Get moving to clear β-amyloid
Sci Signal. 2023 Dec 5;16(814):eadn2344. doi: 10.1126/scisignal.adn2344. Epub 2023 Dec 5.ABSTRACTPhysical exercise stimulates brain cells to secrete a β-amyloid-degrading enzyme.PMID:38051777 | DOI:10.1126/scisignal.adn2344 (Source: Science Signaling)
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics
Sci Signal. 2023 Dec 5;16(814):eadi8645. doi: 10.1126/scisignal.adi8645. Epub 2023 Dec 5.ABSTRACTSeptin proteins are involved in diverse physiological functions, including the formation of specialized cytoskeletal structures. Septin 8 (Sept8) is implicated in spine morphogenesis and dendritic branching through palmitoylation. We explored the role and regulation of a Sept8 variant in human neural-like cells and in the mouse brain. We identified Sept8-204 as a brain-specific variant of Sept8 that was abundant in neurons and modified by palmitoylation, specifically at Cys469, Cys470, and Cys472. Sept8-204 palmitoylation was m...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Huicong Liu Peipei Yan Can Wu Muding Rao Jiangli Zhu Luxian Lv Wenqiang Li Yinming Liang Shiqian Qi Kefeng Lu Eryan Kong Source Type: research
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice
Sci Signal. 2023 Dec 5;16(814):eadd2282. doi: 10.1126/scisignal.add2282. Epub 2023 Dec 5.ABSTRACTConstitutive activation of the transcription factor STAT3 (signal transducer and activator of transcription 3) contributes to the malignancy of many cancers such as hepatocellular carcinoma (HCC) and is associated with poor prognosis. STAT3 activity is increased by the reversible palmitoylation of Cys108 by the palmitoyltransferase DHHC7 (encoded by ZDHHC7). Here, we investigated the consequences of S-palmitoylation of STAT3 in HCC. Increased ZDHHC7 abundance in HCC cases was associated with poor prognosis, as revealed by bioin...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Yi Jiang Yuejie Xu Chengliang Zhu Guifang Xu Lei Xu Zijian Rao Lixing Zhou Ping Jiang Sara Malik Jingyuan Fang Hening Lin Mingming Zhang Source Type: research
Get moving to clear β-amyloid
Sci Signal. 2023 Dec 5;16(814):eadn2344. doi: 10.1126/scisignal.adn2344. Epub 2023 Dec 5.ABSTRACTPhysical exercise stimulates brain cells to secrete a β-amyloid-degrading enzyme.PMID:38051777 | DOI:10.1126/scisignal.adn2344 (Source: Science Signaling)
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics
Sci Signal. 2023 Dec 5;16(814):eadi8645. doi: 10.1126/scisignal.adi8645. Epub 2023 Dec 5.ABSTRACTSeptin proteins are involved in diverse physiological functions, including the formation of specialized cytoskeletal structures. Septin 8 (Sept8) is implicated in spine morphogenesis and dendritic branching through palmitoylation. We explored the role and regulation of a Sept8 variant in human neural-like cells and in the mouse brain. We identified Sept8-204 as a brain-specific variant of Sept8 that was abundant in neurons and modified by palmitoylation, specifically at Cys469, Cys470, and Cys472. Sept8-204 palmitoylation was m...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Huicong Liu Peipei Yan Can Wu Muding Rao Jiangli Zhu Luxian Lv Wenqiang Li Yinming Liang Shiqian Qi Kefeng Lu Eryan Kong Source Type: research
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice
Sci Signal. 2023 Dec 5;16(814):eadd2282. doi: 10.1126/scisignal.add2282. Epub 2023 Dec 5.ABSTRACTConstitutive activation of the transcription factor STAT3 (signal transducer and activator of transcription 3) contributes to the malignancy of many cancers such as hepatocellular carcinoma (HCC) and is associated with poor prognosis. STAT3 activity is increased by the reversible palmitoylation of Cys108 by the palmitoyltransferase DHHC7 (encoded by ZDHHC7). Here, we investigated the consequences of S-palmitoylation of STAT3 in HCC. Increased ZDHHC7 abundance in HCC cases was associated with poor prognosis, as revealed by bioin...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Yi Jiang Yuejie Xu Chengliang Zhu Guifang Xu Lei Xu Zijian Rao Lixing Zhou Ping Jiang Sara Malik Jingyuan Fang Hening Lin Mingming Zhang Source Type: research
Get moving to clear β-amyloid
Sci Signal. 2023 Dec 5;16(814):eadn2344. doi: 10.1126/scisignal.adn2344. Epub 2023 Dec 5.ABSTRACTPhysical exercise stimulates brain cells to secrete a β-amyloid-degrading enzyme.PMID:38051777 | DOI:10.1126/scisignal.adn2344 (Source: Science Signaling)
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics
Sci Signal. 2023 Dec 5;16(814):eadi8645. doi: 10.1126/scisignal.adi8645. Epub 2023 Dec 5.ABSTRACTSeptin proteins are involved in diverse physiological functions, including the formation of specialized cytoskeletal structures. Septin 8 (Sept8) is implicated in spine morphogenesis and dendritic branching through palmitoylation. We explored the role and regulation of a Sept8 variant in human neural-like cells and in the mouse brain. We identified Sept8-204 as a brain-specific variant of Sept8 that was abundant in neurons and modified by palmitoylation, specifically at Cys469, Cys470, and Cys472. Sept8-204 palmitoylation was m...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Huicong Liu Peipei Yan Can Wu Muding Rao Jiangli Zhu Luxian Lv Wenqiang Li Yinming Liang Shiqian Qi Kefeng Lu Eryan Kong Source Type: research
