Homoadamantane and Adamantane Acylphloroglucinols from Hypericum hirsutum
Planta Med DOI: 10.1055/a-1617-7573
1H NMR-guided fractionation of the petroleum ether extract of the aerial parts from Hypericum hirsutum yielded to the isolation of 19 polyprenylated polycyclic acylphloroglucinols. Structure elucidation based on 1D and 2D NMR spectroscopy together with high-resolution electrospray ionization mass spectroscopy revealed 14 acylphloroglucinols with a homoadamantane scaffold (1–14), while 5 further compounds showed an adamantane skeleton (15–19). Except for hookerione C (15), all isolated metabolites are hitherto unknown. While structurally-related metabolites have been isolated fro...
Source: Planta Medica - October 1, 2021 Category: Drugs & Pharmacology Authors: Max, Julianna Heilmann, J örg Tags: Original Papers Source Type: research
Coffee Leaves: An Upcoming Novel Food?
Planta Med DOI: 10.1055/a-1533-0021Unlike those of coffee beans, the healthy properties of coffee leaves have been overlooked for a long time, even if they are consumed as a beverage by local communities of several African countries. Due to the presence of xanthines, diterpenes, xanthones, and several other polyphenol derivatives as main secondary metabolites, coffee leaves might be useful to prevent many daily disorders. At the same time, as for all bioactive molecules, careless use of coffee leaf infusions may be unsafe due to their adverse effects, such as the excessive stimulant effects on the central nervous system or...
Source: Planta Medica - September 24, 2021 Category: Drugs & Pharmacology Authors: Montis, Andrea Souard, Florence Delporte, C édric Stoffelen, Piet St évigny, Caroline Van Antwerpen, Pierre Tags: Reviews Source Type: research
The Low Copy Nuclear Gene Region, Granule Bound Starch Synthase (GBSS1), as a Novel Mini-DNA Barcode for the Identification of Different Sage (Salvia) Species
Planta Med DOI: 10.1055/a-1618-6496Morphological similarity within species makes the identification and authentication of Salvia species challenging, especially in dietary supplements that contain processed root or leaf powder of different sage species. In the present study, the species discriminatory power of 2 potential DNA barcode regions from the nuclear genome was evaluated in 7 medicinally important Salvia species from the family Lamiaceae. The nuclear internal transcribed spacer 2 and the exon 9 – 14 region of low copy nuclear gene WAXY coding for granule-bound starch synthase 1 were tested for their species d...
Source: Planta Medica - September 20, 2021 Category: Drugs & Pharmacology Authors: Parveen, Iffat Techen, Natascha Handy, Sara M. Li, Jing Wu, Charles Chittiboyina, Amar G. Khan, Ikhlas A. Tags: Original Papers Source Type: research
Biological Activities of Extracts from Ageratum fastigiatum: Phytochemical Study and In Silico Target Fishing Approach
Planta Med DOI: 10.1055/a-1576-4080In the present study, the ethanolic extract from aerial parts of Ageratum fastigiatum was evaluated in vitro against epimastigote forms of Trypanosoma cruzi (Y strain), promastigote forms of Leishmania amazonensis (PH8 strain), and L. chagasi (BH400 strain). The extract was also evaluated against Staphylococcus aureus (ATCC 25 923), Escherichia coli (ATCC 11 775), Pseudomonas aeruginosa (ATCC 10 145), and Candida albicans (ATCC 36 802). The phytochemical screening was performed by thin-layer chromatography and high-performance liquid chromatography. The extract was fractionated u...
Source: Planta Medica - September 16, 2021 Category: Drugs & Pharmacology Authors: Sudan, Carolina Reis Cerqueira Pereira, Lucas Campos Silva, Andr éia Fonseca Moreira, Carolina Paula de Souza Scoaris, Denise de Oliveira Faria, Gilson dos Santos, Janete Soares Coelho Leclercq, Sophie Yvette Caldas, Sergio Silva, Cl áudia Gontijo Lopes Tags: Original Papers Source Type: research
Placental Passage of Humulone and Protopine in an Ex Vivo Human Perfusion System
Planta Med DOI: 10.1055/a-1578-3803The placental passage of humulone and protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Only a small portion of humulone initially present in the maternal circuit reached the fetal circuit. The humulone concentration in the maternal circuit rapidly decreased, likely due to metabolization in the placenta. Protopine was transferred...
