New Guaianolide Sesquiterpene Lactones and Other Constituents from Pyrethrum pulchrum
Planta Med DOI: 10.1055/a-1554-2866
Pyrethrum pulchrum is a rare Mongolian plant species that has been traditionally used as an ingredient in various remedies. Bioactivity-guided fractionation performed on the methanol extract of its aerial parts led to the isolation of 2 previously undescribed guaianolide-type sesquiterpene lactones, namely 1β,10β-epoxy-8α-hydroxyguaia-3,11(13)-dien-6,12-olide (1) and 1,8,10-trihydroxyguaia-3,11(13)-dien-6,12-olide (2), along with the isolation or chromatographic identification of 11 compounds, arglabin (3), 3β-hydroxycostunolide (4), isocostic acid (5), (E)-9-(2-thienyl)-6-nonen...
Source: Planta Medica - August 5, 2021 Category: Drugs & Pharmacology Authors: Erdenetsogt, Uugangerel Nadmid, Suvd Paetz, Christian Dahse, Hans-Martin Voigt, Kerstin Gotov, Choijamts Boland, Wilhelm Dagvadorj, Enkhmaa Tags: Original Papers Source Type: research
Cardiovascular Effects Induced by Fruit Peels from Passiflora edulis in Hypertensive Rats and Fingerprint Analysis by HPLC-ESI-MSn spectrometry
This study aimed to perform a fingerprinting analysis of Passiflora edulis fruit peel extract and evaluate its actions on the cardiovascular system in an in vivo model. The extract was obtained from the dried and powdered fruit peels of Passiflora edulis. Glycoside flavonoids were identified in the extract by HPLC-ESI-MSn. The extract showed a significant hypotensive effect after 28 days of treatment and improved vascular function in the mesenteric artery. This effect was verified by decreased vascular hypercontractility and increased vasorelaxant in response to sodium nitroprusside and acetylcholine. There was also a dec...
Source: Planta Medica - August 3, 2021 Category: Drugs & Pharmacology Authors: Cabral, B árbara Gon çalves, Tays Amanda Felisberto Abreu, Lucas Silva Andrade, Anderson Wilbur Lopes de Azevedo, F átima de Lourdes Assunção Araújo de Castro, Francker Duarte Tavares, Josean Fechine Guerra, Gerlane Coelho Bernardo de Rezende, Adria Tags: Original Papers Source Type: research
Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation
Planta Med DOI: 10.1055/a-1527-7611Protein glycation, a post-translational modification found in biological systems, is often associated with a core defect in glucose metabolism. In particular, advanced glycation endproducts are complex heterogeneous sugar-derived protein modifications implicated in the progression of pathological conditions such as atherosclerosis, diabetic complications, skin diseases, rheumatism, hypertension, and neurodegenerative diseases. Undoubtedly, there is the need to expand the knowledge about antiglycation agents that can offer a therapeutic approach in preventing and treating health issues of ...
Source: Planta Medica - August 2, 2021 Category: Drugs & Pharmacology Authors: Velichkova, Stefaniya Foubert, Kenn Pieters, Luc Tags: Reviews Source Type: research
Phytogenic Compounds for Enhancing Intestinal Barrier Function in Poultry –A Review
Planta Med DOI: 10.1055/a-1524-0358After the European Union ban of antibiotic growth promoters, works on different methods of improving gut health have intensified. The poultry industry is struggling with problems that were previously controlled by antibiotic growth promoters, therefore the search for optimal solutions continues. Simultaneously, there is also increasing social pressure to minimize the use of antibiotics and replace them with alternative feed additives. A variety of available alternatives is considered safe by consumers, among which phytogenics play a significant role. However, there are still some limitati...
Source: Planta Medica - July 30, 2021 Category: Drugs & Pharmacology Authors: Latek, Urszula Ch łopecka, Magdalena Karlik, Wojciech Mendel, Marta Tags: Reviews Source Type: research
Benzoylcyclopropane Derivatives from Hypoxis hemerocallidea Corms
Planta Med DOI: 10.1055/a-1540-4978Two monobenzoylcyclopropane (hypoxhemerol A (1) and hypoxhemeroloside G (2)) and three dibenzoylcyclopropane (hypoxhemerol B (3), hypoxhemeroloside H (4), and hypoxhemeroloside I (5)) derivatives were isolated from the hydro-alcoholic extract of Hypoxis hemerocallidea corms. This is the first instance where benzoylcyclopropane analogs were isolated from any natural source. Structure elucidation was mainly based on 1D- and 2D-NMR and HRESIMS data. The absolute configuration (2R, 4R) of 1 was determined via NOESY NMR and experimental and calculated ECD data analyses. Compounds 1–5 and 11 ...
