Elevated Choroidal Thickness and Central Serous Chorioretinopathy in the Fellow Eyes of Patients with Circumscribed Choroidal Hemangioma
Conclusion: In this pilot study, elevated CT was associated with a risk of developing CCH as well as CSCR in patients of varying ages. Patients diagnosed with CCH should be screened for CSCR in the fellow eye. Further exploration of this association may reveal useful clues about the biology of abnormally elevated choroidal hyperpermeability and its various clinical manifestations.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 20, 2018 Category: Opthalmology Source Type: research
Society News
Ocul Oncol Pathol 2018;4:199 –199 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 18, 2018 Category: Opthalmology Source Type: research
Insights from a Case of Vitreoretinal Lymphoma
Conclusions: The clinical features suggest that occlusion of the inferotemporal retinal arteriole prevented sub-RPE lymphomatous deposits and subsequent RPE atrophy in this area of vascular nonperfusion. This suggests that “primary” vitreoretinal lymphoma is secondary to hematogenous spread from systemic loci. This finding, together with the ocular tumor control achieved entirely by systemic therapy, indicates scope for studies investigating systemic treatment protocols, especially those including immune-modulator y agents.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 17, 2018 Category: Opthalmology Source Type: research
Two Uveal Melanomas in One Eye: A Choroidal Nevus Giving Rise to a Melanoma in an Eye with a Separate Large Choroidal Melanoma
Multifocal uveal melanomas are extremely rare. In this case report, we describe a patient with 2 independent uveal melanomas in the same eye. A 52-year-old woman presented with a large choroidal melanoma and a smaller ciliary body mass, clinically thought to be a nevus, in her left eye. Enucleated specimen showed 2 primary lesions that were anatomically separate. Lesion 1 was a melanoma and lesion 2 was a melanoma arising centrally from a nevus. Both lesions harbored GNAQ mutations. This patient had no family history of uveal melanomas or signs of ocular melanocytosis and was negative for the BAP1 mutation. This case demon...
Source: Ocular Oncology and Pathology - March 2, 2018 Category: Opthalmology Source Type: research
Optic Nerve Haemangioblastoma: Signs of Chronicity
Optic nerve haemangioblastomas remain exceedingly rare extrinsic tumours of the optic nerve, often associated with von Hippel-Lindau disease. The authors report a 25-year-old female with a slowly progressive unilateral optic nerve lesion, causing reduced vision and bilateral optic tract oedema. A diagnosis of optic nerve haemangioblastoma with piloid gliosis was made histologically after surgical resection. This is the first reported case of such dual pathology occurring in the optic nerve. The patient has been monitored without further adjuvant treatment, and has not had a recurrence to date, at 6 years of follow-up.Ocul ...
Source: Ocular Oncology and Pathology - February 23, 2018 Category: Opthalmology Source Type: research
Scleral Thinning after Transscleral Biopsy for Uveal Melanoma Using Lamellar Scleral Flap
Conclusions: Patients with scleral flaps created for biopsy of uveal melanoma are at risk for scleral thinning and extrascleral extension of tumor recurrence through the flap.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 23, 2018 Category: Opthalmology Source Type: research
Society News AAOOP
Ocul Oncol Pathol 2018;4:134 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 22, 2018 Category: Opthalmology Source Type: research
Primary Myoepithelial Carcinoma of the Conjunctiva
A 38-year-old female, otherwise fit and well, presented with a mass on her left medial bulbar conjunctiva that had been enlarging for several months. Examinations showed a fixed pinkish tumour, 9 mm in maximum extent, spanning from the plica to the medial limbus. The tumour was removed in toto. Histology revealed it to be a biphasic tumour composed of lobules and infiltrative cords within a sclerotic matrix. The cells were spindle-shaped to epithelioid, with nuclear atypia and occasional mitotic figures. The tumour was positive for smooth muscle actin, beta-catenin, and vimentin. All other markers of myoepithelial differen...
Source: Ocular Oncology and Pathology - February 21, 2018 Category: Opthalmology Source Type: research
The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma
Conclusion: In case 1, the uninflamed extracellular cholesterol crystalloids were associated with severely dysregulated systemic hyperlipidemia. In cases 2 and 3, the cholesterol granulomas were interpreted as a local manifestation of a cyst that might have partially ruptured and did not portend serious hyperlipidemia.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 21, 2018 Category: Opthalmology Source Type: research
Primary Extraskeletal Osteosarcoma Arising from the Optic Nerve: A Rare Case Report
We present the case of a 32-year-old female who presented with proptosis and complete loss of vision of the left eye. Contrast-enhanced computed tomography scan showed a densely calcified lobulated lesion in the left optic nerve showing strong enhancement. A left fronto-occipito-zygomatic osteotomy was conducted and a greyish brown tumor was identified. Histopathological and immunohistochemical examination of the curetted material revealed it to be extraskeletal osteosarcoma. A left partial maxillectomy with ethmoidectomy and left orbital exenteration was done and the patient was advised chemotherapy with radiotherapy.Ocul...
Source: Ocular Oncology and Pathology - February 15, 2018 Category: Opthalmology Source Type: research
Photodynamic Therapy for Circumscribed Choroidal Haemangioma in a Scottish Cohort
Conclusions: PDT is a safe and effective treatment for CCH which results in both structural and functional improvements, and these findings are particularly applicable to patients of Caucasian ethnicity. OCT provides a useful and readily available option to monitor CCH disease activity and its response to PDT.Ocul Oncol Pathol 2018;4:322 –330 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 15, 2018 Category: Opthalmology Source Type: research
Choroidal Lymphoma Discovered on Ultrasound in a Patient with Suspected Corneal Tumor
Conclusion: This is an unusual presentation of choroidal lymphoma in an eye with severe corneal opacification and scarring, and underscores the diagnostic value of ultrasonography in examination of eyes without view to the posterior segment.Ocul Oncol Pathol 2018;4:318 –321 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 15, 2018 Category: Opthalmology Source Type: research
Atypical Presentation of Bilateral Retinoblastoma with Floaters and Sub-Internal Limiting Membrane Seeds in an 11-Year-Old Asian Indian Male
Conclusion: Atypical manifestation of retinoblastoma can be seen in older children presenting with “floaters” and bilateral deposits of sub-ILM seeds, without solid tumor.Ocul Oncol Pathol 2018;4:309 –312 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 14, 2018 Category: Opthalmology Source Type: research
Conjunctival Dehiscence and Scleral Necrosis following Iodine-125 Plaque Brachytherapy for Uveal Melanoma: A Report of 3 Cases
Conclusions: While delayed corneoscleral necrosis following plaque brachytherapy has been previously reported, occurring many months to years after treatment, the 3 cases in this series presented within 2 –6 weeks in the postoperative period. While we were unable to identify a specific etiology, we believe this represents a distinct clinical entity of post-brachytherapy cornea-scleral necrosis that is important to recognize. Possible causes include acute radiation toxicity, mechanical trauma, and/o r conjunctival microinfection.Ocul Oncol Pathol 2018;4:291 –296 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 13, 2018 Category: Opthalmology Source Type: research
BAP1 Immunostaining in Uveal Melanoma: Potentials and Pitfalls
Ocul Oncol Pathol 2018;4:297 –297 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - February 13, 2018 Category: Opthalmology Source Type: research
