Waking up melanoma
Sci Signal. 2022 Jun 21;15(739):eadd5252. doi: 10.1126/scisignal.add5252. Epub 2022 Jun 21.ABSTRACTDormant melanoma cells in the lung can be reactivated by age-related environmental cues in the stroma.PMID:35727865 | DOI:10.1126/scisignal.add5252 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: Amy E Baek Source Type: research

Editorial expression of concern
Sci Signal. 2022 Jun 21;15(739):eadd4323. doi: 10.1126/scisignal.add4323. Epub 2022 Jun 21.NO ABSTRACTPMID:35727862 | DOI:10.1126/scisignal.add4323 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

Editorial expression of concern
Sci Signal. 2022 Jun 21;15(739):eadd4322. doi: 10.1126/scisignal.add4322. Epub 2022 Jun 21.NO ABSTRACTPMID:35727863 | DOI:10.1126/scisignal.add4322 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: John F Foley Source Type: research

Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization
Sci Signal. 2022 Jun 21;15(739):eabg2505. doi: 10.1126/scisignal.abg2505. Epub 2022 Jun 21.ABSTRACTThe trans-synaptic adhesion molecule neuroligin-2 (NL2) is essential for the development and function of inhibitory synapses. NL2 recruits the postsynaptic scaffold protein gephyrin, which, in turn, stabilizes γ-aminobutyric acid type A receptors (GABAARs) in the postsynaptic domain. Thus, the amount of NL2 at the synapse can control synaptic GABAAR concentration to tune inhibitory neurotransmission efficacy. Here, using biochemistry, imaging, single-particle tracking, and electrophysiology, we uncovered a key role for cAMP-...
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: Els F Halff Saad Hannan Jaturon Kwanthongdee Flavie Lesept Trevor G Smart Josef T Kittler Source Type: research

Waking up melanoma
Sci Signal. 2022 Jun 21;15(739):eadd5252. doi: 10.1126/scisignal.add5252. Epub 2022 Jun 21.ABSTRACTDormant melanoma cells in the lung can be reactivated by age-related environmental cues in the stroma.PMID:35727865 | DOI:10.1126/scisignal.add5252 (Source: Science Signaling)
Source: Science Signaling - June 21, 2022 Category: Biomedical Science Authors: Amy E Baek Source Type: research

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice
Sci Signal. 2022 Jun 14;15(738):eabj4583. doi: 10.1126/scisignal.abj4583. Epub 2022 Jun 14.ABSTRACTResistance to thyroid hormone due to mutations in THRA, which encodes the thyroid hormone receptor α (TRα1), shows variable clinical presentation. Mutations affecting TRβ1 and TRβ2 cause deafness in mice and have been associated with deafness in humans. To test whether TRα1 also affects hearing function, we used mice heterozygous for a frameshift mutation in Thra that is similar to human THRA mutations (ThraS1/+ mice) and reduces tissue sensitivity to thyroid hormone. Compared to wild-type littermates, ThraS1/+ mice show...
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Corentin Affortit Fabian Blanc Jamal Nasr Jean-Charles Ceccato Suzy Markossian Romain Guyot Jean-Luc Puel Fr édéric Flamant Jing Wang Source Type: research

Get up and sweat to treat cancer
Sci Signal. 2022 Jun 14;15(738):eadd4188. doi: 10.1126/scisignal.add4188. Epub 2022 Jun 14.ABSTRACTBy mobilizing certain T cells, exercise joins forces with chemo- and immunotherapy to fight cancer.PMID:35700265 | DOI:10.1126/scisignal.add4188 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

Voltage-gated Ca < sup > 2+ < /sup > channel proteins do not function as ion channels in T cells
Sci Signal. 2022 Jun 14;15(738):eabq5594. doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.ABSTRACTCalcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.PMID:35700266 | DOI:10.1126/scisignal.abq5594 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Michael D Cahalan Source Type: research

