Ocular Pathology Recommendations during COVID-19 from the American Association of Ophthalmic Oncologists and Pathologists (AAOOP)
Ocul Oncol Pathol 2020;6:223 –224 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 21, 2020 Category: Opthalmology Source Type: research
Case Report with Review of the Literature: Uveal Melanoma in a Patient with Carney Complex – Another Rare Component of the Syndrome?
A 74-year-old woman with Carney complex (CNC) and complaints of poor vision was found, on ophthalmic examination, to have a pigmented tumor involving the peripheral choroid and ciliary body in her right eye. The eye was enucleated and showed a ciliochoroidal melanoma with marked pleomorphism. The tumor did not recur or metastasize after almost 10 years of follow-up, and the patient died of unrelated causes. Molecular studies revealed a complex genome with multiple whole-chromosome losses including monosomy of chromosomes 1, 2 (including loss ofCNC2at 2p16), 14, 17 (including loss of a copy ofPRAKA1 at 17q24.2), 18, 19, 21,...
Source: Ocular Oncology and Pathology - April 21, 2020 Category: Opthalmology Source Type: research
Considerations for the Management and Triage of Ocular Oncology Cases during the COVID-19 Pandemic
Ocul Oncol Pathol 2020;6:219 –222 (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 21, 2020 Category: Opthalmology Source Type: research
Villous Sebaceous Adenoma Arising from the Caruncular Surface Squamous Epithelium
A 68-year-old woman developed an asymptomatic left caruncular multilobular lesion over one year. Excision of the lesion displayed a benign sebaceous neoplasm taking origin from the surface squamous epithelium which invaginated into the stroma to create crypts resembling the conjunctival pseudoglands of Henle or the glands of Lieberkuhn of the small intestine. Scattered sebaceous cells were also discovered in the surface squamous epithelium. The cryptal walls spawned lateral sebaceous gland lobules that were adipophilin positive. p16 was positive in the surface epithelium, the cryptal walls, and in the basal cells of the se...
Source: Ocular Oncology and Pathology - March 10, 2020 Category: Opthalmology Source Type: research
Angiolymphoid Hyperplasia with Eosinophilia with Clinical Presentation Concerning for Juvenile Temporal Arteritis
A 20-year-old boy presented with a mass superotemporal to the right eyebrow of 1 month ’s duration without a history of recent trauma. Complete examination and workup, including laboratory analysis, Doppler ultrasound imaging, and magnetic resonance imaging, suggested a diagnosis of juvenile temporal arteritis. Excisional biopsy and histopathology contradicted the preoperative worku p and yielded the final diagnosis of angiolymphoid hyperplasia with eosinophilia, a rare eosinophilic dermatosis of unknown etiology. This case highlights the need for better characterization of temporal vascular tumors in the pediatric popul...
Source: Ocular Oncology and Pathology - June 28, 2019 Category: Opthalmology Source Type: research
Histopathologic Patterns of Recurrent Choroidal Melanoma Following I-125 Plaque Brachytherapy
Conclusion: Our observations provide a correlation between histopathologic and clinical patterns of local recurrence of choroidal melanoma after brachytherapy.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 18, 2019 Category: Opthalmology Source Type: research
Critical Diagnoses in Ophthalmic Pathology: Suspected Important Unanticipated Diagnoses in Surgically Removed Eyes
Conclusions: The proportion of critical diagnoses among surgically removed eyes is small, but not inconsequential. Some “critical alerts” would be unnecessary if relevant clinical information was provided when the tissue is submitted to the laboratory. Laboratory guidelines for critical values in surgical pathology should be flexible since they need to anticipate the vicissitudes of clinical practice. Surgeons ne ed to appreciate that relevant clinical information must be provided to pathologists because it can play a role in formulating anatomic diagnoses.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 12, 2019 Category: Opthalmology Source Type: research
3D Wrap < sup > TM < /sup > Ultra-Widefield Reconstruction in Stereotactic Radiosurgery for Choroidal Melanoma
Choroidal melanoma (CM) is the most commonly diagnosed primary intraocular malignancy in adults. Gamma knife radiosurgery (GKR) has demonstrated reliable results in the treatment of CM, but it is limited by the risk of radiation-induced ocular complications. To optimize the dose of radiation focused on the tumor, and limit side effects, the eye should be properly immobilized before treatment. A recently released ultra-widefield imaging instrument (Optomap California; Optos, Dunfermline, Scotland, UK) allows for an interactive three-dimensional (3D) virtual reconstruction of the globe, called 3D WrapTM. The authors share th...
