The < em > Candida albicans < /em > toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
Sci Signal. 2022 Apr 5;15(728):eabj6915. doi: 10.1126/scisignal.abj6915. Epub 2022 Apr 5.ABSTRACTThe fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and the transcription factor c-Fos. In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos. p38 activation was not ...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Spyridoula-Angeliki Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M Coleman Mary J Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Source Type: research

Erratum for the Research Article "IKK β-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice" by S. E. Catheline < em > et al < /em >
Sci Signal. 2022 Apr 5;15(728):eabq3030. doi: 10.1126/scisignal.abq3030. Epub 2022 Apr 5.NO ABSTRACTPMID:35380880 | DOI:10.1126/scisignal.abq3030 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Source Type: research

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
Sci Signal. 2022 Apr 5;15(728):eabm2496. doi: 10.1126/scisignal.abm2496. Epub 2022 Apr 5.ABSTRACTPAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of reproductive tract organs. Nearly all ovarian carcinomas express PAX8, and its knockdown results in apoptosis of ovarian cancer cells. To explore the role of PAX8 in these tissues, we purified the PAX8 protein complex from nonmalignant fallopian tube cells and high-grade serous ovarian ca...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Daniele Chaves-Moreira Marilyn A Mitchell Cristina Arruza Priyanka Rawat Simone Sidoli Robbin Nameki Jessica Reddy Rosario I Corona Lena K Afeyan Isaac A Klein Sisi Ma Boris Winterhoff Gottfried E Konecny Benjamin A Garcia Donita C Brady Kate Lawrenson Pa Source Type: research

Brain aging by gut AGE
Sci Signal. 2022 Apr 5;15(728):eabq3005. doi: 10.1126/scisignal.abq3005. Epub 2022 Apr 5.ABSTRACTAn advanced glycation end product (AGE) links the gut microbiome, a "leaky gut," and microglial aging.PMID:35380878 | DOI:10.1126/scisignal.abq3005 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

The < em > Candida albicans < /em > toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
Sci Signal. 2022 Apr 5;15(728):eabj6915. doi: 10.1126/scisignal.abj6915. Epub 2022 Apr 5.ABSTRACTThe fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and the transcription factor c-Fos. In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos. p38 activation was not ...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Spyridoula-Angeliki Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M Coleman Mary J Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Source Type: research

Erratum for the Research Article "IKK β-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice" by S. E. Catheline < em > et al < /em >
Sci Signal. 2022 Apr 5;15(728):eabq3030. doi: 10.1126/scisignal.abq3030. Epub 2022 Apr 5.NO ABSTRACTPMID:35380880 | DOI:10.1126/scisignal.abq3030 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Source Type: research

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
Sci Signal. 2022 Apr 5;15(728):eabm2496. doi: 10.1126/scisignal.abm2496. Epub 2022 Apr 5.ABSTRACTPAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of reproductive tract organs. Nearly all ovarian carcinomas express PAX8, and its knockdown results in apoptosis of ovarian cancer cells. To explore the role of PAX8 in these tissues, we purified the PAX8 protein complex from nonmalignant fallopian tube cells and high-grade serous ovarian ca...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Daniele Chaves-Moreira Marilyn A Mitchell Cristina Arruza Priyanka Rawat Simone Sidoli Robbin Nameki Jessica Reddy Rosario I Corona Lena K Afeyan Isaac A Klein Sisi Ma Boris Winterhoff Gottfried E Konecny Benjamin A Garcia Donita C Brady Kate Lawrenson Pa Source Type: research

Brain aging by gut AGE
Sci Signal. 2022 Apr 5;15(728):eabq3005. doi: 10.1126/scisignal.abq3005. Epub 2022 Apr 5.ABSTRACTAn advanced glycation end product (AGE) links the gut microbiome, a "leaky gut," and microglial aging.PMID:35380878 | DOI:10.1126/scisignal.abq3005 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

