The efficacy of a visiting surgical service versus that of a hospital-based surgical service in providing endoscopic endonasal surgery to remove nonfunctioning pituitary adenomas in rural communities
ConclusionPituitary surgeries performed via the mobile EEA system for nonfunctioning PAs may help maintain local community healthcare. Furthermore, this system can also contribute to the efficient training of surgeons by the same experienced pituitary surgeon using the same protocol. (Source: Pituitary)
Source: Pituitary - July 21, 2023 Category: Endocrinology Source Type: research

Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations
ConclusionHypopituitarism, radiation therapy after TSS, and financial stressors are associated with more impaired QoL in patients with NFPMA. Awareness of these factors can better guide use and timing of radiation therapy in addition to identifying patients who can benefit from multidisciplinary surveillance. (Source: Pituitary)
Source: Pituitary - July 21, 2023 Category: Endocrinology Source Type: research

The efficacy of a visiting surgical service versus that of a hospital-based surgical service in providing endoscopic endonasal surgery to remove nonfunctioning pituitary adenomas in rural communities
ConclusionPituitary surgeries performed via the mobile EEA system for nonfunctioning PAs may help maintain local community healthcare. Furthermore, this system can also contribute to the efficient training of surgeons by the same experienced pituitary surgeon using the same protocol. (Source: Pituitary)
Source: Pituitary - July 21, 2023 Category: Endocrinology Source Type: research

Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations
ConclusionHypopituitarism, radiation therapy after TSS, and financial stressors are associated with more impaired QoL in patients with NFPMA. Awareness of these factors can better guide use and timing of radiation therapy in addition to identifying patients who can benefit from multidisciplinary surveillance. (Source: Pituitary)
Source: Pituitary - July 21, 2023 Category: Endocrinology Source Type: research

Risk of impulse control disorders in patients with Cushing ’s disease: do not blame cabergoline but do not give up caution
ConclusionCBG-treated patients with CD appeared to have a low risk of ICDs, suggesting that CBG still holds promise as a safe agent in CD. (Source: Pituitary)
Source: Pituitary - July 20, 2023 Category: Endocrinology Source Type: research

Sporadic pituitary adenoma with somatic double-hit loss of MEN1
ConclusionTo our knowledge, this is the first case of pituitary adenoma to arise from somatic loss ofMEN1 and in the absence of an underlying germlineMEN1 mutation. (Source: Pituitary)
Source: Pituitary - July 13, 2023 Category: Endocrinology Source Type: research

The treatment of aggressive prolactinomas with everolimus
ConclusionEverolimus is an active agent in the treatment of prolactinomas that warrants further investigation. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research

Dabrafenib as a diagnostic and therapeutic strategy for the non-surgical management of papillary craniopharyngioma
ConclusionPatients with a suspected papillary craniopharyngioma can be challenged with dabrafenib as a potentially effective diagnostic and therapeutic strategy, given that rapid regression with dabrafenib is only observed in tumors harboring aBRAF V600 mutation. Further work is needed to explore the optimal regimen and dose of the targeted therapy. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research

The treatment of aggressive prolactinomas with everolimus
ConclusionEverolimus is an active agent in the treatment of prolactinomas that warrants further investigation. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research

Dabrafenib as a diagnostic and therapeutic strategy for the non-surgical management of papillary craniopharyngioma
ConclusionPatients with a suspected papillary craniopharyngioma can be challenged with dabrafenib as a potentially effective diagnostic and therapeutic strategy, given that rapid regression with dabrafenib is only observed in tumors harboring aBRAF V600 mutation. Further work is needed to explore the optimal regimen and dose of the targeted therapy. (Source: Pituitary)
Source: Pituitary - July 10, 2023 Category: Endocrinology Source Type: research

Characteristics of inflammatory and infectious diseases of the pituitary gland in patients undergoing transsphenoidal surgery
ConclusionIn conclusion, correct preoperative diagnosis of IIPD remains challenging, as neither radiographic findings nor preoperative laboratory workup unequivocally identify these lesions. Surgical treatment facilitates decompression of supra- and parasellar structures. Furthermore, this low-morbidity procedure enables the identification of pathogens or inflammatory diseases requiring targeted medical treatment, which is crucial for these patients. Establishing a correct diagnosis through surgery and histopathological confirmation thus remains of utmost importance. (Source: Pituitary)
Source: Pituitary - June 30, 2023 Category: Endocrinology Source Type: research

Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis
ConclusionsThis systematic review and patient-level meta-analysis provides a robust prognostication of surgically treated NFPA. We reinforce current guidelines stating that GTR should be the standard of surgical resection. Postoperative radiotherapy is of considerable benefit, especially for patients with STR. Surgical approach does not significantly affect long-term prognosis.RegistrationPROSPERO CRD42022374034. (Source: Pituitary)
Source: Pituitary - June 30, 2023 Category: Endocrinology Source Type: research