Activation of gp130 signaling in T cells drives T < sub > H < /sub > 17-mediated multi-organ autoimmunity
Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20.ABSTRACTThe IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3GOF) are associated with multi-organ autoimmunity, severe morbidity, and adverse prognosis. To dissect crucial cellular subsets and disease biology involved in activated gp130 signaling, the gp130-JAK-STAT3 axis was constitutively activated using a transgene, L-gp130, specifically targeted to T cells. Activating gp130 signaling in T cells in vivo resul...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Francis Baumgartner Stefanos A Bamopoulos Laura Faletti Hsiang-Jung Hsiao Maximilian Holz Irene Gonzalez-Menendez Lloren ç Boldo Arik Horne Sanket Gosavi Ceren Özerdem Nikita Singh Sven Liebig Senthilkumar Ramamoorthy Malte Lehmann Uta Demel Anja A K ü Source Type: research
Poachers turned gamekeepers in T cells
Sci Signal. 2024 Feb 20;17(824):eado6463. doi: 10.1126/scisignal.ado6463. Epub 2024 Feb 20.ABSTRACTThe efficacy of therapeutic T cells is enhanced by incorporating mutations associated with autoimmunity or lymphoma.PMID:38377178 | DOI:10.1126/scisignal.ado6463 (Source: Science Signaling)
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20.ABSTRACTHigh-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulat...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Yueh-Chien Lin Steven Swendeman Irina S Moreira Avishek Ghosh Andrew Kuo N ícia Rosário-Ferreira Shihui Guo Alan Culbertson Michel V Levesque Andreane Cartier Takahiro Seno Alec Schmaier Sylvain Galvani Asuka Inoue Samir M Parikh Garret A FitzGerald Dav Source Type: research
Activation of gp130 signaling in T cells drives T < sub > H < /sub > 17-mediated multi-organ autoimmunity
Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20.ABSTRACTThe IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3GOF) are associated with multi-organ autoimmunity, severe morbidity, and adverse prognosis. To dissect crucial cellular subsets and disease biology involved in activated gp130 signaling, the gp130-JAK-STAT3 axis was constitutively activated using a transgene, L-gp130, specifically targeted to T cells. Activating gp130 signaling in T cells in vivo resul...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Francis Baumgartner Stefanos A Bamopoulos Laura Faletti Hsiang-Jung Hsiao Maximilian Holz Irene Gonzalez-Menendez Lloren ç Boldo Arik Horne Sanket Gosavi Ceren Özerdem Nikita Singh Sven Liebig Senthilkumar Ramamoorthy Malte Lehmann Uta Demel Anja A K ü Source Type: research
Poachers turned gamekeepers in T cells
Sci Signal. 2024 Feb 20;17(824):eado6463. doi: 10.1126/scisignal.ado6463. Epub 2024 Feb 20.ABSTRACTThe efficacy of therapeutic T cells is enhanced by incorporating mutations associated with autoimmunity or lymphoma.PMID:38377178 | DOI:10.1126/scisignal.ado6463 (Source: Science Signaling)
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20.ABSTRACTHigh-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulat...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Yueh-Chien Lin Steven Swendeman Irina S Moreira Avishek Ghosh Andrew Kuo N ícia Rosário-Ferreira Shihui Guo Alan Culbertson Michel V Levesque Andreane Cartier Takahiro Seno Alec Schmaier Sylvain Galvani Asuka Inoue Samir M Parikh Garret A FitzGerald Dav Source Type: research
Activation of gp130 signaling in T cells drives T < sub > H < /sub > 17-mediated multi-organ autoimmunity
Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20.ABSTRACTThe IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3GOF) are associated with multi-organ autoimmunity, severe morbidity, and adverse prognosis. To dissect crucial cellular subsets and disease biology involved in activated gp130 signaling, the gp130-JAK-STAT3 axis was constitutively activated using a transgene, L-gp130, specifically targeted to T cells. Activating gp130 signaling in T cells in vivo resul...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Francis Baumgartner Stefanos A Bamopoulos Laura Faletti Hsiang-Jung Hsiao Maximilian Holz Irene Gonzalez-Menendez Lloren ç Boldo Arik Horne Sanket Gosavi Ceren Özerdem Nikita Singh Sven Liebig Senthilkumar Ramamoorthy Malte Lehmann Uta Demel Anja A K ü Source Type: research
Poachers turned gamekeepers in T cells
