Anti-glutamatergic Effects of Three Lignan Compounds: Arctigenin, Matairesinol and Trachelogenin – An ex vivo Study on Rat Brain Slices
Planta Med DOI: 10.1055/a-2005-5497Arctigenin is a bioactive dibenzylbutyrolactone-type lignan exhibiting various pharmacological activities. The neuroprotective effects of arctigenin were demonstrated to be mediated via
inhibition of AMPA and KA type glutamate receptors in the somatosensory cortex of the rat brain. The aim of this study was to compare the effects of arctigenin with matairesinol and
trachelogenin on synaptic activity in ex vivo rat brain slices. Arctigenin, matairesinol and trachelogenin were isolated from Arctium lappa, Centaurea scabiosa and Cirsium
arvense, respectively, and applied on brain slices via perfusion medium at the concentration range of 0.5 – 40 µM. The effects of the lignans were examined in the CA1 hippocampus and the
somatosensory cortex by recording electrically evoked field potentials. Arctigenin and trachelogenin caused a significant dose-dependent decrease in the amplitude of hippocampal population
spikes (POPS) and the slope of excitatory postsynaptic potentials (EPSPs), whereas matairesinol (1 µM and 10 µM) decreased EPSP slope but had no effect on POPS amplitude. Trachelogenin
effect (0.5 µM, 10 µM, 20 µM) was comparable to arctigenin (1 µM, 20 µM, 40 µM) (p > 0.05). In the neocortex, arctigenin (10 µM, 20 µM) and trachelogenin (10 µM) significantly decreased
the amplitude of evoked potential early component, while matairesinol (1 µM and 10 µM) h...
Source: Planta Medica - Category: Drugs & Pharmacology Authors: Koech, Peter Kiplang ʼat J ócsák, Gergely Boldizs ár, Imre Moldov án, Kinga Borb ély, Sándor Vil ági, Ildikó Dobolyi, Arp ád Varr ó, Petra Tags: Original Papers Source Type: research