Taking the STING out of aging?
Sci Signal. 2022 Jul 5;15(741):eadd7524. doi: 10.1126/scisignal.add7524. Epub 2022 Jul 5.ABSTRACTBy preventing STING activation, the transcriptional coactivators YAP/TAZ suppress cellular senescence.PMID:35857638 | DOI:10.1126/scisignal.add7524 (Source: Science Signaling)
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations
Sci Signal. 2022 Jul 12;15(742):eabm5995. doi: 10.1126/scisignal.abm5995. Epub 2022 Jul 12.ABSTRACTThe E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene encoding it, RLIM, is mutated in the X-linked human developmental disorder Tonne-Kalscheuer syndrome (TOKAS). Substrates of RNF12 include transcriptional regulators such as the pluripotency-associated transcriptional repressor REX1. Using global quantitative proteomics in male mouse embryonic stem cells, we identified the deubiquitylase USP26 as a putative downstream target of RNF12 activity. RNF12 relieved REX1-mediated repression of Usp26, ...
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Anna Segarra-Fas Carmen Espejo-Serrano Francisco Bustos Houjiang Zhou Feng Wang Rachel Toth Thomas Macartney Ingolf Bach Gino Nardocci Greg M Findlay Source Type: research

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals
Sci Signal. 2022 Jul 12;15(742):eabl5343. doi: 10.1126/scisignal.abl5343. Epub 2022 Jul 12.ABSTRACTSignals that determine the differentiation of naïve CD4+ T helper (TH) cells into specific effector cell subsets are primarily stimulated by cytokines, but additional signals are required to adjust the magnitude of TH cell responses and set the balance between effective immunity and immunological tolerance. By inducing the post-thymic deletion of the T cell lineage signaling protein THEMIS, we showed that THEMIS promoted the development of optimal type 1 immune responses to foreign antigens but stimulated signals that favore...
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Cui Yang Ga ëtan Blaize R émi Marrocco Nelly Rouqui é Cyrielle Bories Myl ène Gador Suzanne M élique Emeline Joulia Mehdi Benamar Anne S Dejean H élène Daniels-Treffandier Paul E Love Nicolas Fazilleau Abdelhadi Saoudi Renaud Lesourne Source Type: research

A pancreatic pause in breast cancer
Sci Signal. 2022 Jul 12;15(742):eadd8568. doi: 10.1126/scisignal.add8568. Epub 2022 Jul 12.ABSTRACTBreast cancer-derived extracellular vesicles suppress insulin release to increase systemic glucose availability.PMID:35857632 | DOI:10.1126/scisignal.add8568 (Source: Science Signaling)
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells
Sci Signal. 2022 Jul 19;15(743):eabl9169. doi: 10.1126/scisignal.abl9169. Epub 2022 Jul 19.ABSTRACTThe integrin lymphocyte function-associated antigen 1 (LFA-1) helps to coordinate the migration, adhesion, and activation of T cells through interactions with intercellular adhesion molecule 1 (ICAM-1) and ICAM-2. LFA-1 is activated during the engagement of chemokine receptors and the T cell receptor (TCR) through inside-out signaling, a process that is partially mediated by phosphoinositide 3-kinase (PI3K) and its product phosphatidylinositol 3,4,5-trisphosphate (PIP3). To evaluate potential roles of PI3K in LFA-1 activation...
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Kristoffer H Johansen Dominic P Golec Bonnie Huang Chung Park Julie H Thomsen Silvia Preite Jennifer L Cannons Fabien Gar çon Edward C Schrom Christina J F Courr èges Tibor Z Veres James Harrison Meritxell Nus James D Phelan Wolfgang Bergmeier John H Ke Source Type: research

Sex-dependent signaling of social isolation
Sci Signal. 2022 Jul 19;15(743):eaadd9512. doi: 10.1126/scisignal.add9512. Epub 2022 Jul 19.ABSTRACTThe neurological effects of social isolation stress differ between males and females.PMID:35857634 | DOI:10.1126/scisignal.add9512 (Source: Science Signaling)
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

