Raw and wine processed Schisandra chinensis regulate NREM-sleep and alleviate cardiovascular dysfunction associated with insomnia by modulating HPA Axis
This study may provide theoretical support for explicating the advantages of SC and other phytomedicines in the treatment of insomnia. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract (Source: Planta Medica)
Source: Planta Medica - December 15, 2021 Category: Drugs & Pharmacology Authors: Su, Dan Luo, Jian Ge, Junqi Liu, Yali Jin, Chen Xu, Pengfei Zhang, Ruowen Zhu, Genhua Yang, Ming Ai, Zhifu Song, Yonggui Tags: Original Papers Source Type: research
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Planta Medica 2021; 15 Article in Thieme eJournals: Table of contents | Congress (Source: Planta Medica)
Source: Planta Medica - December 13, 2021 Category: Drugs & Pharmacology Source Type: research
Phloridzin Highly Accumulated in Malus rockii Rehder and Its Structure Revision and Hypolipidemic Activity
Planta Med DOI: 10.1055/a-1716-0958Phloridzin is a lead compound of the prestigious antidiabetic gliflozins. The present study found that phloridzin highly accumulated in Malus rockii Rehder. The content of phloridzin in M. rockii was the highest among wild plants, with the percentage of 15.54% in the dry leaves. The structure of phloridzin was revised by proton exchange experiments and extensive 2D NMR spectra. Phloridzin exhibited significant hypolipidemic activity in golden Syrian hamsters maybe by increasing the expression of CYP7A1, at the doses of 50 mg/kg and 200 mg/kg. The total performance of anti-hyperlipide...
Source: Planta Medica - December 7, 2021 Category: Drugs & Pharmacology Authors: Lang, Li-Juan Wang, Min Lei, Chang Shen, Yi Zhu, Qi-Jie Diao, Hong-Mei Chen, Hao Shen, Lei Dong, Xiang Jiang, Bei Xiao, Chao-Jiang Tags: Original Papers Source Type: research
TCQA, A Natural Caffeoylquinic Acid Derivative Attenuates H2O2-Induced Neuronal Apoptosis by Suppressing Phosphorylation of MAPKs Signaling Pathway
Planta Med DOI: 10.1055/a-1683-63611,3,5-Tri-O-caffeoyl quinic acid is a caffeoylquinic acid derivative isolated from the roots of Arctium lappa L. Our previous studies have revealed that the ethyl acetate extract of the roots of A. lappa L. and the caffeoylquinic acids contained in it possess antioxidant properties, especially 1,3,5-tri-O-caffeoyl quinic acid. The present study aimed to investigate the protective effects of 1,3,5-tri-O-caffeoyl quinic acid against hydrogen peroxide-induced oxidative stress and explore the underlying mechanism. We found that 1,3,5-tri-O-caffeoyl quinic acid prevented the decline of cell ...
Source: Planta Medica - December 3, 2021 Category: Drugs & Pharmacology Authors: Yang, Yue Ding, Yufang Gao, Huan Jiang, Xiaowen Zhao, Qingchun Tags: Original Papers Source Type: research
In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract
This study investigated the effects of C. ruber extract against glycation on collagen-linked AGEs in vitro and streptozotocin-induced diabetic rats (STZ-DM rats) in vivo. The antiglycation activities of C. ruber extract and aminoguanidine (AG) were examined using a collagen glycation assay kit. Nonfluorescent AGE, Nε-carboxymethyl lysine (CML), Nω-carboxymethyl arginine, and Nε-carboxyethyl lysine levels were measured via electrospray ionization-liquid chromatography-tandem mass spectrometry. The effect of the extract on the cytotoxicity of methylglyoxal (MG), a precursor of AGEs, was examined in HL60
cells. STZ-DM...
