Bioassay-Guided Isolation and Identification of Antiplasmodial Compounds from the Stem Bark of Clausena excavata
Planta Med DOI: 10.1055/a-2112-6631
Clausena excavata is a medicinal plant widely distributed in Southeast Asia. It is used for a variety of indications, including to treat malaria. In our present study, a
phytochemical study of the methanol extract from the stem bark of C. excavata led to the isolation of five pyranocoumarins, nordentatin (1), dentatin (2), kinocoumarin
(3), clausarin (4), and clausenidin (5), and a coumarin, 8-hydroxy-3″,4″-dihydrocapnolactone-2′,3′-diol (6). The isolation of compound 6 from C.
excavata and the antiplasmodial activities against a multidrug-resistant K1 strain ...
Source: Planta Medica - July 6, 2023 Category: Drugs & Pharmacology Authors: Seephonkai, Prapairat Kaewtong, Chatthai Wangchuk, Phurpa Jearawuttanakul, Kedchin Kanjanasirirat, Phongthon Borwornpinyo, Suparerk Khulmanee, Tachin Patrapuvich, Rapatbhorn Tags: Original Papers Source Type: research
Editorial for the Special Issue Dedicated to Prof. Gerhard Franz
Planta Med 2023; 89: 776-777 DOI: 10.1055/a-2086-1569 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - July 5, 2023 Category: Drugs & Pharmacology Authors: Alban, Susanne F ürst, Robert Tags: Editorial Source Type: research
Molecular Descriptors and QSAR Models for Sedative Activity of Sesquiterpenes Administered to Mice via Inhalation
Planta Med DOI: 10.1055/a-1770-7581Essential oils are often utilized for therapeutic purposes and are composed of complex structural molecules, including sesquiterpenes, with high molecular weight and potential for
stereochemistry. A detailed study on the properties of selected sesquiterpenes was conducted as part of a broader investigation on the effects of sesquiterpenes on the central nervous
system. A set of 18 sesquiterpenes, rigorously selected from an original list of 114, was divided into 2 groups i.e., the training and test sets, with each containing 9 compounds. The
training set was evaluated for t...
Source: Planta Medica - July 3, 2023 Category: Drugs & Pharmacology Authors: Dougnon, Godfried Ito, Michiho Tags: Original Papers Source Type: research
Influence of Garlic on the Glycemic Control and Lipid Profile in Animals with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Planta Med DOI: 10.1055/a-2112-6204Nonalcoholic fatty liver disease is the hepatic sign of metabolic syndrome. Here, we aimed to assess the effects of garlic and its major components on fasting plasma glucose, fasting
insulin, and lipid profile levels in animal models of nonalcoholic fatty liver disease. A systematic search in PubMed, Scopus, ProQuest, and Web of Science was performed. After the screening
process and data extraction, the pooled effect sizes were estimated using a random-effect model and stated as standardized mean differences and a 95% confidence interval. Out of 839 reports,
22 articles wer...
Source: Planta Medica - June 29, 2023 Category: Drugs & Pharmacology Authors: Shojaei-Zarghani, Sara Najafi, Nastaran Fattahi, Mohammad Reza Safarpour, Ali Reza Tags: Reviews Source Type: research
Polyphenols for Preventing Dental Erosion in Pre-clinical Studies with in situ Designs and Simulated Acid Attack
This study describes a comprehensive review to interpret the effects of polyphenols on dental
erosion of pre-clinical models with in situ designs and simulated acid attacks on enamel and dentin samples. We aim to evaluate evidence about Polyphenolsʼ effects in the type of
dental substrate, parameters of erosive cycling chosen in the in situ models, and the possible mechanisms involved. An evidence-based literature review was conducted using appropriate
search strategies developed for main electronic databases (PubMed, Scopus, Web of Science, LILACS, EMBASE, LIVIVO, CINAHL, and DOSS) and gray literature (Goo...
Source: Planta Medica - June 29, 2023 Category: Drugs & Pharmacology Authors: Leal, Isabelly de Carvalho Rabelo, Cibele Sales de Melo, Mary Anne Sampaio Silva, Paulo Goberl ânio de Barros Costa, F ábio Wildson Gurgel Passos, Vanara Flor êncio Tags: Reviews Source Type: research
Sustaining Traditional Ethnomedicinal Knowledge and Protected Areas in Synergy: A Case Study of Overa-Aru Wildlife Sanctuary in Kashmir Himalaya
In this study, we aimed to document the ethnomedicinal plants of the Overa-Aru wildlife
sanctuary in Kashmir Himalaya. We conducted a systematic field survey in the study area during 2020 – 2021 to collect primary data from 110 participants through semi-structured interviews
and questionnaires. The data was analyzed using quantitative indices and Pearsonʼs correlation. We recorded 64 plant species used against 8 human disease categories, including some
first-time reports from the region. Asteraceae and Lamiaceae were the most dominant families and herbs were the dominant growth form. The most common p...
