ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis
Sci Signal. 2022 May 10;15(733):eabj8204. doi: 10.1126/scisignal.abj8204. Epub 2022 May 10.ABSTRACTVariants in the gene encoding ankyrin repeat and SOCS box-containing 4 (ASB4) are linked to human obesity. Here, we characterized the pathways underlying the metabolic functions of ASB4. Hypothalamic Asb4 expression was suppressed by fasting in wild-type mice but not in mice deficient in AgRP, which encodes Agouti-related protein (AgRP), an appetite-stimulating hormone, suggesting that ASB4 is a negative target of AgRP. Many ASB4 neurons in the brain were adjacent to AgRP terminals, and feeding induced by AgRP neuronal activa...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Eirini Vagena Jasmina Crneta Pauline Engstr öm Li He Ernie Yulyaningsih Nikita L Korpel Rachel T Cheang Tomas P Bachor Alyssa Huang Guillermina Michel Kush Attal David I Berrios Martin Valdearcos Suneil K Koliwad David P Olson Chun-Xia Yi Allison W Xu Source Type: research

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling
Sci Signal. 2022 May 10;15(733):eabh3066. doi: 10.1126/scisignal.abh3066. Epub 2022 May 10.ABSTRACTSynapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synaptic molecular components, which is mediated in part by cell adhesion signaling pathways. Here, we found that the enzyme biliverdin reductase (BVR) physically links together key focal adhesion signaling molecules at the synapse. BVR-null (BVR-/-) mice exhibited substantial deficits...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Chirag Vasavda Evan R Semenza Jason Liew Ruchita Kothari Ryan S Dhindsa Shruthi Shanmukha Anthony Lin Robert Tokhunts Cristina Ricco Adele M Snowman Lauren Albacarys Francesco Pastore Cristian Ripoli Claudio Grassi Eugenio Barone Michael D Kornberg Xinzho Source Type: research

Cleaved to keep dying cells alive
Sci Signal. 2022 May 10;15(733):eabq8516. doi: 10.1126/scisignal.abq8516. Epub 2022 May 10.ABSTRACTUpon DNA damage, caspase-3 sends the kinase AMPK to the nucleus to prevent apoptotic progression.PMID:35536886 | DOI:10.1126/scisignal.abq8516 (Source: Science Signaling)
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis
Sci Signal. 2022 May 10;15(733):eabj8204. doi: 10.1126/scisignal.abj8204. Epub 2022 May 10.ABSTRACTVariants in the gene encoding ankyrin repeat and SOCS box-containing 4 (ASB4) are linked to human obesity. Here, we characterized the pathways underlying the metabolic functions of ASB4. Hypothalamic Asb4 expression was suppressed by fasting in wild-type mice but not in mice deficient in AgRP, which encodes Agouti-related protein (AgRP), an appetite-stimulating hormone, suggesting that ASB4 is a negative target of AgRP. Many ASB4 neurons in the brain were adjacent to AgRP terminals, and feeding induced by AgRP neuronal activa...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Eirini Vagena Jasmina Crneta Pauline Engstr öm Li He Ernie Yulyaningsih Nikita L Korpel Rachel T Cheang Tomas P Bachor Alyssa Huang Guillermina Michel Kush Attal David I Berrios Martin Valdearcos Suneil K Koliwad David P Olson Chun-Xia Yi Allison W Xu Source Type: research

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling
Sci Signal. 2022 May 10;15(733):eabh3066. doi: 10.1126/scisignal.abh3066. Epub 2022 May 10.ABSTRACTSynapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synaptic molecular components, which is mediated in part by cell adhesion signaling pathways. Here, we found that the enzyme biliverdin reductase (BVR) physically links together key focal adhesion signaling molecules at the synapse. BVR-null (BVR-/-) mice exhibited substantial deficits...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Chirag Vasavda Evan R Semenza Jason Liew Ruchita Kothari Ryan S Dhindsa Shruthi Shanmukha Anthony Lin Robert Tokhunts Cristina Ricco Adele M Snowman Lauren Albacarys Francesco Pastore Cristian Ripoli Claudio Grassi Eugenio Barone Michael D Kornberg Xinzho Source Type: research

