Antimicrobial Isoflavans and Other Metabolites of Dalea jamesii
Planta Med DOI: 10.1055/a-2013-3008The phytochemical investigation of extracts of Dalea jamesii root and aerial portions led to the isolation of ten phenolic compounds. Six previously undescribed prenylated isoflavans, summarily named ormegans A – F (1 – 6), were characterized, along with two new arylbenzofurans (7, 8), a known flavone (9), and a known chroman (10). The structures of the new compounds were deduced by NMR spectroscopy, supported by HRESI mass spectrometry. The absolute configurations of 1 – 6 were determined by circular dichroism spectroscopy. Compounds 1 – 9 exhibited in vitro antim...
Source: Planta Medica - March 2, 2023 Category: Drugs & Pharmacology Authors: Belofsky, Gil Ahn, Hyojin Zapata, Maxwell Wilcox, Dominique Salomon, Christine E. Spiegel, P. Clint Tags: Original Papers Source Type: research
New Ionone Glycosides from the Aerial Parts of Allium sativum and Their Anti-Platelet Aggregation Activity
In this study, two new ionone glycosides,
dasuanxinosides D and E (1, 2), are isolated from the aerial parts together with 13 known compounds including alkanes derivatives and alkyl glycosides (3 – 15), which are reported for the first time from this plant. Their structures are identified by extensive NMR and HRMS analyses. The isolated compounds are evaluated for their
inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full tex...
Source: Planta Medica - February 23, 2023 Category: Drugs & Pharmacology Authors: Hu, Bin Hu, Haibo Pu, Chuan Peng, Donghui Wei, Zheng Kuang, Haixue Wang, Qiuhong Tags: Original Papers Source Type: research
Influence of Flaxseed (Linum usitatissimum) on Female Reproduction
Planta Med DOI: 10.1055/a-2013-2966This review describes the chemical composition of flaxseed (Linum usitatissimum) and its general health effects, as well as the currently available knowledge concerning its action on
the female reproductive state, functions on the ovary and ovarian cells and reproductive hormones, as well as possible constituents and extra- and intracellular mediators mediating its
effects on female reproductive processes. Flaxseed contains a number of biologically active molecules, which, acting through multiple signalling pathways, can determine numerous
physiological, protective and ther...
Source: Planta Medica - February 20, 2023 Category: Drugs & Pharmacology Authors: Sirotkin, Alexander V. Tags: Reviews Source Type: research
Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin – An ex vivo Study on Rat Brain Slices
Planta Med DOI: 10.1055/a-2005-5497Arctigenin is a bioactive dibenzylbutyrolactone-type lignan exhibiting various pharmacological activities. The neuroprotective effects of arctigenin were demonstrated to be mediated via
inhibition of AMPA and KA type glutamate receptors in the somatosensory cortex of the rat brain. The aim of this study was to compare the effects of arctigenin with matairesinol and
trachelogenin on synaptic activity in ex vivo rat brain slices. Arctigenin, matairesinol and trachelogenin were isolated from Arctium lappa, Centaurea scabiosa and Cirsium
arvense, respectively, and applied on br...
Source: Planta Medica - February 16, 2023 Category: Drugs & Pharmacology Authors: Koech, Peter Kiplang ʼat J ócsák, Gergely Boldizs ár, Imre Moldov án, Kinga Borb ély, Sándor Vil ági, Ildikó Dobolyi, Arp ád Varr ó, Petra Tags: Original Papers Source Type: research
Cytotoxicity of Carvotacetones from Sphaeranthus africanus Against Cancer Cells and Their Potential to Induce Apoptosis
Planta Med DOI: 10.1055/a-1988-2207Three carvotacetones (1 – 3) isolated from Sphaeranthus africanus were screened in 60 cancer cell lines at the National Cancer Institute (NCI) within the Developmental Therapeutics Program (DTP).
At the concentration of 10−5 M, compound 1 (3,5-diangeloyloxy-7-hydroxycarvotacetone) turned out to be the most active compound against ACHN and UO-31 renal cancer cell
lines with growth percent values of − 100% (all cells dead). Compound 2 (3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone) showed strong effects in SK-MEL-5
melanoma and ...
Source: Planta Medica - January 31, 2023 Category: Drugs & Pharmacology Authors: Tran, Huyen Thi Kretschmer, Nadine Huynh, Loi Bauer, Rudolf Tags: Original Papers Source Type: research
Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)
This study evaluates the pharmacological potential of cis-jasmone (CJ) in adult zebrafish (Danio rerio; aZF). Initially, aZF (n = 6/group) were pretreated (20 µL; p. o.) with CJ (0.1 or 0.3 or 1.0 mg/mL) or vehicle (0.5% Tween 80). The animals were submitted to acute toxicity and locomotion tests, pentylenetetrazole-induced seizure, carrageenan-induced abdominal edema, and cinnamaldehyde-, capsaicin-, menthol-, glutamate-, and acid saline-induced orofacial nociception. The possible mechanisms of anticonvulsant, anxiolytic, and antinociceptive action were evaluated. The involvement of central afferent fibers sens...
