Usefulness of a clinicopathological classification in predicting treatment-related outcomes and multimodal therapeutic approaches in pituitary adenoma patients: retrospective analysis on a Portuguese cohort of 129 patients from a tertiary pituitary center
ConclusionsThis clinicopathological classification appears to be a useful grading system to identify PAs that may be more refractory and more often require complex multimodal and multiple therapeutic approaches. Invasive PAs, especially grade 2b tumors, may be more likely to need complex treatment approach, including radiotherapy, and may display higher rates of active disease at last follow-up, despite receiving higher number of treatments. (Source: Pituitary)
Source: Pituitary - April 18, 2023 Category: Endocrinology Source Type: research
How to manage intolerance to dopamine agonist in patients with prolactinoma
ConclusionsDue to limited data, no guidelines have been developed for the management of intolerance in DA treatment. The most frequent management is to perform transsphenoidal surgery. Nevertheless, this manuscript provides data derived from published literature and expert opinion, suggesting new approaches to this clinical issue. (Source: Pituitary)
Source: Pituitary - April 7, 2023 Category: Endocrinology Source Type: research
Patient-reported outcomes in refractory hormone-producing pituitary adenomas: an unmet need
ConclusionThere is a scarcity of data on PROs in the subset of pituitary adenomas that is more difficult to treat, e.g., refractory and these patients are difficult to isolate from the total cohort. The patients' perspective on quality of life, therefore, remains largely unknown in refractory patients. Thus, PROs in refractory pituitary adenomas require adequate analysis using properly reported disease specific PROMs in large cohorts to enable appropriate interpretation for use in clinical practice. (Source: Pituitary)
Source: Pituitary - April 4, 2023 Category: Endocrinology Source Type: research
Machine learning models predict delayed hyponatremia post-transsphenoidal surgery using clinically available features
ConclusionsThe proposed machine learning models with pre- and post-resection features predicted DHN after the resection of PitNETs. (Source: Pituitary)
Source: Pituitary - March 30, 2023 Category: Endocrinology Source Type: research
Novel imaging techniques in refractory pituitary adenomas
AbstractAccurate localization of the site(s) of active disease is key to informing decision-making in the management of refractory pituitary adenomas when autonomous hormone secretion and/or continued tumor growth challenge conventional therapeutic approaches. In this context, the use of non-standard MR sequences, alternative post-acquisition image processing, or molecular (functional) imaging may provide valuable additional information to inform patient management. (Source: Pituitary)
Source: Pituitary - March 27, 2023 Category: Endocrinology Source Type: research
TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours
ConclusionTGFBR3L was selectively detected in half (52%) of gonadotroph NF-PitNETs. The association to LH β staining and plasma gonadotropins suggests that TGFBR3L may be involved in hormone production in gonadotroph NF-PitNETs. (Source: Pituitary)
Source: Pituitary - March 23, 2023 Category: Endocrinology Source Type: research
Letter to the editor regarding “Vascular anomalies in patients with growth hormone-secreting pituitary adenomas: illustrative case report and systematic review of the literature”
(Source: Pituitary)
Source: Pituitary - March 18, 2023 Category: Endocrinology Source Type: research
IGF-1 is positively associated with BMI in patients with acromegaly
ConclusionIn contrast to individuals without acromegaly, BMI is significantly and positively associated with IGF-1 in acromegaly across the weight spectrum. Future studies are needed to determine if obese patients with acromegaly experience more significant symptoms related to their disease, or if patients with a low BMI may require different diagnostic criteria. (Source: Pituitary)
Source: Pituitary - March 17, 2023 Category: Endocrinology Source Type: research
