Cushing ’s disease: adrenal steroidogenesis inhibitors
AbstractCushing ’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of Cushing’s syndrome (CS), accounting for approximately 70% of cases. CD requires a prompt diagnosis, an adequate treatment selection, and long-term management to limit hypercorti solism duration and long-term complications and improve patient outcomes. Pituitary surgery is the first-line option, which is non-curative in one third of patients, therefore requiring additional treatments. Medical therapy has recently acquired an emerging role, with the availability of several d rugs with di...
Source: Pituitary - August 29, 2022 Category: Endocrinology Source Type: research
Predicting hypogonadotropic hypogonadism persistence in male macroprolactinoma
ConclusionIn our cohort of men with macroprolactinoma that reached prolactin normalization with cabergoline treatment, 21% had HH persistence. Pituitary hormone deficiency, visual field defects, and low baseline testosterone levels were independently associated with HH persistence. 91% of men achieved eugonadism within the first year following prolactin normalization. These findings may support informed clinical decision-making regarding the initiation of testosterone replacement in men with macroprolactinomas. (Source: Pituitary)
Source: Pituitary - August 29, 2022 Category: Endocrinology Source Type: research
Cushing ’s disease: adrenal steroidogenesis inhibitors
AbstractCushing ’s disease (CD), caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor, is the most common form of Cushing’s syndrome (CS), accounting for approximately 70% of cases. CD requires a prompt diagnosis, an adequate treatment selection, and long-term management to limit hypercorti solism duration and long-term complications and improve patient outcomes. Pituitary surgery is the first-line option, which is non-curative in one third of patients, therefore requiring additional treatments. Medical therapy has recently acquired an emerging role, with the availability of several d rugs with di...
Source: Pituitary - August 29, 2022 Category: Endocrinology Source Type: research
Cost-effectiveness of direct surgery versus preoperative octreotide therapy for growth-hormone secreting pituitary adenomas
ConclusionsUsing standard benchmarks for cost-effectiveness in the US ($100,000/QALY), preoperative octreotide therapy followed by surgery may not be cost-effective compared to direct surgery for patients with growth-hormone secreting pituitary adenomas but the result is highly sensitive to initial treatment failure and duration of preoperative treatment. (Source: Pituitary)
Source: Pituitary - August 27, 2022 Category: Endocrinology Source Type: research
Treatment of Cushing ’s syndrome with osilodrostat: practical applications of recent studies with case examples
AbstractEndogenous Cushing ’s syndrome (CS) is a rare endocrine condition frequently caused by a tumor resulting in elevated cortisol levels. Cushing’s disease (CD) caused by an adrenocorticotropic hormone–secreting pituitary adenoma is the most common form of endogenous CS. Medical therapy for CD is mostly used as seco nd-line treatment after failed surgery or recurrence and comprises several pituitary-directed drugs, adrenal steroidogenesis inhibitors, and a glucocorticoid receptor blocker, some of which are US Food and Drug Administration (FDA)–approved for this condition. The recent Pituitary Society consensu s...
Source: Pituitary - August 24, 2022 Category: Endocrinology Source Type: research
Special issue: Cushing's disease update
(Source: Pituitary)
Source: Pituitary - August 24, 2022 Category: Endocrinology Source Type: research
Treatment of Cushing ’s syndrome with osilodrostat: practical applications of recent studies with case examples
AbstractEndogenous Cushing ’s syndrome (CS) is a rare endocrine condition frequently caused by a tumor resulting in elevated cortisol levels. Cushing’s disease (CD) caused by an adrenocorticotropic hormone–secreting pituitary adenoma is the most common form of endogenous CS. Medical therapy for CD is mostly used as seco nd-line treatment after failed surgery or recurrence and comprises several pituitary-directed drugs, adrenal steroidogenesis inhibitors, and a glucocorticoid receptor blocker, some of which are US Food and Drug Administration (FDA)–approved for this condition. The recent Pituitary Society consensu s...
Source: Pituitary - August 24, 2022 Category: Endocrinology Source Type: research
Special issue: Cushing's disease update
(Source: Pituitary)
Source: Pituitary - August 24, 2022 Category: Endocrinology Source Type: research
Demonstration of the inferior intercavernous sinus is closely linked to the extent of pneumatization of the sphenoid sinus: useful information for the pituitary surgeon
ConclusionsThe IICS can be identified on coronal T2W images in patients with an incompletely pneumatized sphenoid sinus, but very rarely in patients with a totally pneumatized sinus. This information can help to increase awareness among pituitary surgeons of the need to potentially manage IICS bleeding during transsphenoidal surgery in patients with an incompletely pneumatized sphenoid sinus. (Source: Pituitary)
Source: Pituitary - August 20, 2022 Category: Endocrinology Source Type: research
Influence of growth hormone therapy on germinoma survivors
ConclusionsGHT did not increase the risks of tumor recurrence and development with SN in pure germinoma survivors. (Source: Pituitary)
Source: Pituitary - August 20, 2022 Category: Endocrinology Source Type: research
Demonstration of the inferior intercavernous sinus is closely linked to the extent of pneumatization of the sphenoid sinus: useful information for the pituitary surgeon
ConclusionsThe IICS can be identified on coronal T2W images in patients with an incompletely pneumatized sphenoid sinus, but very rarely in patients with a totally pneumatized sinus. This information can help to increase awareness among pituitary surgeons of the need to potentially manage IICS bleeding during transsphenoidal surgery in patients with an incompletely pneumatized sphenoid sinus. (Source: Pituitary)
Source: Pituitary - August 20, 2022 Category: Endocrinology Source Type: research
Influence of growth hormone therapy on germinoma survivors
ConclusionsGHT did not increase the risks of tumor recurrence and development with SN in pure germinoma survivors. (Source: Pituitary)
Source: Pituitary - August 20, 2022 Category: Endocrinology Source Type: research
Generating novel pituitary datasets from open-source imaging data and deep volumetric segmentation
ConclusionsWe present the first and largest dataset of pituitary imaging constructed using existing MRI data and deep volumetric segmentation models trained to identify sellar and parasellar anatomy. The model generalizes well across patient populations and MRI scanner types. We hope our pituitary dataset will be an integral part of future machine learning research on pituitary pathologies. (Source: Pituitary)
Source: Pituitary - August 9, 2022 Category: Endocrinology Source Type: research
