Bromodomain protein 4 mediates the roles of TGF β1-induced Stat3 signaling in mouse liver fibrogenesis
In conclusion, a network consisting of Stat3 signaling, Smad3 signaling, Egr1, and BrD4 was involved in the effects of TGFβ1 on liver fibrosis, providing new toxicological mechanisms for TGFβ1 in liver fibrogenesis.PMID:37634812 | DOI:10.1016/j.toxlet.2023.08.009 (Source: Toxicology Letters)
Source: Toxicology Letters - August 27, 2023 Category: Toxicology Authors: Feifan Xu Sidan Lu Xin Jia Yajun Zhou Source Type: research
Bromodomain protein 4 mediates the roles of TGF β1-induced Stat3 signaling in mouse liver fibrogenesis
In conclusion, a network consisting of Stat3 signaling, Smad3 signaling, Egr1, and BrD4 was involved in the effects of TGFβ1 on liver fibrosis, providing new toxicological mechanisms for TGFβ1 in liver fibrogenesis.PMID:37634812 | DOI:10.1016/j.toxlet.2023.08.009 (Source: Toxicology Letters)
Source: Toxicology Letters - August 27, 2023 Category: Toxicology Authors: Feifan Xu Sidan Lu Xin Jia Yajun Zhou Source Type: research
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L
This study suggests that 4-hydroxylonchocarpin and corylifol A cause hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction, suggesting that these compounds may be the potential hepatotoxic components of P. corylifolia.PMID:37598872 | DOI:10.1016/j.toxlet.2023.08.008 (Source: Toxicology Letters)
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: Linqi Ouyang Zhiqiang Fan Yang He Long Tan Guoyan Deng Qin He Yiran He Ting Ouyang Congjie Li Qin Zhang Hongyu Liu Yajie Zuo Source Type: research
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L
This study suggests that 4-hydroxylonchocarpin and corylifol A cause hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction, suggesting that these compounds may be the potential hepatotoxic components of P. corylifolia.PMID:37598872 | DOI:10.1016/j.toxlet.2023.08.008 (Source: Toxicology Letters)
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: Linqi Ouyang Zhiqiang Fan Yang He Long Tan Guoyan Deng Qin He Yiran He Ting Ouyang Congjie Li Qin Zhang Hongyu Liu Yajie Zuo Source Type: research
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L
This study suggests that 4-hydroxylonchocarpin and corylifol A cause hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction, suggesting that these compounds may be the potential hepatotoxic components of P. corylifolia.PMID:37598872 | DOI:10.1016/j.toxlet.2023.08.008 (Source: Toxicology Letters)
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: Linqi Ouyang Zhiqiang Fan Yang He Long Tan Guoyan Deng Qin He Yiran He Ting Ouyang Congjie Li Qin Zhang Hongyu Liu Yajie Zuo Source Type: research
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L
This study suggests that 4-hydroxylonchocarpin and corylifol A cause hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction, suggesting that these compounds may be the potential hepatotoxic components of P. corylifolia.PMID:37598872 | DOI:10.1016/j.toxlet.2023.08.008 (Source: Toxicology Letters)
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: Linqi Ouyang Zhiqiang Fan Yang He Long Tan Guoyan Deng Qin He Yiran He Ting Ouyang Congjie Li Qin Zhang Hongyu Liu Yajie Zuo Source Type: research
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L
This study suggests that 4-hydroxylonchocarpin and corylifol A cause hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction, suggesting that these compounds may be the potential hepatotoxic components of P. corylifolia.PMID:37598872 | DOI:10.1016/j.toxlet.2023.08.008 (Source: Toxicology Letters)
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: Linqi Ouyang Zhiqiang Fan Yang He Long Tan Guoyan Deng Qin He Yiran He Ting Ouyang Congjie Li Qin Zhang Hongyu Liu Yajie Zuo Source Type: research
Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine
Toxicol Lett. 2023 Aug 18:S0378-4274(23)00243-6. doi: 10.1016/j.toxlet.2023.08.007. Online ahead of print.ABSTRACTHigenamine (Hige), a plant derived alkaloid is classified as β2 agonist by the World Anti-Doping Agency (WADA). However, pharmacologic mechanisms of its performance-enhancing activity have not been investigated so far. Therefore, we investigate the anabolic activity and associated molecular mechanisms of Hige in C2C12 myotubes. In differentiated C2C12 cells dose-dependent effects of Hige on myotube size were analyzed. The mRNA expression of genes involved in hypertrophy was measured. For mechanistic studies, Î...
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: L Jiang M Piribauer T Kostov S Steidel D A Bizjak J M Steinacker M Parr P Diel Source Type: research
4-hydroxylonchocarpin and corylifol A: The potential hepatotoxic components of Psoralea corylifolia L
This study suggests that 4-hydroxylonchocarpin and corylifol A cause hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction, suggesting that these compounds may be the potential hepatotoxic components of P. corylifolia.PMID:37598872 | DOI:10.1016/j.toxlet.2023.08.008 (Source: Toxicology Letters)
Source: Toxicology Letters - August 20, 2023 Category: Toxicology Authors: Linqi Ouyang Zhiqiang Fan Yang He Long Tan Guoyan Deng Qin He Yiran He Ting Ouyang Congjie Li Qin Zhang Hongyu Liu Yajie Zuo Source Type: research
Cigarette smoke attenuates mesenchymal stem cell-based suppression of immune cell-driven acute liver failure
Toxicol Lett. 2023 Aug 10:S0378-4274(23)00242-4. doi: 10.1016/j.toxlet.2023.08.006. Online ahead of print.ABSTRACTDetrimental effects of smoking on mesenchymal stem cell (MSC)-dependent immunosuppression and hepatoprotection are unknown. Herewith, by using α-galactosylceramide (α-GalCer)-induced liver injury, a well-established murine model of fulminant hepatitis, we examined molecular mechanisms which were responsible for negative effects of cigarette smoke on MSC-dependent immunomodulation. MSC which were grown in cigarette smoke-exposed medium (MSCWS-CM) obtained pro-inflammatory phenotype, were not able to optimally ...
Source: Toxicology Letters - August 12, 2023 Category: Toxicology Authors: Dragica Pavlovic Dragana Miloradovic Milica Dimitrijevic Stojanovic Carl Randall Harrell Riccardo Polosa Sonja Rust Giovanni Li Volti Massimo Caruso Vladimir Jakovljevic Valentin Djonov Vladislav Volarevic Source Type: research