Source: Planta Medica - September 16, 2021 Category: Drugs & Pharmacology Authors: Spiess, Deborah Abegg, Vanessa Fabienne Chauveau, Antoine Treyer, Andrea Reinehr, Michael Oufir, Mouhssin Duong, Elisa Potterat, Olivier Hamburger, Matthias Sim ões-Wüst, Ana Paula Tags: Original Papers Source Type: research
Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species
Planta Med DOI: 10.1055/a-1578-8778Efficient wound treatment that addresses associated infections and inflammation remains one of the big unmet needs, especially in low- and middle-income countries. One strategy for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. A unique novel opportunity could be photo-enhanced wound treatment with a combination of light-sensitive plant preparations and local exposure to daylight. Data mining strategies using existing resources offer an excellent basis for developing such an approach with many po...
Source: Planta Medica - September 15, 2021 Category: Drugs & Pharmacology Authors: Scotti, Francesca Mou, Linru Huang, Chen Booker, Anthony Weckerle, Caroline Maake, Caroline Heinrich, Michael Tags: Original Papers Source Type: research
Medicinal Plants: Guests and Hosts in the Heterologous Expression of High-Value Products
Planta Med DOI: 10.1055/a-1576-4148Medicinal plants play an important dual role in the context of the heterologous expression of high-value pharmaceutical products. On the one hand, the classical biochemical and modern omics approaches allowed for the discovery of various genes encoding biosynthetic pathways in medicinal plants. Recombinant DNA technology enabled introducing these genes and regulatory elements into host organisms and enhancing the heterologous production of the corresponding secondary metabolites. On the other hand, the transient expression of foreign DNA in plants facilitated the production of numerous pr...
Source: Planta Medica - September 14, 2021 Category: Drugs & Pharmacology Authors: Vasilev, Nikolay Tags: Reviews Source Type: research
Accumulation of the Major Components from Polygoni Multiflori Radix in Liver and Kidney after Its Long-Term Oral Administrations in Rats
Planta Med DOI: 10.1055/a-1585-5991Although Polygoni Multiflori Radix (PMR) has been widely used as a tonic and an anti-aging remedy for centuries, the extensively reported hepatotoxicity and potential kidney toxicity hindered its safe use in clinical practice. To better understand its toxicokinetics, the current study was proposed, aiming to evaluate the biodistributions of the major PMR components including 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG), emodin, emodin-8-O-β-D-glucopyranoside (EMG) and physcion as well as their corresponding glucuronides following bolus and multiple oral administrations ...
Source: Planta Medica - September 14, 2021 Category: Drugs & Pharmacology Authors: Li, Dan Lyu, Yuanfeng Zhao, Jiajia Ji, Xiaoyu Zhang, Yufeng Zuo, Zhong Tags: Original Papers Source Type: research
The Anti-Proliferative Lichen-Compound Protolichesterinic Acid Inhibits Oxidative Phosphorylation and Is Processed via the Mercapturic Pathway in Cancer Cells
Planta Med DOI: 10.1055/a-1579-6454The lichen compound protolichesterinic acid (PA) has an anti-proliferative effect against several cancer cell lines of different origin. This effect cannot be explained by the known inhibitory activity of PA against 5- and 12-lipoxygenases. The aim was therefore to search for mechanisms for the anti-proliferative activity of PA. Two cancer cell lines of different origin, both sensitive to anti-proliferative effects of PA, were selected for this study, T-47D from breast cancer and AsPC-1 from pancreatic cancer. Morphological changes were assessed by transmission electron microscopy, HPLC c...
Source: Planta Medica - September 14, 2021 Category: Drugs & Pharmacology Authors: J óhannsson, Freyr Cherek, Paulina Xu, Maonian Rolfsson, Óttar Ögmundsdóttir, Helga M. Tags: Original Papers Source Type: research
Effect of Gut Microbiota on the Metabolism of Chemical Constituents of Berberis kansuensis Extract Based on UHPLC-Orbitrap-MS Technique
In this study, an ultra-high performance liquid chromatography method coupled with Orbitrap mass spectrometry (UHPLC-Orbitrap-MS) technology was applied to detect and identify prototype components and metabolites in rat intestinal contents and serum samples after oral administration of a B. kansuensis extract. A total of 16 prototype components and 40 metabolites were identified. The primary metabolic pathways of the chemical components from B. kansuensis extract were demethylation, desaturation, deglycosylation, reduction, hydroxylation, and other conjugation reactions including sulfation, glucuronidation,
glycosidat...