Source: Planta Medica - December 3, 2021 Category: Drugs & Pharmacology Authors: Takenokuchi, Mariko Matsumoto, Kinuyo Nitta, Yuko Takasugi, Rumi Inoue, Yukari Iwai, Michi Kadoyama, Keiichi Yoshida, Kazutoshi Takano-Ohmuro, Hiromi Taniguchi, Taizo Tags: Original Papers Source Type: research
In Vitro Cytotoxic and Leishmanicidal Activity of Isolated and
Semisynthetic ent-Pimaranes from Aldama arenaria
Planta Med DOI: 10.1055/a-1708-2081Two pimaranes ent-pimara-8(14),15-dien-19-oic acid (1) and
ent-8(14),15-pimaradien-3β-ol (2), isolated from
Aldama arenaria, and six semi-synthetic derivatives methyl ester of
the ent-pimara-8(14),15-dien-19-oic acid (3),
ent-pimara-8(14),15-dien-19-ol (4), acetate of
ent-pimara-8(14),15-dien-19-ol (5),
ent-pimara-8(14),15-dien-19-ol succinic acid (6), acetate of
ent-8(14),15-pimaradien-3β-ol (7),
ent-8(14),15-pimaradien-3β-ol succinic acid (8) were
evaluated in vitro for their cytotoxic activities to childhood leukemia
cell lines a...
Source: Planta Medica - November 28, 2021 Category: Drugs & Pharmacology Authors: de Oliveira, Adriana da Silva Santos Conrado, Gabrielly Galdino Grazzia, Nathalia Miguel, Danilo Ciccone Franchi J únior, Gilberto Carlos Garcia, Vera L úcia Tags: Original Papers Source Type: research
In vitro cytotoxic and leishmanicidal activity of isolated and semisynthetic ent-pimaranes from Aldama arenaria
Planta Med DOI: 10.1055/a-1708-2081Two pimaranes ent-pimara -8(14),15-dien-19-oic acid (1) and ent-8(14),15-pimaradien-3β-ol (2), isolated from Aldama arenaria, and six semi-synthetic derivatives methyl ester of the ent-pimara-8(14),15-dien-19-oic acid (3), ent-pimara-8(14),15-dien-19-ol (4), acetate of ent-pimara-8(14),15-dien-19-ol (5), ent-pimara-8(14),15-dien-19-ol succinic acid (6), acetate of ent-8(14),15-pimaradien-3β-ol (7), ent-8(14),15-pimaradien-3β-ol succinic acid (8) were evaluated in vitro for their cytotoxic activities to childhood leukemia cell lines and leishmanicidal activity against the parasite Leish...
Source: Planta Medica - November 28, 2021 Category: Drugs & Pharmacology Authors: Oliveira, Adriana S. S. Conrado, Gabrielly Galdino Grazzia, Nathalia Miguel, Danilo Ciccone Franchi Junior, Gilberto Garcia, Vera Tags: Original Papers Source Type: research
Beyond the Psychoactive Effects of Ayahuasca: Cultural and Pharmacological Relevance of Its Emetic and Purging Properties
Planta Med DOI: 10.1055/a-1675-3840The herbal preparation ayahuasca has been an important part of ritual and healing practices, deployed to access invisible worlds in several indigenous groups in the Amazon basin and among mestizo populations of South America. The preparation is usually known to be composed of two main plants, Banisteriopsis caapi and Psychotria viridis, which produce both hallucinogenic and potent purging and emetic effects; currently, these are considered its major pharmacological activities. In recent decades, the psychoactive and visionary effect of ayahuasca has been highly sought after by the shamani...
Source: Planta Medica - November 18, 2021 Category: Drugs & Pharmacology Authors: Politi, Matteo Tresca, Giorgia Menghini, Luigi Ferrante, Claudio Tags: Reviews Source Type: research
Cyanogenesis in Aralia spinosa (Araliaceae)
Planta Med DOI: 10.1055/a-1671-5525A systematic survey of Aralia spinosa (Araliaceae), covering an entire growing season and including aboveground organs at various developmental stages, revealed that only about half of all samples collected showed cyanogenesis. Cyanogenesis was detected in inflorescences and leaves but is apparently restricted to certain harvest times or developmental stages. The structurally unusual triglochinin, characterized by a hex-2-enedioic acid partial structure, was the only cyanogenic glycoside detected. This is the first description of triglochinin in this species and in the family of Araliacea...
