Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition
Sci Signal. 2024 Apr 9;17(831):eadh1922. doi: 10.1126/scisignal.adh1922. Epub 2024 Apr 9.ABSTRACTAndrogen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to overexpression of fatty acid synthase (FASN), making this enzyme a therapeutic target for prostate cancer. Inhibition of FASN results in increased intracellular amounts of ceramides and sphingomyelin, leading to DNA damage through the formation of DNA doubl...
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Caroline Fidalgo Ribeiro Silvia Rodrigues Debora Campanella Bastos Giuseppe Nicol ò Fanelli Hubert Pakula Marco Foiani Giorgia Zadra Massimo Loda Source Type: research
Sensing stretch to suppress appetite
Sci Signal. 2024 Apr 9;17(831):eadp6031. doi: 10.1126/scisignal.adp6031. Epub 2024 Apr 9.ABSTRACTFood intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite.PMID:38593155 | DOI:10.1126/scisignal.adp6031 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition
Sci Signal. 2024 Apr 9;17(831):eadh1922. doi: 10.1126/scisignal.adh1922. Epub 2024 Apr 9.ABSTRACTAndrogen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to overexpression of fatty acid synthase (FASN), making this enzyme a therapeutic target for prostate cancer. Inhibition of FASN results in increased intracellular amounts of ceramides and sphingomyelin, leading to DNA damage through the formation of DNA doubl...
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Caroline Fidalgo Ribeiro Silvia Rodrigues Debora Campanella Bastos Giuseppe Nicol ò Fanelli Hubert Pakula Marco Foiani Giorgia Zadra Massimo Loda Source Type: research
Sensing stretch to suppress appetite
Sci Signal. 2024 Apr 9;17(831):eadp6031. doi: 10.1126/scisignal.adp6031. Epub 2024 Apr 9.ABSTRACTFood intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite.PMID:38593155 | DOI:10.1126/scisignal.adp6031 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition
Sci Signal. 2024 Apr 9;17(831):eadh1922. doi: 10.1126/scisignal.adh1922. Epub 2024 Apr 9.ABSTRACTAndrogen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to overexpression of fatty acid synthase (FASN), making this enzyme a therapeutic target for prostate cancer. Inhibition of FASN results in increased intracellular amounts of ceramides and sphingomyelin, leading to DNA damage through the formation of DNA doubl...
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Caroline Fidalgo Ribeiro Silvia Rodrigues Debora Campanella Bastos Giuseppe Nicol ò Fanelli Hubert Pakula Marco Foiani Giorgia Zadra Massimo Loda Source Type: research
Sensing stretch to suppress appetite
Sci Signal. 2024 Apr 9;17(831):eadp6031. doi: 10.1126/scisignal.adp6031. Epub 2024 Apr 9.ABSTRACTFood intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite.PMID:38593155 | DOI:10.1126/scisignal.adp6031 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wei Wong Source Type: research
Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection
This study reveals a previously unrecognized function of Miz1 in regulating antiviral defense and a potential mechanism for influenza viruses to evade host immune defense.PMID:38593156 | DOI:10.1126/scisignal.adg7867 (Source: Science Signaling)
Source: Science Signaling - April 9, 2024 Category: Biomedical Science Authors: Wenjiao Wu Vinothini Arunagiri Hanh Chi Do-Umehara Cong Chen Shuyin Gu Indrani Biswas Karen M Ridge G R Scott Budinger Shuwen Liu Jing Liu Source Type: research
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation
Sci Signal. 2024 Apr 2;17(830):eade4335. doi: 10.1126/scisignal.ade4335. Epub 2024 Apr 2.ABSTRACTSerum ferritin concentrations increase during hepatic inflammation and correlate with the severity of chronic liver disease. Here, we report a molecular mechanism whereby the heavy subunit of ferritin (FTH) contributes to hepatic inflammation. We found that FTH induced activation of the NLRP3 inflammasome and secretion of the proinflammatory cytokine interleukin-1β (IL-1β) in primary rat hepatic stellate cells (HSCs) through intercellular adhesion molecule-1 (ICAM-1). FTH-ICAM-1 stimulated the expression of Il1b, NLRP3 inflam...