Source: Planta Medica - June 28, 2023 Category: Drugs & Pharmacology Authors: Islam, Tajamul Nawchoo, Irshad A. Magray, Junaid A. Khuroo, Anzar Ahmad Tags: Original Papers Source Type: research
Paecilins Q and R: Antifungal Chromanones Produced by the Endophytic Fungus Pseudofusicoccum stromaticum CMRP4328
Planta Med DOI: 10.1055/a-2063-5481Chemical investigation of the endophyte Pseudofusicoccum stromaticum CMRP4328 isolated from the medicinal plant Stryphnodendron adstringens yielded ten compounds, including
two new dihydrochromones, paecilins Q (1) and R (2). The antifungal activity of the isolated metabolites was assessed against an important citrus pathogen, Phyllosticta
citricarpa. Cytochalasin H (6) (78.3%), phomoxanthone A (3) (70.2%), phomoxanthone B (4) (63.1%), and paecilin Q (1) (50.5%) decreased in vitro the
number of pycnidia produced by P. citricarpa, which are responsible for the disease dissem...
Source: Planta Medica - June 28, 2023 Category: Drugs & Pharmacology Authors: Iantas, Juc élia Savi, Daiani Cristina Ponomareva, Larissa V. Thorson, Jon S. Rohr, J ürgen Glienke, Chirlei Shaaban, Khaled A. Tags: Original Papers Source Type: research
Filamentous Fungi-Derived Orsellinic Acid-Sesquiterpene Meroterpenoids: Fungal Sources, Chemical Structures, Bioactivities, and Biosynthesis
Planta Med DOI: 10.1055/a-2099-4932Fungi-derived polyketide-terpenoid hybrids are important meroterpenoid natural products that possess diverse structure scaffolds with a broad spectrum of bioactivities. Herein, we focus on
an ever-increasing group of meroterpenoids, orsellinic acid-sesquiterpene hybrids comprised of biosynthetic start unit orsellinic acid coupling to a farnesyl group or/and its modified cyclic
products. The review entails the search of China National Knowledge Infrastructure (CNKI), Web of Science, Science Direct, Google Scholar, and PubMed databases up to June 2022. The key terms
include â...
Source: Planta Medica - June 23, 2023 Category: Drugs & Pharmacology Authors: Gao, Hua Zhou, Luning Zhang, Peng Wang, Ying Qian, Xuan Liu, Yujia Wu, Guangwei Tags: Reviews Source Type: research
Lyonensinols A  – C, 24-Norursane-Type Triterpenoids from the Twigs and Leaves of Lyonia doyonensis and Their Potential Anti-inflammatory and PTP1B Inhibitory
Activities
Planta Med DOI: 10.1055/a-2090-0733
Lyonia doyonensis is a deciduous shrub native to high-altitude regions of Asia. So far, there is no report on any chemical and biological properties of L. doyonensis. An EtOH
extract of L. doyonensis twigs and leaves showed inhibitory activities on protein tyrosine phosphatase 1B and lipopolysaccharide-induced inflammation in BV-2 microglial cells. A
phytochemical investigation of this extract led to the isolation of a, so far only ambiguously described, 24-norursane-type triterpenoid, now named lyonensinol A (1), along with its
two new derivatives, lyonensinols B a...
