Impact of the diagnostic delay of acromegaly on bone health: data from a real life and long term follow-up experience
ConclusionOur data showed that the diagnostic delay in acromegaly has a significant impact on VF risk, further supporting the clinical relevance of an early acromegaly diagnosis. (Source: Pituitary)
Source: Pituitary - August 3, 2022 Category: Endocrinology Source Type: research
Implementation of functional imaging using 11C-methionine PET-CT co-registered with MRI for advanced surgical planning and decision making in prolactinoma surgery
ConclusionMet-PET/MRICR can provide additional information to guide multidisciplinary preoperative and intraoperative decision making in selected cases of prolactinoma. This approach resulted in a high remission rate with a low rate of complications in our expert centre. (Source: Pituitary)
Source: Pituitary - August 1, 2022 Category: Endocrinology Source Type: research
Preoperative differentiation of hypophysitis and pituitary adenomas using a novel clinicoradiologic scoring system
ConclusionsThe proposed scoring system may aid preoperative diagnosis of hypophysitis, preventing unnecessary surgery in these patients. (Source: Pituitary)
Source: Pituitary - August 1, 2022 Category: Endocrinology Source Type: research
Treatment of non-functioning pituitary adenoma with cabergoline: a systematic review and meta-analysis
ConclusionsEffect of CBG to promote tumor shrinkage in NFPAs was low, while prevention of tumor progression after surgery was seen in half of the cases, with a low frequency of adverse events.Systematic review registrationPROSPERO CRD42020206778. (Source: Pituitary)
Source: Pituitary - July 28, 2022 Category: Endocrinology Source Type: research
Hypercoagulability in Cushing ’s syndrome: incidence, pathogenesis and need for thromboprophylaxis protocols
AbstractCushing's syndrome (CS) is associated with a hypercoagulable state resulting in an increased risk on venous thromboembolism (VTE). In patients with untreated active CS VTE incidence is up to 18-fold higher compared to the general population, whereas after pituitary and adrenal surgery a postoperative VTE risk between 2.6 and 5.6% has been reported. Interestingly, after surgery the VTE risk is not only increased in the first week but also during several months postoperatively. The hypercoagulable state in CS is thought to be caused, at least in part, by an imbalance between activity of pro- and anticoagulant pathway...
Source: Pituitary - July 26, 2022 Category: Endocrinology Source Type: research
Cushing ’s disease: role of bilateral adrenalectomy
ConclusionBAD is a safe and effective treatment of CD used in specific situations and requiring long term monitoring. (Source: Pituitary)
Source: Pituitary - July 26, 2022 Category: Endocrinology Source Type: research
Hypercoagulability in Cushing ’s syndrome: incidence, pathogenesis and need for thromboprophylaxis protocols
AbstractCushing's syndrome (CS) is associated with a hypercoagulable state resulting in an increased risk on venous thromboembolism (VTE). In patients with untreated active CS VTE incidence is up to 18-fold higher compared to the general population, whereas after pituitary and adrenal surgery a postoperative VTE risk between 2.6 and 5.6% has been reported. Interestingly, after surgery the VTE risk is not only increased in the first week but also during several months postoperatively. The hypercoagulable state in CS is thought to be caused, at least in part, by an imbalance between activity of pro- and anticoagulant pathway...
Source: Pituitary - July 26, 2022 Category: Endocrinology Source Type: research
Cushing ’s disease: role of bilateral adrenalectomy
ConclusionBAD is a safe and effective treatment of CD used in specific situations and requiring long term monitoring. (Source: Pituitary)
Source: Pituitary - July 26, 2022 Category: Endocrinology Source Type: research
Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis
ConclusionPatients with acromegaly are at increased risk of VFs, mainly because of deterioration in bone microarchitecture. (Source: Pituitary)
Source: Pituitary - July 22, 2022 Category: Endocrinology Source Type: research
Cardiovascular health and mortality in Cushing ’s disease
AbstractExposure to cortisol excess in Cushing ’s disease (CD) results in increased cardiovascular morbidity and reduces survival, with cardiovascular disease being a leading cause of death. At diagnosis, a significant number of patients have adverse cardiovascular profiles (e.g., obesity, diabetes or impaired glucose tolerance, dyslipidemia, hypertension, cardiac abnormalities and vascular disease). Remission of hypercortisolemia reduces but does not completely eliminate the cardiovascular complications; hazard ratios for myocardial infarction and stroke are high during long-term monitoring, highlighting the long-lastin...
Source: Pituitary - July 22, 2022 Category: Endocrinology Source Type: research
Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis
ConclusionPatients with acromegaly are at increased risk of VFs, mainly because of deterioration in bone microarchitecture. (Source: Pituitary)
Source: Pituitary - July 22, 2022 Category: Endocrinology Source Type: research
Cardiovascular health and mortality in Cushing ’s disease
AbstractExposure to cortisol excess in Cushing ’s disease (CD) results in increased cardiovascular morbidity and reduces survival, with cardiovascular disease being a leading cause of death. At diagnosis, a significant number of patients have adverse cardiovascular profiles (e.g., obesity, diabetes or impaired glucose tolerance, dyslipidemia, hypertension, cardiac abnormalities and vascular disease). Remission of hypercortisolemia reduces but does not completely eliminate the cardiovascular complications; hazard ratios for myocardial infarction and stroke are high during long-term monitoring, highlighting the long-lastin...
Source: Pituitary - July 22, 2022 Category: Endocrinology Source Type: research
Pituitary surgery in Cushing ’s disease: first line treatment and role of reoperation
AbstractCushing ’s disease is the most common cause of endogenous hypercortisolemia, and transsphenoidal surgery remains the first line therapy for removal of the ACTH-secreting adenoma. While post-operative remission rates are high in experienced hands, there remains a 2% risk of recurrence per year. Patients wi th the highest chance for cure are those with small, non-invasive tumors that are visible on pre-operative MRI and identified during surgery and are performed by high-volume pituitary neurosurgeons. Surgery for persistent or recurrent disease is frequently indicated and is most successful in the han ds of experi...
Source: Pituitary - July 20, 2022 Category: Endocrinology Source Type: research
