Contents Vol. 7, 2021
Ocul Oncol Pathol 2021;7:I –VI (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - December 17, 2021 Category: Opthalmology Source Type: research

Acknowledgment to Reviewers
Ocul Oncol Pathol 2021;7:449 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - December 17, 2021 Category: Opthalmology Source Type: research

Impact of educational nursing intervention on compression therapy adherence and recurrence of venous leg ulcers: a quasi-experimental study
This study is conducted in one of Egypt's largest teaching hospitals associated with Menoufia University. A 20-month study included 80 adult patients with healed venous leg ulcers. Each participant is randomized to either a control (got regular leg ulcer information) or study (received educational interventions) group. The following tools are used in the study: bio-sociodemographic variables, knowledge evaluation, compression therapy adherence scale, and recurrence follow-up, after three, six, and twelve months of implementation. Furthermore, there is a statistically significant difference between the study groups during t...
Source: Ocular Oncology and Pathology - December 16, 2021 Category: Opthalmology Source Type: research

Combination of brachytherapy and intravitreal chemotherapy in the treatment of retinoblastoma with vitreous seeding
Conclusion: Rutheni um-106 plaque therapy in combination with intravitreal chemotherapy is an effective local therapy with good tumour control rates even in advanced eyes. Overall, the analysed therapeutic approach shows an acceptable side effect profile, especially when considering that EBRT and systemic polychemother apy, or at least the number of cycles needed, with their increased incidence of adverse events can thus be avoided. (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - November 30, 2021 Category: Opthalmology Source Type: research

Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review
We report a case of necrotic uveal melanoma presenting with orbital inflammation mimicking orbital cellulitis and present a comprehensive review of the literature and tabulation of reported cases.Summary: Our review found 44 published reports of spontaneously necrotic uveal melanoma involving 55 patients. Of these reports, 26 patients (47%) presented with orbital cellulitis. Presenting symptoms of necrotic uveal melanoma with orbital cellulitis included proptosis (82.8%), pain (80.7%), vision loss (61.5%), and restricted extraocular movements (46.2%).Key Messages: Uveal melanoma can rarely mimic orbital cellulitis. Autoinf...
Source: Ocular Oncology and Pathology - November 23, 2021 Category: Opthalmology Source Type: research

Single Time Frame Overview of the Genetic Changes in Conjunctival Melanoma from Intraepithelial Disease to Invasive Melanoma: A Study of 4 Exenteration Specimens Illustrating the Potential Role of Cyclin D1
Conclusion: CMILs harbour amplifications of CCND1 (3 cases), MDM2 (1 case), and loss of CDKN2A (1 case), which are also present when the lesion progresses to invasive melanoma, implicating these amplifications in the early pathogenesis of CMILs. This study represents the first attempt to capture the mutational landscape of all stages of conjunctival melanoma in a single tissue excision.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - November 17, 2021 Category: Opthalmology Source Type: research

Single time frame overview of the genetic changes in conjunctival melanoma from, intraepithelial disease to invasive melanoma. A study of 4 exenteration specimens illustrating the potential role of Cyclin D1.
Conclusion: Conjunctival melanocytic intraepithelial lesions harbour amplifications of CCND1 (3 cases), MDM2 (1 case) and loss of CDKN2A (1 case), which are also present when the lesion progresses to invasive melanoma, implicating these amplifications in the early pathogenesis of conjunctival melanocytic intraepithelial lesions. This study represents the first attempt to capture the mutational landscape of at all stages of conjunctival melanoma in a single tissue excision. (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - November 17, 2021 Category: Opthalmology Source Type: research

Clinical applications of OCTA in ocular oncology: pearls and pitfalls
Background: Optical Coherence Tomography Angiography (OCTA) is a valuable imaging tool for the diagnosis of several retinal and choroidal diseases. Its role in ocular oncology is clinically promising but still controversial. In this review we report the main applications and limits of the use of OCTA for the study of intraocular tumors. Summary: OCTA allows a rapid, safe, low-cost and high-resolution visualization of the retinal and choroidal vasculature. Attempts have been made to use this technology in ocular oncology to differentiate benign and malignant lesions and to assist physicians in the evaluation and monitor...
Source: Ocular Oncology and Pathology - November 17, 2021 Category: Opthalmology Source Type: research

BAP1 Immunostain Status in Intraocular Biopsy Specimens for Uveal Melanoma Highly Correlates with Other Prognostic Markers
Conclusion: BAP1 immunostaining in biopsies highly correlates with results in subsequent enucleations and with well-established UM prognostic markers, representing a potential additional prognostic tool for UM biopsies.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - November 15, 2021 Category: Opthalmology Source Type: research

Impact of adjuvant ocular interventions on the quality of life of patients with uveal melanoma after proton beam therapy
Conclusion Post-treatment adjuvant interventions had no long-lasting effects on QOL in patients with uveal melan oma. (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - November 8, 2021 Category: Opthalmology Source Type: research

Improved prognostic precision in uveal melanoma through a combined score of clinical stage and molecular prognostication
Conclusions: Clinical staging and molecular prognostication of UM can be discordant. There is important information provided by each system that is not provided by the other. The Total Risk Score provides a simple method to combine information from both the A JCC stage and the GEP class in order to provide patients and care teams with a more complete understanding of metastatic risk. (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - November 1, 2021 Category: Opthalmology Source Type: research

Clinicopathological Features of 19 Eyelid Pilomatrixomas
Conclusions: Eyelid pilomatrixoma is rarely suspected clinically, and can be mistaken for cyst, chalazion, sebaceous carcinoma and other tumors. Physicians should consider the possibility of pilomatrixoma in the eyelid area, especially in children or young female patients. Complete excision is curative, and diagnosis can generally be established by histopathological examination. (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 25, 2021 Category: Opthalmology Source Type: research

Two cases of angiosarcoma with persistent unilateral eyelid swelling
We present two such cases. Case 1 was an 82-year-old woman who presented with indulated swelling of the right eyelid that extended to the upper forehead. Biopsy revealed a poorly circumscribed tumor infiltrated throughout the dermis and fat tissue, exhibiting both angiomatous and solid patterns. Immunohistochemistry showed CD31 (-) and D2-40/podoplanin(+), suggesting angiosarcoma. The patient had multiple lung metastases and died 14 months later. Case 2 was a 77-year-old man who presented with swelling of the left eyelid and erythema on the left temporal skin developed ulcerated nodules. Biopsy showed proliferated tumor ce...
Source: Ocular Oncology and Pathology - October 21, 2021 Category: Opthalmology Source Type: research

Lacrimal Sac Tumors: A case series
(Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 18, 2021 Category: Opthalmology Source Type: research

Hemorrhagic mass-like presentation of vitreoretinal lymphoma
(Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 22, 2021 Category: Opthalmology Source Type: research