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice
Sci Signal. 2022 Jun 14;15(738):eabj4583. doi: 10.1126/scisignal.abj4583. Epub 2022 Jun 14.ABSTRACTResistance to thyroid hormone due to mutations in THRA, which encodes the thyroid hormone receptor α (TRα1), shows variable clinical presentation. Mutations affecting TRβ1 and TRβ2 cause deafness in mice and have been associated with deafness in humans. To test whether TRα1 also affects hearing function, we used mice heterozygous for a frameshift mutation in Thra that is similar to human THRA mutations (ThraS1/+ mice) and reduces tissue sensitivity to thyroid hormone. Compared to wild-type littermates, ThraS1/+ mice show...
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Corentin Affortit Fabian Blanc Jamal Nasr Jean-Charles Ceccato Suzy Markossian Romain Guyot Jean-Luc Puel Fr édéric Flamant Jing Wang Source Type: research

Get up and sweat to treat cancer
Sci Signal. 2022 Jun 14;15(738):eadd4188. doi: 10.1126/scisignal.add4188. Epub 2022 Jun 14.ABSTRACTBy mobilizing certain T cells, exercise joins forces with chemo- and immunotherapy to fight cancer.PMID:35700265 | DOI:10.1126/scisignal.add4188 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

Voltage-gated Ca < sup > 2+ < /sup > channel proteins do not function as ion channels in T cells
Sci Signal. 2022 Jun 14;15(738):eabq5594. doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.ABSTRACTCalcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.PMID:35700266 | DOI:10.1126/scisignal.abq5594 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Michael D Cahalan Source Type: research

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice
Sci Signal. 2022 Jun 14;15(738):eabj4583. doi: 10.1126/scisignal.abj4583. Epub 2022 Jun 14.ABSTRACTResistance to thyroid hormone due to mutations in THRA, which encodes the thyroid hormone receptor α (TRα1), shows variable clinical presentation. Mutations affecting TRβ1 and TRβ2 cause deafness in mice and have been associated with deafness in humans. To test whether TRα1 also affects hearing function, we used mice heterozygous for a frameshift mutation in Thra that is similar to human THRA mutations (ThraS1/+ mice) and reduces tissue sensitivity to thyroid hormone. Compared to wild-type littermates, ThraS1/+ mice show...
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Corentin Affortit Fabian Blanc Jamal Nasr Jean-Charles Ceccato Suzy Markossian Romain Guyot Jean-Luc Puel Fr édéric Flamant Jing Wang Source Type: research

Get up and sweat to treat cancer
Sci Signal. 2022 Jun 14;15(738):eadd4188. doi: 10.1126/scisignal.add4188. Epub 2022 Jun 14.ABSTRACTBy mobilizing certain T cells, exercise joins forces with chemo- and immunotherapy to fight cancer.PMID:35700265 | DOI:10.1126/scisignal.add4188 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research

Voltage-gated Ca < sup > 2+ < /sup > channel proteins do not function as ion channels in T cells
Sci Signal. 2022 Jun 14;15(738):eabq5594. doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.ABSTRACTCalcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.PMID:35700266 | DOI:10.1126/scisignal.abq5594 (Source: Science Signaling)
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Michael D Cahalan Source Type: research

A disease-associated mutation in thyroid hormone receptor α1 causes hearing loss and sensory hair cell patterning defects in mice
Sci Signal. 2022 Jun 14;15(738):eabj4583. doi: 10.1126/scisignal.abj4583. Epub 2022 Jun 14.ABSTRACTResistance to thyroid hormone due to mutations in THRA, which encodes the thyroid hormone receptor α (TRα1), shows variable clinical presentation. Mutations affecting TRβ1 and TRβ2 cause deafness in mice and have been associated with deafness in humans. To test whether TRα1 also affects hearing function, we used mice heterozygous for a frameshift mutation in Thra that is similar to human THRA mutations (ThraS1/+ mice) and reduces tissue sensitivity to thyroid hormone. Compared to wild-type littermates, ThraS1/+ mice show...
Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Corentin Affortit Fabian Blanc Jamal Nasr Jean-Charles Ceccato Suzy Markossian Romain Guyot Jean-Luc Puel Fr édéric Flamant Jing Wang Source Type: research