Anterior-posterior diameter is a key driver of resectability and complications for pituitary adenomas with suprasellar extension in endoscopic transsphenoidal surgery
ConclusionsThis study is unique in its examination of endoscopic transsphenoidal surgical outcomes for pituitary adenomas with suprasellar extension. Our findings suggest that previously established grading systems based on lateral extension into the cavernous sinus lose their predictive value in lesions with suprasellar extension and, more specifically, with increasing suprasellar anterior-posterior diameter. (Source: Pituitary)
Source: Pituitary - September 15, 2023 Category: Endocrinology Source Type: research
Pituitary metastases: a case series and scoping review
ConclusionsThis scoping review showed that both radiosurgery and surgical resection have been frequently used to treat pituitary metastases with good response. Vision improvement is more likely to happen following surgical resection, likely at the expense of endocrine dysfunction. Despite treatment and radiographic response, patient survival remains less than a year. (Source: Pituitary)
Source: Pituitary - September 12, 2023 Category: Endocrinology Source Type: research
Clinico-radiological correlation of pituitary stalk interruption syndrome in children with growth hormone deficiency
ConclusionMale gender, breech presentation, external congenital anomalies like cryptorchidism, midline defects and nystagmus were more common in children with PSIS. MPHD were more frequently seen in PSIS whereas IGHD in non-PSIS cohort. AVP deficiency is very rare in PSIS despite of absent or ectopic posterior pituitary in MRI. High index of clinical suspicion in all severe short stature may lead to early diagnosis and prompt initiation of growth hormone treatment for better outcome. (Source: Pituitary)
Source: Pituitary - September 11, 2023 Category: Endocrinology Source Type: research
Care trajectories of surgically treated patients with a prolactinoma: why did they opt for surgery?
ConclusionCare trajectories were highly individualized based on patient and tumor characteristics, as well as the multidisciplinary team ’s assessment (need for alternative treatment, surgical chances and risks). Most patients were pretreated pharmacologically and had broad variation in timing of referral, undergoing surgery as last-resort treatment predominantly due to DA intolerance. High quality imaging and multidisciplinary con sultations with experienced neurosurgeons and endocrinologists enabling treatment tailored to patients’ needs were prerequisites for adequate counseling in treatment of patients with prolact...
Source: Pituitary - September 10, 2023 Category: Endocrinology Source Type: research
Pituitary Tumor Centers of Excellence (PTCOE) should now include neuro-oncologic input
(Source: Pituitary)
Source: Pituitary - September 7, 2023 Category: Endocrinology Source Type: research
Neuromedin B receptor as a potential therapeutic target for corticotroph adenomas
ConclusionNMBR antagonist represents a potential treatment for CD and its effect may be mediated by cyclin E suppression. (Source: Pituitary)
Source: Pituitary - August 29, 2023 Category: Endocrinology Source Type: research
Pilot study to define criteria for Pituitary Tumors Centers of Excellence (PTCOE): results of an audit of leading international centers
ConclusionThis is, to our knowledge, the first study to survey and evaluate the activity of a relevant number of high-volume centers in the pituitary field. This effort, internally validated by ad hoc reviewers, allowed for transformation of previously formulated theoretical criteria for the definition of a PTCOE to precise numerical definitions based on real-life evidence. The application of a derived synopsis of criteria could be used by independent bodies for accreditation of pituitary centers as PTCOEs. (Source: Pituitary)
Source: Pituitary - August 28, 2023 Category: Endocrinology Source Type: research