Source: Planta Medica - November 16, 2021 Category: Drugs & Pharmacology Authors: Lechtenberg, Matthias Sendker, Jandirk Kastner, Lisa Hensel, Andreas Tags: Original Papers Source Type: research
cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice
In conclusion, cis-aconitic acid has significant anti-inflammatory effects in antigen-induced arthritis and monosodium urate-induced arthritis in mice, suggesting its potential for the treatment of inflammatory diseases of the joint in humans. Additionally, our findings suggest that this compound may contribute to the anti-inflammatory effect previously reported for E. grandiflorus extracts. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - November 11, 2021 Category: Drugs & Pharmacology Authors: de Oliveira, Diego Pinto Garcia, Eliana de Faria de Oliveira, Mariana Ass íria Candido, Luiza C. M. Coelho, Fernanda M. Costa, Vivian Vasconcelos Batista, Nath ália Vieira Queiroz-Junior, Celso Martins Brito, Larissa Froede Sousa, Lirl ândia Pires Souz Tags: Original Papers Source Type: research
Travelogues from the Rainforest: Notes on Prof. Otto Sticher ʼs 85th birthday
Planta Med 2021; 87: 1123-1127 DOI: 10.1055/a-1508-0613 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Planta Medica)
Source: Planta Medica - November 11, 2021 Category: Drugs & Pharmacology Authors: Gertsch, J ürg Tags: Editorial Source Type: research
A (Far Too Short) Homage to Prof. Otto Sticher in Honor of His 85th Birthday
Planta Med 2021; 87: 1120-1121 DOI: 10.1055/a-1485-0187 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Planta Medica)
Source: Planta Medica - November 11, 2021 Category: Drugs & Pharmacology Authors: Heilmann, J örg Tags: Editorial Source Type: research
The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides
Planta Med DOI: 10.1055/a-1582-9794Pyrrolizidine alkaloids (PAs) are a large group of plant constituents of which especially the 1,2- unsaturated PAs raise a concern because of their liver toxicity and potential genotoxic carcinogenicity. This toxicity of PAs depends on their kinetics. Differences in absorption, distribution, metabolism, and excretion (ADME) characteristics of PAs may substantially alter the relative toxicity of PAs. As a result, kinetics will also affect relative potency (REP) values. The present review summarizes the current state-of-the art on PA kinetics and resulting consequences for toxicity and illu...
Source: Planta Medica - November 5, 2021 Category: Drugs & Pharmacology Authors: Widjaja, Frances Alhejji, Yasser Rietjens, Ivonne M. C. M. Tags: Reviews Source Type: research
Rosmarinic Acid Suppresses Abdominal Aortic Aneurysm Progression in Apolipoprotein E-deficient Mice
Planta Med DOI: 10.1055/a-1659-3908An abdominal aortic aneurysm is a life-threatening cardiovascular disorder caused by dissection and rupture. No effective medicine is currently available for the > 90% of patients whose aneurysms are below the surgical threshold. The present study investigated the impact of rosmarinic acid, salvianolic acid C, or salvianolic acid B on experimental abdominal aortic aneurysms. Abdominal aortic aneurysms were induced in apolipoprotein E-deficient mice via infusion of angiotensin II for 4 wks. Rosmarinic acid, salvianolic acid C, salvianolic acid B, or doxycycline as a positive control...
Source: Planta Medica - November 5, 2021 Category: Drugs & Pharmacology Authors: Bian, Huimiao Wang, Yang Wu, Peng Han, Na Wang, Linlin Li, Xue Zhang, XianJing Cho, Kenka Zhang, Yongyu Yin, Jun Jiang, Baohong Tags: Original Papers Source Type: research
Novel Insights into Pyrrolizidine Alkaloid Toxicity and Implications for Risk Assessment: Occurrence, Genotoxicity, Toxicokinetics, Risk Assessment –A Workshop Report
Planta Med DOI: 10.1055/a-1646-3618This paper reports on the major contributions and results of the 2nd International Workshop of Pyrrolizidine Alkaloids held in September 2020 in Kaiserslautern, Germany. Pyrrolizidine alkaloids are among the most relevant plant toxins contaminating food, feed, and medicinal products of plant origin. Hundreds of PA congeners with widespread occurrence are known, and thousands of plants are assumed to contain PAs. Due to certain PAsʼ pronounced liver toxicity and carcinogenicity, their occurrence in food, feed, and phytomedicines has raised serious human health concerns. This is particular...
Source: Planta Medica - October 29, 2021 Category: Drugs & Pharmacology Authors: Schrenk, Dieter Fahrer, J örg Allemang, Ashley Fu, Peter Lin, Ge Mahony, Catherine Mulder, Patrick P.J. Peijnenburg, Ad Pfuhler, Stefan Rietjens, Ivonne M.C.M. Sachse, Benjamin Steinhoff, Barbara These, Anja Troutman, John Wiesner, Jacqueline Tags: Reviews Source Type: research
