Biasing microglia to help, not hurt
Sci Signal. 2024 Mar 26;17(829):eadp3241. doi: 10.1126/scisignal.adp3241. Epub 2024 Mar 26.ABSTRACTBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.PMID:38530879 | DOI:10.1126/scisignal.adp3241 (Source: Science Signaling)
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Biasing microglia to help, not hurt
Sci Signal. 2024 Mar 26;17(829):eadp3241. doi: 10.1126/scisignal.adp3241. Epub 2024 Mar 26.ABSTRACTBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.PMID:38530879 | DOI:10.1126/scisignal.adp3241 (Source: Science Signaling)
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Biasing microglia to help, not hurt
Sci Signal. 2024 Mar 26;17(829):eadp3241. doi: 10.1126/scisignal.adp3241. Epub 2024 Mar 26.ABSTRACTBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.PMID:38530879 | DOI:10.1126/scisignal.adp3241 (Source: Science Signaling)
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Biasing microglia to help, not hurt
Sci Signal. 2024 Mar 26;17(829):eadp3241. doi: 10.1126/scisignal.adp3241. Epub 2024 Mar 26.ABSTRACTBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.PMID:38530879 | DOI:10.1126/scisignal.adp3241 (Source: Science Signaling)
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Biasing microglia to help, not hurt
Sci Signal. 2024 Mar 26;17(829):eadp3241. doi: 10.1126/scisignal.adp3241. Epub 2024 Mar 26.ABSTRACTBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.PMID:38530879 | DOI:10.1126/scisignal.adp3241 (Source: Science Signaling)
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Biasing microglia to help, not hurt
Sci Signal. 2024 Mar 26;17(829):eadp3241. doi: 10.1126/scisignal.adp3241. Epub 2024 Mar 26.ABSTRACTBlocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.PMID:38530879 | DOI:10.1126/scisignal.adp3241 (Source: Science Signaling)
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Sci Signal. 2024 Mar 26;17(829):eadk8249. doi: 10.1126/scisignal.adk8249. Epub 2024 Mar 26.ABSTRACTMutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces neuroinflammation. We found that GC accumulati...
Source: Science Signaling - March 26, 2024 Category: Biomedical Science Authors: Rui Wang Hongyang Sun Yifan Cao Zhixiong Zhang Yajing Chen Xiying Wang Lele Liu Jin Wu Hao Xu Dan Wu Chenchen Mu Zongbing Hao Song Qin Haigang Ren Junhai Han Ming Fang Guanghui Wang Source Type: research
Polarizing itch
Sci Signal. 2024 Mar 19;17(828):eadp2197. doi: 10.1126/scisignal.adp2197. Epub 2024 Mar 19.ABSTRACTAn itch-associated GPCR on neutrophils controls their activation during bacterial infection.PMID:38502731 | DOI:10.1126/scisignal.adp2197 (Source: Science Signaling)
Source: Science Signaling - March 19, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Exercise-induced BDNF promotes PPAR δ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery
Sci Signal. 2024 Mar 19;17(828):eadh2783. doi: 10.1126/scisignal.adh2783. Epub 2024 Mar 19.ABSTRACTPost-exercise recovery is essential to resolve metabolic perturbations and promote long-term cellular remodeling in response to exercise. Here, we report that muscle-generated brain-derived neurotrophic factor (BDNF) elicits post-exercise recovery and metabolic reprogramming in skeletal muscle. BDNF increased the post-exercise expression of the gene encoding PPARδ (peroxisome proliferator-activated receptor δ), a transcription factor that is a master regulator of lipid metabolism. After exercise, mice with muscle-specific B...
Source: Science Signaling - March 19, 2024 Category: Biomedical Science Authors: Wing Suen Chan Chun Fai Ng Brian Pak Shing Pang Miaojia Hang Margaret Chui Ling Tse Elsie Chit Yu Iu Xin Ci Ooi Xiuying Yang Jason K Kim Chi Wai Lee Chi Bun Chan Source Type: research
CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans
Sci Signal. 2024 Mar 19;17(828):eabl3758. doi: 10.1126/scisignal.abl3758. Epub 2024 Mar 19.ABSTRACTCXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial properties. CXCL17 is also implicated in the pathology of inflammatory disorders and progression of several cancers, and its expression is increased during viral infections of the lung. However, the exact role of CXCL17 in health and disease requires further investigation, and there is a need for confirmed molecular targets mediating CXCL17 functional responses. U...
Source: Science Signaling - March 19, 2024 Category: Biomedical Science Authors: Carl W White Simon Platt Laura E Kilpatrick Natasha Dale Rekhati S Abhayawardana Sebastian Dekkers Nicholas D Kindon Barrie Kellam Michael J Stocks Kevin D G Pfleger Stephen J Hill Source Type: research
