Optimizing the Antimicrobial Synergism of Melaleuca alternifolia (Tea Tree) Essential Oil Combinations for Application against Respiratory Related
Pathogens
This study aimed to determine the antimicrobial activity of four essential
oil combinations, all inclusive of M. alternifolia, against nine pathogens associated with the respiratory tract. The minimum inhibitory concentration assay was used to determine the
antimicrobial activity of four essential oil combinations, M. alternifolia in combination with Cupressus sempervirens, Origanum majorana, Myrtus communis, and Origanum
vulgare essential oils. The interactions between essential oil combinations were analyzed using isobolograms and SynergyFinder 2.0 software to visualize the synergistic potential at
...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Rapper, Stephanie Leigh-de Viljoen, Alvaro van Vuuren, Sandy Tags: Original Papers Source Type: research
Sesquiterpene Lactones with Astrodaucane Skeleton from Astrodaucus
orientalis
Planta Med DOI: 10.1055/a-1822-1486Four sesquiterpene lactones, astrodaucanolide A – D (1–4) with
unique structures, toghether with two known phenylpropanoid esters (5 and
6) were isolated from a flower extract of Astrodaucus
orientalis. The structures were established by 1D and 2D NMR
spectroscopy and high-resolution mass spectrometry (HRESIMS), and the absolute
configuration of 1–4 was determined by electronic circular
dichroism (ECD). Compounds 1–4 novel architecture represents a new
class of sesquiterpenes with new skeleton. A putativ...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Hashempour, Hossein Herfati, Farshid Valizadeh, Hassan Mahmoudi-Kordi, Fatemeh Ebrahimi, Samad Nejad Hamburger, Matthias Farimani, Mahdi Moridi Tags: Original Papers Source Type: research
Five New Diarylbutyrolactones and Sesquilignans from Saussurea medusa and Their Inhibitory Effects on LPS-induced NO Production
Planta Med DOI: 10.1055/a-1956-7829Five new diarylbutyrolactones and sesquilignans (1a/1b – 4), including one pair of enantiomers (1a/1b), together with 10 known analogues (5 – 14), were isolated from the whole plants of Saussurea
medusa. Compound 1 was found to possess an unusual 7,8′-diarylbutyrolactone lignan structure. Separation by chiral HPLC analysis led to the isolation of one pair of enantiomers,
(+)-1a and (−)-1b. The structures of the new compounds were elucidated by extensive spectroscopic data. All compounds, except compounds 5, 7 and 9, were
isolated from S. medusa for the fi...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Cao, Jing-Ya Wang, Zhi-Yao Stewart, Alan J. Dong, Qi Zhao, Ye Mei, Li-Juan Tao, Yan-Duo Yu, Rui-Tao Tags: Original Papers Source Type: research
Phytochemical Characterization of Phitosia crocifolia, a Monotypic Representative of Greek Flora
Planta Med DOI: 10.1055/a-1939-7473Within the large Compositae family, Phitosia is considered a monotypic genus of the Greek flora, with its only species P. crocifolia (Boiss. & Heldr.) Kamari & Greuter
growing wild with limited distribution, exclusively on the mountains Taigetos and Parnonas in Peloponnese. P. crocifoliaʼs chemical profile was obtained, herein, for the first time
and led to the isolation of 20 compounds, thirteen of which were characterized as sesquiterpene lactones and the rest mainly as phenolic derivatives. The isolates 1–3, 5 – 7 and 11 – 13 represent new chemical str...
Source: Planta Medica - January 10, 2023 Category: Drugs & Pharmacology Authors: Barda, Christina Tzoumaka, Alexia Grafakou, Maria-Eleni Kalpoutzakis, Eleutherios Heilmann, Joerg Skaltsa, Helen Tags: Original Papers Source Type: research
The Anti-inflammatory Effects of Isoflavonoids from Radix Astragali in Hepatoprotective Potential against LPS/D-gal-induced Acute Liver Injury
Planta Med DOI: 10.1055/a-1953-0369Radix Astragali (RA) is an important Traditional Chinese Medicine widely used in the treatment of various diseases, such as pneumonia, atherosclerosis, diabetes, kidney and liver fibrosis.
The role of isoflavonoids from RA in the treatment of liver injury remains unclear. The study aimed to explore hepatoprotective and anti-inflammatory effects of isoflavonoids from
Astragalus mongholicus. Network pharmacological analysis showed that RA had a multi-target regulating effect on alleviating liver injury and inhibiting inflammation through its
active ingredients, among which i...
