Evaluation of a Zingiber officinale and Bixa orellana
Supplement on the Gut Microbiota of Male Athletes: A Randomized
Placebo-Controlled Trial
Planta Med DOI: 10.1055/a-1671-5766The gut microbiota has emerged as a factor that influences exercise performance
and recovery. The present study aimed to test the effect of a polyherbal
supplement containing ginger and annatto called “ReWin(d)” on the gut microbiota
of recreational athletes in a pilot, randomized, triple-blind,
placebo-controlled trial. Thirty-four participants who practice physical
activity at least three times weekly were randomly allocated to two groups, a
ReWin(d) group or a maltodextrin (placebo) group. We evaluated the gut
microbiota, the production of short-c...
Source: Planta Medica - February 28, 2022 Category: Drugs & Pharmacology Authors: Dom ínguez-Balmaseda, Diego Bressa, Carlo Fern ández-Romero, Arantxa de Lucas, Beatriz P érez-Ruiz, Margarita San Juan, Alejandro F. Roller, Marc Issaly, Nicolas Larrosa, Mar Tags: Original Papers Source Type: research
(+)-Magnolin Enhances Melanogenesis in Melanoma Cells and Three-Dimensional Human Skin Equivalent; Involvement of PKA and p38 MAPK Signaling Pathways
Planta Med DOI: 10.1055/a-1740-7325Magnoliae Flos is a traditional herbal medicine used to treat nasal congestion associated with headache, empyema, and allergic rhinitis. In our preliminary screening of crude drugs used in
Japanese Kampo formulas for melanin synthesis, the methanol extract of Magnoliae Flos was found to exhibit strong melanin synthesis activity. However, there have been no studies evaluating
the effects of Magnoliae Flos or its constituents on melanogenesis. The present study aimed to isolate the active compounds from Magnoliae Flos that activate melanin synthesis in melanoma
cells and thre...
Source: Planta Medica - February 24, 2022 Category: Drugs & Pharmacology Authors: Uto, Takuhiro Tung, Nguyen Huu Ohta, Tomoe Shoyama, Yukihiro Tags: Original Papers Source Type: research
Screening of Antimicrobial Activity of Essential Oils against Bovine Respiratory Pathogens – Focusing on Pasteurella multocida
In conclusion, cinnamon cassia and lemongrass as well as
coriander, winter savory, and thyme oil are promising candidates for treatment of P. multocida-associated bovine respiratory infections. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - February 18, 2022 Category: Drugs & Pharmacology Authors: Bismarck, Doris Becker, Jens M üller, Elisabeth Becher, Vera Nau, Lisa Mayer, Philipp Tags: Original Papers Source Type: research
Targeted isolation of two new anti-inflammatory and UV-A protective dipyrroloquinones from the sponge-associated fungus Aspergillus tamarii MCCF102
Planta Med DOI: 10.1055/a-1769-8480In following up on observed in vitro anti-inflammatory activity of the organic extract of the marine sponge-derived fungus Aspergillus tamarii MCCF102, two new dipyrrolobenzoquinones, terreusinone B and C (1 and 2), were discovered along with the known analogue, terreusinone (3). The structures of 1–3 were determined by spectroscopic and spectrometric analyses, along with chemical inter-conversion. In vitro testing on lipopolysaccharide (LPS) stimulated RAW 264.7 murine macrophage cells revealed that 1–3 exhibit anti-inflammatory activity by inhibiting nitric oxide production in a dos...
Source: Planta Medica - February 11, 2022 Category: Drugs & Pharmacology Authors: Niveditha, Lekshmi Fu, Peng Leao, Tiago F. Li, Te Wang, Tingting Poulin, Remington X. Gaspar, Lorena Rigo Naman, C. Benjamin Thavarool Puthiyedathu, Sajeevan Tags: Original Papers Source Type: research
Variation of Secondary Metabolite Contents and Activities against
Bovine Diarrheal Pathogens among Zygophyllaceae Species in Benin and
Implications for Conservation
This study was based on optimal defense theory, which
distinguished 2 categories of plants: K-strategist species and r-strategist
species. Phytochemical screening was carried out based on aqueous extracts of
the leafy stems of B. aegyptiaca and Guaiacum officinale
(K-strategist species) and Tribulus terrestris and Kallstroemia
pubescens (r-strategist species) for the identification of chemical
compounds. The phenolic compounds were quantified by quercetin and vanillin
methods. The extracts were tested against 5 bacterial strains responsible for
severe diarrhea in bovines. Our result...
