Mind over asthma
Sci Signal. 2024 Jan 9;17(818):eadn8527. doi: 10.1126/scisignal.adn8527. Epub 2024 Jan 9.ABSTRACTJAK1 in the vagal sensory nerves that innervate lungs suppresses allergic inflammation and asthma.PMID:38194475 | DOI:10.1126/scisignal.adn8527 (Source: Science Signaling)
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
The NF- κB signaling system in the immunopathogenesis of inflammatory bowel disease
Sci Signal. 2024 Jan 9;17(818):eadh1641. doi: 10.1126/scisignal.adh1641. Epub 2024 Jan 9.ABSTRACTInflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system describes a family of dimeric transcription factors. Canonical NF-κB signaling is stimulated by and enhances inflammation, whereas noncanonical NF-κB signaling contributes to immune organogenesis. Dysregulation of NF-κB factors drives various inflammatory pathologies, including IBD. Signals from many immune sensors activate NF-κB subunits in the ...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Tapas Mukherjee Naveen Kumar Meenakshi Chawla Dana J Philpott Soumen Basak Source Type: research
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS
Sci Signal. 2024 Jan 9;17(818):eadf8016. doi: 10.1126/scisignal.adf8016. Epub 2024 Jan 9.ABSTRACTType I interferons (IFNs) are produced by almost all cell types and play a vital role in host defense against viral infection. Infection with an RNA virus activates receptors such as RIG-I, resulting in the recruitment of the adaptor protein MAVS to the RIG-I-like receptor (RLR) signalosome and the formation of prion-like functional aggregates of MAVS, which leads to IFN-β production. Here, we identified the aldehyde dehydrogenase 1B1 (ALDH1B1) as a previously uncharacterized IFN-stimulated gene (ISG) product with critical rol...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Nina Sun Qiaomei Cai Yurui Zhang Rong-Rong Zhang Jingmei Jiang Heng Yang Cheng-Feng Qin Genhong Cheng Source Type: research
Mind over asthma
Sci Signal. 2024 Jan 9;17(818):eadn8527. doi: 10.1126/scisignal.adn8527. Epub 2024 Jan 9.ABSTRACTJAK1 in the vagal sensory nerves that innervate lungs suppresses allergic inflammation and asthma.PMID:38194475 | DOI:10.1126/scisignal.adn8527 (Source: Science Signaling)
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
The NF- κB signaling system in the immunopathogenesis of inflammatory bowel disease
Sci Signal. 2024 Jan 9;17(818):eadh1641. doi: 10.1126/scisignal.adh1641. Epub 2024 Jan 9.ABSTRACTInflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system describes a family of dimeric transcription factors. Canonical NF-κB signaling is stimulated by and enhances inflammation, whereas noncanonical NF-κB signaling contributes to immune organogenesis. Dysregulation of NF-κB factors drives various inflammatory pathologies, including IBD. Signals from many immune sensors activate NF-κB subunits in the ...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Tapas Mukherjee Naveen Kumar Meenakshi Chawla Dana J Philpott Soumen Basak Source Type: research
The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through the aggregation of the adaptor MAVS
Sci Signal. 2024 Jan 9;17(818):eadf8016. doi: 10.1126/scisignal.adf8016. Epub 2024 Jan 9.ABSTRACTType I interferons (IFNs) are produced by almost all cell types and play a vital role in host defense against viral infection. Infection with an RNA virus activates receptors such as RIG-I, resulting in the recruitment of the adaptor protein MAVS to the RIG-I-like receptor (RLR) signalosome and the formation of prion-like functional aggregates of MAVS, which leads to IFN-β production. Here, we identified the aldehyde dehydrogenase 1B1 (ALDH1B1) as a previously uncharacterized IFN-stimulated gene (ISG) product with critical rol...
Source: Science Signaling - January 9, 2024 Category: Biomedical Science Authors: Nina Sun Qiaomei Cai Yurui Zhang Rong-Rong Zhang Jingmei Jiang Heng Yang Cheng-Feng Qin Genhong Cheng Source Type: research
Cooperative transcriptional regulation by ATAF1 and HY5 promotes light-induced cotyledon opening in < em > Arabidopsis thaliana < /em >
Sci Signal. 2024 Jan 2;17(817):eadf7318. doi: 10.1126/scisignal.adf7318. Epub 2024 Jan 2.ABSTRACTThe opening of the embryonic leaves (cotyledons) as seedlings emerge from the dark soil into the light is crucial to ensure the survival of the plant. Seedlings that sprout in the dark elongate rapidly to reach light but keep their cotyledons closed. During de-etiolation, the transition from dark to light growth, elongation slows and the cotyledons open. Here, we report that the transcription factor ACTIVATING FACTOR1 (ATAF1) participates in de-etiolation and facilitates light-induced cotyledon opening. The transition from dark...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Xiuhong Yao Ke Fang Kang Qiao Jiawei Xiong Jiayi Lan Juan Chen Yuang Tian Xinke Kang Wei Lei Dawei Zhang Honghui Lin Source Type: research
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation
Sci Signal. 2024 Jan 2;17(817):eadg4422. doi: 10.1126/scisignal.adg4422. Epub 2024 Jan 2.ABSTRACTThousand-and-one-amino acid kinase 3 (TAOK3) is a serine and threonine kinase that belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling and increases the interaction of the tyrosine phosphatase SHP-1, a major negative regulator of proximal TCR signaling, with the kinase LCK, a component of the core TCR signaling complex. Here, we used mouse models and human cell lines to investigate the mechanism by which TAOK3 limits the interaction of SHP-1 with LCK. The loss of TAOK3 decreased the surv...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Alexandre Poirier Jo ão Vitor Silva Ormonde Isabelle Aubry Belma Melda Abidin Chu-Han Feng Zuzet Martinez-Cordova Ana Maria Hincapie Chenyue Wu Luis Alberto P érez-Quintero Chia-Lin Wang Anne Claude Gingras Joaqu ín Madrenas Michel L Tremblay Source Type: research
