High-Risk Histopathologic Features of Retinoblastoma Treated at a Tertiary Hospital in West Java, Indonesia
Conclusion: The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged #x3e;2 years old.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - July 20, 2021 Category: Opthalmology Source Type: research
Vitrectomy-Assisted Biopsy: An in vitro Study on the Impact of Cut Rate and Probe Size
Conclusions: The higher the cut rate, the larger is the amount of aspirated cellular material. There were no significant differences between 23-gauge and 25-gauge biopsies. Cut rates up to 6,000 cpm did not adversely affect the cytohistological features of the samples.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - July 8, 2021 Category: Opthalmology Source Type: research
Germ Line < b > < i > BAP1 < /i > < /b > Mutation in Patients with Uveal Melanoma and Renal Cell Carcinoma
Uveal melanoma (UM) and renal cell carcinoma (RCC) can occur sporadically and as a manifestation ofBAP1 tumor predisposition syndrome. We aimed to understand the prevalence of germ lineBAP1 pathogenic variants in patients with UM and RCC. We reviewed patients managed at Cleveland Clinic between November 2003 and November 2019 who were diagnosed with UM and RCC. Charts were reviewed for demographic and cancer-related characteristics. RCC samples were tested forBAP1 protein expression using immunohistochemical (IHC) staining, and testing for germ lineBAP1 pathogenic variants was performed as part of routine clinical care. Th...
Source: Ocular Oncology and Pathology - June 30, 2021 Category: Opthalmology Source Type: research
What ’s in a Name? Large Choroidal Nevus, Small Choroidal Melanoma, or Indeterminate Melanocytic Tumor
Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 7, 2021 Category: Opthalmology Source Type: research
Peripapillary Neuroendocrine Carcinoma Metastasis: A Novel Approach to Treatment
We present a patient with large-cell neuroendocrine carcinoma with metastasis to the peripapillary retina who was treated with intravitreal topotecan and with intravitreal aflibercept. Serial fundus photos, ultrasound, and optical coherence tomography demonstrated a reduction in size of the lesion and a decrease in subretinal fluid with intravitreal topotecan and aflibercept. In addition, visual acuity was stabilized during treatment. Intravitreal chemotherapy for intraocular metastases in vision-sensitive areas such as the peripapillary retina may be a viable alternative for patients who seek to preserve their vision and ...
Source: Ocular Oncology and Pathology - June 2, 2021 Category: Opthalmology Source Type: research
Novel Guarded Needle Trans-Scleral Biopsy for Uveal Melanoma: A Pilot Study
Conclusion: This novel trans-scleral biopsy technique appears to be safe and effective when obtaining UM tissue for GEP. This method may provide a more controlled biopsy depth thereby minimizing the risk of tumor perforation and its associated complications while still obtaining adequate biopsy yield.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 2, 2021 Category: Opthalmology Source Type: research
Optical Coherence Tomography Angiography Microvascular Variations in Pre- and Posttreatment of Retinoblastoma Tumors
Conclusions: OCTA may offer a noninvasive and sensitive technique to evaluate the vasculature of both the tumor and the surrounding retina in retinoblastoma. With additional research and development into its use in patients with retinoblastoma, OCTA may one day be useful in assessing treatment response and residual tumor activity.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 2, 2021 Category: Opthalmology Source Type: research
Iris Melanoma in a Patient with Retinitis Pigmentosa
This report describes the histopathological findings of an iris melanoma that developed in a patient with retinitis pigmentosa (RP). A 66-year-old man was referred to our hospital with a diagnosis of iris tumor. He had a medical history of RP for over 25 years. His best corrected visual acuity at presentation was 20/20 (OD) and 20/200 (OS). Slit lamp examination revealed an iris melanocytoma in his right eye and a brown iris mass involving the pupil in his left eye. Ocular fundus examination of his right eye showed diffuse chorioretinal atrophy with attenuated retinal vessels and scattered pigment. A diagnosis of iris mela...
Source: Ocular Oncology and Pathology - May 27, 2021 Category: Opthalmology Source Type: research
Recurrence of Primary Breast Lymphoma Presenting as Bilateral Vitreoretinal Lymphoma
Conclusion: Relapsed PBL can present as bilateral VRL.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - May 19, 2021 Category: Opthalmology Source Type: research
Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy
Conclusions and Relevance: Potentially actionable ER expression is present in greater than half of UM cases by IHC. Gene expression ofESR1 andESR2 was elevated in a subset of UM tumors with poor prognostic features. These data provide a rationale to evaluate ER as a potential target for therapy in UM.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - May 7, 2021 Category: Opthalmology Source Type: research
Decreased Retinal Sensitivity Overlying Choroidal Nevi
Conclusion: Our results indicate that choroidal nevi may cause significant retinal sensitivity impairment, as shown by microperimetry, but preserved mfERG response indicates that the retinal function may be only partially impaired.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - May 6, 2021 Category: Opthalmology Source Type: research
Neoadjuvant Systemic Chemotherapy in Sebaceous Gland Carcinoma of the Eyelid: A Retrospective Study
There are sparse data on neoadjuvant systemic chemotherapy (NACT) in eyelid sebaceous gland carcinoma (SGC). The aim of this study was to evaluate efficacy and outcomes with NACT in eyelid SGC. We retrospectively analyzed 8 patients who received platinum-based NACT. The median number of cycles per patient was 4 (range, 3 –5). The mean percentage reduction of tumor diameter after NACT was 71% (range, 30–100%). Two patients had a radiological complete response (CR). After NACT, surgical treatment for residual tumor was performed in 5 cases. One patient had a pathological CR and is recurrence free for 11 years. Aft er a m...
Source: Ocular Oncology and Pathology - May 5, 2021 Category: Opthalmology Source Type: research
Choroidal Melanoma with Ultrasound-Guided Episcleral Brachytherapy: Long-Term Results and Risk of Metastasis
Conclusion: Ultrasound-guided episcleral brachytherapy with 125-I seeds yielded excellent local control for choroidal melanoma, with low complication rates and 90% eye preservation. Given the association between tumour stage and liver metastases, which remain the main cause of death, stricter control should be employed for T3 –T4 tumours for the early detection and treatment of relapses.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - May 5, 2021 Category: Opthalmology Source Type: research
Is Uveal Melanoma a Hormonally Sensitive Cancer? A Review of the Impact of Sex Hormones and Pregnancy on Uveal Melanoma
Background: Despite a higher incidence and worse prognosis of uveal melanoma (UM) in men, there have been many case reports of pregnant patients with aggressive UM. This has led researchers to explore the influence of sex hormones and pregnancy on the development and progression of UM and hormones as potential therapeutic targets.Summary: A systematic literature review was conducted. More work is needed to elucidate the basis of sex differences in UM incidence and survival. The evaluation of germlineBAP1 mutation would be beneficial in patients with UM presenting at a young age. Importantly, multiple studies reported no si...
Source: Ocular Oncology and Pathology - April 22, 2021 Category: Opthalmology Source Type: research
Successful Treatment of Late Isolated Bone Metastasis in a Patient with Bilateral Retinoblastoma Using an Unconventional Method
We report a case of bilateral RB in a 7-month-old baby who was treated with chemotherapy, transpupillary thermotherapy, and periocular carboplatin for both eyes following which there was complete regression of tumour. Six and a half years after treatment, the child presented with metastatic recurrence of tumour in the left ulna. He was treated successfully with chemotherapy, extracorporeal radiation and reimplantation therapy. A less aggressive treatment approach for isolated bone relapse may be considered in selected cases.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 14, 2021 Category: Opthalmology Source Type: research