Cleaved to keep dying cells alive
Sci Signal. 2022 May 10;15(733):eabq8516. doi: 10.1126/scisignal.abq8516. Epub 2022 May 10.ABSTRACTUpon DNA damage, caspase-3 sends the kinase AMPK to the nucleus to prevent apoptotic progression.PMID:35536886 | DOI:10.1126/scisignal.abq8516 (Source: Science Signaling)
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis
Sci Signal. 2022 May 10;15(733):eabj8204. doi: 10.1126/scisignal.abj8204. Epub 2022 May 10.ABSTRACTVariants in the gene encoding ankyrin repeat and SOCS box-containing 4 (ASB4) are linked to human obesity. Here, we characterized the pathways underlying the metabolic functions of ASB4. Hypothalamic Asb4 expression was suppressed by fasting in wild-type mice but not in mice deficient in AgRP, which encodes Agouti-related protein (AgRP), an appetite-stimulating hormone, suggesting that ASB4 is a negative target of AgRP. Many ASB4 neurons in the brain were adjacent to AgRP terminals, and feeding induced by AgRP neuronal activa...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Eirini Vagena Jasmina Crneta Pauline Engstr öm Li He Ernie Yulyaningsih Nikita L Korpel Rachel T Cheang Tomas P Bachor Alyssa Huang Guillermina Michel Kush Attal David I Berrios Martin Valdearcos Suneil K Koliwad David P Olson Chun-Xia Yi Allison W Xu Source Type: research

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling
Sci Signal. 2022 May 10;15(733):eabh3066. doi: 10.1126/scisignal.abh3066. Epub 2022 May 10.ABSTRACTSynapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synaptic molecular components, which is mediated in part by cell adhesion signaling pathways. Here, we found that the enzyme biliverdin reductase (BVR) physically links together key focal adhesion signaling molecules at the synapse. BVR-null (BVR-/-) mice exhibited substantial deficits...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Chirag Vasavda Evan R Semenza Jason Liew Ruchita Kothari Ryan S Dhindsa Shruthi Shanmukha Anthony Lin Robert Tokhunts Cristina Ricco Adele M Snowman Lauren Albacarys Francesco Pastore Cristian Ripoli Claudio Grassi Eugenio Barone Michael D Kornberg Xinzho Source Type: research

Cleaved to keep dying cells alive
Sci Signal. 2022 May 10;15(733):eabq8516. doi: 10.1126/scisignal.abq8516. Epub 2022 May 10.ABSTRACTUpon DNA damage, caspase-3 sends the kinase AMPK to the nucleus to prevent apoptotic progression.PMID:35536886 | DOI:10.1126/scisignal.abq8516 (Source: Science Signaling)
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis
Sci Signal. 2022 May 10;15(733):eabj8204. doi: 10.1126/scisignal.abj8204. Epub 2022 May 10.ABSTRACTVariants in the gene encoding ankyrin repeat and SOCS box-containing 4 (ASB4) are linked to human obesity. Here, we characterized the pathways underlying the metabolic functions of ASB4. Hypothalamic Asb4 expression was suppressed by fasting in wild-type mice but not in mice deficient in AgRP, which encodes Agouti-related protein (AgRP), an appetite-stimulating hormone, suggesting that ASB4 is a negative target of AgRP. Many ASB4 neurons in the brain were adjacent to AgRP terminals, and feeding induced by AgRP neuronal activa...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Eirini Vagena Jasmina Crneta Pauline Engstr öm Li He Ernie Yulyaningsih Nikita L Korpel Rachel T Cheang Tomas P Bachor Alyssa Huang Guillermina Michel Kush Attal David I Berrios Martin Valdearcos Suneil K Koliwad David P Olson Chun-Xia Yi Allison W Xu Source Type: research

