Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b
Conclusion: Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.Ocul Oncol Pathol 2018;4:298 –303 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 13, 2018 Category: Opthalmology Source Type: research
Long-Term Follow-Up of 4 Patients with Conjunctival Amyloidosis
Conjunctival amyloidosis is a rare cause of ocular inflammation, mass, and hemorrhage that can be difficult to diagnose and treat. In this case series, we describe 4 patients with a histopathological diagnosis of conjunctival amyloidosis treated at a single institution. All patients underwent surgical excision and biopsy. On histopathological examination, 3 patients had local deposition of either kappa or lambda monoclonal immunoglobulin light chains, favoring localized amyloid light-chain amyloidosis. Systemic workup to exclude rheumatologic disorders (e.g., anti-neutrophil cytoplasmic antibody and rheumatoid factors) and...
Source: Ocular Oncology and Pathology - February 13, 2018 Category: Opthalmology Source Type: research
The Patient's Experience of Ocular Melanoma in the US: A Survey of the Ocular Melanoma Foundation
Conclusions: This patients' perspective highlights directions for research, education, and other measures to improve the care of patients with ocular melanoma in the US and elsewhere.Ocul Oncol Pathol 2018;4:280-290 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 7, 2018 Category: Opthalmology Source Type: research
Ectopic Tubular Papillary Apocrine Adenoma on the Eyelid: A Case Report of Misleading Clinical Presentation and Location
We report the case of a 38-year-old patient with a tubular apocrine adenoma with papillary differentiation. The clinician was challenged in her diagnosis by the initially misleading appearance and ectopic location. Histopathological findings and immunohistochemistry delivered conclusive proof for the correct diagnosis. Therefore, it is important for the ophthalmologist to request histopathological analysis to diagnose and differentiate from malignancy. A complete local excision is recommended to prevent recurrence.Ocul Oncol Pathol 2018;4:267 –271 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 6, 2018 Category: Opthalmology Source Type: research
Giant Perivascular Epithelioid Cell Tumor of the Orbit: A Clinicopathological Analysis and Review of the Literature
Conclusions: PEComas are uncommon mesenchymal neoplasms that have typical histological features, with an immunohistochemical profile of negativity for epithelial markers and positivity for melanocytic markers. For benign PEComas, complete excision is advised. However, since PEComas elsewhere in the body have been known to be malignant, a close follow-up of such cases is recommended.Ocul Oncol Pathol 2018;4:272 –279 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 6, 2018 Category: Opthalmology Source Type: research
Eye-Sparing Treatment for Diffuse Invasive Conjunctival Melanoma
We describe a patient with diffuse invasive conjunctival melanoma and lymph node involvement treated by tumor debulking, brachytherapy (custom unshielded radioactive device), and adjuvant ipilimumab who has had a favorable outcome without emergence of local tumor relapse or distant metastasis during 16 months of follow up.Ocul Oncol Pathol 2018;4:261 –266 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 1, 2018 Category: Opthalmology Source Type: research
Liver Imaging Techniques: Recognition of Uveal Melanoma Metastases
Conclusions: New multiple enhancing solid liver lesions should raise suspicion of uveal melanoma liver metastases. Discussion of challenging cases with the radiologist may be beneficial, as pertinent information such as size, location, and molecular prognostication status of the primary tumor can guide radiological interpretation of hepatic lesions.Ocul Oncol Pathol 2018;4:254-260 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - January 18, 2018 Category: Opthalmology Source Type: research
A Tale of Absent Crystalline Lens in an Eye with Retinoblastoma
Conclusion: We report for the first time clinicopathologically proven absence of crystalline lens in an eye with retinoblastoma.Ocul Oncol Pathol 2018;4:250-253 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - January 18, 2018 Category: Opthalmology Source Type: research
Conjunctival Squamous Cell Carcinoma with Corneal Stromal Invasion in Presumed Pterygia: A Case Series
Conclusions: This series demonstrates the importance of maintaining clinical suspicion of conjunctival squamous neoplasia in pterygia. We recommend that all excised pterygia be submitted for histopathologic evaluation and be carefully evaluated for dysplasia and variants of SCC associated with increased risk of intraocular invasion. Undetected ocular surface squamous neoplasia may give rise to potentially vision- and eye-threatening invasive corneal SCC.Ocul Oncol Pathol 2018;4:240-249 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - January 18, 2018 Category: Opthalmology Source Type: research
Successive Uveal Melanomas with Different Gene Expression Profiles in an Eye with Ocular Melanocytosis
Ocular melanocytosis portends a higher risk of uveal melanoma. Multifocal uveal melanoma has been described previously and has been associated with ocular melanocytosis. Historically, histopathology has been used to differentiate tumors; however, molecular profiling now allows for better prognostication and determination of metastatic risk. The present case describes a patient with ocular melanocytosis who developed two sequential uveal melanomas in the same eye separated by 4 years. The uveal melanoma-specific gene expression profile (GEP) testing for the first tumor was class 1A and the second tumor was class 2. While th...
Source: Ocular Oncology and Pathology - January 16, 2018 Category: Opthalmology Source Type: research
Primary Cutaneous Angiosarcoma of the Eyelid: A Diagnostic and Therapeutic Challenge
We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Foci of atypia were noted in the tumor, raising speculation of evolution into a more aggressive neoplasm, such as conventional angiosarcoma. The patient subsequently underwent two additional wide resections with frozen section control of margins in an attempt to obtain...
Source: Ocular Oncology and Pathology - January 11, 2018 Category: Opthalmology Source Type: research
Late Apical Recurrence of Choroidal Melanoma 10 Years after Successful Treatment with Brachytherapy
Conclusion: Current literature suggests the majority of choroidal melanoma recurrences occur within 5 years following treatment. However, this case of recurrence 10 years after brachytherapy emphasizes the importance of life-long ophthalmic care for these patients. Additionally, this case demonstrates the possibility of a rare recurrence at a prior biopsy site.Ocul Oncol Pathol 2018;4:225-229 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - December 21, 2017 Category: Opthalmology Source Type: research
Rapidly Progressive, Isolated Subretinal Leukemic Relapse: A Case Report
Conclusion: Retinal detachment in any patient with a history of leukemia should raise the possibility of relapse and may warrant aspiration/biopsy if other means of diagnosing relapse are inconclusive. Subretinal infiltrate may progress rapidly and prompt diagnosis is paramount to tailoring therapy and preserving vision.Ocul Oncol Pathol 2018;4:220-224 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - December 21, 2017 Category: Opthalmology Source Type: research
Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma
Conclusions: This case highlights the significance of considering SFT/HPC in the diagnosis of intraocular spindle cell tumors and the importance of STAT6 immunohistochemistry in the evaluation of such tumors.Ocul Oncol Pathol 2018;4:213-219 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - December 15, 2017 Category: Opthalmology Source Type: research
Optical Coherence Tomography: Clinicopathologic Correlations - The 2016 Gordon K. Klintworth Lecture
Conclusion: The meaningful interpretation of SD-OCT's striking visual imagery requires a firm foundation in ocular histology and pathology. The accuracy of interpretation can be improved by correlative studies that directly compare OCT and histopathology.Ocul Oncol Pathol 2018;4:203-212 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - December 15, 2017 Category: Opthalmology Source Type: research
