Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

Editorial expression of concern
Sci Signal. 2022 Jun 21;15(739):eadd4323. doi: 10.1126/scisignal.add4323. Epub 2022 Jun 21.NO ABSTRACTPMID:35727862 | DOI:10.1126/scisignal.add4323 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

Editorial expression of concern
Sci Signal. 2022 Jun 21;15(739):eadd4322. doi: 10.1126/scisignal.add4322. Epub 2022 Jun 21.NO ABSTRACTPMID:35727863 | DOI:10.1126/scisignal.add4322 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization
Sci Signal. 2022 Jun 21;15(739):eabg2505. doi: 10.1126/scisignal.abg2505. Epub 2022 Jun 21.ABSTRACTThe trans-synaptic adhesion molecule neuroligin-2 (NL2) is essential for the development and function of inhibitory synapses. NL2 recruits the postsynaptic scaffold protein gephyrin, which, in turn, stabilizes γ-aminobutyric acid type A receptors (GABAARs) in the postsynaptic domain. Thus, the amount of NL2 at the synapse can control synaptic GABAAR concentration to tune inhibitory neurotransmission efficacy. Here, using biochemistry, imaging, single-particle tracking, and electrophysiology, we uncovered a key role for cAMP-...
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: Els F Halff Saad Hannan Jaturon Kwanthongdee Flavie Lesept Trevor G Smart Josef T Kittler Source Type: research

Waking up melanoma
Sci Signal. 2022 Jun 21;15(739):eadd5252. doi: 10.1126/scisignal.add5252. Epub 2022 Jun 21.ABSTRACTDormant melanoma cells in the lung can be reactivated by age-related environmental cues in the stroma.PMID:35727865 | DOI:10.1126/scisignal.add5252 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: Amy E Baek Source Type: research

Editorial expression of concern
Sci Signal. 2022 Jun 21;15(739):eadd4323. doi: 10.1126/scisignal.add4323. Epub 2022 Jun 21.NO ABSTRACTPMID:35727862 | DOI:10.1126/scisignal.add4323 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

Editorial expression of concern
Sci Signal. 2022 Jun 21;15(739):eadd4322. doi: 10.1126/scisignal.add4322. Epub 2022 Jun 21.NO ABSTRACTPMID:35727863 | DOI:10.1126/scisignal.add4322 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research