Source: Planta Medica - July 30, 2021 Category: Drugs & Pharmacology Authors: Zulfiqar, Fazila Pandey, Pankaj Tripathi, Siddharth K. Ali, Zulfiqar Chittiboyina, Amar G. Khan, Ikhlas A. Tags: Original Papers Source Type: research
Biomarker-Based Determination of Equiseti herba Contamination by Equisetum palustre Using HPLC-MS/MS
Planta Med DOI: 10.1055/a-1521-8386Equiseti herba has been traditionally indicated in bacterial diseases of the efferent urinary tract or bad healing wounds in many regions worldwide. Most of the plant material used for medical purposes comes from collections of wild growing plants. The European Pharmacopoeia requires that Equiseti herba should consist of a minimum of 95% Equisetum arvense and a maximum of 5% foreign ingredients. This includes Equisetum palustre, which is known for its potentially toxic alkaloid palustrine. However, both Equisetum species are quite common, look morphologically very similar, and share simil...
Source: Planta Medica - July 22, 2021 Category: Drugs & Pharmacology Authors: Nowak, Monika Tipke, Isabel B ücker, Luise Franke, Kerstin Lubienski, Marcus Beuerle, Till Tags: Original Papers Source Type: research
Cytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4
Planta Med DOI: 10.1055/a-1538-5289
Haplophyllum tuberculatum is a plant commonly used in folk medicine to treat several diseases including vomiting, nausea, infections, rheumatism, and gastric pains. In the current study, H. tuberculatum essential oils, hydrosols, the pure compounds R-(+)-limonene, S-(−)-limonene, and 1-octanol, as well as their combinations R-(+)-limonene/1-octanol and S-(−)-limonene/1-octanol, were screened for their cytotoxicity on HEp-2 cells after 24, 48, and 72 h, and then tested for their activity against Coxsackievirus B3 and B4 (CV-B3 and CV-B4) at 3 different moments: addition of the ...
Source: Planta Medica - July 22, 2021 Category: Drugs & Pharmacology Authors: Hamdi, Assia Halouani, Aymen Aouf, Ines Viaene, Johan Marzouk, Belsem Kraiem, Jamil Ja ïdane, Hela Heyden, Yvan Vander Tags: Original Papers Source Type: research
Quantitative Removal of Pyrrolizidine Alkaloids from Essential Oils by the Hydrodistillation Step in Their Manufacturing Process
Planta Med DOI: 10.1055/a-1534-6928Pyrrolizidine alkaloids are naturally occurring toxins produced by certain weeds that can, if accidentally co-harvested, contaminate plant-based food, feed, and herbal medicinal products. Focusing on herbal medicinal products, the presence of pyrrolizidine alkaloids is restricted by regulatory prescribed thresholds to assure patient safety. Among the multitude of different herbal active substances utilized in herbal medicinal products, the class of pharmaceutically effective essential oils is considered to exhibit a negligible contribution to pyrrolizidine alkaloid contamination. Within t...
Source: Planta Medica - July 22, 2021 Category: Drugs & Pharmacology Authors: Giera, David S. Preisitsch, Michael Brevard, Hugues Nemetz, J örn Tags: Original Papers Source Type: research
Suffrutines A and B Inhibit the Expression of Inflammatory Mediators in LPS-Induced RAW264.7 Cells by Suppressing the NF- κB Signaling Pathway
Planta Med DOI: 10.1055/a-1528-1760
Flueggea suffruticosa is a traditional Chinese medicine that has been commonly used for the treatment of inflammatory ailments, including rheumatism and lumbago. Suffrutines A and suffrutines B are a pair of novel E,E and Z,E isomeric indolizidine alkaloids isolated from the roots of F. suffruticosa. However, their anti-inflammatory activity has not been reported thus far. The aim of this study was to investigate the inhibitory effect of inflammatory mediators and possible mechanisms of suffrutines A and B in lipopolysaccharide-induced RAW264.7 cells. Results showed that suffrutines...
Source: Planta Medica - July 22, 2021 Category: Drugs & Pharmacology Authors: Chen, Chun Zhu, Ze-Feng Nie, Wen-Xing Zou, Yong Tags: Original Papers Source Type: research
Pharmacognostic Evaluation of Ten Species of Medicinal Importance of Cecropia: Current Knowledge and Therapeutic Perspectives
Planta Med DOI: 10.1055/a-1495-9785This work covers a systematic review of literature about the genus Cecropia from 1978 to 2020, emphasizing the analysis of 10 of the most relevant species and their associated biological activities. Cecropia is a neotropical genus, which comprises about 61 native species in the American continent where it is known to be part of the traditional medicine of numerous countries. Secondary metabolites described for this genus showed an elevated structural and functional diversity, where polyphenols have been the most abundant. Based on this diversity, Cecropia phytochemicals represent an impor...
