Polyphenols, Antioxidants, and Wound Healing of Lecythis pisonis Seed Coats
Planta Med DOI: 10.1055/a-2212-0262To better use the Lecythis pisonis Cambess. biomass, this study investigates whether Sapucaia seed coats present wound healing properties. We analyzed the antibacterial, antioxidant, and wound healing-promoting potentials, plus cytotoxicity and stimulation of vascular endothelial growth factor-A. The chemical composition was analyzed by positive ion mode electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. A total of 19 compounds were identified, such as proanthocyanidin A1, procyanidins A1, B2, and C1, epigallocatechin, and kaempferol (p-cou...
Source: Planta Medica - January 10, 2024 Category: Drugs & Pharmacology Authors: Pimentel, Elis ângela Flávia de Oliveira, Bruno Gomes Pereira, Ana Claudia Hertel Figueira, Mariana Moreira Portes, Danielle Braga Scherer, Rodrigo Ruas, Fabiana Gomes Rom ão, Wanderson Fronza, M árcio Endringer, Denise Coutinho Tags: Original Papers Source Type: research

Zingiber zerumbet: A Scoping Review of its Medicinal Properties
In conclusion, Z. zerumbet and zerumbone have various pharmacological effects, especially in analgesic and anti-inflammatory models. However, there is still a pressing need for comprehensive safety data to conduct clinical trials. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Planta Medica)
Source: Planta Medica - December 20, 2023 Category: Drugs & Pharmacology Authors: Chan, Janice Sue Wen Lim, Xin Yi Japri, Norfarahana Ahmad, Ida Farah Tan, Terence Yew Chin Tags: Reviews Source Type: research

The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review
Planta Med DOI: 10.1055/a-2209-6357In early 2020, a global pandemic was announced due to the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known to cause COVID-19. Despite worldwide efforts, there are only limited options regarding antiviral drug treatments for COVID-19. Although vaccines are now available, issues such as declining efficacy against different SARS-CoV-2 variants and the aging of vaccine-induced immunity highlight the importance of finding more antiviral drugs as a second line of defense against the disease. Drug repurposing has been used to rapidly find COVID-19 t...
Source: Planta Medica - December 7, 2023 Category: Drugs & Pharmacology Authors: Alipour, Zahra Zarezadeh, Somayeh Ghotbi-Ravandi, Ali Akbar Tags: Reviews Source Type: research

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Planta Medica 2023; 14 Article in Thieme eJournals: Table of contents  |  Congress (Source: Planta Medica)
Source: Planta Medica - November 16, 2023 Category: Drugs & Pharmacology Source Type: research

Medicinal Cannabis: Extended Stability of Cannabis Extracts Produced Using a New Ethanol-based Extraction Method
Planta Med DOI: 10.1055/a-2189-8155Cannabis as a therapeutic agent is increasing in popularity all around the globe, particularly in Western countries, and its potential is now well assessed. On the other hand, each country has its own regulation for the preparation of cannabis macerated oils; in Italy, there are only a few preparation methods allowed. With this work, we aim to perform a stability study of cannabis oils produced with a novel method for the extraction of cannabinoids from cannabis inflorescence. Three different varieties of cannabis were used, with and without the adding of tocopherol acetate...
Source: Planta Medica - November 14, 2023 Category: Drugs & Pharmacology Authors: Morano, Camillo Dei Cas, Michele Casagni, Eleonora Pallavicini, Marco Bolchi, Cristiano Penati, Sara Cuomo, Arturo Cascella, Marco Bimonte, Sabrina Spensiero, Antonia Ferrari, Andrea Lombardi, Annunziata Roda, Gabriella Tags: Original Papers Source Type: research