Source: Planta Medica - January 31, 2023 Category: Drugs & Pharmacology Authors: Bezerra, Francisca Magn ólia Diógenes Holanda Vieira-Neto, Ant ônio Eufrásio Benevides, Samara Casemiro Tavares, Kaio C ésar Simiano Ribeiro, Antonia Deyse de Castro Santos, Sacha Aubrey Alves Rodrigues Leite, Gerl ânia de Oliveira Alves Magalh ães Tags: Original Papers Source Type: research
Development and Validation of a GC-FID Method for the Quantitation of 20 Different Acidic and Neutral Cannabinoids
Planta Med DOI: 10.1055/a-1962-8165For decades, Cannabis sativa had been illegal to sell or consume around the world, including in the United States. However, in light of the recent 2018 Farm Bill and the legalization
of hemp across the US, various cannabis preparations have flooded the market, making it essential to be able to quantitate the levels of the different acidic and neutral cannabinoids in
C. sativa and to have a complete cannabinoid profile of the different chemovars of the cannabis plant. A GC-FID method was developed and validated for the analysis of 20 acidic and
neutral cannabinoids as trime...
Source: Planta Medica - January 24, 2023 Category: Drugs & Pharmacology Authors: Gul, Waseem Ibrahim, Elsayed A. Gul, Sharjeel W. Shahzadi, Iram Radwan, Mohamed M. Chandra, Suman Lata, Hemant ElSohly, Mahmoud A. Tags: Original Papers Source Type: research
Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38 α in Alcoholic Liver Disease
In conclusion, the results suggest that honokiol might be an effective regulator of p38α by downregulating the nuclear factor kappa B
signaling pathway, thereby reducing the inflammatory response and lipid metabolism disorder in alcoholic liver disease. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - January 23, 2023 Category: Drugs & Pharmacology Authors: Yang, Chenchen Zhao, Yinglian Luo, Zhipan Hu, Ying Wang, Shuxian Hu, Shuang Yao, Yan Pan, Linxin Shen, Chuanpu Xu, Tao Tags: Original Papers Source Type: research
Comparative Pharmacokinetic Investigation on Multiple Active Aminoalcohol-Diterpenoid Alkaloids after Single Oral Administrations of Monomers and Aqueous Extract of Fuzi
(Aconiti Lateralis Radix Praeparata) by UFLC-MS/MS
Planta Med DOI: 10.1055/a-1984-8515To further study the aminoalcohol-diterpenoid alkaloids (ADAs) in Fuzi (Aconiti Lateralis Radix Praeparata), a simple and sensitive UFLC-MS/MS method was established and validated for the
determination of five ADAs, aconine, mesaconine, hypaconine, deoxyaconine and fuziline, in rat plasma to compare the pharmacokinetic characteristics of pure ADAs and Fuzi decoction. After
precipitating protein with methanol, plasma samples were isolated at 0.5 mL/min flow rate on Waters Acquity UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 µm). The mobile phase was
composed of 0.1%...
Source: Planta Medica - January 23, 2023 Category: Drugs & Pharmacology Authors: Tang, Ming-Hai Peng, Fu-Li Liu, Xiu-Xiu Chao, Ruo-Bing Tags: Original Papers Source Type: research
Euryachincoside, a Novel Phenolic Glycoside with Anti-Hepatic Fibrosis Activity from Eurya chinensis
Planta Med DOI: 10.1055/a-1828-2671
Eurya chinensis has been recorded as a folk medicine traditionally used for treatment of a variety of symptoms. However, the phytochemical and pharmacological investigations of this
plant are still scarce. A novel phenolic glycoside named Euryachincoside (ECS) was isolated by chromatographic separation from E. chinensis, and its chemical structure was identified
by analysis of HRMS and NMR data. Its anti-hepatic fibrosis effects were evaluated in both HSC-T6 (rat hepatic stellate cells) and carbon tetrachloride (CCl4)-induced mice with
Silybin (SLB) as the positive co...
Source: Planta Medica - January 23, 2023 Category: Drugs & Pharmacology Authors: Li, Bai-Lin Liang, Hui-Jun Li, Qian-Ran Wang, Qian Ao, Zhuo-Yi Fan, Yu-Wen Zhang, Wei-Jie Lian, Xin Chen, Jia-Yan Yuan, Jie Wu, Jie-Wei Tags: Original Papers Source Type: research
Metabolite Profiling of Talatisamine in Heart Tissue After Oral Administration and Analysis of Cardiac Bioactivities
In this study, metabolite profiling of TA was performed in rat heart by UPLC-MS
following oral administration. Metabolites were identified by comparing protonated molecules, fragmentation patterns, and chromatographic behaviors with those of standard compounds.
