Proportion and predictors of Hypogonadism Recovery in Men with Macroprolactinomas treated with dopamine agonists
ConclusionsAbout two-thirds of men with macroprolactinoma recover from hypogonadism, mostly with 24 months of therapy. Smaller adenoma size, lower prolactin level, earlier prolactin normalization, and higher testosterone patients were related to testosterone normalization. (Source: Pituitary)
Source: Pituitary - July 6, 2022 Category: Endocrinology Source Type: research
Prolactin immunoassay: does the high-dose hook effect still exist?
ConclusionThe high-dose hook effect still exists in a very small minority of prolactin assays. The evolution of assay methods may lead to new assays that remain sensitive to this effect in the future. We therefore advise that the hook effect should still be mentioned in prolactin assay recommendations. (Source: Pituitary)
Source: Pituitary - July 6, 2022 Category: Endocrinology Source Type: research
Lateral orientation of Rathke cleft cysts may be associated with high rates of recurrence after surgery
AbstractRathke cleft cysts (RCC) arise from the remnants of Rathke ’s pouch, a structure that is midline in the pituitary. Therefore, an off-midline location on imaging is a finding that is often used to distinguish Rathke cleft cysts from pituitary adenomas, with RCCs being more commonly in the midline than in a purely lateral position. Given the rarity of these laterally oriented RCCs, the incidence and behavior of RCCs that are purely lateral have not been described in current literature. Retrospective investigation was performed through review of patient records of 122 patients who underwent surgical resection for RC...
Source: Pituitary - July 4, 2022 Category: Endocrinology Source Type: research
Cushing ’s disease: role of preoperative and primary medical therapy
AbstractTranssphenoidal surgery is the first-line treatment for Cushing ’s disease. However, some situations may require the use of a primary medical treatment, such as in patients with severe life-threatening hypercortisolism, a situation which can be handled by fast-acting steroidogenesis inhibitors, instead of classical bilateral adrenalectomy. Primary medical trea tment could also be considered in patients with non-severe hypercortisolism, but the evidence is far less convincing for its systematic use. The aim of this short review is to explain briefly the different circumstances in which primary medical therapy coul...
Source: Pituitary - July 2, 2022 Category: Endocrinology Source Type: research
