A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice
Sci Signal. 2022 Jun 14;15(738):eabj4583. doi: 10.1126/scisignal.abj4583. Epub 2022 Jun 14.ABSTRACTResistance to thyroid hormone due to mutations in THRA, which encodes the thyroid hormone receptor α (TRα1), shows variable clinical presentation. Mutations affecting TRβ1 and TRβ2 cause deafness in mice and have been associated with deafness in humans. To test whether TRα1 also affects hearing function, we used mice heterozygous for a frameshift mutation in Thra that is similar to human THRA mutations (ThraS1/+ mice) and reduces tissue sensitivity to thyroid hormone. Compared to wild-type littermates, ThraS1/+ mice show...
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Corentin Affortit Fabian Blanc Jamal Nasr Jean-Charles Ceccato Suzy Markossian Romain Guyot Jean-Luc Puel Fr édéric Flamant Jing Wang Source Type: research

Get up and sweat to treat cancer
Sci Signal. 2022 Jun 14;15(738):eadd4188. doi: 10.1126/scisignal.add4188. Epub 2022 Jun 14.ABSTRACTBy mobilizing certain T cells, exercise joins forces with chemo- and immunotherapy to fight cancer.PMID:35700265 | DOI:10.1126/scisignal.add4188 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

Voltage-gated Ca < sup > 2+ < /sup > channel proteins do not function as ion channels in T cells
Sci Signal. 2022 Jun 14;15(738):eabq5594. doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.ABSTRACTCalcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.PMID:35700266 | DOI:10.1126/scisignal.abq5594 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Michael D Cahalan Source Type: research

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice
Sci Signal. 2022 Jun 14;15(738):eabj4583. doi: 10.1126/scisignal.abj4583. Epub 2022 Jun 14.ABSTRACTResistance to thyroid hormone due to mutations in THRA, which encodes the thyroid hormone receptor α (TRα1), shows variable clinical presentation. Mutations affecting TRβ1 and TRβ2 cause deafness in mice and have been associated with deafness in humans. To test whether TRα1 also affects hearing function, we used mice heterozygous for a frameshift mutation in Thra that is similar to human THRA mutations (ThraS1/+ mice) and reduces tissue sensitivity to thyroid hormone. Compared to wild-type littermates, ThraS1/+ mice show...
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Corentin Affortit Fabian Blanc Jamal Nasr Jean-Charles Ceccato Suzy Markossian Romain Guyot Jean-Luc Puel Fr édéric Flamant Jing Wang Source Type: research

Get up and sweat to treat cancer
Sci Signal. 2022 Jun 14;15(738):eadd4188. doi: 10.1126/scisignal.add4188. Epub 2022 Jun 14.ABSTRACTBy mobilizing certain T cells, exercise joins forces with chemo- and immunotherapy to fight cancer.PMID:35700265 | DOI:10.1126/scisignal.add4188 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

Voltage-gated Ca < sup > 2+ < /sup > channel proteins do not function as ion channels in T cells
Sci Signal. 2022 Jun 14;15(738):eabq5594. doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.ABSTRACTCalcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.PMID:35700266 | DOI:10.1126/scisignal.abq5594 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Michael D Cahalan Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research

Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research

Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research

Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research

Making memories, one at a time
Sci Signal. 2022 Jun 7;15(737):eadd3194. doi: 10.1126/scisignal.add3194. Epub 2022 Jun 7.ABSTRACTThe chemokine receptor CCR5 restricts the time period during which memories can be contextually linked.PMID:35671341 | DOI:10.1126/scisignal.add3194 (Source: Science Signaling)
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Wei Wong Source Type: research

A cholesterol analog stabilizes the human β < sub > 2 < /sub > -adrenergic receptor nonlinearly with temperature
Sci Signal. 2022 Jun 7;15(737):eabi7031. doi: 10.1126/scisignal.abi7031. Epub 2022 Jun 7.ABSTRACTIn cell membranes, G protein-coupled receptors (GPCRs) interact with cholesterol, which modulates their assembly, stability, and conformation. Previous studies have shown how cholesterol modulates the structural properties of GPCRs at ambient temperature. Here, we characterized the mechanical, kinetic, and energetic properties of the human β2-adrenergic receptor (β2AR) in the presence and absence of the cholesterol analog cholesteryl hemisuccinate (CHS) at room temperature (25°C), at physiological temperature (37°C), and at...
Source: Science Signaling - June 7, 2022 Category: Biomedical Science Authors: Tetiana Serdiuk Moutusi Manna Cheng Zhang Stefania A Mari Waldemar Kulig Kristyna Pluhackova Brian K Kobilka Ilpo Vattulainen Daniel J M üller Source Type: research