Source: Planta Medica - July 20, 2021 Category: Drugs & Pharmacology Authors: Rivera-Mondrag ón, Andrés Ort íz, Orlando O. Gupta, Mahabir P. Caballero-George, Catherina Tags: Reviews Source Type: research
Cytotoxicity of Poupartone B, an Alkyl Cyclohexenone Derivative from Poupartia borbonica, against Human Cancer Cell Lines
Planta Med DOI: 10.1055/a-1532-2384
Poupartia borbonica is an endemic tree from the Mascarene Islands that belongs to the Anacardiaceae family. The leaves of this plant were phytochemically studied previously, and isolated alkyl cyclohexenone derivatives, poupartones A – C, demonstrated antiplasmodial and antimalarial activities. In addition to their high potency against the Plasmodium sp., high toxicity on human cells was also displayed. The present study aims to investigate in more detail the cytotoxicity and pharmacological interest of poupartone B, one of the most abundant derivatives in the leaves of P. bor...
Source: Planta Medica - July 16, 2021 Category: Drugs & Pharmacology Authors: Ledoux, Allison B ériot, Daphnée Mamede, Lucia Desdemoustier, Pauline Detroz, Fanny Jansen, Olivia Fr édérich, Michel Maquoi, Erik Tags: Original Papers Source Type: research
Alkaloids from Lime Flower (Tiliae flos) Exert Spasmodic Activity on Murine Airway Smooth Muscle Involving Acetylcholinesterase
Planta Med DOI: 10.1055/a-1534-3766Lime flower (Tiliae flos) is traditionally used either for treatment of the common cold or to relieve symptoms of mental stress. Recently, the presence of a new class of piperidine and dihydro-pyrrole alkaloids from lime flower has been described. The present study aimed to investigate the pharmacological activity of hydroacetonic lime flower extracts, alkaloid-enriched lime flower fractions, and isolated alkaloids on the murine airway smooth muscle and the cholinergic system. While a hydroacetonic lime flower extract did not show any pharmacological activity, enriched Tilia alkaloid frac...
Source: Planta Medica - July 16, 2021 Category: Drugs & Pharmacology Authors: Hake, Alexander Symma, Nico Esch, Stefan Hensel, Andreas D üfer, Martina Tags: Original Papers Source Type: research
Multi-Class UHPLC-MS/MS Method for Plant Toxins and Cyanotoxins in Food Supplements and Application for Belgian Market Samples
Planta Med DOI: 10.1055/a-1517-5828The presence of plant toxins and/or cyanotoxins in food supplements implies consumer health risks. Therefore, a targeted ultra-high performance liquid chromatographic-tandem mass spectrometric method to detect/quantify 25 toxins simultaneously in food supplement formulations was developed and validated. Full validation for tablets/powders and secondary validation for a liquid and soft gel capsule indicated that most compounds were efficiently extracted (≥ 75%), while others were only partly extracted (18 – 61%). Trueness was fulfilled (70 – 120%), with some exceptions (mos...
Source: Planta Medica - July 9, 2021 Category: Drugs & Pharmacology Authors: Van Pamel, Els Henrottin, Jean Van Poucke, Christof Gillard, Nathalie Daeseleire, Els Tags: Original Papers Source Type: research
Chemical Differentiation of Plant Latexes and Their Anti-herbivory Activity against Thrips Frankliniella occidentalis
Planta Med DOI: 10.1055/a-1529-8370Despite the extensive studies on latex, some fundamental questions on their chemical specialization and the factors influencing this specialization have yet to be investigated. To address this issue, latexes and their bearing tissues from diverse species were profiled by 1HNMR and GC-MS. Additionally, the antiherbivory activity of these materials was tested against thrips (Frankliniella occidentalis Pergande, 1895). The multivariate data analysis showed a clear separation between latexes and leaves from the same species. Conversely, the chemical profiles of latexes from different species ...
Source: Planta Medica - July 8, 2021 Category: Drugs & Pharmacology Authors: Salom é-Abarca, Luis Francisco van der Toorn, Thomas van Vugt, Rogier Klinkhamer, Peter G. L. Choi, Young Hae Tags: Original Papers Source Type: research
Effects of Chemopreventive Natural Compounds on the Accuracy of 8-oxo-7,8-dihydro-2 ′-deoxyguanosine Translesion Synthesis
Planta Med DOI: 10.1055/a-1527-1435Translesion synthesis is a DNA damage tolerance mechanism that relies on a series of specialized DNA polymerases able to bypass a lesion on a DNA template strand during replication or post-repair synthesis. Specialized translesion synthesis DNA polymerases pursue replication by inserting a base opposite to this lesion, correctly or incorrectly depending on the lesion nature, involved DNA polymerase(s), sequence context, and still unknown factors. To measure the correct or mutagenic outcome of 8-oxo-7,8-dihydro-2′-deoxyguanosine bypass by translesion synthesis, a primer-extension assay w...
Source: Planta Medica - July 8, 2021 Category: Drugs & Pharmacology Authors: Nachtergael, Amandine Lanterbecq, D éborah Spanoghe, Martin Belayew, Alexandra Duez, Pierre Tags: Original Papers Source Type: research