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice
Sci Signal. 2023 Dec 5;16(814):eadd2282. doi: 10.1126/scisignal.add2282. Epub 2023 Dec 5.ABSTRACTConstitutive activation of the transcription factor STAT3 (signal transducer and activator of transcription 3) contributes to the malignancy of many cancers such as hepatocellular carcinoma (HCC) and is associated with poor prognosis. STAT3 activity is increased by the reversible palmitoylation of Cys108 by the palmitoyltransferase DHHC7 (encoded by ZDHHC7). Here, we investigated the consequences of S-palmitoylation of STAT3 in HCC. Increased ZDHHC7 abundance in HCC cases was associated with poor prognosis, as revealed by bioin...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Yi Jiang Yuejie Xu Chengliang Zhu Guifang Xu Lei Xu Zijian Rao Lixing Zhou Ping Jiang Sara Malik Jingyuan Fang Hening Lin Mingming Zhang Source Type: research
Get moving to clear β-amyloid
Sci Signal. 2023 Dec 5;16(814):eadn2344. doi: 10.1126/scisignal.adn2344. Epub 2023 Dec 5.ABSTRACTPhysical exercise stimulates brain cells to secrete a β-amyloid-degrading enzyme.PMID:38051777 | DOI:10.1126/scisignal.adn2344 (Source: Science Signaling)
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics
Sci Signal. 2023 Dec 5;16(814):eadi8645. doi: 10.1126/scisignal.adi8645. Epub 2023 Dec 5.ABSTRACTSeptin proteins are involved in diverse physiological functions, including the formation of specialized cytoskeletal structures. Septin 8 (Sept8) is implicated in spine morphogenesis and dendritic branching through palmitoylation. We explored the role and regulation of a Sept8 variant in human neural-like cells and in the mouse brain. We identified Sept8-204 as a brain-specific variant of Sept8 that was abundant in neurons and modified by palmitoylation, specifically at Cys469, Cys470, and Cys472. Sept8-204 palmitoylation was m...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Huicong Liu Peipei Yan Can Wu Muding Rao Jiangli Zhu Luxian Lv Wenqiang Li Yinming Liang Shiqian Qi Kefeng Lu Eryan Kong Source Type: research
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice
Sci Signal. 2023 Dec 5;16(814):eadd2282. doi: 10.1126/scisignal.add2282. Epub 2023 Dec 5.ABSTRACTConstitutive activation of the transcription factor STAT3 (signal transducer and activator of transcription 3) contributes to the malignancy of many cancers such as hepatocellular carcinoma (HCC) and is associated with poor prognosis. STAT3 activity is increased by the reversible palmitoylation of Cys108 by the palmitoyltransferase DHHC7 (encoded by ZDHHC7). Here, we investigated the consequences of S-palmitoylation of STAT3 in HCC. Increased ZDHHC7 abundance in HCC cases was associated with poor prognosis, as revealed by bioin...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Yi Jiang Yuejie Xu Chengliang Zhu Guifang Xu Lei Xu Zijian Rao Lixing Zhou Ping Jiang Sara Malik Jingyuan Fang Hening Lin Mingming Zhang Source Type: research
Get moving to clear β-amyloid
Sci Signal. 2023 Dec 5;16(814):eadn2344. doi: 10.1126/scisignal.adn2344. Epub 2023 Dec 5.ABSTRACTPhysical exercise stimulates brain cells to secrete a β-amyloid-degrading enzyme.PMID:38051777 | DOI:10.1126/scisignal.adn2344 (Source: Science Signaling)
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Leslie K Ferrarelli Source Type: research
Palmitoylated Sept8-204 modulates learning and anxiety by regulating filopodia arborization and actin dynamics
Sci Signal. 2023 Dec 5;16(814):eadi8645. doi: 10.1126/scisignal.adi8645. Epub 2023 Dec 5.ABSTRACTSeptin proteins are involved in diverse physiological functions, including the formation of specialized cytoskeletal structures. Septin 8 (Sept8) is implicated in spine morphogenesis and dendritic branching through palmitoylation. We explored the role and regulation of a Sept8 variant in human neural-like cells and in the mouse brain. We identified Sept8-204 as a brain-specific variant of Sept8 that was abundant in neurons and modified by palmitoylation, specifically at Cys469, Cys470, and Cys472. Sept8-204 palmitoylation was m...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Huicong Liu Peipei Yan Can Wu Muding Rao Jiangli Zhu Luxian Lv Wenqiang Li Yinming Liang Shiqian Qi Kefeng Lu Eryan Kong Source Type: research
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice
Sci Signal. 2023 Dec 5;16(814):eadd2282. doi: 10.1126/scisignal.add2282. Epub 2023 Dec 5.ABSTRACTConstitutive activation of the transcription factor STAT3 (signal transducer and activator of transcription 3) contributes to the malignancy of many cancers such as hepatocellular carcinoma (HCC) and is associated with poor prognosis. STAT3 activity is increased by the reversible palmitoylation of Cys108 by the palmitoyltransferase DHHC7 (encoded by ZDHHC7). Here, we investigated the consequences of S-palmitoylation of STAT3 in HCC. Increased ZDHHC7 abundance in HCC cases was associated with poor prognosis, as revealed by bioin...
Source: Science Signaling - December 5, 2023 Category: Biomedical Science Authors: Yi Jiang Yuejie Xu Chengliang Zhu Guifang Xu Lei Xu Zijian Rao Lixing Zhou Ping Jiang Sara Malik Jingyuan Fang Hening Lin Mingming Zhang Source Type: research