Source: Planta Medica - December 12, 2022 Category: Drugs & Pharmacology Authors: Aobulikasimu, Nuerbiye Zheng, Dan Guan, Peipei Xu, Lixiao Liu, Bo Li, Minglei Huang, Xueshi Han, Li Tags: Original Papers Source Type: research
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Planta Medica 2022; 15 Article in Thieme eJournals: Table of contents | Congress (Source: Planta Medica)
Source: Planta Medica - December 12, 2022 Category: Drugs & Pharmacology Source Type: research
Phyllobilins – Bioactive Natural Products Derived from Chlorophyll – Plant Origins, Structures, Absorption Spectra, and Biomedical Properties
Planta Med DOI: 10.1055/a-1955-4624Phyllobilins are open-chain products of the biological degradation of chlorophyll a in higher plants. Recent studies reveal that phyllobilins exert anti-oxidative and
anti-inflammatory properties, as well as activities against cancer cells, that contribute to the human health benefits of numerous plants. In general, phyllobilins have been overlooked in
phytochemical analyses, and – more importantly – in the analyses of medicinal plant extracts. Nevertheless, over the past three decades, > 70 phyllobilins have been identified upon
examination of more than 30 plant s...
Source: Planta Medica - December 8, 2022 Category: Drugs & Pharmacology Authors: Karg, Cornelia A. Taniguchi, Masahiko Lindsey, Jonathan S. Moser, Simone Tags: Reviews Source Type: research
Transporter-mediated Natural Product-Drug Interactions
Planta Med DOI: 10.1055/a-1803-1744The increasing use of natural products in clinical practice has raised great concerns about the potential natural product-drug interactions (NDIs). Drug transporters mediate the
transmembrane passage of a broad range of drugs, and thus are important determinants for drug pharmacokinetics and pharmacodynamics. Generally, transporters can be divided into ATP binding
cassette (ABC) family and solute carrier (SLC) family. Numerous natural products have been identified as inhibitors, substrates, inducers, and/or activators of drug transporters. This review
article aims to provid...
Source: Planta Medica - December 8, 2022 Category: Drugs & Pharmacology Authors: Bi, Yajuan Wang, Xue Ding, Hui He, Feng Han, Lifeng Zhang, Youcai Tags: Reviews Source Type: research
Antimicrobial Acylphloroglucinol Meroterpenoids and Acylphloroglucinols from Dryopteris crassirhizoma
Planta Med DOI: 10.1055/a-1917-7910Ten novel meroterpenoids, dryoptins/11″-epi-dryoptins A~E (1~10) with an unprecedented skeleton consisting of dimeric or trimeric acylphloroglucinols and
dehydrotheonelline, two undescribed acylphloroglucinol-nerolidol meroterpenoids (11~12), and ten known acylphloroglucinol derivatives (13~22), were isolated from
D. crassirhizoma. The novel structures including absolute configurations were established by comprehensive spectroscopic analyses and quantum chemical electronic circular dichroism
(ECD) calculations. A biosynthetic pathway of 1~10 was assumed. The trimeric acy...
Source: Planta Medica - December 8, 2022 Category: Drugs & Pharmacology Authors: Hai, Ping He, Yunqing Wang, Ruirui Yang, Jian Gao, Yuan Wu, Xudong Chen, Nie Ye, Li Li, Rongtao Tags: Original Papers Source Type: research
2,6-Disubstituted Piperidine Alkaloids with Neuroprotective Activity from Hippobroma longiflora
Planta Med DOI: 10.1055/a-1903-2663Three new alkaloids, hipporidine A (1), hipporidine B (2), and (−)-lobeline N-oxide (3), were discovered from the whole plant of Hippobroma longiflora
together with five known compounds (4–8). Their 2,6-disubstituted piperidine structures were established based on the HRESIMS, NMR (COSY, HMBC, HSQC, NOESY), and UV
spectroscopic data. Hipporidines A (1) and B (2) possess a rare 1,3-oxazinane moiety. Compound 3 is the N-oxide derivative of (−)-lobeline (6). Moreover,
the absolute configuration of norlobeline (5) was established by single-crystal X-ray diffraction analys...
Source: Planta Medica - December 8, 2022 Category: Drugs & Pharmacology Authors: Chen, Shu-Rong Chen, Yih-Fung Lin, Jue-Jun Ke, Tzu-Yi Lin, Yun-Sheng Cheng, Yuan-Bin Tags: Original Papers Source Type: research
A Lignan from Alnus japonica Activates Myogenesis and Alleviates Dexamethasone-induced Myotube Atrophy
Planta Med DOI: 10.1055/a-1891-3366To find inhibitors against skeletal muscle loss, we isolated a lignan compound ((−)-(2R,3R-1,4-O-diferuloylsecoisolarciresinol, DFS) from the stem of Alnus japonica.