The omega-3 hydroxy fatty acid 7( < em > S < /em > )-HDHA is a high-affinity PPAR α ligand that regulates brain neuronal morphology
Sci Signal. 2022 Jul 5;15(741):eabo1857. doi: 10.1126/scisignal.abo1857. Epub 2022 Jul 5.ABSTRACTThe nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging as an important target in the brain for the treatment or prevention of cognitive disorders. The identification of high-affinity ligands for brain PPARα may reveal the mechanisms underlying the synaptic effects of this receptor and facilitate drug development. Here, using an affinity purification-untargeted mass spectrometry (AP-UMS) approach, we identified an endogenous, selective PPARα ligand, 7(S)-hydroxy-docosahexaenoic acid [7(S)-HD...
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Jiabao Liu Cigdem Sahin Samar Ahmad Lilia Magomedova Minhao Zhang Zhengping Jia Adam H Metherel Arturo Orellana Gennady Poda Richard P Bazinet Liliana Attisano Carolyn L Cummins Hui Peng Henry M Krause Source Type: research

Balancing energy and protein homeostasis at ER-mitochondria contact sites
Sci Signal. 2022 Jul 5;15(741):eabm7524. doi: 10.1126/scisignal.abm7524. Epub 2022 Jul 5.ABSTRACTThe endoplasmic reticulum (ER) is the largest organelle of the cell and participates in multiple essential functions, including the production of secretory proteins, lipid synthesis, and calcium storage. Sustaining proteostasis requires an intimate coupling with energy production. Mitochondrial respiration evolved to be functionally connected to ER physiology through a physical interface between both organelles known as mitochondria-associated membranes. This quasi-synaptic structure acts as a signaling hub that tunes the funct...
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: Amado Carreras-Sureda Guido Kroemer Julio Cesar Cardenas Claudio Hetz Source Type: research

Taking the STING out of aging?
Sci Signal. 2022 Jul 5;15(741):eadd7524. doi: 10.1126/scisignal.add7524. Epub 2022 Jul 5.ABSTRACTBy preventing STING activation, the transcriptional coactivators YAP/TAZ suppress cellular senescence.PMID:35857638 | DOI:10.1126/scisignal.add7524 (Source: Science Signaling)
Source: Science Signaling - July 20, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research

< em > Bacteroides < /em > fight fatty liver
Sci Signal. 2022 Jun 28;15(740):eadd6194. doi: 10.1126/scisignal.add6194. Epub 2022 Jun 28.ABSTRACTSphingolipids from commensal bacteria transit to the liver and normalize lipid accumulation in a mouse model of hepatic steatosis.PMID:35763559 | DOI:10.1126/scisignal.add6194 (Source: Science Signaling)
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Annalisa M VanHook Source Type: research

Coordinated activation of TGF- β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication
Sci Signal. 2022 Jun 28;15(740):eabn4395. doi: 10.1126/scisignal.abn4395. Epub 2022 Jun 28.ABSTRACTLigands of the transforming growth factor-β (TGF-β) superfamily, including TGF-βs, activins, and bone morphogenetic proteins (BMPs), have been implicated in hepatic development, homeostasis, and pathophysiology. We explored the mechanisms by which hepatocytes decode and integrate injury-induced signaling from TGF-βs and activins (TGF-β/Activin) and BMPs. We mapped the spatiotemporal patterns of pathway activation during liver injury induced by acetaminophen (APAP) in dual reporter mice carrying a fluorescent reporter of ...
Source: Science Signaling - June 28, 2022 Category: Biomedical Science Authors: Athanasios Stavropoulos Georgios Divolis Maria Manioudaki Ariana Gavriil Ismini Kloukina Despina N Perrea Alexandros Sountoulidis Ethan Ford Athanasia Doulou Anastasia Apostolidou Elena Katsantoni Olli Ritvos Georgios Germanidis Maria Xilouri Paschalis Si Source Type: research