The treatment of aggressive prolactinomas with everolimus
ConclusionEverolimus is an active agent in the treatment of prolactinomas that warrants further investigation. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research
Dabrafenib as a diagnostic and therapeutic strategy for the non-surgical management of papillary craniopharyngioma
ConclusionPatients with a suspected papillary craniopharyngioma can be challenged with dabrafenib as a potentially effective diagnostic and therapeutic strategy, given that rapid regression with dabrafenib is only observed in tumors harboring aBRAF V600 mutation. Further work is needed to explore the optimal regimen and dose of the targeted therapy. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research
The treatment of aggressive prolactinomas with everolimus
ConclusionEverolimus is an active agent in the treatment of prolactinomas that warrants further investigation. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research
Dabrafenib as a diagnostic and therapeutic strategy for the non-surgical management of papillary craniopharyngioma
ConclusionPatients with a suspected papillary craniopharyngioma can be challenged with dabrafenib as a potentially effective diagnostic and therapeutic strategy, given that rapid regression with dabrafenib is only observed in tumors harboring aBRAF V600 mutation. Further work is needed to explore the optimal regimen and dose of the targeted therapy. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research
Characteristics of inflammatory and infectious diseases of the pituitary gland in patients undergoing transsphenoidal surgery
ConclusionIn conclusion, correct preoperative diagnosis of IIPD remains challenging, as neither radiographic findings nor preoperative laboratory workup unequivocally identify these lesions. Surgical treatment facilitates decompression of supra- and parasellar structures. Furthermore, this low-morbidity procedure enables the identification of pathogens or inflammatory diseases requiring targeted medical treatment, which is crucial for these patients. Establishing a correct diagnosis through surgery and histopathological confirmation thus remains of utmost importance. (Source: Pituitary)
Source: Pituitary - June 30, 2023 Category: Endocrinology Source Type: research
Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis
ConclusionsThis systematic review and patient-level meta-analysis provides a robust prognostication of surgically treated NFPA. We reinforce current guidelines stating that GTR should be the standard of surgical resection. Postoperative radiotherapy is of considerable benefit, especially for patients with STR. Surgical approach does not significantly affect long-term prognosis.RegistrationPROSPERO CRD42022374034. (Source: Pituitary)
Source: Pituitary - June 30, 2023 Category: Endocrinology Source Type: research
Characteristics of inflammatory and infectious diseases of the pituitary gland in patients undergoing transsphenoidal surgery
ConclusionIn conclusion, correct preoperative diagnosis of IIPD remains challenging, as neither radiographic findings nor preoperative laboratory workup unequivocally identify these lesions. Surgical treatment facilitates decompression of supra- and parasellar structures. Furthermore, this low-morbidity procedure enables the identification of pathogens or inflammatory diseases requiring targeted medical treatment, which is crucial for these patients. Establishing a correct diagnosis through surgery and histopathological confirmation thus remains of utmost importance. (Source: Pituitary)
Source: Pituitary - June 30, 2023 Category: Endocrinology Source Type: research
Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis
ConclusionsThis systematic review and patient-level meta-analysis provides a robust prognostication of surgically treated NFPA. We reinforce current guidelines stating that GTR should be the standard of surgical resection. Postoperative radiotherapy is of considerable benefit, especially for patients with STR. Surgical approach does not significantly affect long-term prognosis.RegistrationPROSPERO CRD42022374034. (Source: Pituitary)
Source: Pituitary - June 30, 2023 Category: Endocrinology Source Type: research
Efficacy and safety of cavernous sinus medial wall resection in pituitary adenoma surgery: a systematic review and a single-arm meta-analysis
ConclusionThe cavernous sinus was ruled out, proving the MWCS excision is safe. Limiting population selection to Knosp 3A or lower enhanced GTR frequencies and lowered recurrence, according to subgroup analyses. This meta-analysis shows that MWCS resection can be a beneficial treatment option for pituitary tumors, when there is no macroscopic medial wall invasion and careful patient selection is done, especially for GH- and ACTH-producing tumors that can cause life-threatening metabolic changes. (Source: Pituitary)
Source: Pituitary - June 29, 2023 Category: Endocrinology Source Type: research
Refractory pituitary adenomas: preface
(Source: Pituitary)
Source: Pituitary - June 26, 2023 Category: Endocrinology Source Type: research
GHR disruption in mature adult mice alters xenobiotic metabolism gene expression in the liver
ConclusionThe present study shows for the first time the specific hepatic gene expression profile, cellular pathways, biological processes and molecular mechanisms that are driven by ablating GH action at a mature adult age in males and females. Importantly, these results and future studies on xenobiotic metabolism may help explain the lifespan extension seen in 6mGHRKO mice. (Source: Pituitary)
Source: Pituitary - June 23, 2023 Category: Endocrinology Source Type: research
An update on, and genetics of refractory adenomas of childhood
AbstractPituitary adenomas in childhood tend to be more frequently due to germline genetic changes and are often diagnosed at late stages due to delayed recognition by pediatricians and other caretakers who are not familiar with this rare disease in childhood. As a result, often, pediatric pituitary adenomas are aggressive or remain refractory to treatment. In this review, we discuss germline genetic defects that account for the most common pediatric pituitary adenomas that are refractory to treatment. We also discuss some somatic genetic events, such as chromosomal copy number changes that characterize some of the most ag...
Source: Pituitary - June 15, 2023 Category: Endocrinology Source Type: research
Refractory somatotroph adenomas
AbstractSomatotroph adenomas are usually controlled with standard therapy, which can include surgery, medical treatment and radiotherapy. Some tumors have a more aggressive behavior and are refractory to standard therapy. In this review, we summarize the phenotype of these tumors and the current options for their management. (Source: Pituitary)
Source: Pituitary - June 15, 2023 Category: Endocrinology Source Type: research
