Actin' off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse
Sci Signal. 2023 Nov 28;16(813):eadl3956. doi: 10.1126/scisignal.adl3956. Epub 2023 Nov 28.ABSTRACTProgrammed cell death molecule 1 (PD-1) is a negative regulator of T cell activation; however, the mechanisms by which it acts are unclear. In this issue of Science Signaling, Paillon et al. show that PD-1 inhibits actin cytoskeletal rearrangements and associated effector responses in cytotoxic T cells.PMID:38015912 | DOI:10.1126/scisignal.adl3956 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Sayanti Acharya Sudha Kumari Source Type: research

PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs
Sci Signal. 2023 Nov 28;16(813):eadh2456. doi: 10.1126/scisignal.adh2456. Epub 2023 Nov 28.ABSTRACTEngagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell-mediated immune responses. Blocking such signaling provides the clinical effects of PD-1-targeted immunotherapy. Here, we investigated the mechanisms underlying PD-1-mediated inhibition. Because dynamic actin remodeling is crucial for T cell functions, we characterized the effects of PD-1 engagement on actin remodeling at the immunological synapse, the interface between a T cell and an antigen-presenting cell (APC...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: No émie Paillon Violette Mouro St éphanie Dogniaux Mathieu Maurin Juan-Jos é Saez Pons Hermine Ferran Laurence Bataille Andr és Ernesto Zucchetti Claire Hivroz Source Type: research

Stress granules plug holes
Sci Signal. 2023 Nov 28;16(813):eadn0652. doi: 10.1126/scisignal.adn0652. Epub 2023 Nov 28.ABSTRACTRuptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair.PMID:38015914 | DOI:10.1126/scisignal.adn0652 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: John F Foley Source Type: research

PI3K-C2 β limits mTORC1 signaling and angiogenic growth
Sci Signal. 2023 Nov 28;16(813):eadg1913. doi: 10.1126/scisignal.adg1913. Epub 2023 Nov 28.ABSTRACTPhosphoinositide 3-kinases (PI3Ks) phosphorylate intracellular inositol lipids to regulate signaling and intracellular vesicular trafficking. Mammals have eight PI3K isoforms, of which class I PI3Kα and class II PI3K-C2α are essential for vascular development. The class II PI3K-C2β is also abundant in endothelial cells. Using in vivo and in vitro approaches, we found that PI3K-C2β was a critical regulator of blood vessel growth by restricting endothelial mTORC1 signaling. Mice expressing a kinase-inactive form of PI3K-C2Î...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Piotr Kobialka Judith Llena Nerea Deleyto-Seldas Margalida Munar-Gelabert Jose A Dengra Pilar Villacampa Alba Albiny à-Pedrós Laia Muixi Jorge Andrade Hielke van Splunder Ana Angulo-Urarte Michael Potente Joaquim Grego-Bessa Sandra D Castillo Bart Vanha Source Type: research

Actin' off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse
Sci Signal. 2023 Nov 28;16(813):eadl3956. doi: 10.1126/scisignal.adl3956. Epub 2023 Nov 28.ABSTRACTProgrammed cell death molecule 1 (PD-1) is a negative regulator of T cell activation; however, the mechanisms by which it acts are unclear. In this issue of Science Signaling, Paillon et al. show that PD-1 inhibits actin cytoskeletal rearrangements and associated effector responses in cytotoxic T cells.PMID:38015912 | DOI:10.1126/scisignal.adl3956 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Sayanti Acharya Sudha Kumari Source Type: research

PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs
Sci Signal. 2023 Nov 28;16(813):eadh2456. doi: 10.1126/scisignal.adh2456. Epub 2023 Nov 28.ABSTRACTEngagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell-mediated immune responses. Blocking such signaling provides the clinical effects of PD-1-targeted immunotherapy. Here, we investigated the mechanisms underlying PD-1-mediated inhibition. Because dynamic actin remodeling is crucial for T cell functions, we characterized the effects of PD-1 engagement on actin remodeling at the immunological synapse, the interface between a T cell and an antigen-presenting cell (APC...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: No émie Paillon Violette Mouro St éphanie Dogniaux Mathieu Maurin Juan-Jos é Saez Pons Hermine Ferran Laurence Bataille Andr és Ernesto Zucchetti Claire Hivroz Source Type: research

Stress granules plug holes
Sci Signal. 2023 Nov 28;16(813):eadn0652. doi: 10.1126/scisignal.adn0652. Epub 2023 Nov 28.ABSTRACTRuptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair.PMID:38015914 | DOI:10.1126/scisignal.adn0652 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: John F Foley Source Type: research

PI3K-C2 β limits mTORC1 signaling and angiogenic growth
Sci Signal. 2023 Nov 28;16(813):eadg1913. doi: 10.1126/scisignal.adg1913. Epub 2023 Nov 28.ABSTRACTPhosphoinositide 3-kinases (PI3Ks) phosphorylate intracellular inositol lipids to regulate signaling and intracellular vesicular trafficking. Mammals have eight PI3K isoforms, of which class I PI3Kα and class II PI3K-C2α are essential for vascular development. The class II PI3K-C2β is also abundant in endothelial cells. Using in vivo and in vitro approaches, we found that PI3K-C2β was a critical regulator of blood vessel growth by restricting endothelial mTORC1 signaling. Mice expressing a kinase-inactive form of PI3K-C2Î...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Piotr Kobialka Judith Llena Nerea Deleyto-Seldas Margalida Munar-Gelabert Jose A Dengra Pilar Villacampa Alba Albiny à-Pedrós Laia Muixi Jorge Andrade Hielke van Splunder Ana Angulo-Urarte Michael Potente Joaquim Grego-Bessa Sandra D Castillo Bart Vanha Source Type: research