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling
Sci Signal. 2022 May 10;15(733):eabh3066. doi: 10.1126/scisignal.abh3066. Epub 2022 May 10.ABSTRACTSynapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synaptic molecular components, which is mediated in part by cell adhesion signaling pathways. Here, we found that the enzyme biliverdin reductase (BVR) physically links together key focal adhesion signaling molecules at the synapse. BVR-null (BVR-/-) mice exhibited substantial deficits...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Chirag Vasavda Evan R Semenza Jason Liew Ruchita Kothari Ryan S Dhindsa Shruthi Shanmukha Anthony Lin Robert Tokhunts Cristina Ricco Adele M Snowman Lauren Albacarys Francesco Pastore Cristian Ripoli Claudio Grassi Eugenio Barone Michael D Kornberg Xinzho Source Type: research

Cleaved to keep dying cells alive
Sci Signal. 2022 May 10;15(733):eabq8516. doi: 10.1126/scisignal.abq8516. Epub 2022 May 10.ABSTRACTUpon DNA damage, caspase-3 sends the kinase AMPK to the nucleus to prevent apoptotic progression.PMID:35536886 | DOI:10.1126/scisignal.abq8516 (Source: Science Signaling)
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis
Sci Signal. 2022 May 10;15(733):eabj8204. doi: 10.1126/scisignal.abj8204. Epub 2022 May 10.ABSTRACTVariants in the gene encoding ankyrin repeat and SOCS box-containing 4 (ASB4) are linked to human obesity. Here, we characterized the pathways underlying the metabolic functions of ASB4. Hypothalamic Asb4 expression was suppressed by fasting in wild-type mice but not in mice deficient in AgRP, which encodes Agouti-related protein (AgRP), an appetite-stimulating hormone, suggesting that ASB4 is a negative target of AgRP. Many ASB4 neurons in the brain were adjacent to AgRP terminals, and feeding induced by AgRP neuronal activa...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Eirini Vagena Jasmina Crneta Pauline Engstr öm Li He Ernie Yulyaningsih Nikita L Korpel Rachel T Cheang Tomas P Bachor Alyssa Huang Guillermina Michel Kush Attal David I Berrios Martin Valdearcos Suneil K Koliwad David P Olson Chun-Xia Yi Allison W Xu Source Type: research

Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling
Sci Signal. 2022 May 10;15(733):eabh3066. doi: 10.1126/scisignal.abh3066. Epub 2022 May 10.ABSTRACTSynapses connect discrete neurons into vast networks that send, receive, and encode diverse forms of information. Synaptic function and plasticity, the neuronal process of adapting to diverse and variable inputs, depend on the dynamic nature of synaptic molecular components, which is mediated in part by cell adhesion signaling pathways. Here, we found that the enzyme biliverdin reductase (BVR) physically links together key focal adhesion signaling molecules at the synapse. BVR-null (BVR-/-) mice exhibited substantial deficits...
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Chirag Vasavda Evan R Semenza Jason Liew Ruchita Kothari Ryan S Dhindsa Shruthi Shanmukha Anthony Lin Robert Tokhunts Cristina Ricco Adele M Snowman Lauren Albacarys Francesco Pastore Cristian Ripoli Claudio Grassi Eugenio Barone Michael D Kornberg Xinzho Source Type: research

Cleaved to keep dying cells alive
Sci Signal. 2022 May 10;15(733):eabq8516. doi: 10.1126/scisignal.abq8516. Epub 2022 May 10.ABSTRACTUpon DNA damage, caspase-3 sends the kinase AMPK to the nucleus to prevent apoptotic progression.PMID:35536886 | DOI:10.1126/scisignal.abq8516 (Source: Science Signaling)
Source: Science Signaling - May 10, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research