mechanistic aspects of gelsenicine toxicity: a reverse screening study pointing to the possible involvement of acetylcholine binding receptor
Toxicol Lett. 2023 Sep 6:S0378-4274(23)01034-2. doi: 10.1016/j.toxlet.2023.09.003. Online ahead of print.ABSTRACTGelsedine-type alkaloids are highly toxic plant secondary metabolites produced by shrubs belonging to the Gelsemium genus. Gelsenicine is one of the most concerning gelsedine-type alkaloids with a lethal dose lower than 1mg/Kg in mice. Several reported episodes of poisoning in livestock and fatality cases in humans due to the usage of Gelsemium plants extracts were reported. Also, gelsedine-type alkaloids were found in honey constituting a potential food safety issue. However, their toxicological understanding i...
Source: Toxicology Letters - September 8, 2023 Category: Toxicology Authors: Lorenzo Pedroni Jean Lou C M Dorne Chiara Dall'Asta Luca Dellafiora Source Type: research