Actin' off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse
Sci Signal. 2023 Nov 28;16(813):eadl3956. doi: 10.1126/scisignal.adl3956. Epub 2023 Nov 28.ABSTRACTProgrammed cell death molecule 1 (PD-1) is a negative regulator of T cell activation; however, the mechanisms by which it acts are unclear. In this issue of Science Signaling, Paillon et al. show that PD-1 inhibits actin cytoskeletal rearrangements and associated effector responses in cytotoxic T cells.PMID:38015912 | DOI:10.1126/scisignal.adl3956 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Sayanti Acharya Sudha Kumari Source Type: research

PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs
Sci Signal. 2023 Nov 28;16(813):eadh2456. doi: 10.1126/scisignal.adh2456. Epub 2023 Nov 28.ABSTRACTEngagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell-mediated immune responses. Blocking such signaling provides the clinical effects of PD-1-targeted immunotherapy. Here, we investigated the mechanisms underlying PD-1-mediated inhibition. Because dynamic actin remodeling is crucial for T cell functions, we characterized the effects of PD-1 engagement on actin remodeling at the immunological synapse, the interface between a T cell and an antigen-presenting cell (APC...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: No émie Paillon Violette Mouro St éphanie Dogniaux Mathieu Maurin Juan-Jos é Saez Pons Hermine Ferran Laurence Bataille Andr és Ernesto Zucchetti Claire Hivroz Source Type: research

Stress granules plug holes
Sci Signal. 2023 Nov 28;16(813):eadn0652. doi: 10.1126/scisignal.adn0652. Epub 2023 Nov 28.ABSTRACTRuptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair.PMID:38015914 | DOI:10.1126/scisignal.adn0652 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: John F Foley Source Type: research

PI3K-C2 β limits mTORC1 signaling and angiogenic growth
Sci Signal. 2023 Nov 28;16(813):eadg1913. doi: 10.1126/scisignal.adg1913. Epub 2023 Nov 28.ABSTRACTPhosphoinositide 3-kinases (PI3Ks) phosphorylate intracellular inositol lipids to regulate signaling and intracellular vesicular trafficking. Mammals have eight PI3K isoforms, of which class I PI3Kα and class II PI3K-C2α are essential for vascular development. The class II PI3K-C2β is also abundant in endothelial cells. Using in vivo and in vitro approaches, we found that PI3K-C2β was a critical regulator of blood vessel growth by restricting endothelial mTORC1 signaling. Mice expressing a kinase-inactive form of PI3K-C2Î...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Piotr Kobialka Judith Llena Nerea Deleyto-Seldas Margalida Munar-Gelabert Jose A Dengra Pilar Villacampa Alba Albiny à-Pedrós Laia Muixi Jorge Andrade Hielke van Splunder Ana Angulo-Urarte Michael Potente Joaquim Grego-Bessa Sandra D Castillo Bart Vanha Source Type: research

Actin' off: PD-1 suppresses F-actin rearrangement and degranulation at the immunological synapse
Sci Signal. 2023 Nov 28;16(813):eadl3956. doi: 10.1126/scisignal.adl3956. Epub 2023 Nov 28.ABSTRACTProgrammed cell death molecule 1 (PD-1) is a negative regulator of T cell activation; however, the mechanisms by which it acts are unclear. In this issue of Science Signaling, Paillon et al. show that PD-1 inhibits actin cytoskeletal rearrangements and associated effector responses in cytotoxic T cells.PMID:38015912 | DOI:10.1126/scisignal.adl3956 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: Sayanti Acharya Sudha Kumari Source Type: research

PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs
Sci Signal. 2023 Nov 28;16(813):eadh2456. doi: 10.1126/scisignal.adh2456. Epub 2023 Nov 28.ABSTRACTEngagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell-mediated immune responses. Blocking such signaling provides the clinical effects of PD-1-targeted immunotherapy. Here, we investigated the mechanisms underlying PD-1-mediated inhibition. Because dynamic actin remodeling is crucial for T cell functions, we characterized the effects of PD-1 engagement on actin remodeling at the immunological synapse, the interface between a T cell and an antigen-presenting cell (APC...
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: No émie Paillon Violette Mouro St éphanie Dogniaux Mathieu Maurin Juan-Jos é Saez Pons Hermine Ferran Laurence Bataille Andr és Ernesto Zucchetti Claire Hivroz Source Type: research

Stress granules plug holes
Sci Signal. 2023 Nov 28;16(813):eadn0652. doi: 10.1126/scisignal.adn0652. Epub 2023 Nov 28.ABSTRACTRuptures in lysosomal membranes stimulate the formation of stress granules that plug the holes to enable repair.PMID:38015914 | DOI:10.1126/scisignal.adn0652 (Source: Science Signaling)
Source: Science Signaling - November 28, 2023 Category: Biomedical Science Authors: John F Foley Source Type: research