Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research

Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research

Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK
Sci Signal. 2022 May 31;15(736):eabg5216. doi: 10.1126/scisignal.abg5216. Epub 2022 May 31.ABSTRACTThe Bruton's tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481, inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling. Although ibrutinib is durably effective in patients with B cell malignancies, many patients still develop ibrutinib-resistant disease. Resistance can arise because of mutations at the ibrutinib-binding site in BTK. Here, we characterized the mechanism by which two BTK mutations, C481F and C481Y, may lead to ibrutinib resistance. Both mutants ...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Kamaldeep Dhami Anirban Chakraborty Tarikere L Gururaja Leo W-K Cheung Chaohong Sun Felix DeAnda XiaoDong Huang Source Type: research

The perception and response of T cells to a changing environment are based on the law of initial value
Sci Signal. 2022 May 31;15(736):eabj9842. doi: 10.1126/scisignal.abj9842. Epub 2022 May 31.ABSTRACTαβ T cells are critical components of the adaptive immune system and are capable of inducing sterilizing immunity after pathogen infection and eliminating transformed tumor cells. The development and function of T cells are controlled through the T cell antigen receptor, which recognizes peptides displayed on major histocompatibility complex (MHC) molecules. Here, we review how T cells generate the ability to recognize self-peptide-bound MHC molecules and use signals derived from these interactions to instruct cellular deve...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Eric S Huseby Emma Teixeiro Source Type: research

Formate for tumor progression
Sci Signal. 2022 May 31;15(736):eadd1844. doi: 10.1126/scisignal.add1844. Epub 2022 May 31.ABSTRACTA bacterial metabolite promotes the progression of colorectal cancer.PMID:35639857 | DOI:10.1126/scisignal.add1844 (Source: Science Signaling)
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK
Sci Signal. 2022 May 31;15(736):eabg5216. doi: 10.1126/scisignal.abg5216. Epub 2022 May 31.ABSTRACTThe Bruton's tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481, inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling. Although ibrutinib is durably effective in patients with B cell malignancies, many patients still develop ibrutinib-resistant disease. Resistance can arise because of mutations at the ibrutinib-binding site in BTK. Here, we characterized the mechanism by which two BTK mutations, C481F and C481Y, may lead to ibrutinib resistance. Both mutants ...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Kamaldeep Dhami Anirban Chakraborty Tarikere L Gururaja Leo W-K Cheung Chaohong Sun Felix DeAnda XiaoDong Huang Source Type: research

The perception and response of T cells to a changing environment are based on the law of initial value
Sci Signal. 2022 May 31;15(736):eabj9842. doi: 10.1126/scisignal.abj9842. Epub 2022 May 31.ABSTRACTαβ T cells are critical components of the adaptive immune system and are capable of inducing sterilizing immunity after pathogen infection and eliminating transformed tumor cells. The development and function of T cells are controlled through the T cell antigen receptor, which recognizes peptides displayed on major histocompatibility complex (MHC) molecules. Here, we review how T cells generate the ability to recognize self-peptide-bound MHC molecules and use signals derived from these interactions to instruct cellular deve...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Eric S Huseby Emma Teixeiro Source Type: research

Formate for tumor progression
Sci Signal. 2022 May 31;15(736):eadd1844. doi: 10.1126/scisignal.add1844. Epub 2022 May 31.ABSTRACTA bacterial metabolite promotes the progression of colorectal cancer.PMID:35639857 | DOI:10.1126/scisignal.add1844 (Source: Science Signaling)
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK
Sci Signal. 2022 May 31;15(736):eabg5216. doi: 10.1126/scisignal.abg5216. Epub 2022 May 31.ABSTRACTThe Bruton's tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481, inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling. Although ibrutinib is durably effective in patients with B cell malignancies, many patients still develop ibrutinib-resistant disease. Resistance can arise because of mutations at the ibrutinib-binding site in BTK. Here, we characterized the mechanism by which two BTK mutations, C481F and C481Y, may lead to ibrutinib resistance. Both mutants ...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Kamaldeep Dhami Anirban Chakraborty Tarikere L Gururaja Leo W-K Cheung Chaohong Sun Felix DeAnda XiaoDong Huang Source Type: research

The perception and response of T cells to a changing environment are based on the law of initial value
Sci Signal. 2022 May 31;15(736):eabj9842. doi: 10.1126/scisignal.abj9842. Epub 2022 May 31.ABSTRACTαβ T cells are critical components of the adaptive immune system and are capable of inducing sterilizing immunity after pathogen infection and eliminating transformed tumor cells. The development and function of T cells are controlled through the T cell antigen receptor, which recognizes peptides displayed on major histocompatibility complex (MHC) molecules. Here, we review how T cells generate the ability to recognize self-peptide-bound MHC molecules and use signals derived from these interactions to instruct cellular deve...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Eric S Huseby Emma Teixeiro Source Type: research

Formate for tumor progression
Sci Signal. 2022 May 31;15(736):eadd1844. doi: 10.1126/scisignal.add1844. Epub 2022 May 31.ABSTRACTA bacterial metabolite promotes the progression of colorectal cancer.PMID:35639857 | DOI:10.1126/scisignal.add1844 (Source: Science Signaling)
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK
Sci Signal. 2022 May 31;15(736):eabg5216. doi: 10.1126/scisignal.abg5216. Epub 2022 May 31.ABSTRACTThe Bruton's tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481, inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling. Although ibrutinib is durably effective in patients with B cell malignancies, many patients still develop ibrutinib-resistant disease. Resistance can arise because of mutations at the ibrutinib-binding site in BTK. Here, we characterized the mechanism by which two BTK mutations, C481F and C481Y, may lead to ibrutinib resistance. Both mutants ...
Source: Science Signaling - May 31, 2022 Category: Biomedical Science Authors: Kamaldeep Dhami Anirban Chakraborty Tarikere L Gururaja Leo W-K Cheung Chaohong Sun Felix DeAnda XiaoDong Huang Source Type: research