New Perspectives for the Use of Potentilla alba Rhizomes to Treat Thyroid Gland Impairments
Planta Med DOI: 10.1055/a-1663-6461
Potentilla alba is a valuable medicinal plant that has been highly praised even before its first appearance in herbal books; however, it has now been forgotten in Western Europe. Currently, this species is used in Eastern Europe as a remedy to treat dysentery and various thyroid gland dysfunctions. The present review summarizes the advances in the phytochemical, pharmacological, and toxicological research related to this plant species. Clinical trials that have been conducted to date support its traditional use for treating thyroid disorders, although its exact mechanism of action, ...
Source: Planta Medica - October 29, 2021 Category: Drugs & Pharmacology Authors: Augustynowicz, Daniel Podolak, Magdalena Latt é, Klaus Peter Tomczyk, Micha ł Tags: Reviews Source Type: research
Chemical Analysis by LC-MS of Cannabis sativa Root Samples from Northeast Brazil and Evaluation of Antitussive and Expectorant Activities
Planta Med DOI: 10.1055/a-1628-2299
Cannabis sativa is a millenary medicinal plant. However, contrary to worldwide paradigm-shifting, countries like Brazil still prohibit C. sativa cultivation and its medicinal use, even though many populations use aerial parts and roots of this plant for healthcare. As such, the objective of this work was to identify substances in the samples of the C. sativa roots, tracing a correlation with antitussive and expectorant effects. Therefore, samples of C. sativa roots were donated by the Polícia Federal Brasileira, and its aqueous extract (AECsR) was prepared with subsequent lyophiliz...
Source: Planta Medica - October 29, 2021 Category: Drugs & Pharmacology Authors: Menezes, Pedro Modesto Nascimento Pereira, Emanuella Chiara Valen ça Lima, K átia Simoni Bezerra Silva, Bismarques Augusto Oliveira da Brito, Mariana Coelho Ara újo, Tarcísio Cícero de Lima Neto, Janaine Almeida Ribeiro, Luciano Augusto de Araujo Sil Tags: Original Papers Source Type: research
Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora
Planta Med DOI: 10.1055/a-1530-1128Two new maytansinoids, N-methyltreflorine (1) and methyltrewiasine (2), were isolated from the dried fruits of Trewia nudiflora, together with three known congeners (3 – 5). Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 and 2 was determined by X-ray crystallographic analysis. Compounds 1 – 5 exhibited strong cytotoxicity against human tumor cell lines, including HeLa, MV-4 – 11, and MCF-7, with IC50 values ranging from 0.12 to 11 nM. Compounds 1 and 4 also showed inhibitory activity against the MCF-7/ADR cell line with I...
Source: Planta Medica - October 29, 2021 Category: Drugs & Pharmacology Authors: Lei, Chun Li, Ya-Nan Li, Jia-Nan Zhou, Yu-Bo Cui, Ming-Jun Fu, Kai-Cong Li, Jia Hou, Ai-Jun Tags: Original Papers Source Type: research
Silicon Resorption from Equisetum arvense Tea – A Randomized, Three-Armed Pilot Study
We examined the resorption of silicon after TEA consumption. Safety and immunological effects were secondary outcomes. A monocentric, randomized, three-armed pilot study was conducted with 12 voluntary, healthy, male subjects. The study is registered in the German register for clinical trials (DRKS-ID: DRKS00016628). After a low silicon diet for 36 hours, 1000 mL TEA1 with approximately 200 000 µg silicon/L, TEA2 with approximately 750 000 µg silicon/L, or Si-low-Water (approximately 10 – 10 000 µg silicon/L as a control) were ingested on three consecutive days. Blood and urine samples were collected...
Source: Planta Medica - October 27, 2021 Category: Drugs & Pharmacology Authors: Waterstradt, Aljoscha Winker, Moritz Zimmermann-Klemd, Amy Marisa Devi, Seema Lederer, Ann-Kathrin Huber, Roman Gr ündemann, Carsten Tags: Original Papers Source Type: research
More Than Just a Weed: An Exploration of the Antimicrobial Activity of Rumex crispus using a Multivariate Data Analysis Approach
Planta Med DOI: 10.1055/a-1652-1547Plants have a long history of use for their medicinal properties. The complexity of botanical extracts presents unique challenges and necessitates the application of innovative approaches to correctly identify and quantify bioactive compounds. For this study, we used untargeted metabolomics to explore the antimicrobial activity of Rumex crispus (yellow dock), a member of the Polygonaceae family used as an herbal remedy for bacterial infections. Ultra-performance liquid chromatography coupled with high resolution mass-spectrometry (UPLC-MS) was used to identify and quantify the known antim...
