An update on, and genetics of refractory adenomas of childhood
AbstractPituitary adenomas in childhood tend to be more frequently due to germline genetic changes and are often diagnosed at late stages due to delayed recognition by pediatricians and other caretakers who are not familiar with this rare disease in childhood. As a result, often, pediatric pituitary adenomas are aggressive or remain refractory to treatment. In this review, we discuss germline genetic defects that account for the most common pediatric pituitary adenomas that are refractory to treatment. We also discuss some somatic genetic events, such as chromosomal copy number changes that characterize some of the most ag...
Source: Pituitary - June 15, 2023 Category: Endocrinology Source Type: research
Refractory somatotroph adenomas
AbstractSomatotroph adenomas are usually controlled with standard therapy, which can include surgery, medical treatment and radiotherapy. Some tumors have a more aggressive behavior and are refractory to standard therapy. In this review, we summarize the phenotype of these tumors and the current options for their management. (Source: Pituitary)
Source: Pituitary - June 15, 2023 Category: Endocrinology Source Type: research
The acromegaly treatment satisfaction questionnaire (Acro-TSQ): turkish adaptation, validity, and reliability study
ConclusionThe Acro-TSQ, a patient-reported outcome tool, shows good internal consistency, and good reliability, suggesting it is an appropriate assessment tool for patients with acromegaly in the Turkish population. (Source: Pituitary)
Source: Pituitary - June 9, 2023 Category: Endocrinology Source Type: research
[68 Ga]-DOTATATE PET/MR-based evaluation of physiologic somatostatin receptor 2 expression in the adult pituitary gland as a function of age and sex in a prospective cohort
ConclusionThis study provides an empiric profiling of the physiological [68 Ga]-DOTATATE avidity of the pituitary gland. The findings suggest that SUV may vary by age and sex and can help guide the use of [68 Ga]-DOTATATE PET/MRI in clinical and research settings. Future studies can build on these findings to investigate further the relationship between pituitary biology and demographic factors. (Source: Pituitary)
Source: Pituitary - June 7, 2023 Category: Endocrinology Source Type: research
Neuropathic foot ulcers in the tallest patients with acromegalic gigantism: a common and significant problem. Historical overview
ConclusionsNeuropathic foot ulcers leading to hospital admissions and surgical and medical interventions were reported in 6 patients with acromegalic gigantism. These ulcers significantly impaired the daily activities of these individuals. Neuropathies of the sural nerve in patients with acromegalic gigantism can lead to hypoesthesia and hypoalgesia of the lower legs and feet. Potential contributing factors for the development of neuropathic ulcers of the feet in patients with acromegalic gigantism and neuropathy might be leg and foot deformities, muscle weakness and poor quality footwear. Diabetes mellitus, or impaired gl...
Source: Pituitary - June 4, 2023 Category: Endocrinology Source Type: research
Refractory pituitary adenomas: preface
(Source: Pituitary)
Source: Pituitary - June 1, 2023 Category: Endocrinology Source Type: research
Sleep quality in patients with non-functioning pituitary adenoma: impact of replacement therapies with an emphasis on the time of hydrocortisone
ConclusionOur study indicated the presence of depression, and a free T4 level in the upper half of the normal range have an impact on the sleep quality of patients with NFPA. The time of hydrocortisone replacement might be important factor for improved sleep quality in patients with secondary adrenal insufficiency. (Source: Pituitary)
Source: Pituitary - June 1, 2023 Category: Endocrinology Source Type: research
Importance of 24 h ambulatory blood pressure monitoring in patients with acromegaly and correlation with cardiac magnetic resonance findings
ConclusionsWe observed, that 24 h-ABPM in acromegaly allows the diagnosis of AH in some patients with normal BP in OBP and also to allow a better treatment. 24 h-ABPM shows a better correlation with VM by CMR. (Source: Pituitary)
Source: Pituitary - May 29, 2023 Category: Endocrinology Source Type: research
Clinical and imaging findings for the evaluation of large Rathke ’s cleft cysts and cystic craniopharyngiomas
ConclusionsLRCCs can be differentiated from CCPs based on their clinical and imaging findings, especially their specific anatomical growth patterns. We suggest using the pretreatment diagnosis to select the appropriate surgical approach and thus improve the clinical outcome.Keywords: Rathke ’s cleft cyst, craniopharyngioma, sellar mass, magnetic resonance imaging. (Source: Pituitary)
Source: Pituitary - May 25, 2023 Category: Endocrinology Source Type: research