Bone Fracture-healing Properties and UPLC-MS Analysis of an Enriched Flavonoid Fraction from Oxystelma esculentum
Planta Med DOI: 10.1055/a-2192-2138 Oxystelma esculentum has been used as a folk medicine to treat jaundice, throat infections, and skin problems. In the current study, the bone fracture-healing properties of a flavonoid-enriched fraction (Oxy50-60F) of O. esculentum were investigated in Swiss mice using a drill-hole injury model. Oxy50-60F (1 mg/kg/day, 5 mg/kg/day, and 10 mg/kg/day) was administered orally (from the next day) after a 0.6 mm drill-hole injury in mice femur mid-diaphysis for 7 days and 14 days. Parathyroid hormone (40 µg/kg; 5 times/week) was given subcutaneously as the posit...
Source: Planta Medica - November 10, 2023 Category: Drugs & Pharmacology Authors: Rawat, Priyanka Sharma, Kriti Khanka, Sonu Singh, Yatendra Prakash, Ravi Rais, Nisha Maurya, Arvind Kumar Gupta, Ritika Mishra, Dipak K. Singh, Divya Kanojiya, Sanjeev Tags: Original Papers Source Type: research

Synergism Between Essential Oils and Evaluation of Their Activities with a Focus on Malassezia furfur Control
Planta Med DOI: 10.1055/a-2196-2087Seborrheic dermatitis is a chronic inflammatory disease caused by Malassezia yeast species that affects the regions of the body where the sebaceous glands are present. The combined use of different essential oils (EOs) can increase their spectrum of action. Thus, the present study aimed to evaluate the action of EOs alone and in combination with each other on M. furfur, in planktonic and biofilm form, and their anti-inflammatory and mutagenic potential, in addition to the effects on the viability of cells lines. Of the 40 evaluated EOs, 22 showed activity against M. furfu...
Source: Planta Medica - November 7, 2023 Category: Drugs & Pharmacology Authors: Cassola, F ábio Ram írez, Nedy Ribeiro, Guilherme da Silva, Lucas Henrique Domingos Gambero, Alessandra de Oliveira, Adriana da Silva Santos Vieira, Pedro Manoel Mendes de Moraes Nogueira, Fl ávia Aparecida Resende Duarte, Marta Cristina Teixeira Tags: Original Papers Source Type: research

Investigation of the Metabolism of Astragaloside IV in a Puromycin-Damaged Rat Model by UPLC-Q-TOF-MS/MS Analysis
This study aims to explore the metabolic pathway of AS-IV in vivo in the classical puromycin aminonucleoside (PAN)-induced kidney injury in a rat model. Twelve Wistar rats were randomly divided into the AS-IV (CA) and the PAN+AS-IV (PA) treatment groups. PAN was injected by a single tail intravenous (i. v.) injection at 5 mg/100 g body weight, and AS-IV was administered intragastrically (i. g.) at 40 mg/kg for 10 days. Fecal samples of these rats were collected, and metabolites of AS-IV were detected by ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry...
Source: Planta Medica - November 6, 2023 Category: Drugs & Pharmacology Authors: Zhang, Bing Huang, Shiying Liu, Zhuoting Liu, Xinhui Jiang, Zilan Chen, Jianping Zeng, Youjia Tags: Original Papers Source Type: research

Identification of Major Bioactive Anti-inflammatory Compounds of Derris scandens Stem Using RAW 264.7 Cells and HPLC-UV Analysis
Planta Med DOI: 10.1055/a-2192-2281 Derris scandens (DS) is widely recognized for its therapeutic properties, specifically its analgesic effects, which significantly alleviate muscle pain. The chemical constituents of DS stem include various isoflavone derivatives. However, there is currently a lack of specified anti-inflammatory chemical markers and analytical methods for quality control. The present study aimed to evaluate the anti-inflammatory activity of DS and its constituents using the RAW 264.7 cell model. The expression of inflammatory genes such as inducible nitric oxide synthase (iNOS), cycloo...
Source: Planta Medica - November 6, 2023 Category: Drugs & Pharmacology Authors: Sae-Foo, Worapol Yusakul, Gorawit Nualkaew, Natsajee Putalun, Waraporn Tags: Original Papers Source Type: research

Correction: The Potential of Berberine to Target Telocytes in Rabbit Heart
Planta Med DOI: 10.1055/a-2198-5523 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Planta Medica)
Source: Planta Medica - November 6, 2023 Category: Drugs & Pharmacology Authors: Yang, Min Yang, Tong Mei, Lu Zhang, Yingxing Liang, Chunhua Bai, Xuebing Zhang, Zhenwei Shi, Yonghong Chen, Qiusheng Tags: Erratum Source Type: research

