New Phenolic Glycosides and Lignans from the Roots of Lilium dauricum
Planta Med DOI: 10.1055/a-1527-9602Three new phenolic glycosides, carvacrol-2-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (1), 1-methyl-3-isopropylphenol-4-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (2), p-methoxythymol-5-O-β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranoside (3), and a pair of new 8-O-4′ neolignan enantiomers (5a/5b), together with 26 known compounds (4, 6 – 30) were isolated from the roots of Lilium dauricum. The structures of the new compounds were elucidated based on extensive spectroscopic and chemical methods, and the absolute configurations of 5a and 5b were establi...
Source: Planta Medica - July 6, 2021 Category: Drugs & Pharmacology Authors: Xia, Xiao Zhang, Jiao Wang, Xiao-Jiang Lu, Yan Chen, Dao-Feng Tags: Original Papers Source Type: research
The Reassessed Impact of Nicotine against Neurotoxicity in Mesencephalic Dopaminergic Cell Cultures and Neuroblastoma N18TG2 Cells
Planta Med DOI: 10.1055/a-1527-1390Neuroprotective effects of nicotine are still under debate, so further studies on its effectiveness against Parkinsonʼs disease are required. In our present study, we used primary dopaminergic cell cultures and N18TG2 neuroblastoma cells to investigate the effect of nicotine and its neuroprotective potential against rotenone toxicity. Nicotine protected dopaminergic (tyrosine hydroxylase immunoreactive) neurons against rotenone. This effect was not nAChR receptor-dependent. Moreover, the alkaloid at a concentration of 5 µM caused an increase in neurite length, and at a concentration o...
Source: Planta Medica - July 6, 2021 Category: Drugs & Pharmacology Authors: Delijewski, Marcin Radad, Khaled Krewenka, Christopher Kranner, Barbara Moldzio, Rudolf Tags: Original Papers Source Type: research
Malaria in Guinean Rural Areas: Prevalence, Management, and Ethnotherapeutic Investigations in Dionfo, Sub-Prefecture of Labe
Planta Med DOI: 10.1055/a-1519-5847As part of a validation program of antimalarial traditional recipes, an ethnotherapeutic approach was applied in Dionfo, a meso-endemic Guinean rural area where conventional health facilities are insufficient. A prevalence investigation indicated a malarial burden of 4.26%. Ethnomedical and ethnobotanical surveys led to a collection of 63 plant species used against malaria from which Terminalia albida (Combretaceae) was one of the most cited. Ethnotherapeutic evaluation of a remedy based on T. albida was applied to 9 voluntary patients suffering from uncomplicated malaria. Treatment of 7 ...
Source: Planta Medica - July 6, 2021 Category: Drugs & Pharmacology Authors: Bald é, Aliou Mamadou Balde, Alpha Oumar Bah, Bilo Barry, Halimatou Traore, Saidou Bah, Fatoumata Balde, Mamadou Aliou Camara, Aissata Traore, Mohamed Sahar Balde, Elhadj Saidou Sylla, Ibrahima Kalil Diallo, Sadou Tags: Original Papers Source Type: research
Functional and Mechanistic Studies of Two Anti-coccidial Herbs, Bidens pilosa and Artemisia indica
In this study, we investigated the anti-coccidial function and mechanism of phytogenic formulations composed of Bidens pilosa, Artemisia indica, and both used in combination. We found that these formulations increased the survival rate and reduced body weight loss, the feed conversion ratio, oocyst excretion, bloody stools, and gut lesions of chickens. Mechanistic studies showed that A. indica, but not B. pilosa, reduced the survival of Eimeria oocysts. Accordingly, they both inhibited oocyst sporulation and sporozoite invasion into Madin-Darby bovine kidney (MDBK) cells. Overall, we demonstrate that these formulations pr...
Source: Planta Medica - June 29, 2021 Category: Drugs & Pharmacology Authors: Yang, Meng-Ting Lin, Yi-Xian Yang, Greta Kuo, Tien-Fen Liang, Yu-Chen Lee, Tsung-Han Chang, Cicero Lee-Tian Yang, Wen-Chin Tags: Original Papers Source Type: research
Regulatory Perspectives of Pyrrolizidine Alkaloid Contamination in Herbal Medicinal Products
Planta Med DOI: 10.1055/a-1494-1363The toxicity of plants containing certain pyrrolizidine alkaloids has long been recognized in grazing animals and humans. Genotoxicity and carcinogenicity data from in vitro and in vivo (animal) studies were published over the last few decades for some of the 1,2-unsaturated pyrrolizidine alkaloids, leading to regulatory action on herbal medicinal products with pyrrolizidine alkaloid-containing plants more than 30 years ago. In recent years, it has become evident that in addition to herbal medicinal products containing pyrrolizidine alkaloid-containing plants, these products may also cont...
Source: Planta Medica - June 24, 2021 Category: Drugs & Pharmacology Authors: Wiesner, Jacqueline Tags: Reviews Source Type: research