Sci Signal. 2024 Feb 20;17(824):eado6463. doi: 10.1126/scisignal.ado6463. Epub 2024 Feb 20.ABSTRACTThe efficacy of therapeutic T cells is enhanced by incorporating mutations associated with autoimmunity or lymphoma.PMID:38377178 | DOI:10.1126/scisignal.ado6463 (Source: Science Signaling)
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20.ABSTRACTHigh-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulat...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Yueh-Chien Lin Steven Swendeman Irina S Moreira Avishek Ghosh Andrew Kuo N ícia Rosário-Ferreira Shihui Guo Alan Culbertson Michel V Levesque Andreane Cartier Takahiro Seno Alec Schmaier Sylvain Galvani Asuka Inoue Samir M Parikh Garret A FitzGerald Dav Source Type: research
Activation of gp130 signaling in T cells drives T < sub > H < /sub > 17-mediated multi-organ autoimmunity
Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20.ABSTRACTThe IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3GOF) are associated with multi-organ autoimmunity, severe morbidity, and adverse prognosis. To dissect crucial cellular subsets and disease biology involved in activated gp130 signaling, the gp130-JAK-STAT3 axis was constitutively activated using a transgene, L-gp130, specifically targeted to T cells. Activating gp130 signaling in T cells in vivo resul...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Francis Baumgartner Stefanos A Bamopoulos Laura Faletti Hsiang-Jung Hsiao Maximilian Holz Irene Gonzalez-Menendez Lloren ç Boldo Arik Horne Sanket Gosavi Ceren Özerdem Nikita Singh Sven Liebig Senthilkumar Ramamoorthy Malte Lehmann Uta Demel Anja A K ü Source Type: research
Poachers turned gamekeepers in T cells
Sci Signal. 2024 Feb 20;17(824):eado6463. doi: 10.1126/scisignal.ado6463. Epub 2024 Feb 20.ABSTRACTThe efficacy of therapeutic T cells is enhanced by incorporating mutations associated with autoimmunity or lymphoma.PMID:38377178 | DOI:10.1126/scisignal.ado6463 (Source: Science Signaling)
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20.ABSTRACTHigh-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulat...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Yueh-Chien Lin Steven Swendeman Irina S Moreira Avishek Ghosh Andrew Kuo N ícia Rosário-Ferreira Shihui Guo Alan Culbertson Michel V Levesque Andreane Cartier Takahiro Seno Alec Schmaier Sylvain Galvani Asuka Inoue Samir M Parikh Garret A FitzGerald Dav Source Type: research
Activation of gp130 signaling in T cells drives T < sub > H < /sub > 17-mediated multi-organ autoimmunity
Sci Signal. 2024 Feb 20;17(824):eadc9662. doi: 10.1126/scisignal.adc9662. Epub 2024 Feb 20.ABSTRACTThe IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3GOF) are associated with multi-organ autoimmunity, severe morbidity, and adverse prognosis. To dissect crucial cellular subsets and disease biology involved in activated gp130 signaling, the gp130-JAK-STAT3 axis was constitutively activated using a transgene, L-gp130, specifically targeted to T cells. Activating gp130 signaling in T cells in vivo resul...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Francis Baumgartner Stefanos A Bamopoulos Laura Faletti Hsiang-Jung Hsiao Maximilian Holz Irene Gonzalez-Menendez Lloren ç Boldo Arik Horne Sanket Gosavi Ceren Özerdem Nikita Singh Sven Liebig Senthilkumar Ramamoorthy Malte Lehmann Uta Demel Anja A K ü Source Type: research
Poachers turned gamekeepers in T cells
Sci Signal. 2024 Feb 20;17(824):eado6463. doi: 10.1126/scisignal.ado6463. Epub 2024 Feb 20.ABSTRACTThe efficacy of therapeutic T cells is enhanced by incorporating mutations associated with autoimmunity or lymphoma.PMID:38377178 | DOI:10.1126/scisignal.ado6463 (Source: Science Signaling)
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: John F Foley Source Type: research
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
Sci Signal. 2024 Feb 20;17(824):eadg9256. doi: 10.1126/scisignal.adg9256. Epub 2024 Feb 20.ABSTRACTHigh-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulat...
Source: Science Signaling - February 20, 2024 Category: Biomedical Science Authors: Yueh-Chien Lin Steven Swendeman Irina S Moreira Avishek Ghosh Andrew Kuo N ícia Rosário-Ferreira Shihui Guo Alan Culbertson Michel V Levesque Andreane Cartier Takahiro Seno Alec Schmaier Sylvain Galvani Asuka Inoue Samir M Parikh Garret A FitzGerald Dav Source Type: research