Source: Planta Medica - June 21, 2023 Category: Drugs & Pharmacology Authors: Zhang, Ming-Zhu Jiang, Meng-Yuan Kong, Ling-Ping Liu, Cai-Ying Kang, Huai-Xin Liu, Ai-Hong Wang, Bin Mao, Shui-Chun Tags: Original Papers Source Type: research
Hop-derived Humulinones Reveal Protective Effects in in vitro Models of Hepatic Steatosis, Inflammation and Fibrosis
In conclusion, humulinones beneficially affect different pathophysiological
steps of NAFLD. Our data suggest humulinones as promising therapeutic agents for the prevention and treatment of NAFLD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - June 21, 2023 Category: Drugs & Pharmacology Authors: Mahli, Abdo Thasler, Wolfgang E. Biendl, Martin Hellerbrand, Claus Tags: Original Papers Source Type: research
Anti-viral and Anti-inflammatory Isoflavonoids from Ukrainian Iris aphylla Rhizomes: Structure-Activity Relationship Coupled with ChemGPS-NP Analysis
Planta Med DOI: 10.1055/a-2063-5265Dried Iris rhizomes have been used in Chinese and European traditional medicine for the treatment of various diseases such as bacterial infections, cancer, and inflammation, as well
as for being astringent, laxative, and diuretic agents. Eighteen phenolic compounds including some rare secondary metabolites, such as irisolidone, kikkalidone, irigenin, irisolone,
germanaism B, kaempferol, and xanthone mangiferin, were isolated for the first time from Iris aphylla rhizomes. The hydroethanolic Iris aphylla extract and some of its isolated
constituents showed protective effects ...
Source: Planta Medica - June 5, 2023 Category: Drugs & Pharmacology Authors: Mykhailenko, Olha Hsieh, Chung-Fan El-Shazly, Mohamed Nikishin, Alexander Kovalyov, Vladimir Shynkarenko, Pavlo Ivanauskas, Liudas Chen, Bing-Hung Horng, Jim-Tong Hwang, Tsong-Long Georgiyants, Victoriya Korinek, Michal Tags: Original Papers Source Type: research
Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F
In conclusion, our data
suggest that caseargrewiin F and casearin B present low oral bioavailability due to extensive gastric degradation and high hepatic extraction. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - May 26, 2023 Category: Drugs & Pharmacology Authors: Oda, Fernando Bombarda Carvalho, Fl ávio Alexandre Yamamoto, Priscila Akemi de Oliveira, Jonata Augusto Peccinini, Ros ângela Gonçalves Zocolo, Guilherme Juli ão Ribeiro, Paulo Riceli Vasconcelos de Moraes, Nat ália Valadares dos Santos, Andr é Gonz Tags: Original Papers Source Type: research
Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine
In this study, we investigated the inhibitory effect of Shuganning injection and its four main ingredients (baicalin, geniposide,
chlorogenic acid, and oroxylin A) on 9 drug transporters. Shuganning injection strongly inhibited organic anion transporter 1 and organic anion transporter 3 with IC50 values
< 0.1% (v/v), and moderately inhibited organic anion transporter 2, organic anion transporting-polypeptide 1B1, and organic anion transporting-polypeptide 1B3 with IC50 values
< 1.0%. Baicalin, the most abundant bioactive ingredient in the Shuganning injection, was identified as both an inhibitor an...
Source: Planta Medica - May 26, 2023 Category: Drugs & Pharmacology Authors: Bi, Yajuan Xing, Yanchao Gui, Chunshan Tian, Yiqing Zhang, Mingzhe Yao, Yao Hu, Ge Han, Lifeng He, Feng Zhang, Youcai Tags: Original Papers Source Type: research
Metabolic Fingerprinting of Different Sideritis Taxa Infusions and Their Neurogenic Activity
This study is the first report on the neurogenic potential of Sideritis taxa and might support the use of Sideritis herbal
preparations in the context of neurodegenerative diseases. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - May 23, 2023 Category: Drugs & Pharmacology Authors: Tomou, Ekaterina-Michaela Bieler, Lara Sp öttl, Tobias Couillard-Despres, Sebastien Skaltsa, Helen Urmann, Corinna Tags: Original Papers Source Type: research
Molecular Farming Strategy for the Rapid Production of Protein-Based Reagents for Use in Infectious Disease Diagnostics
Planta Med DOI: 10.1055/a-2076-2034Recombinant proteins are a major breakthrough in biomedical research with a wide range of applications from diagnostics to therapeutics. Strategic construct design, consistent expression
platforms, and suitable upstream and downstream techniques are key considerations to produce commercially viable recombinant proteins. The recombinant antigenic protein production for use
either as a diagnostic reagent or subunit vaccine formulation is usually carried out in prokaryotic or eukaryotic expression platforms. Microbial and mammalian systems dominate the
biopharmaceutical indust...
Source: Planta Medica - May 15, 2023 Category: Drugs & Pharmacology Authors: Shanmugaraj, Balamurugan Jirarojwattana, Perawat Phoolcharoen, Waranyoo Tags: Reviews Source Type: research
