TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis
Sci Signal. 2024 Jan 23;17(820):eabo0465. doi: 10.1126/scisignal.abo0465. Epub 2024 Jan 23.ABSTRACTPrimary cilia are enriched in signaling receptors, and defects in their formation or function can induce conditions such as polycystic kidney disease, postaxial hexadactyly, and microphthalmia. Mammalian Hedgehog (Hh) signaling is important in the development of primary cilia, and TMEM216, a transmembrane protein that localizes to the base of cilia, is also implicated in ciliogenesis in zebrafish. Here, we found that Tmem216-deficient mice had impaired Hh signaling and displayed typical ciliopathic phenotypes. These phenomena...
Source: Science Signaling - January 23, 2024 Category: Biomedical Science Authors: Yingying Wang Huili Yao Yu Zhang Ning Mu Tong Lu Zhiyuan Du Yingdi Wu Xiaopeng Li Min Su Ming Shao Xiaoyang Sun Ling Su Xiangguo Liu Source Type: research
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome
Sci Signal. 2024 Jan 23;17(820):eabg8145. doi: 10.1126/scisignal.abg8145. Epub 2024 Jan 23.ABSTRACTInflammasomes are multiprotein complexes that drive inflammation and contribute to protective immunity against pathogens and immune pathology in autoinflammatory diseases. Inflammasomes assemble when an inflammasome scaffold protein senses an activating signal and forms a signaling platform with the inflammasome adaptor protein ASC. The NLRP subfamily of NOD-like receptors (NLRs) includes inflammasome nucleators (such as NLRP3) and also NLRP12, which is genetically linked to familial autoinflammatory disorders that resemble d...
Source: Science Signaling - January 23, 2024 Category: Biomedical Science Authors: Jared R Coombs Alina Zamoshnikova Caroline L Holley Madhavi P Maddugoda Daniel Eng Thiam Teo Camille Chauvin Lionel F Poulin Nazarii Vitak Connie M Ross Manasa Mellacheruvu Rebecca C Coll Leonhard X Heinz Sabrina S Burgener Stefan Emming Mathias Chamailla Source Type: research
Promoting DNA repair to prevent fibrosis
Sci Signal. 2024 Jan 23;17(820):eado0928. doi: 10.1126/scisignal.ado0928. Epub 2024 Jan 23.ABSTRACTYTHDC1 activates the DNA repair kinase ATR to suppress bleomycin-induced lung fibrosis.PMID:38261658 | DOI:10.1126/scisignal.ado0928 (Source: Science Signaling)
Source: Science Signaling - January 23, 2024 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2
Sci Signal. 2024 Jan 16;17(819):eabn1101. doi: 10.1126/scisignal.abn1101. Epub 2024 Jan 16.ABSTRACTUbiquitination is a posttranslational modification that is crucial for the dynamic regulation of diverse signaling pathways. To enhance our understanding of ubiquitination-mediated signaling, we generated a new class of bispecific antibodies that combine recognition of ubiquitination substrates and specific polyubiquitin linkages. RIP1-K63 and RIP1-linear (Lin) linkage polyubiquitin bispecific antibodies detected linkage-specific ubiquitination of the proinflammatory kinase RIP1 in cells and in tissues and revealed RIP1 ubiqu...
Source: Science Signaling - January 16, 2024 Category: Biomedical Science Authors: Tatiana Goncharov L ászló G Kőműves Matthias Kist Erick R Castellanos Axel Witt Anna V Fedorova Anita Izrael-Tomasevic Kebing Yu Mary Keir Marissa L Matsumoto Domagoj Vucic Source Type: research
Systemic inflammation from the brain
Sci Signal. 2024 Jan 16;17(819):eadn9627. doi: 10.1126/scisignal.adn9627. Epub 2024 Jan 16.ABSTRACTThe actions of glucagon-like peptide 1 receptor agonists in the CNS reduce systemic inflammation.PMID:38227685 | DOI:10.1126/scisignal.adn9627 (Source: Science Signaling)
Source: Science Signaling - January 16, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Balancing act of small GTPases downstream of plexin-A4 signaling motifs promotes dendrite elaboration in mammalian cortical neurons
Sci Signal. 2024 Jan 16;17(819):eadh7673. doi: 10.1126/scisignal.adh7673. Epub 2024 Jan 16.ABSTRACTThe precise development of neuronal morphologies is crucial to the establishment of synaptic circuits and, ultimately, proper brain function. Signaling by the axon guidance cue semaphorin 3A (Sema3A) and its receptor complex of neuropilin-1 and plexin-A4 has multifunctional outcomes in neuronal morphogenesis. Downstream activation of the RhoGEF FARP2 through interaction with the lysine-arginine-lysine motif of plexin-A4 and consequent activation of the small GTPase Rac1 promotes dendrite arborization, but this pathway is disp...