Source: Planta Medica - September 14, 2021 Category: Drugs & Pharmacology Authors: Du, Huan Xu, Tong Yi, Huan Xu, Xinmei Zhao, Chengcheng Ge, Yiman Zhang, Chuantao Fan, Gang Tags: Original Papers Source Type: research
Seven-day Oral Intake of Orthosiphon stamineus Leaves Infusion Exerts Antiadhesive Ex Vivo Activity Against Uropathogenic E. coli in Urine Samples
Planta Med DOI: 10.1055/a-1585-6322
Orthosiphon stamineus leaves (Java tea) extract is traditionally used for the treatment of urinary tract infections. According to recent in vitro data, animal infection studies, and transcriptomic investigations, polymethoxylated flavones from Java tea exert antiadhesive activity against uropathogenic Escherichia coli (UPEC). This antiadhesive activity has been shown to reduce bladder and kidney lesion in a mice infection model. As no data on the antivirulent activity of Java tea intake on humans are available, a biomedical study was performed on 20 healthy volunteers who self-admin...
Source: Planta Medica - September 14, 2021 Category: Drugs & Pharmacology Authors: Deipenbrock, Melanie Scotti, Francesca Mo, Boris Heinrich, Michael Hensel, Andreas Tags: Original Papers Source Type: research
Herbal Medicines in the Treatment of Dyspepsia: An Overview
Planta Med DOI: 10.1055/a-1580-7782This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included al...
Source: Planta Medica - September 2, 2021 Category: Drugs & Pharmacology Authors: Boeing, Thaise de Souza, Priscila da Silva, Luisa Mota Gasparotto Junior, Arquimedes Tags: Reviews Source Type: research
An in-depth look into a well-known herbal drug: Fingerprinting, isolation, identification, and content estimation of saponins in different Strophanthus seeds
Planta Med DOI: 10.1055/a-1586-1915Seeds of Strophanthus species are known as a source of rapid-acting cardenolides. These water-soluble glycosides are listed as the sole critical constituents of this raw herbal drug. A non-standard cardioprotective medication with ouabain-containing oral remedies has become popular in Europe as a result of the withdrawal of corresponding registered drugs from the market. However, the bioequivalence of pure ouabain solutions, tinctures, and home-made extracts from Strophanthus seeds is unknown. Thus, this study aimed to update the information on the composition of Strophanthus seeds used f...
Source: Planta Medica - September 2, 2021 Category: Drugs & Pharmacology Authors: W łodarczyk, Maciej Gle ńsk, Michał Tags: Original Papers Source Type: research
Flavanols and Flavanes from Crinum asiaticum and Their Effects on LPS Signaling Pathway Through the Inhibition of NF- κB Activation
Planta Med DOI: 10.1055/a-1585-5877Three new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1), (2R,3S)-7-hydroxy-flavan-3-ol (2), and (2R,3S)-2′-hydroxy-7-methoxy-flavan-3-ol (3), together with two known flavans (4 and 5), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1 and 3−5 showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF-κB pathway mechanisms indicated that 1 and 3−5 inhibited the LPS-induced IL-6 produc...
Source: Planta Medica - September 2, 2021 Category: Drugs & Pharmacology Authors: Do, Kiep Minh Shin, Min-Kyoung Kodama, Takeshi Win, Nwet Nwet Prema, Prema Nguyen, Hien Minh Hayakawa, Yoshihiro Morita, Hiroyuki Tags: Original Papers Source Type: research
Development and Validation of an HPLC Method for the Analysis of Flowers of Wild-Growing Primula veris from Epirus, Greece
Planta Med DOI: 10.1055/a-1578-8731An HPLC-PDA method was developed for the determination of the flavonoids in the flowers of Primula veris from Epirus, Greece. The aim was to investigate the chemical content of the over-harvested P. veris populations of Epirus and to develop and optimize an extraction protocol to allow fast, exhaustive, and repeatable extraction. Qualitative analysis revealed that the P. veris flowers from Epirus were particularly rich in flavonoids, especially flavonol triglycosides including derivatives of quercetin, isorhamnetin, and kaempferol. A phytochemical investigation of a 70% hydromethanolic ex...
Source: Planta Medica - September 2, 2021 Category: Drugs & Pharmacology Authors: Chintiroglou, Panagiota-Iro Krigas, Nikos Chatzopoulou, Paschalina Karioti, Anastasia Tags: Original Papers Source Type: research