Source: Planta Medica - October 25, 2021 Category: Drugs & Pharmacology Authors: Pelzer, Chantal V. Houriet, Jo ëlle Crandall, William J. Todd, Daniel A. Cech, Nadja B. Jones, Derick D. Tags: Original Papers Source Type: research
Critical Assessment of In Vitro Screening of α-Glucosidase Inhibitors from Plants with Acarbose as a Reference Standard
Planta Med DOI: 10.1055/a-1557-7379Postprandial hyperglycemia is treated with the oral antidiabetic drug acarbose, an intestinal α-glucosidase inhibitor. Side effects of acarbose motivated a growing number of screening studies to identify novel α-glucosidase inhibitors derived from plant extracts and other natural sources. As “gold standard”, acarbose is frequently included as the reference standard to assess the potency of these candidate α-glucosidase inhibitors, with many outperforming acarbose by several orders of magnitude. The results are subsequently used to identify suitable compounds/products with strong po...
Source: Planta Medica - October 18, 2021 Category: Drugs & Pharmacology Authors: Miller, Neil Joubert, Elizabeth Tags: Reviews Source Type: research
HPTLC Fingerprint Authentication of Selected Sideritis spp. Using a Pharmacognostic Approach
This study presents results of a first pharmacognostic examination of the botanical and phytochemical differences among and between these emerging commercial species, and other, less studied species. An HPTLC method is proposed for normal phase separation of the species; this means applying two mobile phases on silica plates and subsequent derivatization with natural product reagent (NP/PEG) for visualization of phenolic compounds and anisaldehyde for a broader detection. With the help of selected reference
compounds, a system suitability test was established for proper chromatographic separation. The method was appli...
Source: Planta Medica - October 15, 2021 Category: Drugs & Pharmacology Authors: Pihan, Lisa-Anna-Maria Peter, Samuel Vollmer, G ünter Meier, Beat Wolfram, Evelyn Tags: Original Papers Source Type: research
Activity of THC, CBD, and CBN on Human ACE2 and SARS-CoV1/2 Main Protease to Understand Antiviral Defense Mechanism
This study aims to determine the mechanism of action of THC, CBD, and CBN by selecting two essential targets that directly affect the coronavirus infections as viral main proteases and human angiotensin-converting enzyme2. Tested THC and CBD presented a dual-action action against both selected targets. Only CBD acted as a potent viral main protease inhibitor at the IC50 value of 1.86 ± 0.04 µM and exhibited only moderate activity against human angiotensin-converting enzyme2 at the IC50 value of 14.65 ± 0.47 µM. THC acted as a moderate inhibitor against both viral main protease and human angiotensin-converti...
Source: Planta Medica - October 12, 2021 Category: Drugs & Pharmacology Authors: Pitakbut, Thanet Nguyen, Gia-Nam Kayser, Oliver Tags: Original Papers Source Type: research
Correction: Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System
Planta Med DOI: 10.1055/a-1666-5352 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | open access Full text (Source: Planta Medica)
Source: Planta Medica - October 12, 2021 Category: Drugs & Pharmacology Authors: Spiess, Deborah Abegg, Vanessa Fabienne Chauveau, Antoine Treyer, Andrea Reinehr, Michael Oufir, Mouhssin Duong, Elisa Potterat, Olivier Hamburger, Matthias Sim ões-Wüst, Ana Paula Tags: Erratum Source Type: research
Folklore, Animal Self-Medication, and Phytotherapy –Something Old, Something New, Something Borrowed, Some Things True
Planta Med DOI: 10.1055/a-1586-1665The use of medicines was long considered by Western schools of thought to be a a domain unique to humans; however, folklore/Traditional Ecological Knowledge (TEK) from around the world suggests that animals have also long provided inspiration for the discovery of some medicinal plants used to treat humans and their livestock. Searching for medicinal knowledge from animals depends on the recognition of their ability to select and effectively use medicinal plants to prevent or actively ameliorate disease and other homeostatic imbalances. The interdisciplinary field of animal self-medication...