The expanding footprint of basic biology research in India
Sci Signal. 2024 Jan 2;17(817):eadn0865. doi: 10.1126/scisignal.adn0865. Epub 2024 Jan 2.ABSTRACTBasic biology research in India has expanded in recent years, and addressing key challenges should enable this momentum to continue.PMID:38166032 | DOI:10.1126/scisignal.adn0865 (Source: Science Signaling)
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Arun K Shukla Source Type: research
Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders
Sci Signal. 2024 Jan 2;17(817):eadg0876. doi: 10.1126/scisignal.adg0876. Epub 2024 Jan 2.ABSTRACTThousand and one amino acid kinases (TAOKs) are relatively understudied and functionally pleiotropic protein kinases that have emerged as important regulators of neurodevelopment. Through their conserved amino-terminal catalytic domain, TAOKs mediate phosphorylation at serine/threonine residues in their substrates, but it is their divergent regulatory carboxyl-terminal domains that confer both exquisite functional specification and cellular localization. In this Review, we discuss the physiological roles of TAOKs and the intric...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Sujin Byeon Smita Yadav Source Type: research
Cooperative transcriptional regulation by ATAF1 and HY5 promotes light-induced cotyledon opening in < em > Arabidopsis thaliana < /em >
Sci Signal. 2024 Jan 2;17(817):eadf7318. doi: 10.1126/scisignal.adf7318. Epub 2024 Jan 2.ABSTRACTThe opening of the embryonic leaves (cotyledons) as seedlings emerge from the dark soil into the light is crucial to ensure the survival of the plant. Seedlings that sprout in the dark elongate rapidly to reach light but keep their cotyledons closed. During de-etiolation, the transition from dark to light growth, elongation slows and the cotyledons open. Here, we report that the transcription factor ACTIVATING FACTOR1 (ATAF1) participates in de-etiolation and facilitates light-induced cotyledon opening. The transition from dark...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Xiuhong Yao Ke Fang Kang Qiao Jiawei Xiong Jiayi Lan Juan Chen Yuang Tian Xinke Kang Wei Lei Dawei Zhang Honghui Lin Source Type: research
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation
Sci Signal. 2024 Jan 2;17(817):eadg4422. doi: 10.1126/scisignal.adg4422. Epub 2024 Jan 2.ABSTRACTThousand-and-one-amino acid kinase 3 (TAOK3) is a serine and threonine kinase that belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling and increases the interaction of the tyrosine phosphatase SHP-1, a major negative regulator of proximal TCR signaling, with the kinase LCK, a component of the core TCR signaling complex. Here, we used mouse models and human cell lines to investigate the mechanism by which TAOK3 limits the interaction of SHP-1 with LCK. The loss of TAOK3 decreased the surv...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Alexandre Poirier Jo ão Vitor Silva Ormonde Isabelle Aubry Belma Melda Abidin Chu-Han Feng Zuzet Martinez-Cordova Ana Maria Hincapie Chenyue Wu Luis Alberto P érez-Quintero Chia-Lin Wang Anne Claude Gingras Joaqu ín Madrenas Michel L Tremblay Source Type: research
The expanding footprint of basic biology research in India
Sci Signal. 2024 Jan 2;17(817):eadn0865. doi: 10.1126/scisignal.adn0865. Epub 2024 Jan 2.ABSTRACTBasic biology research in India has expanded in recent years, and addressing key challenges should enable this momentum to continue.PMID:38166032 | DOI:10.1126/scisignal.adn0865 (Source: Science Signaling)
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Arun K Shukla Source Type: research
Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders
Sci Signal. 2024 Jan 2;17(817):eadg0876. doi: 10.1126/scisignal.adg0876. Epub 2024 Jan 2.ABSTRACTThousand and one amino acid kinases (TAOKs) are relatively understudied and functionally pleiotropic protein kinases that have emerged as important regulators of neurodevelopment. Through their conserved amino-terminal catalytic domain, TAOKs mediate phosphorylation at serine/threonine residues in their substrates, but it is their divergent regulatory carboxyl-terminal domains that confer both exquisite functional specification and cellular localization. In this Review, we discuss the physiological roles of TAOKs and the intric...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Sujin Byeon Smita Yadav Source Type: research
Cooperative transcriptional regulation by ATAF1 and HY5 promotes light-induced cotyledon opening in < em > Arabidopsis thaliana < /em >
Sci Signal. 2024 Jan 2;17(817):eadf7318. doi: 10.1126/scisignal.adf7318. Epub 2024 Jan 2.ABSTRACTThe opening of the embryonic leaves (cotyledons) as seedlings emerge from the dark soil into the light is crucial to ensure the survival of the plant. Seedlings that sprout in the dark elongate rapidly to reach light but keep their cotyledons closed. During de-etiolation, the transition from dark to light growth, elongation slows and the cotyledons open. Here, we report that the transcription factor ACTIVATING FACTOR1 (ATAF1) participates in de-etiolation and facilitates light-induced cotyledon opening. The transition from dark...
Source: Science Signaling - January 2, 2024 Category: Biomedical Science Authors: Xiuhong Yao Ke Fang Kang Qiao Jiawei Xiong Jiayi Lan Juan Chen Yuang Tian Xinke Kang Wei Lei Dawei Zhang Honghui Lin Source Type: research