C2C12 myoblasts were treated with DFS during differentiation. To induce an in vitro atrophic condition, differentiated myotubes were treated with dexamethasone (a synthetic
glucocorticoid). DFS (10 nM) increased expression levels of myogenic factors and the number of multi-nucleated myotubes expressing myosin heavy chain (MHC). The myogenic potential of DFS
could be attributed to p38 MAPK activation. DFS al...
Source: Planta Medica - December 5, 2022 Category: Drugs & Pharmacology Authors: Lee, Hyejin Jeong, Ji Hye Hwang, Seung Hwan Yeon, Sung Hum Ryu, Jae-Ha Tags: Original Papers Source Type: research
Comparative Inhibitory Effects of Natural Biflavones from Ginkgo against Human CYP1B1 in Recombinant Enzymes and MCF-7 Cells
Planta Med DOI: 10.1055/a-1936-4807Human cytochrome P450 1B1 (CYP1B1) is an extrahepatic enzyme overexpressed in many tumors and associated with angiogenesis. Ginkgetin, isoginkgetin, sciadopitysin, and amentoflavone, the
primary biflavones found in Ginkgo biloba, have excellent anti-inflammatory and anti-tumor effects. However, the effect of biflavones on CYP1B1 activities remains unknown. In this
study, 7-ethoxyresorufin O-deethylation (EROD) was used to characterize the activities of CYP1 families. The impacts of four ginkgo biflavones on CYP1B1 activity and the cellular
protein expression of CYP1B1 were ...
Source: Planta Medica - December 5, 2022 Category: Drugs & Pharmacology Authors: Chen, Xiaodong Zhao, Tingting Du, Jie Guan, Xintong Yu, Hong Wang, Dalong Wang, Changyuan Meng, Qiang Yao, Jialin Sun, Huijun Liu, Kexin Wu, Jingjing Tags: Original Papers Source Type: research
The Therapeutic Potential of Salidroside for Parkinson ʼs Disease
Planta Med DOI: 10.1055/a-1948-3179Parkinsonʼs disease (PD), a neurological disorder, is characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. Its incidence increases with age.
Salidroside, a phenolic compound extracted from Sedum roseum, reportedly has multiple biological and pharmacological activities in the nervous system. However, its effects on PD
remain unclear. In this review, we summarize the effects of salidroside on PD with regard to DA metabolism, neuronal protection, and glial activation. In addition, we summarize the
susceptibility genes and their underlyin...
Source: Planta Medica - November 21, 2022 Category: Drugs & Pharmacology Authors: Li, Li Yao, Wenlong Tags: Reviews Source Type: research
Metabolite Profiling of Swertia cincta Extract in Rats and Pharmacokinetics Study of Three Bioactive Compounds Using UHPLC-MS/MS
In this study, the compounds of Swertia cincta in
serum, bile, feces, and urine of rats were analyzed using a ultra-high-performance liquid chromatography-tandem mass spectrometry. A total of 9 prototype components and 48 metabolites were
detected in biological samples. Furthermore, we determined the main components absorbed in the blood of Swertia cincta and established a method for simultaneously determining these
components (sweroside, swertiamarin, and gentiopicroside) in positive ionization mode within 6 min. The quantitative method was successfully applied for the multiple-component
pharmacokine...
Source: Planta Medica - November 20, 2022 Category: Drugs & Pharmacology Authors: Ye, Xiaoyin Zhang, Tong Han, Han Tags: Original Papers Source Type: research
Unravelling the Chemotaxonomic Identity of “White” and “Black” Oregano (Origanum vulgare) in Northern Greece
Planta Med DOI: 10.1055/a-1949-8895The two types of oregano used by the inhabitants of the villages of Μount Belles (GR1260001), the “white” oregano with white flowers and “black” oregano with purple flowers, were studied.
The two oregano types were collected from five localities along an altitudinal gradient from 217 m up to 1299 m. “White” oregano, was found in the three lowland regions (up to 752 m) where
the Pannonian-Balkanic turkey oak-sessile oak forest habitat (code 91M0) dominates. The “black” oregano was collected from the two higher altitudes, at 1177 m and 1299 m, where the
...
Source: Planta Medica - November 20, 2022 Category: Drugs & Pharmacology Authors: Mertzanidis, Dimitrios Nakas, Alexandros Assimopoulou, Andreana N. Kokkini, Stella Tags: Original Papers Source Type: research