Metabolites of TA were then prepared and tested for cardiotonic activity on isolated frog hearts. The metabolite cammaconine, a C19 diterpenoid alkaloid with a hydroxyl group at
C-18, exhibited substantial cardiotonic activity during frog heart perfusion. To further investigate the structure–cardiac effect relationships, a series of C19-diterpenoid
...
Source: Planta Medica - January 18, 2023 Category: Drugs & Pharmacology Authors: Huang, Shuai Lv, Yang Wang, Jian-Zhu Ye, Mei-Zhen Lu, Rui-Jie Chen, Lin Xie, Jiang Gao, Feng Zhou, Xian-Li Tags: Original Papers Source Type: research
Use of Milk Thistle in Farm and Companion Animals: A Review
Planta Med DOI: 10.1055/a-1969-2440Milk thistle, Silybum marianum, is a medicinal plant grown for its bioactive compounds with well-documented antioxidant and hepatoprotective properties. Milk thistle has a
well-established pharmacological reputation for treatments of human liver disease, but it is also used in animals. This review summarizes the experimental evidence of milk thistleʼs effects
on animals when administered as silymarin extract (feed additive) or a feed ingredient, if administered as seed or expeller/cake with the seed residue still containing the bioactive
components. The use as a feed addit...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Tedesco, Doriana Eurosia Angela Guerrini, Alessandro Tags: Reviews Source Type: research
Acteoside from Conandron ramondioides Reduces Microcystin-LR Cytotoxicity by Inhibiting Intracellular Uptake Mediated by OATP1B3
Planta Med DOI: 10.1055/a-1978-8768The hepatotoxin microcystin-LR is a strong inhibitor of serine/threonine protein phosphatase (PP) 1 and PP2A. The onset of its cytotoxicity depends on its selective uptake via the
hepatocyte uptake transporters, organic anion transporting polypeptide (OATP) 1B1 and OATP1B3. Understanding and preventing the cytotoxicity of microcystin-LR is crucial to maintain human
health. This chemoprevention study demonstrates that the herbal plant extract of iwajisha (20 µg/mL) reduced microcystin-LR cytotoxicity in OATP1B3-expressing cells by approximately six
times. In addition, 20â...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Takumi, Shota Hashimoto, Kairi Tomioka, Masaru Sato, Mina He, Weijie Komatsu, Yumiko Aoki, Shunji Ikeda, Ryuji Shiozaki, Kazuhiro Furukawa, Tatsuhiko Komatsu, Masaharu Tags: Original Papers Source Type: research
UPLC/Q-TOF-MS-based Metabolomics Study of the Antiosteoporosis Effects of Vaccarin in Ovariectomized Mice
In this study, multivariate statistical analysis and ultrahigh-performance liquid chromatography and quadrupole
time-of-flight tandem mass spectrometry were used to analyze the serum metabolites of ovariectomized mice treated with or without vaccarin. As a result, 9 serum metabolites were identified
as biomarkers. The metabolic levels of 3 crucial biomarkers, namely, lysophosphatidylcholine [22 : 6, (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)], 1-linoleoylglycerophosphocholine and
1-palmitoyl-Sn-glycero-3-phosphocholine, that were correlated with glycerophospholipid metabolism increased and then decreased significantly...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Song, Fangming Xie, Tianyu Liu, Xi Chin, Bonnie Luo, Xiaoting Liao, Shijie Feng, Wenyu He, Mingwei Huang, Nenggan Su, Zhiheng Liu, Yun Tags: Original Papers Source Type: research
Urease and Carbonic Anhydrase Inhibitory Effect of Xanthones from Aspergillus nidulans, an Endophytic Fungus of Nyctanthes arbor-tristis
Planta Med DOI: 10.1055/a-1908-0935Urease plays a major role in the pathogenesis of peptic and gastric ulcer and also causes acute pyelonephritis and development of infection-induced reactive arthritis. Carbonic anhydrases
(CA) cause pathological disorders such as epilepsy (CA I), glaucoma, gastritis, renal, pancreatic carcinomas, and malignant brain tumors (CA II). Although various synthetic urease and
carbonic anhydrase inhibitors are known, these have many side effects. Hence, present studies were undertaken on ethyl acetate extract of Aspergillus nidulans, an endophytic fungus
separated from the leaves o...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Sana, Talea Khan, Majid Jabeen, Almas Shams, Sidrah Hadda, Taibi Ben Begum, Sabira Siddiqui, Bina Shaheen Tags: Original Papers Source Type: research