Source: Ocular Oncology and Pathology - June 12, 2019 Category: Opthalmology Source Type: research
Concomitant Orbital Tumours: Small Lymphocytic Lymphoma Involving the Lacrimal Gland of a Patient with Clinical Diagnoses of Muir-Torre Syndrome and Extensive Sebaceous Gland Carcinoma of the Ipsilateral Eyelid
Conclusion: We report for the first time a case of a patient with Muir-Torre syndrome who developed an orbital recurrent SC with an incidental finding of a lacrimal gland B non-Hodgkin lymphoma consistent with SLL. Clinicians should be aware of the possibility of this coexistence of multiple cancer types in patients with sebaceous carcinoma and Muir-Torre syndrome.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 5, 2019 Category: Opthalmology Source Type: research
Intra-Arterial Chemotherapy for Retinoblastoma: Four-Year Results from Tertiary Center in India
Conclusion: IAC has enhanced globe salvage rates in eyes with RB. Multicenter studies with longer follow-up are necessary to better understand outcomes in the long term.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 4, 2019 Category: Opthalmology Source Type: research
< b > < i > BAP1 < /i > < /b > Germline Mutation Associated with Bilateral Primary Uveal Melanoma
Conclusion: Bilateral uveal melanoma is exceedingly rare. Patients with bilateral uveal melanoma, especially when coincident with remote systemic cancers or a family history of cancer, should be evaluated for germlineBAP1 mutation. Lifelong monitoring for related systemic malignancies is advised.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - June 4, 2019 Category: Opthalmology Source Type: research
Fundus Autofluorescence Change as an Early Indicator of Treatment Effect of Brachytherapy for Choroidal Melanomas
Conclusion: The effect of106Ru plaque treatment on fundus UW imaging is detected as homogenous and well-demarcated hyperautofluorescence before visible RPE atrophy.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - May 17, 2019 Category: Opthalmology Source Type: research
Understanding and Classification of Ocular Lymphomas
Background: Lymphomas that involve the tissues of the ocular adnexae and the eye itself can be confusing for both the new and seasoned learner alike. In this review, I present a simple way of classifying these disorders that will help to facilitate understanding of these myriad entities.Summary: Classifications of lymphomas have changed significantly over the last 40 years, but in recent decades, the basic structure of the WHO classification has remained the same, facilitating understanding.Key Messages: The ocular lymphomas can be divided into those that are external to the eye (ocular adnexae) and those that are internal...
Source: Ocular Oncology and Pathology - May 16, 2019 Category: Opthalmology Source Type: research
Multimodal Imaging and Histopathological Evaluation of Berger ’s Space
Conclusions: Berger ’s space is an actual space in pathological conditions and can be an important site of pathology. Additionally, to our knowledge, this is the first time that Berger’s space has been documented by anterior segment OCT in a clinical setting.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - May 14, 2019 Category: Opthalmology Source Type: research
Histopathologic Analysis of Explanted KAMRA Corneal Inlays Demonstrating Adherent Fibroconnective Tissue Scar Formation
Conclusions: Corneal inlay implantation can lead to the formation of an adherent fibroconnective tissue membrane, suggesting keratocyte-to-myofibroblast transdifferentiation and reactive fibroconnective tissue scar formation that could potentially impact visual potential. Prospective patients should be counseled regarding the risk of this complication, as this may be associated with some risk of incomplete reversibility of the procedure.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - April 17, 2019 Category: Opthalmology Source Type: research
