Bacteria benefit tumor cells
Sci Signal. 2022 Apr 12;15(729):eabq4492. doi: 10.1126/scisignal.abq4492. Epub 2022 Apr 12.ABSTRACTIntracellular bacteria enhance the survival of circulating tumor cells.PMID:35412851 | DOI:10.1126/scisignal.abq4492 (Source: Science Signaling)
Source: Science Signaling - April 12, 2022 Category: Biomedical Science Authors: Amy E Baek Source Type: research

SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response
Sci Signal. 2022 Apr 12;15(729):eabg8744. doi: 10.1126/scisignal.abg8744. Epub 2022 Apr 12.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the unprecedented coronavirus disease 2019 (COVID-19) pandemic. Critical cases of COVID-19 are characterized by the production of excessive amounts of cytokines and extensive lung damage, which is partially caused by the fusion of SARS-CoV-2-infected pneumocytes. Here, we found that cell fusion caused by the SARS-CoV-2 spike (S) protein induced a type I interferon (IFN) response. This function of the S protein required its cleavage by proteases at the S1/S2 a...
Source: Science Signaling - April 12, 2022 Category: Biomedical Science Authors: Xiaoman Liu Liang Wei Fengwen Xu Fei Zhao Yu Huang Zhangling Fan Shan Mei Yamei Hu Linxuan Zhai Justin Guo Aihua Zheng Shan Cen Chen Liang Fei Guo Source Type: research

Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism
Sci Signal. 2022 Apr 12;15(729):eabm5011. doi: 10.1126/scisignal.abm5011. Epub 2022 Apr 12.ABSTRACTToll-like receptor (TLR) stimulation induces glycolysis and the production of mitochondrial reactive oxygen species (ROS), both of which are critical for inflammatory responses in macrophages. Here, we demonstrated that cyclin J, a TLR-inducible member of the cyclin family, reduced cytokine production in macrophages by coordinately controlling glycolysis and mitochondrial functions. Cyclin J interacted with cyclin-dependent kinases (CDKs), which increased the phosphorylation of a subset of CDK substrates, including the transc...
Source: Science Signaling - April 12, 2022 Category: Biomedical Science Authors: Yee Kien Chong Sarang Tartey Yuki Yoshikawa Koshi Imami Songling Li Masanori Yoshinaga Ai Hirabayashi Guohao Liu Alexis Vandenbon Fabian Hia Takuya Uehata Takashi Mino Yutaka Suzuki Takeshi Noda Dominique Ferrandon Daron M Standley Yasushi Ishihama Osamu Source Type: research

Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity
Sci Signal. 2022 Apr 12;15(729):eabo0264. doi: 10.1126/scisignal.abo0264. Epub 2022 Apr 12.ABSTRACTDiacylglycerol (DAG) is a lipid second messenger that is generated in response to extracellular stimuli and channels intracellular signals that affect mammalian cell proliferation, survival, and motility. DAG exerts a myriad of biological functions through protein kinase C (PKC) and other effectors, such as protein kinase D (PKD) isozymes and small GTPase-regulating proteins (such as RasGRPs). Imbalances in the fine-tuned homeostasis between DAG generation by phospholipase C (PLC) enzymes and termination by DAG kinases (DGKs)...
Source: Science Signaling - April 12, 2022 Category: Biomedical Science Authors: Mariana Cooke Marcelo G Kazanietz Source Type: research

Bacteria benefit tumor cells
Sci Signal. 2022 Apr 12;15(729):eabq4492. doi: 10.1126/scisignal.abq4492. Epub 2022 Apr 12.ABSTRACTIntracellular bacteria enhance the survival of circulating tumor cells.PMID:35412851 | DOI:10.1126/scisignal.abq4492 (Source: Science Signaling)
Source: Science Signaling - April 12, 2022 Category: Biomedical Science Authors: Amy E Baek Source Type: research