Source: Planta Medica - February 10, 2022 Category: Drugs & Pharmacology Authors: Ouachinou, J éronime Marie-Ange Sènami Dassou, Gb èwonmèdéa Hospice Agbankp é, Alidehou Jerrold Koudoro, Yaya Alain Agbangnan, Pascal Hidalgo Triana, Noelia Favi, Gnimansou Abraham Djidohokpin, Donald Adomou, Aristide Cossi Tags: Original Papers Source Type: research
NCCIH Priorities for Natural Products Research
Planta Med DOI: 10.1055/a-1767-2226The National Center for Complementary and Integrative Health (NCCIH) is the lead agency within the U. S. federal government for complementary and integrative health research, which includes
natural products. Although NCCIH is one of the smaller components of the National Institutes of Health (NIH), NCCIH funds a disproportionately high percentage of natural products research at
NIH. This stems from NCCIH being the only NIH grant issuing component that includes natural products as an explicit part of its mission. This perspective provides an overview of the NCCIH
mission a...
Source: Planta Medica - February 9, 2022 Category: Drugs & Pharmacology Authors: Still, Patrick Chen, Wen Weber, Wendy Hopp, D. Craig Tags: Reviews Source Type: research
NCCIH Priorities for Natural Products Research*
*Dedicated to Professor Dr. Douglas Kinghorn on the occasion of his 75th birthday
Planta Med DOI: 10.1055/a-1767-2226The National Center for Complementary and Integrative Health is the lead agency within the U.S. Federal Government for complementary and integrative health, which includes natural products. Although NCCIH is one of the smaller components of the NIH, NCCIH funds a disproportionately high percentage of natural products research at NIH. This stems from the fact that NCCIH is the only NIH grant issuing component for which natural products are an explicit part of our mission. This perspective will provide an overview of the NCCIH mission and summarize NCCIH funding priorities for natural produ...
Source: Planta Medica - February 9, 2022 Category: Drugs & Pharmacology Authors: Still, Patrick Chen, Wen Weber, Wendy Hopp, Craig Tags: Reviews Source Type: research
Quantitative Proteomics Based on iTRAQ Reveal that Nitidine Chloride
Induces Apoptosis by Activating JNK/c-Jun Signaling in Hepatocellular Carcinoma
Cells
Planta Med DOI: 10.1055/a-1676-4307The aim of the present study was to investigate the cytotoxic effects and
underlying molecular mechanisms of nitidine chloride (NC) in hepatocellular
carcinoma cells via quantitative proteomics. MTT assays were used to detect the
inhibitory effects of NC in Bel-7402 liver cancer cells, and the number of
apoptotic cells was measured by flow cytometry. Quantitative proteomics
technology based on iTRAQ was used to discover differential expressed proteins
after NC treatment, and bioinformatic techniques were further used to screen
potential targets of NC. Mo...
Source: Planta Medica - February 1, 2022 Category: Drugs & Pharmacology Authors: Chen, Shipeng Liao, Yinan Lv, Jinyan Hou, Huaxin Feng, Jie Tags: Original Papers Source Type: research
Editorial
Planta Med 2022; 88: 97-97 DOI: 10.1055/a-1660-1370 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Planta Medica)
Source: Planta Medica - February 1, 2022 Category: Drugs & Pharmacology Tags: Editorial Source Type: research
Antiproliferative and microtubule-stabilizing activities of two iboga-vobasine bisindoles alkaloids from Tabernaemontana corymbosa in colorectal adenocarcinoma HT-29 cells
Planta Med DOI: 10.1055/a-1755-5605Two iboga-vobasine bisindoles, 16'-decarbomethoxyvoacamine (1) and its 19,20-dihydro derivative, 16'-decarbomethoxydihydrovoacamine (2) from Tabernaemontana corymbosa exhibited potent cytotoxicity against the human colorectal adenocarcinoma HT-29 cells in our previous studies. Bisindoles 1 and 2 selectively inhibited the growth of HT-29 cells without significant cytotoxicity to normal human colon fibroblasts CCD-18Co. Treatment with bisindoles 1 and 2 suppressed the formation of HT-29 colonies via G0/G1 cell cycle arrest and induction of mitochondrial apoptosis. Owing to its higher antipr...