Source: Science Signaling - January 16, 2024 Category: Biomedical Science Authors: Oday Abushalbaq Jiyeon Baek Avraham Yaron Tracy S Tran Source Type: research
Mind over asthma
Sci Signal. 2024 Jan 9;17(818):eadn8527. doi: 10.1126/scisignal.adn8527. Epub 2024 Jan 9.ABSTRACTJAK1 in the vagal sensory nerves that innervate lungs suppresses allergic inflammation and asthma.PMID:38194475 | DOI:10.1126/scisignal.adn8527 (Source: Science Signaling)
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
The NF- κB signaling system in the immunopathogenesis of inflammatory bowel disease
Sci Signal. 2024 Jan 9;17(818):eadh1641. doi: 10.1126/scisignal.adh1641. Epub 2024 Jan 9.ABSTRACTInflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system describes a family of dimeric transcription factors. Canonical NF-κB signaling is stimulated by and enhances inflammation, whereas noncanonical NF-κB signaling contributes to immune organogenesis. Dysregulation of NF-κB factors drives various inflammatory pathologies, including IBD. Signals from many immune sensors activate NF-κB subunits in the ...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Tapas Mukherjee Naveen Kumar Meenakshi Chawla Dana J Philpott Soumen Basak Source Type: research
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS
Sci Signal. 2024 Jan 9;17(818):eadf8016. doi: 10.1126/scisignal.adf8016. Epub 2024 Jan 9.ABSTRACTType I interferons (IFNs) are produced by almost all cell types and play a vital role in host defense against viral infection. Infection with an RNA virus activates receptors such as RIG-I, resulting in the recruitment of the adaptor protein MAVS to the RIG-I-like receptor (RLR) signalosome and the formation of prion-like functional aggregates of MAVS, which leads to IFN-β production. Here, we identified the aldehyde dehydrogenase 1B1 (ALDH1B1) as a previously uncharacterized IFN-stimulated gene (ISG) product with critical rol...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Nina Sun Qiaomei Cai Yurui Zhang Rong-Rong Zhang Jingmei Jiang Heng Yang Cheng-Feng Qin Genhong Cheng Source Type: research
Mind over asthma
Sci Signal. 2024 Jan 9;17(818):eadn8527. doi: 10.1126/scisignal.adn8527. Epub 2024 Jan 9.ABSTRACTJAK1 in the vagal sensory nerves that innervate lungs suppresses allergic inflammation and asthma.PMID:38194475 | DOI:10.1126/scisignal.adn8527 (Source: Science Signaling)
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
The NF- κB signaling system in the immunopathogenesis of inflammatory bowel disease
Sci Signal. 2024 Jan 9;17(818):eadh1641. doi: 10.1126/scisignal.adh1641. Epub 2024 Jan 9.ABSTRACTInflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system describes a family of dimeric transcription factors. Canonical NF-κB signaling is stimulated by and enhances inflammation, whereas noncanonical NF-κB signaling contributes to immune organogenesis. Dysregulation of NF-κB factors drives various inflammatory pathologies, including IBD. Signals from many immune sensors activate NF-κB subunits in the ...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Tapas Mukherjee Naveen Kumar Meenakshi Chawla Dana J Philpott Soumen Basak Source Type: research
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS
Sci Signal. 2024 Jan 9;17(818):eadf8016. doi: 10.1126/scisignal.adf8016. Epub 2024 Jan 9.ABSTRACTType I interferons (IFNs) are produced by almost all cell types and play a vital role in host defense against viral infection. Infection with an RNA virus activates receptors such as RIG-I, resulting in the recruitment of the adaptor protein MAVS to the RIG-I-like receptor (RLR) signalosome and the formation of prion-like functional aggregates of MAVS, which leads to IFN-β production. Here, we identified the aldehyde dehydrogenase 1B1 (ALDH1B1) as a previously uncharacterized IFN-stimulated gene (ISG) product with critical rol...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Nina Sun Qiaomei Cai Yurui Zhang Rong-Rong Zhang Jingmei Jiang Heng Yang Cheng-Feng Qin Genhong Cheng Source Type: research
Cooperative transcriptional regulation by ATAF1 and HY5 promotes light-induced cotyledon opening in < em > Arabidopsis thaliana < /em >
Sci Signal. 2024 Jan 2;17(817):eadf7318. doi: 10.1126/scisignal.adf7318. Epub 2024 Jan 2.ABSTRACTThe opening of the embryonic leaves (cotyledons) as seedlings emerge from the dark soil into the light is crucial to ensure the survival of the plant. Seedlings that sprout in the dark elongate rapidly to reach light but keep their cotyledons closed. During de-etiolation, the transition from dark to light growth, elongation slows and the cotyledons open. Here, we report that the transcription factor ACTIVATING FACTOR1 (ATAF1) participates in de-etiolation and facilitates light-induced cotyledon opening. The transition from dark...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Xiuhong Yao Ke Fang Kang Qiao Jiawei Xiong Jiayi Lan Juan Chen Yuang Tian Xinke Kang Wei Lei Dawei Zhang Honghui Lin Source Type: research
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation
Sci Signal. 2024 Jan 2;17(817):eadg4422. doi: 10.1126/scisignal.adg4422. Epub 2024 Jan 2.ABSTRACTThousand-and-one-amino acid kinase 3 (TAOK3) is a serine and threonine kinase that belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling and increases the interaction of the tyrosine phosphatase SHP-1, a major negative regulator of proximal TCR signaling, with the kinase LCK, a component of the core TCR signaling complex. Here, we used mouse models and human cell lines to investigate the mechanism by which TAOK3 limits the interaction of SHP-1 with LCK. The loss of TAOK3 decreased the surv...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Alexandre Poirier Jo ão Vitor Silva Ormonde Isabelle Aubry Belma Melda Abidin Chu-Han Feng Zuzet Martinez-Cordova Ana Maria Hincapie Chenyue Wu Luis Alberto P érez-Quintero Chia-Lin Wang Anne Claude Gingras Joaqu ín Madrenas Michel L Tremblay Source Type: research
The expanding footprint of basic biology research in India
Sci Signal. 2024 Jan 2;17(817):eadn0865. doi: 10.1126/scisignal.adn0865. Epub 2024 Jan 2.ABSTRACTBasic biology research in India has expanded in recent years, and addressing key challenges should enable this momentum to continue.PMID:38166032 | DOI:10.1126/scisignal.adn0865 (Source: Science Signaling)
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Arun K Shukla Source Type: research
