Delayed postoperative hyponatremia in patients with acromegaly: incidence and predictive factors
ConclusionThe findings suggested that lower preoperative weight and a postoperative transient gain in body weight are associated with an increased risk of DPH in acromegaly patients undergoing transsphenoidal surgery. (Source: Pituitary)
Source: Pituitary - November 2, 2022 Category: Endocrinology Source Type: research
Serum copeptin levels at day two after pituitary surgery and ratio to baseline predict postoperative central diabetes insipidus
ConclusionThe copeptin level at postoperative day 2 and its ratio to baseline can predict the occurrence of permanent central diabetes insipidus after pituitary surgery. (Source: Pituitary)
Source: Pituitary - November 2, 2022 Category: Endocrinology Source Type: research
Delayed postoperative hyponatremia in patients with acromegaly: incidence and predictive factors
ConclusionThe findings suggested that lower preoperative weight and a postoperative transient gain in body weight are associated with an increased risk of DPH in acromegaly patients undergoing transsphenoidal surgery. (Source: Pituitary)
Source: Pituitary - November 2, 2022 Category: Endocrinology Source Type: research
Serum copeptin levels at day two after pituitary surgery and ratio to baseline predict postoperative central diabetes insipidus
ConclusionThe copeptin level at postoperative day 2 and its ratio to baseline can predict the occurrence of permanent central diabetes insipidus after pituitary surgery. (Source: Pituitary)
Source: Pituitary - November 2, 2022 Category: Endocrinology Source Type: research
Development of a cost-effective diagnostic algorithm incorporating transcription factor immunohistochemistry in the evaluation of pituitary tumours
ConclusionA diagnostic algorithm omitting hormone IHC except in cases of PIT1 positivity is an accurate and cost-effective approach to diagnose the type of pituitary tumour. A significant subgroup of pituitary tumours with no distinct cell lineage, frequently plurihormonal, remains difficult to classify with the new WHO criteria and requires further evaluation. (Source: Pituitary)
Source: Pituitary - October 22, 2022 Category: Endocrinology Source Type: research
Impact of histopathological classification of non-functioning adenomas on long term outcomes: comparison of the 2004 and 2017 WHO classifications
ConclusionsThe majority of null cell adenomas diagnosed under the 2004 WHO classification system are reclassified as gonadotroph or corticotroph adenomas under the 2017 WHO classification system. Rates of progression and recurrence between subtypes are not as different as previously believed at our institution and require a larger cohort to further investigate. (Source: Pituitary)
Source: Pituitary - October 19, 2022 Category: Endocrinology Source Type: research
Idiopathic central diabetes insipidus in a large cohort of patients: the hypopituitarism ENEA rare observational (HEROS) study
AbstractCentral Diabetes Insipidus (CDI) is mainly associated with structural pathologies of the hypothalamic-pituitary area. Etiologies underlying CDI are identified in most patients, however idiopathic CDI is reported in 13 –17% of cases after excluding other etiologies. The Hypopituitarism ENEA Rare Observational Study (HEROS study) retrospectively collected data of patients with idiopathic CDI from 14 pituitary centers in 9 countries. The cohort included 92 patients (59 females 64%), mean age at diagnosis was 35.4 ± 20.7 years, and a mean follow up of 19.1 ± 13.5 years following CDI diagnosis. In 6 women...
Source: Pituitary - October 19, 2022 Category: Endocrinology Source Type: research
Impact of histopathological classification of non-functioning adenomas on long term outcomes: comparison of the 2004 and 2017 WHO classifications
ConclusionsThe majority of null cell adenomas diagnosed under the 2004 WHO classification system are reclassified as gonadotroph or corticotroph adenomas under the 2017 WHO classification system. Rates of progression and recurrence between subtypes are not as different as previously believed at our institution and require a larger cohort to further investigate. (Source: Pituitary)
Source: Pituitary - October 19, 2022 Category: Endocrinology Source Type: research
Idiopathic central diabetes insipidus in a large cohort of patients: the hypopituitarism ENEA rare observational (HEROS) study
AbstractCentral Diabetes Insipidus (CDI) is mainly associated with structural pathologies of the hypothalamic-pituitary area. Etiologies underlying CDI are identified in most patients, however idiopathic CDI is reported in 13 –17% of cases after excluding other etiologies. The Hypopituitarism ENEA Rare Observational Study (HEROS study) retrospectively collected data of patients with idiopathic CDI from 14 pituitary centers in 9 countries. The cohort included 92 patients (59 females 64%), mean age at diagnosis was 35.4 ± 20.7 years, and a mean follow up of 19.1 ± 13.5 years following CDI diagnosis. In 6 women...
Source: Pituitary - October 19, 2022 Category: Endocrinology Source Type: research
Long-term hepatic and cardiac health in patients diagnosed with Sheehan ’s syndrome
ConclusionNAFLD, especially severe hepatic steatosis, is highly prevalent in SS. Subclinical cardiac systolic dysfunction (impaired GLS) is also more common, but of mild intensity. (Source: Pituitary)
Source: Pituitary - October 15, 2022 Category: Endocrinology Source Type: research
Long-term efficacy and safety of osilodrostat in Cushing ’s disease: final results from a Phase II study with an optional extension phase (LINC 2)
ConclusionsIn the longest prospective study of a steroidogenesis inhibitor to date, osilodrostat provided sustained reductions in mUFC for up to 6.7 years of treatment, with no new safety signals emerging during the extension. These findings support osilodrostat as an effective long-term treatment for patients with CD. (Source: Pituitary)
Source: Pituitary - October 11, 2022 Category: Endocrinology Source Type: research