Source: Planta Medica - January 31, 2022 Category: Drugs & Pharmacology Authors: Tan, Chun Hoe Sim, Dawn Su Yin Lim, Siew Huah Mohd Mohidin, Taznim Begam Mohan, Gokula Low, Yun-Yee Kam, Toh-Seok Sim, Kae Shin Tags: Original Papers Source Type: research
TRAIL-sensitizing Cytochalasins from the Endophytic Fungus Phoma multirostrata
Planta Med DOI: 10.1055/a-1755-5411Seven undescribed cytochalasins, multirostratins K–Q (2–8), together with one known analogue, cytochalasin Z3 (1), were isolated from the culture of Phoma multirostrata XJ-2-1, an endophytic fungus obtained from the root of Parasenecio albus. Their structures with absolute configurations were determined by 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), electronic circular dichroism (ECD), single-crystal X-ray crystallography, and chemical methods. The structure of ascochalasin was revised from Δ13 to Δ21 by detailed analysis of the NMR data and b...
Source: Planta Medica - January 31, 2022 Category: Drugs & Pharmacology Authors: Ruan, Hanli Peng, Xiaogang Ouyang, Qianxi Pei, Jiao Chang, Jinling Qin, Chunlun Tags: Original Papers Source Type: research
Correction: VC8 Gaseous methyl jasmonate can increase hypericins content in Hypericum perforatum aseptic plants
Planta Med 2021; 87: e1-e1 DOI: 10.1055/s-0042-1743041 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Planta Medica)
Source: Planta Medica - January 31, 2022 Category: Drugs & Pharmacology Authors: Lystvan, K Belokurova, V Salivon, A Kuchuk, M Tags: Erratum Source Type: research
Potential anti-allergic effects of bibenzyl derivatives from liverworts, Radula perrottetii
In conclusion, perD and Ac-perD suppressed the phosphorylation of signal transduction molecules downstream of the FcεRI and consequently inhibited degranulation, and/or IL-4 production. These may be beneficial potential lead compounds for the development of novel anti-allergic and anti-inflammatory drugs. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract (Source: Planta Medica)
Source: Planta Medica - January 26, 2022 Category: Drugs & Pharmacology Authors: Asai, Haruka Kato, Kohichi Suzuki, Moe Takahashi, Misato Miyata, Erika Aoi, Moeka Kumazawa, Reika Nagashima, Fumihiro Kurosaki, Hiromasa Aoyagi, Yutaka Fukuishi, Nobuyuki Tags: Original Papers Source Type: research
Systematic identification of the main constituents from Agrimonia pilosa Ledeb. and their metabolites in rats using HPLC-Q-TOF-MS/MS
In this study, the phytochemical profile of A. pilosa was investigated using HPLC-Q-TOF-MS/MS combined with a nontargeted diagnostic ion network analysis strategy. An information-dependent acquisition method with multiple filters was utilized to screen possible prototypes and metabolites in complex biological matrices. Furthermore, various data-processing techniques were applied to analyze possible prototypes and their metabolites in rat plasma, feces, and urine following oral administration of A. pilosa extract. A total of 62 compounds, which belonged to five main structural classes (21 phenols, 22 flavonoids, 6 coumarins...
Source: Planta Medica - January 21, 2022 Category: Drugs & Pharmacology Authors: Song, Mengmeng Xu, Zhuicheng Han, Sixuan Sheng, Xianjie Chen, Yan Li, Xinru Su, Yan Li, Qin Shan, Chenxiao Xie, Tong Kang, An Tags: Original Papers Source Type: research
New Isoquinoline Alkaloids from Paraphaeosphaeria sporulosa F03, a Fungal Endophyte Isolated from Paepalanthus planifolius
Planta Med DOI: 10.1055/a-1706-4642As part of our continuing efforts to discover new bioactive compounds from endophytic fungal sources, we have investigated the extract of the Paraphaeosphaeria sporulosa F03 strain. The study led to the isolation of four new 3-methyl-isoquinoline alkaloids (1 – 4) and four known polyketides (5 – 8). The structures of compounds 1 – 4 were elucidated by 1D and 2D NMR experiments and HRMS analysis. The absolute configuration of 4 was determined by comparison of its experimental electronic circular dichroism spectrum with calculated data. Compounds 1 – 4 exhibited ant...
Source: Planta Medica - January 19, 2022 Category: Drugs & Pharmacology Authors: de Amorim, Marcelo R. Paz, Tiago A. Pinto, Luciano da S. Hil ário, Felipe Zanini, Camila L. Aguiar, Anna Caroline C. Silva, D ébora E. S. Furlan, Maysa Guido, Rafael V. C. Bauab, Ta ís M. Netto, Adelino V. de G. dos Santos, Lourdes C. Tags: Original Papers Source Type: research