Source: Planta Medica - October 8, 2021 Category: Drugs & Pharmacology Authors: Huffman, Michael A. Tags: Reviews Source Type: research
Medicinal Plants for the Treatment of Mental Diseases in Pregnancy: An In Vitro Safety Assessment
This study suggests that all tested preparations from St. Johnʼs wort, California poppy, valerian, lavender, and hops, in concentrations up to 30 µg/mL, do not possess any cytotoxic or genotoxic potential and do not compromise placental cell viability, metabolic activity, and differentiation. Empirical and clinical studies during pregnancy are needed to support these in vitro data. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Planta Medica)
Source: Planta Medica - October 8, 2021 Category: Drugs & Pharmacology Authors: Spiess, Deborah Winker, Moritz Chauveau, Antoine Abegg, Vanessa Fabienne Potterat, Olivier Hamburger, Matthias Gr ündemann, Carsten Sim ões-Wüst, Ana Paula Tags: Original Papers Source Type: research
Efficacy of Norway Spruce Ointments and Bacterial and Fungal Alterations in the Treatment of Castration Wounds in Piglets
This study aimed to evaluate the efficacy of Norway spruce ointments on wound healing of castration wounds in piglets. This study included 95 male pigs randomly divided into five treatment groups: Norway spruce balm (Vulpuran), Norway spruce resin (Abilar), pork lard (ointment base of Vulpuran), no treatment (negative control) and antibiotic blue spray (Cyclo spray, positive control). Wound healing parameters (such as healing time, wound size, reddening of wound edges and surrounding, swelling, secretion and wound contamination), microbiological status and the haptoglobin level as an inflammation parameter were investigate...
Source: Planta Medica - October 8, 2021 Category: Drugs & Pharmacology Authors: Prokop, D ésirée Spergser, Joachim Hagm üller, Werner Tichy, Alexander Zitterl-Eglseer, Karin Tags: Original Papers Source Type: research
Gut Microbiota of Pigs Metabolizes Extracts of Filipendula ulmaria and Orthosiphon aristatus –Herbal Remedies Used in Urinary Tract Disorders
Planta Med DOI: 10.1055/a-1647-2866Urinary tract infections influence the mortality rate in pigs and are linked to extensive antibiotic usage in the farm industry. Filipendula ulmaria (L.) Maxim. and Orthosiphon aristatus (Blume) Miq. are widespread medicinal plants traditionally used to treat urinary tract disorders. As their preparations are orally administered, the metabolism of their constituents by gut microbiota before absorption should be considered. Until now, no experiments had been performed to describe the biotransformation of tthose plantsʼ extracts by animal gut microbiota. The study evaluates the influence o...
Source: Planta Medica - October 8, 2021 Category: Drugs & Pharmacology Authors: Popowski, Dominik Zentek, J ürgen Piwowarski, Jakub P. Granica, Sebastian Tags: Original Papers Source Type: research
A Systematic Review of the Potential Effects of Lippia sidoides on Dental Plaque and Periodontal Diseases
Planta Med DOI: 10.1055/a-1554-6947
Lippia sidoides is a typical shrub from Brazil that has been used in traditional medicine. This is a systematic review on the effect of L. sidoides for controlling dental plaque, gingivitis, and periodontitis. A database search through May 2021 in Medline/PubMed, SCOPUS, BVS, and Web of Science identified 711 reports of which 17 met our inclusion criteria. Five randomized controlled trials and three animal studies were included that compared L. sidoides-based products (toothpaste, mouthrinse, and gel) to cetylpyridinium chloride, chlorhexidine, and placebo products. Among the huma...
Source: Planta Medica - October 1, 2021 Category: Drugs & Pharmacology Authors: de Assis, Ellen Lima Silveira, Felipe Dantas da Ponte, Alan Victor Ara újo Regis, R ômulo Rocha Tags: Reviews Source Type: research
Ethnoveterinary Uses of Certain Yemeni Plants: A Review of the Scientific Evidence
Planta Med DOI: 10.1055/a-1612-4556Livestock is an important and integral component of agriculture production in Yemen and contributes 28% of the total agricultural production income. Research in the field of Yemeni ethnoveterinary medicine is limited to a few studies. Therefore, our work aims to substantiate scientifically the ethnoveterinary use of some documented plant species based on a literature review of their bioactivities and toxicological properties. Searching the scientific literature has revealed various pharmacological activities that may support the claimed healing activities of 11 out of 14 plant species for...
Source: Planta Medica - October 1, 2021 Category: Drugs & Pharmacology Authors: Alasbahi, Rawiya H. Groot, Maria J. Tags: Reviews Source Type: research
