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Monitoring Antibiotic Consumption in Pediatrics. How Close to Reality Are Days of Therapy and Recommended Daily Dose Methods?
Conclusion: The DOT method is superior to RDD for monitoring antibiotic drug consumption in pediatric cohorts. RDD seems to work satisfactory well for selected antibiotic agents that are administered with little variation in packaging size. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - March 23, 2022 Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

Amoxicillin Adverse Cutaneous Reaction Versus Post Streptococcal Vasculitis: Lymphocyte Transformation Test Solved the Question
We report the case of a 5-year-old girl investigated for a suspected post streptococcal vasculitis where differential diagnosis was improved by an allergy work-up and confirmed by lymphocyte transformation test. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - March 23, 2022 Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

Falsely Undetectable Vancomycin Levels in a Pediatric Patient With Chronic Granulomatous Disease
A child with chronic granulomatous disease on vancomycin treatment had V trough levels that became undetectable, as measured in our hospital’s clinical laboratory by a commonly employed particle-enhanced turbidometric inhibition assay. An alternative laboratory method yielded appropriate results. Recognizing and resolving erroneously low V trough levels could prevent needless adjustments in dosing that could increase risk for acute kidney injury. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - March 23, 2022 Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research

Evaluating a Cluster and the Overall Trend of Invasive Haemophilus influenzae Serotype b in Alaska 2005–2019
Background: In 2019, 5 cases of invasive Haemophilus influenzae serotype b (Hib) occurred in the Anchorage region of Alaska over a period of 16 days. No cases had occurred in Alaska in the preceding 26 months. Methods: Alaska Hib isolates from 2005 through 2019 were analyzed using whole-genome sequencing (WGS). Rates were compared with the CDC’s Active Bacterial Core surveillance (ABCs) data. Results: A total of 33 cases of invasive Hib occurred in Alaska from 2005 through 2019. Of the 5 cases associated with the cluster, 2 (40%) occurred in adults and all occurred in the Anchorage region. In contrast, ...
Source: The Pediatric Infectious Disease Journal - March 23, 2022 Category: Infectious Diseases Tags: Original Studies Source Type: research

Changes in the Epidemiology of Zoonotic Infections in Children: A Nationwide Register Study in Finland
Discussion: Borrelia infections increased most rapidly in children 5–9 years of age and overall expanded geographically in Finland. Tularemia epidemic cycles were shorter than those previously reported. These results will help clinicians to identify these infections in different geographic areas and age groups in Finland. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - March 23, 2022 Category: Infectious Diseases Tags: Original Studies Source Type: research