GHR disruption in mature adult mice alters xenobiotic metabolism gene expression in the liver

ConclusionThe present study shows for the first time the specific hepatic gene expression profile, cellular pathways, biological processes and molecular mechanisms that are driven by ablating GH action at a mature adult age in males and females. Importantly, these results and future studies on xenobiotic metabolism may help explain the lifespan extension seen in 6mGHRKO mice.
Source: Pituitary - Category: Endocrinology Source Type: research