Source: Science Signaling - April 2, 2024 Category: Biomedical Science Authors: Manuel A Fernandez-Rojo Michael A Pearen Anita G Burgess Maria P Ikonomopoulou Diem Hoang-Le Berit Genz Silvia L Saggiomo Sujeevi S K Nawaratna Maura Poli Regina Reissmann Geoffrey N Gobert Urban Deutsch Britta Engelhardt Andrew J Brooks Alun Jones Paolo Source Type: research
Lipid drops in on Alzheimer's disease
Sci Signal. 2024 Apr 2;17(830):eadp4951. doi: 10.1126/scisignal.adp4951. Epub 2024 Apr 2.ABSTRACTMicroglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner.PMID:38564493 | DOI:10.1126/scisignal.adp4951 (Source: Science Signaling)
Source: Science Signaling - April 2, 2024 Category: Biomedical Science Authors: Amy E Baek Source Type: research
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation
Sci Signal. 2024 Apr 2;17(830):eade4335. doi: 10.1126/scisignal.ade4335. Epub 2024 Apr 2.ABSTRACTSerum ferritin concentrations increase during hepatic inflammation and correlate with the severity of chronic liver disease. Here, we report a molecular mechanism whereby the heavy subunit of ferritin (FTH) contributes to hepatic inflammation. We found that FTH induced activation of the NLRP3 inflammasome and secretion of the proinflammatory cytokine interleukin-1β (IL-1β) in primary rat hepatic stellate cells (HSCs) through intercellular adhesion molecule-1 (ICAM-1). FTH-ICAM-1 stimulated the expression of Il1b, NLRP3 inflam...
Source: Science Signaling - April 2, 2024 Category: Biomedical Science Authors: Manuel A Fernandez-Rojo Michael A Pearen Anita G Burgess Maria P Ikonomopoulou Diem Hoang-Le Berit Genz Silvia L Saggiomo Sujeevi S K Nawaratna Maura Poli Regina Reissmann Geoffrey N Gobert Urban Deutsch Britta Engelhardt Andrew J Brooks Alun Jones Paolo Source Type: research
Lipid drops in on Alzheimer's disease
Sci Signal. 2024 Apr 2;17(830):eadp4951. doi: 10.1126/scisignal.adp4951. Epub 2024 Apr 2.ABSTRACTMicroglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner.PMID:38564493 | DOI:10.1126/scisignal.adp4951 (Source: Science Signaling)
Source: Science Signaling - April 2, 2024 Category: Biomedical Science Authors: Amy E Baek Source Type: research
The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation
Sci Signal. 2024 Apr 2;17(830):eade4335. doi: 10.1126/scisignal.ade4335. Epub 2024 Apr 2.ABSTRACTSerum ferritin concentrations increase during hepatic inflammation and correlate with the severity of chronic liver disease. Here, we report a molecular mechanism whereby the heavy subunit of ferritin (FTH) contributes to hepatic inflammation. We found that FTH induced activation of the NLRP3 inflammasome and secretion of the proinflammatory cytokine interleukin-1β (IL-1β) in primary rat hepatic stellate cells (HSCs) through intercellular adhesion molecule-1 (ICAM-1). FTH-ICAM-1 stimulated the expression of Il1b, NLRP3 inflam...
Source: Science Signaling - April 2, 2024 Category: Biomedical Science Authors: Manuel A Fernandez-Rojo Michael A Pearen Anita G Burgess Maria P Ikonomopoulou Diem Hoang-Le Berit Genz Silvia L Saggiomo Sujeevi S K Nawaratna Maura Poli Regina Reissmann Geoffrey N Gobert Urban Deutsch Britta Engelhardt Andrew J Brooks Alun Jones Paolo Source Type: research
Lipid drops in on Alzheimer's disease
Sci Signal. 2024 Apr 2;17(830):eadp4951. doi: 10.1126/scisignal.adp4951. Epub 2024 Apr 2.ABSTRACTMicroglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner.PMID:38564493 | DOI:10.1126/scisignal.adp4951 (Source: Science Signaling)
Source: Science Signaling - April 2, 2024 Category: Biomedical Science Authors: Amy E Baek Source Type: research