Comparative Morphology of Island and Inland Agastache rugosa and Their Gastroprotective Effects in EtOH/HCl-Induced Gastric Mucosal Gastritis
Planta Med DOI: 10.1055/a-2189-7272 Agastache rugosa Kuntze (Lamiaceae; Labiatae), a medicinal and functional herb used to treat gastrointestinal diseases, grows well both on islands and inland areas in South Korea. Thus, we aimed to reveal the morphological and micromorphological differences between A. rugosa grown on island and inland areas and their pharmacological effects on gastritis in an animal model by combining morphological and mass spectrophotometric analyses. Morphological analysis showed that island A. rugosa had slightly smaller plants and leaves than inland plants; however, the density ...
Source: Planta Medica - October 30, 2023 Category: Drugs & Pharmacology Authors: Song, Jun-Ho Nam, Hyeon-Hwa Park, Inkyu Yang, Sungyu Chun, Jin Mi Seo, Yun-Soo Kim, Hyun-Yong Moon, Byeong Cheol Kang, Sohi Moon, Changjong Kang, Seong-IL Song, Ji Hoon Kim, Joong-Sun Tags: Original Papers Source Type: research

Identification and Characterization of Chemical Constituents from Ammopiptanthus nanus Stem and Their Metabolites in Rats by UHPLC-Q-TOF-MS/MS
In conclusion, the chemical components from A. nanus stem and their metabolites in vivo were first studied, which may provide useful chemical information for further study on the effective material basis and pharmacological mechanism of A. nanus. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - October 30, 2023 Category: Drugs & Pharmacology Authors: Chen, Guanru Sun, Yanpei Yushan, Dilnur Shaerbayi, Nuerjiamali Zhang, Hongjuan He, Hongliang Jin, Yang Chen, Lina Tags: Original Papers Source Type: research

New Lupanes from Alstonia scholaris Reducing Uric Acid Level
Planta Med DOI: 10.1055/a-2186-3260Twelve lupanes including three new compounds named alstoscholarilups A−C (1–3) were isolated from the leaves of Alstonia scholaris. Their structures were elucidated by spectroscopic analysis and ECD calculation. Structurally, compound 1 with a rare A ring-seco skeleton formed lactone and degraded C-3, while 2 with a 28-nor and 3 with a 29-nor-lupane skeleton supported the phytochemical diversity and novelty of the plant. Pharmacologically, compounds 4, 7, and 10 reduced the serum uric acid (UA) levels of mice significantly. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70...
Source: Planta Medica - October 19, 2023 Category: Drugs & Pharmacology Authors: Hu, Bin-Yuan Zhao, Yun-Li Xu, Yuan Wang, Xiao-Na Luo, Xiao-Dong Tags: Original Papers Source Type: research

Establishment of the Daucus carota SMC-1 Cell Suspension Line for Poliovirus Vaccine Development
In conclusion, bioreactor-based production of the VP2 protein by the SMC-1 suspension cell line offers a higher productivity when compared to flask cultures, offering a key perspective to produce low-cost vaccines against poliomyelitis. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - October 18, 2023 Category: Drugs & Pharmacology Authors: Morales-Aguilar, M ónica Bola ños-Martínez, Omayra Citlalli Maldonado, Andrea Romero Govea-Alonso, Dania O. Carre ño-Campos, Christian Villarreal, Mar ía Luisa Rosales-Mendoza, Sergio Ortiz-Caltempa, Anabel Tags: Original Papers Source Type: research

The Potential of Berberine to Target Telocytes in Rabbit Heart
Planta Med DOI: 10.1055/a-2176-5881A brand-new class of interstitial cells, called telocytes, has been detected in the heart. Telocytes can connect and transmit signals to almost all cardiomyocytes; this is highly interrelated with the occurrence and development of heart diseases. Modern studies have shown that berberine has a therapeutic effect on cardiovascular health. However, berberineʼs mechanism of action on the cardiovascular system through cardiac telocytes is unclear. Interestingly, 5 µm of berberine remarkably decreased the concentration of intracell...
Source: Planta Medica - October 17, 2023 Category: Drugs & Pharmacology Authors: Yang, Min Yang, Tong Mei, Lu Zhang, Yingxing Liang, Chunhua Bai, Xuebing Zhang, Zhenwei Shi, Yonghong Chen, Qiusheng Tags: Original Papers Source Type: research