The < em > Candida albicans < /em > toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
Sci Signal. 2022 Apr 5;15(728):eabj6915. doi: 10.1126/scisignal.abj6915. Epub 2022 Apr 5.ABSTRACTThe fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and the transcription factor c-Fos. In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos. p38 activation was not ...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Spyridoula-Angeliki Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M Coleman Mary J Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Source Type: research

Erratum for the Research Article "IKK β-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice" by S. E. Catheline < em > et al < /em >
Sci Signal. 2022 Apr 5;15(728):eabq3030. doi: 10.1126/scisignal.abq3030. Epub 2022 Apr 5.NO ABSTRACTPMID:35380880 | DOI:10.1126/scisignal.abq3030 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Source Type: research

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
Sci Signal. 2022 Apr 5;15(728):eabm2496. doi: 10.1126/scisignal.abm2496. Epub 2022 Apr 5.ABSTRACTPAX8 is a master transcription factor that is essential during embryogenesis and promotes neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract, and its deletion during development results in atresia of reproductive tract organs. Nearly all ovarian carcinomas express PAX8, and its knockdown results in apoptosis of ovarian cancer cells. To explore the role of PAX8 in these tissues, we purified the PAX8 protein complex from nonmalignant fallopian tube cells and high-grade serous ovarian ca...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Daniele Chaves-Moreira Marilyn A Mitchell Cristina Arruza Priyanka Rawat Simone Sidoli Robbin Nameki Jessica Reddy Rosario I Corona Lena K Afeyan Isaac A Klein Sisi Ma Boris Winterhoff Gottfried E Konecny Benjamin A Garcia Donita C Brady Kate Lawrenson Pa Source Type: research

Brain aging by gut AGE
Sci Signal. 2022 Apr 5;15(728):eabq3005. doi: 10.1126/scisignal.abq3005. Epub 2022 Apr 5.ABSTRACTAn advanced glycation end product (AGE) links the gut microbiome, a "leaky gut," and microglial aging.PMID:35380878 | DOI:10.1126/scisignal.abq3005 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

The < em > Candida albicans < /em > toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
Sci Signal. 2022 Apr 5;15(728):eabj6915. doi: 10.1126/scisignal.abj6915. Epub 2022 Apr 5.ABSTRACTThe fungal pathogen Candida albicans secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and the transcription factor c-Fos. In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos. p38 activation was not ...
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Authors: Spyridoula-Angeliki Nikou Chunsheng Zhou James S Griffiths Natalia K Kotowicz Bianca M Coleman Mary J Green David L Moyes Sarah L Gaffen Julian R Naglik Peter J Parker Source Type: research

Erratum for the Research Article "IKK β-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice" by S. E. Catheline < em > et al < /em >
Sci Signal. 2022 Apr 5;15(728):eabq3030. doi: 10.1126/scisignal.abq3030. Epub 2022 Apr 5.NO ABSTRACTPMID:35380880 | DOI:10.1126/scisignal.abq3030 (Source: Science Signaling)
Source: Science Signaling - April 5, 2022 Category: Biomedical Science Source Type: research

Adenosine signaling activates ATP-sensitive K < sup > + < /sup > channels in endothelial cells and pericytes in CNS capillaries
Sci Signal. 2022 Mar 29;15(727):eabl5405. doi: 10.1126/scisignal.abl5405. Epub 2022 Mar 29.ABSTRACTThe dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron- and glial-derived compounds that enhance regional and global cerebral perfusion. The membrane potential (VM) of vascular cells serves as the physiological bridge that translates brain activity into vascular function. In other beds, the ATP-sensitive K+ (KATP) channel regulates VM in vascular smooth muscle, which is absent in the capillary network. Here, w...
Source: Science Signaling - March 29, 2022 Category: Biomedical Science Authors: Maria Sancho Nicholas R Klug Amreen Mughal Masayo Koide Saul Huerta de la Cruz Thomas J Heppner Adrian D Bonev David Hill-Eubanks Mark T Nelson Source Type: research